Product Name

  • Name

    12-DEOXYPHORBOL 13-ACETATE

  • EINECS
  • CAS No. 60857-08-1
  • Article Data4
  • CAS DataBase
  • Density 1.31 g/cm3
  • Solubility Soluble in DMSO or 100% ethanol
  • Melting Point 216-219℃
  • Formula C22H30O6
  • Boiling Point 550.5 ºC at 760 mmHg
  • Molecular Weight 390.477
  • Flash Point 188.7 ºC
  • Transport Information
  • Appearance White to off-white powder.
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 60857-08-1 (12-DEOXYPHORBOL 13-ACETATE)
  • Hazard Symbols
  • Synonyms 5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one,9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-,[1aR-(1aa,1bb,4ab,7aa,7ba,8a,9aa)]-;12-Deoxyphorbol 13-acetate;13-O-Acetyl-12-deoxyphorbol;NSC 623310;SA 101A;Stillingia factorS7;5H-Cyclopropa[3,4]benz[1,2-e]azulen-5-one,9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-,(1aR,1bS,4aR,7aS,7bR,8R,9aS)-;
  • PSA 104.06000
  • LogP 1.53010

Prostratin Chemical Properties


IUPAC name: (1aR,1bS,4aR,7aS,7bR,8R,9aS)-4a,7b-Dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1,1a,1b,4,4a,5,7a,7b,8,9-decahydro-9aH-cyclopropa[3,4]benzo[1,2-e]azulen-9a-yl acetate
Molecular Weight: 390.47 [g/mol]
Molecular Formula: C22H30O6
XLogP3-AA: 0.7
H-Bond Donor: 3
H-Bond Acceptor: 6 
Index of Refraction: 1.599
Molar Refractivity: 101.62 cm3
Molar Volume: 297.1 cm3
Surface Tension: 57.9 dyne/cm
Density: 1.31 g/cm3
Flash Point: 188.7 °C
Enthalpy of Vaporization: 95.47 kJ/mol
Boiling Point: 550.5 °C at 760 mmHg
Vapour Pressure: 2.06E-14 mmHg at 25 °C
Product Categories of Prostratin (CAS NO.60857-08-1): Chiral Reagents; Intermediates & Fine Chemicals; Pharmaceuticals; Protein Kinase Inhibitors and Activators

Prostratin History

The antiviral activity of Prostratin (CAS NO.60857-08-1) was discovered during research on the traditional knowledge of Samoan healers by ethnobotanist Paul Alan Cox and a team at the U.S. National Cancer Institute. Samoan healers use the mamala tree to treat hepatitis. Research indicated that prostratin has potential to be useful in the treatment of HIV as it could flush viral reservoirs in latently infected CD4+ T-cells.

Prostratin Uses

 Prostratin (CAS NO.60857-08-1) is a protein kinase C activator found in the bark of the mamala tree of Samoa, Homalanthus nutans (Euphorbiaceae). Research indicated that prostratin has potential to be useful in the treatment of HIV as it flushes viral reservoirs in latently.

Prostratin Specification

  Prostratin (CAS NO.60857-08-1), its Synonyms are 6H-Cyclopropa(3,4)benz(1,2-e)azulen-6-one, 9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, (1aR,1bS,4aR,7aS,7bR,8R,9aS)- ; 6H-Cyclopropa(3,4)benz(1,2-e)azulen-6-one, 9a-(acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-, (1aR-(1aalpha,1bbeta,4abeta,7aalpha,8alpha,9aalpha))- .
 

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