-
Name
Terfenadine
- EINECS 256-710-8
- CAS No. 50679-08-8
- Article Data13
- CAS DataBase
- Density 1.088 g/cm3
- Solubility Very slightly soluble in cold water
- Melting Point 145-152 °C
- Formula C32H41NO2
- Boiling Point 626.8 °C at 760 mmHg
- Molecular Weight 471.683
- Flash Point 306.9 °C
- Transport Information
- Appearance white solid
- Safety 24/25
- Risk Codes
-
Molecular Structure
- Hazard Symbols
- Synonyms Allerplus;Histadin;Histafen;MDL 9918;NSC 665802;Nebralin;Racemic terfenadine;Seldane;Teldane;Terdin;Terfex;Terfinax;Ternadin;Triludan;dl-Terfenadine;a-(p-tert-Butylphenyl)-4-(a-hydroxy-a-phenylbenzyl)-1-piperidinebutanol;Cyater;
- PSA 43.70000
- LogP 6.38370
Terfenadine Chemical Properties
IUPAC Name: 1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)Methyl]piperidin-
1-yl]butan-1-ol (256-710-8)
Synonyms: Alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol ; Terfenadine ; 1-(4-tert-butylphenyl)-4-(4-(alpha-hydroxybenzhydryl)piperidino)-Butan-1-ol ; 1-(4-tert-Butylphenyl)-4-(4-[hydroxy(diphenyl)methyl]-1-piperidinyl)-1-Butanol ; 1-(p-tert-butylphenyl)-4-(4’-(alpha-hydroxydiphenylmethyl)-1’-piperidyl)-Butan ; 1-Piperidinebutanol, alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)- ; 1-piperidinebutanol,alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmeth ; Aldaban
CAS: 50679-08-8
Molecular formula: C32H41NO2
Molecular weight: 471.67
Molecular structure: 
EINECS: 256-710-8
Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Histamine receptor
Mol File: 50679-08-8.mol
Surface Tension: 46.1 dyne/cm
Density: 1.088 g/cm3
Flash Point: 306.9 °C
Melting point: 145-152 °C
Enthalpy of Vaporization: 97.53 kJ/mol
Boiling Point: 626.8 °C at 760 mmHg
Vapour Pressure: 1.41E-16 mmHg at 25°C
Storage temp: 2-8°C
Water Solubility : 0.001 g/100 mL (30 ºC)
Appearance: Teldane (50679-08-8) is white solid .
Terfenadine Uses
Teldane (50679-08-8) belongs to antihistamines,and is used for allergic rhinitis, urticaria, allergic skin diseases.
Terfenadine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
| child | TDLo | oral | 3mg/kg (3mg/kg) | skin and appendages (skin): "dermatitis, other: after systemic exposure" | British Medical Journal. Vol. 293, Pg. 536, 1986. |
| dog | LD | oral | > 1500mg/kg (1500mg/kg) | gastrointestinal: nausea or vomiting | Oyo Yakuri. Pharmacometrics. Vol. 31, Pg. 845, 1986. |
| guinea pig | LD50 | oral | > 2gm/kg (2000mg/kg) | | Merck Index. Vol. 11, Pg. 1443, 1989. |
| human | TDLo | oral | 857ug/kg (0.857mg/kg) | behavioral: somnolence (general depressed activity) | European Journal of Clinical Pharmacology. Vol. 47, Pg. 331, 1994. |
| mammal (species unspecified) | LD50 | intraperitoneal | 43mg/kg (43mg/kg) | | Journal of Medicinal Chemistry. Vol. 38, Pg. 2472, 1995. |
| man | TDLo | oral | 857ug/kg (0.857mg/kg) | skin and appendages (skin): "dermatitis, other: after systemic exposure" | British Medical Journal. Vol. 293, Pg. 536, 1986. |
| man | TDLo | oral | 36mg/kg/3W-I (36mg/kg) | liver: "jaundice, cholestatic" | Lancet. Vol. 348, Pg. 552, 1996. |
| man | TDLo | oral | 156mg/kg/13W- (156mg/kg) | skin and appendages (skin): hair: other | British Medical Journal. Vol. 291, Pg. 940, 1985. |
| mouse | LD50 | intraperitoneal | 100mg/kg (100mg/kg) | | United States Patent Document. Vol. #4908365, |
| mouse | LD50 | oral | 5gm/kg (5000mg/kg) | | Pharmacy International. Vol. 4, Pg. 252, 1983. |
| mouse | LD50 | subcutaneous | > 4500mg/kg (4500mg/kg) | | Drugs in Japan Vol. -, Pg. 707, 1990. |
| rat | LD50 | intraperitoneal | 154mg/kg (154mg/kg) | | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990. |
| rat | LD50 | oral | 5gm/kg (5000mg/kg) | | Pharmacy International. Vol. 4, Pg. 252, 1983. |
| rat | LD50 | subcutaneous | > 1250mg/kg (1250mg/kg) | | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990. |
| women | TDLo | oral | 1200ug/kg (1.2mg/kg) | skin and appendages (skin): "dermatitis, other: after systemic exposure" | British Medical Journal. Vol. 293, Pg. 536, 1986. |
| women | TDLo | oral | 190mg/kg/23W- (190mg/kg) | behavioral: muscle weakness | Annals of Internal Medicine. Vol. 103, Pg. 634, 1985. |
Terfenadine Safety Profile
Safety Statements: 24/25
24/25: Teldane (50679-08-8) is toxic in contact with skin and if swallowed
WGK Germany: 2
RTECS: TM4969000
Terfenadine Specification
1.Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container.
2..Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
3.Storage: Store Teldane (50679-08-8) in a cool, dry place. Store in a tightly closed container.
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