Product Name

  • Name

    Sodium aurothiomalate

  • EINECS 235-479-7
  • CAS No. 12244-57-4
  • Article Data1
  • CAS DataBase
  • Density
  • Solubility Very soluble in water. Practically insoluble in alcohol, ether
  • Melting Point
  • Formula C4H6 O4 S . Au . x Na
  • Boiling Point
  • Molecular Weight 368.096
  • Flash Point
  • Transport Information
  • Appearance
  • Safety Poison by subcutaneous and intramuscular routes. Moderately toxic by intravenous route. Human systemic effects: aggression, agranulocytosis, aplastic anemia, cell count changes, changes in circulation, cholestatic jaundice, dermatitis, encephalitis, fasciculations, flaccid paralysis without anesthesia, hemorrhage, hepatitis (hepatocellular necrosis), increased body temperature, interstitial fibrosis, muscle weakness, proteinuria, recording from peripheral motor nerve, depressed renal function tests, somnolence, structural changes in nerve sheath, thrombocytopenia, uncharacterized allergic reaction, changes in blood, teeth, and supporting structures. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic Na2O and SOx.
  • Risk Codes R20/21/22;R43   
  • Molecular Structure Molecular Structure of 12244-57-4 (Sodium aurothiomalate)
  • Hazard Symbols
  • Synonyms Butanedioicacid, mercapto-, monogold(1+) sodium salt (9CI);Aurolate;Aurothiomalate sodium;Chrysothios;Gold sodium thiomalate;Kidon;Miocrisina;Myochrysin;Myochrysine;Myocrisin;Shiosol;Sodium aurithiomalate;Sodium aurothiomalate;Tauredon;
  • PSA 105.56000
  • LogP -2.56010

Sodium aurothiomalate Chemical Properties

IUPAC Name: Disodium; gold(1+); 2-sulfidobutanedioate
CAS: 12244-57-4
Formula: C4H3AuNa2O4S
Molecular Weight: 390.08
The Molecular Structure of Disodium; gold(1+); 2-sulfidobutanedioate (CAS NO.12244-57-4):

Flash Point: 108.8 °C 
Enthalpy of Vaporization: 54.37 kJ/mol 
Boiling Point: 256.3 °C at 760 mmHg 
Vapour Pressure: 0.00475 mmHg at 25°C 
Product Categories: organic-metal salt.

Sodium aurothiomalate Toxicity Data With Reference

1.    

orl-man TDLo:5500 µg/kg:PNS,KID,BLD

     ARHEAW    Arthritis and Rheumatism. 19 (1976),936.
2.    

ims-wmn TDLo:182 µg/kg:SKN

     BMJOAE    British Medical Journal. 2 (1976),1294.
3.    

ivn-wmn TDLo:2700 µg/kg/4W-I:CNS

     JRHUA9    Journal of Rheumatology. 11 (1984),235.
4.    

ims-wmn TDLo:20 mg/kg/1Y:CNS,KID

     ARPAAQ    Archives of Pathology. 96 (1973),133.
5.    

ims-man TDLo:5 mg/kg/13W:BLD,MSK

     JAMAAP    JAMA, Journal of the American Medical Association. 133 (1947),754.
6.    

ims-wmn LDLo:600 µg/kg/1W-I:PUL,SYS

     JRSMD9    Journal of the Royal Society of Medicine. 77 (1984),960.
7.    

par-wmn TDLo:3366 µg/kg/2W:CNS,PNS

     NEURAI    Neurology. 20 (1970),455.
8.    

par-man TDLo:12,500 µg/kg/7W-I:CNS,PNS

     JRHUA9    Journal of Rheumatology. 11 (1984),233.
9.    

par-man TDLo:7857 µg/kg/11W-I:SKN

     BMJOAE    British Medical Journal. 286 (1983),1547.
10.    

unr-cld TDLo:11,900 µg/kg/18W-I:

     JRHUA9    Journal of Rheumatology. 13 (1986),224.
 

Sodium aurothiomalate Safety Profile

Poison by subcutaneous and intramuscular routes. Moderately toxic by intravenous route. Human systemic effects: aggression, agranulocytosis, aplastic anemia, cell count changes, changes in circulation, cholestatic jaundice, dermatitis, encephalitis, fasciculations, flaccid paralysis without anesthesia, hemorrhage, hepatitis (hepatocellular necrosis), increased body temperature, interstitial fibrosis, muscle weakness, proteinuria, recording from peripheral motor nerve, depressed renal function tests, somnolence, structural changes in nerve sheath, thrombocytopenia, uncharacterized allergic reaction, changes in blood, teeth, and supporting structures. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic Na2O and SOx.
Safety Information about Disodium; gold(1+); 2-sulfidobutanedioate (CAS NO.12244-57-4):
Hazard Codes: 
Xn:
Risk Statements about Disodium; gold(1+); 2-sulfidobutanedioate (CAS NO.12244-57-4):
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
R43: May cause sensitization by skin contact.
Safety Statements about Disodium; gold(1+); 2-sulfidobutanedioate (CAS NO.12244-57-4): 
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: MD5435000

Sodium aurothiomalate Specification

  Disodium ; gold(1+) ; 2-sulfidobutanedioate with CAS number of 12244-57-4 is also known as  ((1,2-Dicarboxyethyl)thio)golddisodiumsalt ; ((1,2-Dicarboxyethyl)thio)-goldisodiumsalt ; (dihydrogenmercaptosuccinato)golddisodiumsalt ; (Mercaptobutanedioato(1-))golddisodiumsalt ; Aurothiomaleatesodium ; Autm ; chrysothios ; disodiumaurothiomalate . It can be used for anti-inflammatory analgesic .

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