Proline supplier | CasNO.344-25-2

Name
D-Pyrrolidine-2-carboxylic acid
EINECS 206-452-7
CAS No. 344-25-2
Article Data44
CAS DataBase
Density 1.186 g/cm³
Solubility Soluble in water
Melting Point 223 °C (dec.)(lit.)
Formula C₅H₉NO₂
Boiling Point 252.2 °C at 760 mmHg
Molecular Weight 225.168
Flash Point 106.3 °C
Transport Information
Appearance White to off-white powder
Safety 22-24/25-36/37/39-26
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms D-Prolin;(R)-pyrrolidine-2-carboxylic acid;D-Proline;(2R)-pyrrolidine-2-carboxylic acid;H-D-Pro-OH;D-(+)-Proline; D-Pyrrolidine-2-carboxylic acid;D-(+)-proline;D-Pyrrolidine-2-carboxylic acid;D-Proline (Food Grade);
PSA 49.33000
LogP 0.15180

Synthetic route

: 6404-31-5
Z-D-proline

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol under 760 Torr; for 5h;	96%

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With potassium permanganate In water at 15 - 20℃; Concentration;	95.65%

: (R)-1-(benzyloxycarbonyl)-2,5-dihydro-1H-pyrrole-2-carboxylic acid

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With hydrogen; palladium(II) hydroxide In tetrahydrofuran; methanol at 20℃; for 3h;	83%
With hydrogen; palladium(II) hydroxide In tetrahydrofuran; methanol at 20℃; for 3h;	83%

: 3,4-dihydro-2H-pyrrole-2-carboxylic acid; hydrochloride

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol	77%

: 143492-63-1
(R)-N-(3,5-dinitrobenzoyl)proline

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With hydrogenchloride
With hydrogenchloride

: 119838-25-4
(2R,5R)-2-t-butyl-1-t-butyloxycarbonyl-5-(3-chloropropyl)-3-methyl-4-imidazolidinone

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
Yield given. Multistep reaction;

: 126147-98-6
(2S,3S)-2,3-Dihydroxy-succinic acid; compound with (R)-pyrrolidine-2-carboxylic acid

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With ammonium hydroxide 1.) methanol, 0.5 h; Yield given. Multistep reaction;

: 96293-17-3, 105024-93-9, 105112-33-2
(S)-N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide

: 107-02-8
acrolein

A: 147-85-3
L-proline

B: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With sodium tetrahydroborate; triethylamine; nickel(II) nitrate Yield given. Multistep reaction. Yields of byproduct given;

...Expand

L-ornithine-dihydrochloride: L-ornithine-dihydrochloride

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With hydrogenchloride; nitrosylchloride Erhitzen des Reaktionsprodukts mit wss. Ba(OH)2;

N-<3-nitro-benzoyl>-dl-proline: N-<3-nitro-benzoyl>-dl-proline

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With Cinchonin

: 107-02-8
acrolein

nickel(II) complex of the Schiff's base derived from (S)-o-<(N-benzylprolyl)amino>benzophenone and glycine: nickel(II) complex of the Schiff's base derived from (S)-o-<(N-benzylprolyl)amino>benzophenone and glycine

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With hydrogenchloride; sodium cyanoborohydride; triethylamine 1.) MeOH, 60 deg C; 2.) EtOH, 80 deg C; 3.) MeOH, r.t., 24 h; Yield given. Multistep reaction;

: 107-02-8
acrolein

Complex (1): Complex (1)

A: 96293-17-3, 105024-93-9, 105112-33-2
(S)-N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide

B: 147-85-3
L-proline

C: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With sodium tetrahydroborate; triethylamine 1.) MeOH, -10 deg C, 2.) water, 25 deg C; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 746639-86-1
N-benzyloxycarbonyl-L-phenylalanyl-D-proline

A: 1161-13-3
N-Cbz-L-Phe

B: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With hydrogenchloride; carboxypeptisae-A In water at 37℃; pH=6.5; Enzyme kinetics; Kinetics; Further Variations:; Reagents;

