TETRAHYDROAMINOCRINE supplier

Name
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
EINECS
CAS No. 321-64-2
Article Data34
CAS DataBase
Density 1.195g/cm³
Solubility
Melting Point 183.5℃
Formula C13H14 N2
Boiling Point 409.4°Cat760mmHg
Molecular Weight 198.268
Flash Point 230.5°C
Transport Information
Appearance
Safety Poison by ingestion, intraperitoneal, and subcutaneous routes. Mutation data reported. Human systemic effects: changes in blood cell count, fatty degeneration, liver function tests impaired. When heated to decomposition it emits toxic fumes of NO_x.
Risk Codes R25;
Molecular Structure
Hazard Symbols T
Synonyms Acridine,9-amino-1,2,3,4-tetrahydro- (7CI,8CI); Acridine, 9-aminotetrahydro- (6CI);1,2,3,4-Tetrahydro-9-acridinamine; 1,2,3,4-Tetrahydro-9-aminoacridine;9-Amino-1,2,3,4-tetrahydroacridine; THA; Tacrine; Tetrahydroaminacrine;Tetrahydroaminocrin; Tetrahydroaminocrine
PSA 38.91000
LogP 3.27700

TETRAHYDROAMINOCRINE Chemical Properties

Product Name: Tetrahydroaminocrine (CAS NO.321-64-2)

Molecular Formula: C₁₃H₁₄N₂
Molecular Weight: 198.26g/mol
Mol File: 321-64-2.mol
Einecs: 206-291-2
Boiling point: 409.4 °C at 760 mmHg
Flash Point: 230.5 °C
Density: 1.195 g/cm³
Surface Tension: 57.7 dyne/cm
Enthalpy of Vaporization: 66.16 kJ/mol
Vapour Pressure: 6.49E-07 mmHg at 25°C
XLogP3: 2.7
H-Bond Donor: 1
H-Bond Acceptor: 2

TETRAHYDROAMINOCRINE Uses

Tetrahydroaminocrine (CAS NO.321-64-2) is the central nervous system activity of physostigmine esterase drugs. It is mainly used to treat Alzheimer's disease.

TETRAHYDROAMINOCRINE Production

Aniline and hydroxylamine and chloral hydrate reaction, and then sulfuric acid catalyzed cyclization of isatin, the yield was 63.4%. Isatin, excess hydroxylamine hydrochloride, sodium acetate trihydrate and water, stirring at 60 °C after sharp overnight at room temperature. Filtration, ethanol - water, recrystallization, may isatin -3 - oxime, yield 92%. Isatin -3 - oxime is heated to melt, severe decomposition of o-amino-benzonitrile, using ether dissolved in the collection. After the vacuum distillation ether distilled product, the yield of 86.8%, boiling point 112 ~ 114 °C / 0.8kPa, melting point 48 ~ 50 °C. O-amino-benzonitrile dissolved in cyclohexanone by adding equimolar zinc chloride anhydrous 2, stirring to return. Cooling and filtering, the solid washed with ether several times, hanging in the water. Plus 30% sodium hydroxide Xeon alkaline, extracted with dichloromethane. Extract washing, drying, concentrated, using toluene recrystallization, may slightly yellow crystalline flakes of tacrine, the yield was 92.6%.

TETRAHYDROAMINOCRINE Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	unreported	31mg/kg (31mg/kg)	BEHAVIORAL: EUPHORIA BEHAVIORAL: ANTIPSYCHOTIC	Pharmaceutical Chemistry Journal Vol. 8, Pg. 409, 1974.
man	TDLo	oral	176mg/kg/7W-I (176mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING LIVER: LIVER FUNCTION TESTS IMPAIRED	Australian and New Zealand Journal of Medicine. Vol. 20, Pg. 193, 1990.
mouse	LD50	intramuscular	29mg/kg (29mg/kg)		Drugs of the Future. Vol. 15, Pg. 126, 1990.
mouse	LD50	intraperitoneal	20mg/kg (20mg/kg)		Indian Journal of Pharmacology. Vol. 19, Pg. 44, 1987.
mouse	LD50	oral	39800ug/kg (39.8mg/kg)		Journal of Medicinal Chemistry. Vol. 31, Pg. 1278, 1988.
mouse	LD50	subcutaneous	25mg/kg (25mg/kg)		British Journal of Experimental Pathology. Vol. 28, Pg. 1, 1947.
rat	LD50	intramuscular	34mg/kg (34mg/kg)		Drugs of the Future. Vol. 15, Pg. 126, 1990.
rat	LD50	intraperitoneal	30mg/kg (30mg/kg)		Iugoslavica Physiologica et Pharmacologica Acta. Vol. 3, Pg. 43, 1967.
rat	LD50	oral	70mg/kg (70mg/kg)		Journal of Medicinal Chemistry. Vol. 38, Pg. 2802, 1995.
rat	LDLo	intravenous	20mg/kg (20mg/kg)		United States Patent Document. Vol. #5409948,
women	TDLo	oral	84mg/kg/6W-I (84mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" LIVER: LIVER FUNCTION TESTS IMPAIRED	Australian and New Zealand Journal of Medicine. Vol. 20, Pg. 193, 1990.
women	TDLo	oral	294mg/kg/14W- (294mg/kg)	LIVER: FATTY LIVER DEGERATION LIVER: LIVER FUNCTION TESTS IMPAIRED BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED)	Lancet. Vol. 1, Pg. 887, 1988.

TETRAHYDROAMINOCRINE Safety Profile

Poison by ingestion, intraperitoneal, and subcutaneous routes. Mutation data reported. Human systemic effects: changes in blood cell count, fatty degeneration, liver function tests impaired. When heated to decomposition it emits toxic fumes of NO_x.

TETRAHYDROAMINOCRINE Specification

Tetrahydroaminocrine ,its CAS NO. is 321-64-2,the synonyms is 1,2,3,4-Tetrahydro-5-aminoacridine ; 1,2,3,4-Tetrahydro-9-acridinamin ; 1,2,3,4-Tetrahydro-9-amino-acridin ; 1,2,3,4-Tetrahydro-9-aminoacridine ; 5-Amino-6,7,8,9-tetrahydroacridine ; Acridine, 1,2,3,4-tetrahydro-9-amino- ; Acridine, 9-amino-1,2,3,4-tetrahydro- ; Acridine, 9-aminotetrahydro- .

Product Name

1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE