TETRAHYDROHARMINE supplier | CasNO.40959-16-8

Name
7-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-beta-carboline hydrochloride (1:1)
EINECS
CAS No. 40959-16-8
Article Data1
CAS DataBase
Density g/cm³
Solubility
Melting Point
Formula C₁₃H₁₆N₂O•ClH
Boiling Point 399.2°Cat760mmHg
Molecular Weight 252.744
Flash Point 195.2°C
Transport Information
Appearance
Safety Poison by intraperitoneal and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NO_x and HCl.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms (+-)-7-Methoxy-1-methyl-2,3,4,9-tetrahydro-1H-β-carbolin, hydrochlorid;7-Methoxy-1-methyl-2,3,4,9-tetrahydro-1H-β-carboline;9H-PYRIDO(3,4-B)INDOLE, 1,2,3,4-TETRAHYDRO-7-METHOXY-1-METHYL-, HYDROCHLORIDE;hydrochloride;7-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride;(+-)-7-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-β-carboline, hydrochloride;
PSA 37.05000
LogP 3.51400

Synthetic route

: 534-15-6
1,1-dimethoxyethane

: 3610-36-4
2-(6-methoxy-1H-indol-3-yl)ethanamine

: 40959-16-8
7-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride

Conditions

Conditions	Yield
Stage #1: 1,1-dimethoxyethane; 2-(6-methoxy-1H-indol-3-yl)ethanamine With trifluoroacetic acid In 1,2-dichloro-ethane at 110℃; for 0.05h; Pictet-Spengler Synthesis; Sealed tube; Microwave irradiation; Stage #2: With hydrogenchloride In ethyl acetate at 20℃;	98%

: 40959-16-8
7-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole hydrochloride

: 442-51-3
harmine

Conditions

Conditions	Yield
With 5 mol% Pd/C; lithium carbonate In ethanol at 150℃; for 0.166667h; Sealed tube; Microwave irradiation;	99%

TETRAHYDROHARMINE Chemical Properties

Product Name: Tetrahydroharmine (CAS NO.40959-16-8)

Molecular Formula: C₁₃H₁₇ClN₂O
Molecular Weight: 252.7399 g/mol
Mol File: 40959-16-8.mol
Boiling point: 399.2 °C at 760 mmHg
Flash Point: 195.2 °C
Enthalpy of Vaporization: 64.99 kJ/mol
Vapour Pressure: 1.4E-06 mmHg at 25°C
H-Bond Donor: 3
H-Bond Acceptor: 2
Rotatable Bond Count: 1
Topological Polar Surface Area: 37.1
Heavy Atom Count: 17
Complexity: 258

TETRAHYDROHARMINE Uses

Some harmala alkaloids can be used as an MAOI (MonoAmine Oxidase Inhibitor) to facilitate the ingestion of DMT and other tryptamines; while not generally used as a hallucinogen alone, there are reports of such use. In high doses, it acts as purgative. Harmala alkaloids from Banisteriopsis caapi have been used to treat Parkinson's disease. Additionally, harmaline is used as a model for Essential Tremor (ET) when injected to animals. Rats being treated with harmaline exhibit severe tremors after 5-7 minutes.
It is important to note that unlike many synthetic pharmaceutical MAOIs such as phenelzine, harmine is reversible and selective meaning it does not have nearly as high a risk for the "cheese syndrome" caused by consuming tyramine-containing foods, which is a risk associated with monoamine oxidase A inhibitors, but not monoamine oxidase B inhibitors.

TETRAHYDROHARMINE Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
frog	LDLo	subcutaneous	270mg/kg (270mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Quarterly Journal of Pharmacy & Pharmacology. Vol. 3, Pg. 1, 1930.
guinea pig	LDLo	subcutaneous	120mg/kg (120mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT	Quarterly Journal of Pharmacy & Pharmacology. Vol. 3, Pg. 1, 1930.
mouse	LDLo	intraperitoneal	240mg/kg (240mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT	Quarterly Journal of Pharmacy & Pharmacology. Vol. 3, Pg. 1, 1930.
mouse	LDLo	subcutaneous	540mg/kg (540mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT	Quarterly Journal of Pharmacy & Pharmacology. Vol. 3, Pg. 1, 1930.
rabbit	LDLo	subcutaneous	320mg/kg (320mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Quarterly Journal of Pharmacy & Pharmacology. Vol. 3, Pg. 1, 1930.

TETRAHYDROHARMINE Safety Profile

Poison by intraperitoneal and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NO_x and HCl.

TETRAHYDROHARMINE Specification

Tetrahydroharmine,its CAS NO. is 40959-16-8,the synonyms is 9H-Pyrido(3,4-b)indole, 1,2,3,4-tetrahydro-7-methoxy-1-methyl-, hydrochloride .

Product Name

7-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-beta-carboline hydrochloride (1:1)