: (R)-2-Amino-5-oxo-pentanoic acid

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. HCl / Heating 2: 77 percent / H2 / Pd/C / methanol View Scheme

: (RS,R)-(-)-(N-p-toluenesulfinyl)-2-amino-5,5-dimethoxypentanonitrile

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aq. HCl / Heating 2: aq. HCl / Heating 3: 77 percent / H2 / Pd/C / methanol View Scheme

: 136963-32-1
methyl 2,3-dideoxy-5,6-O-isopropylidene-4-O-p-tolylsulfonyl-D-erythro-hexonate

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: 91 percent / NaN3 / dimethylformamide / 12 h / 100 °C 2: 82 percent / DIBAL / light petroleum; toluene; hexane / 1 h / -78 °C 3: 76 percent / H2 / 10percent Pd/C / methanol / 7 h / 760 Torr / Ambient temperature 4: 82 percent / NaHCO3 / aq. ethanol 5: 95 percent / 80percent aq. AcOH / 120 h / Ambient temperature 6: 79 percent / aq. NaIO4 / methanol / 2 h 7: 88 percent / aq. NaClO2, Na2HPO4 / various solvent(s) / 1 h 8: 96 percent / H2 / 10percent Pd/C / methanol / 5 h / 760 Torr View Scheme

Yield

Multi-step reaction with 8 steps
1: 91 percent / NaN3 / dimethylformamide / 12 h / 100 °C
2: 82 percent / DIBAL / light petroleum; toluene; hexane / 1 h / -78 °C
3: 76 percent / H2 / 10percent Pd/C / methanol / 7 h / 760 Torr / Ambient temperature
4: 82 percent / NaHCO3 / aq. ethanol
5: 95 percent / 80percent aq. AcOH / 120 h / Ambient temperature
6: 79 percent / aq. NaIO4 / methanol / 2 h
7: 88 percent / aq. NaClO2, Na2HPO4 / various solvent(s) / 1 h
8: 96 percent / H2 / 10percent Pd/C / methanol / 5 h / 760 Torr
View Scheme

: 50463-82-6, 71461-30-8, 105706-84-1, 143393-11-7
(2R)-(+)-phenylmethyl 2-formylpyrrolidine-1-carboxylate

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 88 percent / aq. NaClO2, Na2HPO4 / various solvent(s) / 1 h 2: 96 percent / H2 / 10percent Pd/C / methanol / 5 h / 760 Torr View Scheme

: 200499-55-4
(R)-2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]pyrrolidine

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 82 percent / NaHCO3 / aq. ethanol 2: 95 percent / 80percent aq. AcOH / 120 h / Ambient temperature 3: 79 percent / aq. NaIO4 / methanol / 2 h 4: 88 percent / aq. NaClO2, Na2HPO4 / various solvent(s) / 1 h 5: 96 percent / H2 / 10percent Pd/C / methanol / 5 h / 760 Torr View Scheme

: 200499-54-3
(R)-4-Azido-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butyraldehyde

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 76 percent / H2 / 10percent Pd/C / methanol / 7 h / 760 Torr / Ambient temperature 2: 82 percent / NaHCO3 / aq. ethanol 3: 95 percent / 80percent aq. AcOH / 120 h / Ambient temperature 4: 79 percent / aq. NaIO4 / methanol / 2 h 5: 88 percent / aq. NaClO2, Na2HPO4 / various solvent(s) / 1 h 6: 96 percent / H2 / 10percent Pd/C / methanol / 5 h / 760 Torr View Scheme

Yield

Multi-step reaction with 6 steps
1: 76 percent / H2 / 10percent Pd/C / methanol / 7 h / 760 Torr / Ambient temperature
2: 82 percent / NaHCO3 / aq. ethanol
3: 95 percent / 80percent aq. AcOH / 120 h / Ambient temperature
4: 79 percent / aq. NaIO4 / methanol / 2 h
5: 88 percent / aq. NaClO2, Na2HPO4 / various solvent(s) / 1 h
6: 96 percent / H2 / 10percent Pd/C / methanol / 5 h / 760 Torr
View Scheme

: 200499-58-7
(R)-1-benzyloxycarbonyl-2-[(S)-1,2-dihydroxyethyl]pyrrolidine

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 79 percent / aq. NaIO4 / methanol / 2 h 2: 88 percent / aq. NaClO2, Na2HPO4 / various solvent(s) / 1 h 3: 96 percent / H2 / 10percent Pd/C / methanol / 5 h / 760 Torr View Scheme

: 200499-52-1
(R)-4-Azido-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-butyric acid methyl ester

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 82 percent / DIBAL / light petroleum; toluene; hexane / 1 h / -78 °C 2: 76 percent / H2 / 10percent Pd/C / methanol / 7 h / 760 Torr / Ambient temperature 3: 82 percent / NaHCO3 / aq. ethanol 4: 95 percent / 80percent aq. AcOH / 120 h / Ambient temperature 5: 79 percent / aq. NaIO4 / methanol / 2 h 6: 88 percent / aq. NaClO2, Na2HPO4 / various solvent(s) / 1 h 7: 96 percent / H2 / 10percent Pd/C / methanol / 5 h / 760 Torr View Scheme

Yield

Multi-step reaction with 7 steps
1: 82 percent / DIBAL / light petroleum; toluene; hexane / 1 h / -78 °C
2: 76 percent / H2 / 10percent Pd/C / methanol / 7 h / 760 Torr / Ambient temperature
3: 82 percent / NaHCO3 / aq. ethanol
4: 95 percent / 80percent aq. AcOH / 120 h / Ambient temperature
5: 79 percent / aq. NaIO4 / methanol / 2 h
6: 88 percent / aq. NaClO2, Na2HPO4 / various solvent(s) / 1 h
7: 96 percent / H2 / 10percent Pd/C / methanol / 5 h / 760 Torr
View Scheme

: 200499-57-6
(2R,4'S)-N-Benzyloxycarbonyl-2-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)pyrrolidine

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 95 percent / 80percent aq. AcOH / 120 h / Ambient temperature 2: 79 percent / aq. NaIO4 / methanol / 2 h 3: 88 percent / aq. NaClO2, Na2HPO4 / various solvent(s) / 1 h 4: 96 percent / H2 / 10percent Pd/C / methanol / 5 h / 760 Torr View Scheme

: 99989-76-1, 143492-62-0
1-(3,5-dinitro-benzoyl)-DL-proline

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: brucine; acetone 2: aqueous HCl View Scheme

Co2 (CO)8: Co2 (CO)8

: 23105-58-0
N-[(methyl)carbonyl]-2-pyrroline

: 4128-31-8
rac-octan-2-ol

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With pyridine; H2; CO In tetrahydrofuran; hydrogenchloride

...Expand

: 23105-58-0
N-[(methyl)carbonyl]-2-pyrroline

: 4128-31-8
rac-octan-2-ol

: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With pyridine; H2; CO; Co2(CO)8 In tetrahydrofuran; hydrogenchloride

: 609-36-9
rac-Pro-OH

A: 147-85-3
L-proline

B: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With C24H29CoN2O4 In dichloromethane; water at 10℃; for 24h; Resolution of racemate; optical yield given as %ee;
Stage #1: rac-Pro-OH With C24H29CoN2O4 In dichloromethane; water at 10℃; for 24h; Resolution of racemate; Stage #2: With sodium dithionite In dichloromethane; water for 5h; Resolution of racemate; optical yield given as %ee;
With shaking calcined L-Pro chiral ordered mesoporous silica Resolution of racemate;

: 2-hydroxymethylpyrrolidinium trifluoroacetate

A: 147-85-3
L-proline

B: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With potassium permanganate; sulfuric acid In water at 0 - 20℃; optical yield given as %ee;

: 1281970-89-5
Glu-Gln-Arg-Pro-Arg

A: 56-86-0
L-glutamic acid

B: 74-79-3
L-arginine

C: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With hydrogenchloride; water at 150℃; for 12h;

