quazepam
[3H]-2-Oxoquazepam
Conditions | Yield |
---|---|
With Hg(CH3COO)2 at 20℃; for 0.25h; pH 11.2 (Britton-Robinson buffer); 40percent DMF as solubilisator; | 100% |
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 10℃; | 50% |
mercaptoacetic acid
quazepam
Conditions | Yield |
---|---|
In benzene for 45h; Heating; | 42% |
IUPAC Name: 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-
The MF of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5) is C9H6N2S.
The MW of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5) is 174.22234.
Synonyms of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5): 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- ; 7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-1-(2,2, 2-trifluoroethyl)-2H-1,4-benzodiazepine-2-thione
Apperance: dichloromethane - hexane crystallization
Index of Refraction: 1.595
EINECS: 253-179-4
Density: 1.42 g/ml
Flash Point: 213.8 °C
Boiling Point: 429.9 °C
Melting Point: 137.5-139 °C
2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5) is benzodiazepine class with a typical anti-anxiety, anti-seizure and muscle relaxant effect and low toxicity. Used for a variety of insomnia.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LD | oral | > 1gm/kg (1000mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: ANALGESIA | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 1456, 1982. |
dog | LD | oral | > 1gm/kg (1000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987. | |
mouse | LD50 | intraperitoneal | 845mg/kg (845mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987. |
mouse | LDLo | oral | 5gm/kg (5000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 1456, 1982. | |
rat | LD50 | intraperitoneal | 2749mg/kg (2749mg/kg) | SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987. |
rat | LD50 | oral | > 5gm/kg (5000mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 37, Pg. 906, 1987. |
Safety information of 2H-1,4-Benzodiazepine-2-thione, 7-chloro-5- (2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)- (36735-22-5):
RIDADR 3249
HazardClass 6.1(b)
PackingGroup III
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