Sulconazole

The Sulconazole, with the CAS registry number 61318-90-9, is also known as 1H-Imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2, 4-dichlorophenyl)ethyl]-. This chemical's molecular formula is C₁₈H₁₅Cl₃N₂S and molecular weight is 397.75. What's more, its systematic name is 1-{2-[(4-Chlorobenzyl)sulfanyl]-2-(2, 4-dichlorophenyl)ethyl}-1H-imidazole. In addition, this chemical's classification codes are Anti-Infective Agents; Antifungal Agents.

Physical properties about Sulconazole are: (1)ACD/LogP: 5.66; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 4.57; (4)ACD/LogD (pH 7.4): 5.6; (5)ACD/BCF (pH 5.5): 966.44; (6)ACD/BCF (pH 7.4): 10221.92; (7)ACD/KOC (pH 5.5): 2347.21; (8)ACD/KOC (pH 7.4): 24826.18; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 6; (12)Polar Surface Area: 43.12 Å²; (13)Index of Refraction: 1.642; (14)Molar Refractivity: 106.47 cm³; (15)Molar Volume: 294.7 cm³; (16)Polarizability: 42.21×10^-24 cm³; (17)Surface Tension: 47.7 dyne/cm; (18)Density: 1.34 g/cm³; (19)Flash Point: 291.4 °C; (20)Enthalpy of Vaporization: 80.89 kJ/mol; (21)Boiling Point: 558.2 °C at 760 mmHg; (22)Vapour Pressure: 6.4E-12 mmHg at 25 °C.

Preparation of Sulconazole: this chemical is prepared by the intermediate of the preparation of Miconazole or Econazole.

Uses of Sulconazole: it can be used as broad-spectrum antifungal drugs. And it has good effection to trichophytes and candida albicans In addition, Sulconazole is available as a cream or solution to treat skin infections such as athlete's foot, ringworm, jock itch, and sun fungus.

You can still convert the following datas into molecular structure:
(1) SMILES: Clc1ccc(c(Cl)c1)C(SCc2ccc(Cl)cc2)Cn3ccnc3
(2) InChI: InChI=1/C18H15Cl3N2S/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
(3) InChIKey: AFNXATANNDIXLG-UHFFFAOYAQ