...Expand

: 1334149-95-9
apratoxin S5

A: 3913-67-5
N-methylalanine

B: 4125-98-8
N-methyl-L-isoleucine

C: 6230-11-1
O-Methyltyrosine

D: 344-25-2
D-Prolin

Conditions

Conditions	Yield
With hydrogenchloride; water at 110℃; for 24h;

...Expand

: 67-56-1
methanol

: 344-25-2
D-Prolin

: 2133-40-6
D-proline methyl ester hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 0℃; for 2h;	100%
With thionyl chloride Reflux;	97%
In dimethyl sulfoxide at 10 - 80℃; for 2h;	88%

: 3282-30-2
pivaloyl chloride

: 344-25-2
D-Prolin

: 145612-92-6
ButCO-D-Pro-OH

Conditions

Conditions	Yield
With sodium hydroxide	100%

: 501-53-1
benzyl chloroformate

: 344-25-2
D-Prolin

: 6404-31-5
Z-D-proline

Conditions

Conditions	Yield
With sodium hydroxide In water; toluene at 20℃; for 1h; Inert atmosphere;	100%
With sodium hydroxide In water at 0 - 20℃;	93%
With sodium hydroxide In water Ambient temperature;

: 67-56-1
methanol

: 344-25-2
D-Prolin

: 874964-22-4
methyl (3R)-pyrrolidine-3-carboxylate hydrochloride

Conditions

Conditions	Yield
With thionyl chloride at 20℃; for 16.5h;	100%

: 344-25-2
D-Prolin

: 2133-40-6
D-proline methyl ester hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In methanol Reflux;	100%

: cadmium(II) nitrate tetrhydrate

: 344-25-2
D-Prolin

: Cd[D-proline]2

Conditions

Conditions	Yield
With triethylamine In methanol at 20℃; for 1h;	100%

: 344-25-2
D-Prolin

: 920-46-7
Methacryloyl chloride

: 106089-24-1
(2R)-1-methacryloylpyrrolidin-2-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide In acetone at 0℃; for 0.5h;	99%
With sodium hydroxide In tetrahydrofuran; acetone at 5 - 20℃; for 3h; pH=11 - 12; Cooling with ice;	83.8%
With sodium hydroxide In acetone at 20℃; for 4h; pH=10.3;	81%

: 344-25-2
D-Prolin

: 147-85-3
L-proline

Conditions

Conditions	Yield
With porcine kidney D-amino acid oxidase (EC 1.4.3.3.); sodium cyanoborohydride; flavin adenine dinucleotide In phosphate buffer at 37℃;	99%

: 1481-27-2
4-Fluoro-2-hydroxyacetophenone

: 344-25-2
D-Prolin

: 1305325-82-9
(R)-1-(4-acetyl-3-hydroxyphenyl)pyrrolidine-2-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 95℃; for 2.5h;	99%

: 112-16-3
n-dodecanoyl chloride

: 344-25-2
D-Prolin

: 1248347-91-2
N-lauroyl-D-proline

Conditions

Conditions	Yield
Stage #1: D-Prolin With pyridine; chloro-trimethyl-silane In dichloromethane for 1.16667h; Stage #2: n-dodecanoyl chloride In dichloromethane at 0 - 20℃; for 1.83333h;	99%

: 24424-99-5
di-tert-butyl dicarbonate

: 344-25-2
D-Prolin

: 37784-17-1
N-(tert-butoxycarbonyl)-D-proline

Conditions

Conditions	Yield
With triethylamine	98%
With triethylamine In dichloromethane at 25 - 30℃;	97%
Stage #1: D-Prolin With sodium hydrogencarbonate In 1,4-dioxane; water at 20℃; for 0.5h; Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 0 - 20℃;	95%

: 123-72-8
butyraldehyde

: 344-25-2
D-Prolin

: (R)-1-butylpyrrolidine-2-carboxylic acid

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; under 3750.38 Torr; for 5h; Inert atmosphere;	98%

: 344-25-2
D-Prolin

: 42022-03-7
N-nitroso-D-proline

Conditions

Conditions	Yield
With 3,3-dimethyl-2-nitroso-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide In dichloromethane at 20℃; Sealed tube;	98%

: 14518-69-5
tetra-n-butylphosphonium hydroxide

: 344-25-2
D-Prolin

: tetrabutylphosphonium (S)-(+)-prolinate

Conditions

Conditions	Yield
In water at 20℃; for 2h;	97%

: Λ-[Ir(2-phenylquinoline)2(MeCN)2](PF6)

: 344-25-2
D-Prolin

: Λ-[Ir(2-phenylquinoline)2(D-proline)]

Conditions

Conditions	Yield
With sodium methylate In methanol at 20℃; for 12h; Darkness;	97%
With sodium methylate In methanol at 50℃; for 24h; Inert atmosphere; diastereoselective reaction;

: 85-46-1
1-Naphthalenesulfonyl chloride

: 344-25-2
D-Prolin

: 126522-72-3
(R)-1-(naphthalen-1-ylsulfonyl)pyrrolidine-2-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran at 50℃; for 5h;	96.2%

: 541-41-3
chloroformic acid ethyl ester

: 344-25-2
D-Prolin

: 175725-27-6
(R)-1-ethoxycarbonylprolin

Conditions

Conditions	Yield
With sodium carbonate In tetrahydrofuran; water at 0 - 20℃; for 3.75h;	96%
With potassium carbonate In water 1) 0 deg C, 1 h, 2) r.t., 2 h; Yield given;
Stage #1: chloroformic acid ethyl ester; D-Prolin With sodium hydroxide; water at 0 - 20℃; pH=9 - 10; Stage #2: With hydrogenchloride; water at 0℃; pH=1;

: 118-48-9
isatoic anhydride

: 344-25-2
D-Prolin

: 154802-75-2
(11aS)-2,3,5,10,11,11a-hexahydro-1H-pyrrolo<2,1-c><1,4>benzodiazepin-5,11-dione

Conditions

Conditions	Yield
In dimethyl sulfoxide at 180℃; Condensation;	96%
In dimethyl sulfoxide at 150℃; for 2h; Inert atmosphere;	82%
In dimethyl sulfoxide at 100℃; for 5h;	81%

: 50-00-0
formaldehyd

: 344-25-2
D-Prolin

: 475-11-6, 58123-62-9, 68078-09-1
N-methyl-D-proline

Conditions

Conditions	Yield
Stage #1: formaldehyd; D-Prolin Stage #2: With hydrogen	96%
With hydrogen; palladium 10% on activated carbon In methanol under 775.743 Torr; for 18h;	96%
With hydrogen; palladium 10% on activated carbon In methanol under 775.743 Torr; for 18h;	96%

: 1972-08-3
dronabinol

: 344-25-2
D-Prolin

: C21H30O2*C5H9NO2

Conditions

Conditions	Yield
In n-heptane at 20℃; for 48h; Inert atmosphere;	96%

: 616-42-2
dimethylsulfite

: 104-15-4
toluene-4-sulfonic acid

: 344-25-2
D-Prolin

: 104848-85-3
(D)-proline, methyl ester, tosylate salt

Conditions

Conditions	Yield
In diethyl ether at 90℃; for 7h;	95%

...Expand

: 3434-04-6
2-(2-bromobenzyloxy)aniline

: 344-25-2
D-Prolin

: 4693-91-8
4-methoxyphenyl-acetic chloride

: (R)-1-[(4-methoxyphenyl)acetyl]pyrrolidine-2-carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide In water; acetone	95%

...Expand

: 1085704-41-1
2-(3-fluoro-6-nitrophenyl)benzothiazole

: 344-25-2
D-Prolin

: (2R)-1-[3-(1,3-benzothiazol-2-yl)-4-nitrophenyl]pyrrolidine-2-carboxylic acid

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran; water for 16h; Reflux;	95%

: 79-04-9
chloroacetyl chloride

: 344-25-2
D-Prolin

: 23500-11-0
1-(2-chloroacetyl)proline

Conditions

Conditions	Yield
With dmap at 20℃; for 5.16667h; Reagent/catalyst;	94.8%

: tetrabutylammonium hydroxide triacontahydrate

: 344-25-2
D-Prolin

: 1198400-65-5
tetrabutylammonium (R)-prolinate

Conditions

Conditions	Yield
In water at 100℃; for 65h;	94%

: 14518-69-5
tetra-n-butylphosphonium hydroxide

: 344-25-2
D-Prolin

: tetrabutylphosphonium (R)-(-)-prolinate

Conditions

Conditions	Yield
In water at 100℃; for 24h;	94%

: 2899-60-7
Cbz-Gly-ONSuc

: 23150-65-4
L-glutamic dimethyl ester hydrochloride

: 344-25-2
D-Prolin

: dimethyl N-(benzyloxycarbonyl)glycyl-D-prolyl-L-glutamate

Conditions

Yield

Stage #1: Cbz-Gly-ONSuc; D-Prolin With N-ethyl-N,N-diisopropylamine In ethyl acetate for 12h; Inert atmosphere; Green chemistry;
Stage #2: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In ethyl acetate for 0.5h; Inert atmosphere; Green chemistry;
Stage #3: L-glutamic dimethyl ester hydrochloride In ethyl acetate for 1h; Inert atmosphere; Green chemistry; chemoselective reaction;

94%

...Expand

: 2386-60-9
perfluoro-1-butanesulfonyl fluoride

: 344-25-2
D-Prolin

: 910481-82-2
(R)-1-(butylsulfonyl)pyrrolidine-2-carboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In tetrahydrofuran at 50℃; for 5h;	93.1%

Proline Chemical Properties

Molecular Structure of D-Proline (CAS NO.344-25-2):

IUPAC Name: (2R)-pyrrolidin-1-ium-2-carboxylate
Empirical Formula: C₅H₉NO₂
Molecular Weight: 115.1305
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 29.54 Å²
Index of Refraction: 1.487
Molar Refractivity: 27.9 cm³
Molar Volume: 96.9 cm³
Surface Tension: 43.4 dyne/cm
Density: 1.186 g/cm³
Flash Point: 106.3 °C
Enthalpy of Vaporization: 53.9 kJ/mol
Boiling Point: 252.2 °C at 760 mmHg
Vapour Pressure: 0.00615 mmHg at 25°C
EINECS: 206-452-7
Melting point:223 °C (dec.)(lit.)
Alpha: 84.75 ^o (C=4, H₂O)
Refractive index: 85 ° (C=4, H₂O)
Storage temp: Store at RT
Water Solubility: soluble >1000 g/L (20 ^oC)
Melting point: 223 °C (dec.)(lit.)
Product Categories: Amino Acids series; Miscellaneous Biochemicals; Proline [Pro, P]; Amino Acids and Derivatives; alpha-Amino Acids; Amino Acids;Biochemistry; Amino Acids and Derivatives

Proline Uses

D-Proline (CAS NO.344-25-2) is used as synthesizing the drugs.

Proline Safety Profile

Hazard Codes of D-Proline (CAS NO.344-25-2): Irritant Xi, Harmful Xn
Risk Statements: 22-36/37/38
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36/37/39-26
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
F: 3-10
Hazard Note: Irritant

Proline Specification

D-Proline , with CAS number of 344-25-2, can be called (2R)-2-Pyrrolidinecarboxylic acid ; (R)-(+)-Proline ; (+)-(R)-Proline ; (R)-Proline ; (R)-Pyrrolidine-2-carboxylic acid ; D-(+)-Proline; D-Pyrrolidine-2-carboxylic acid ; (R)-pyrrolidine-2-carboxylic acid . It is a white to off-white powder.

Product Name

D-Pyrrolidine-2-carboxylic acid

Synthetic route

Proline Chemical Properties

Proline Uses

Proline Safety Profile

Proline Specification

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