Product Name

  • Name

    Tetrabenzyl pyrophosphate

  • EINECS 628-817-3
  • CAS No. 990-91-0
  • Article Data28
  • CAS DataBase
  • Density 1.289 g/cm3
  • Solubility Slightly soluble in water.
  • Melting Point 63-66 °C(lit.)
  • Formula C28H28O7P2
  • Boiling Point 601.6 °C at 760 mmHg
  • Molecular Weight 538.474
  • Flash Point 330.4 °C
  • Transport Information UN 3261 8/PG 2
  • Appearance
  • Safety 26-36/37/39-45
  • Risk Codes 34
  • Molecular Structure Molecular Structure of 990-91-0 (Tetrabenzyl pyrophosphate)
  • Hazard Symbols CorrosiveC
  • Synonyms Benzylpyrophosphate ([(C7H7O)2PO]2O) (7CI);Diphosphoric acid, tetrakis(phenylmethyl)ester (9CI);Pyrophosphoric acid, tetrabenzyl ester (8CI);Tetrabenzyldiphosphate;Tetrabenzyl pyrophosphate;Tetrabenzylpyrophosphate;
  • PSA 99.91000
  • LogP 8.08640

Synthetic route

phosphoric acid dibenzyl ester
1623-08-1

phosphoric acid dibenzyl ester

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In Isopropyl acetate at 0 - 6℃; for 1.5h; Inert atmosphere;96%
With N,N-dicyclohexylurea In toluene at 20℃; for 5h;95%
With dicyclohexyl-carbodiimide In Isopropyl acetate at 3℃; for 0.916667 - 1.08333h;91%
Dibenzyl phosphite
17176-77-1

Dibenzyl phosphite

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

Conditions
ConditionsYield
With N,N,N,N,-tetramethylethylenediamine; copper(ll) bromide In tetrahydrofuran at 25℃; for 15h;90%
With tetrachloromethane; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In toluene at 60℃; for 0.5h;88%
With N-chloro-succinimide; benzene anschliessendes Behandeln mit Phosphorsaeure-dibenzylester und Triaethylamin;
1.3-butanediol
18826-95-4, 107-88-0

1.3-butanediol

tribenzyl phosphite
15205-57-9

tribenzyl phosphite

A

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

B

dibenzyl hydrogen phosphite
538-60-3

dibenzyl hydrogen phosphite

C

3-(dibenzyl)phosphoryloxy-1-methyl-1-propanol
123417-01-6

3-(dibenzyl)phosphoryloxy-1-methyl-1-propanol

Conditions
ConditionsYield
Stage #1: tribenzyl phosphite With iodine In dichloromethane at 0 - 20℃; for 0.416667h;
Stage #2: 1.3-butanediol With pyridine In dichloromethane at 20℃; for 0.5h;		A n/a
B n/a
C 65%
...Expand
pyridine
110-86-1

pyridine

phosphoric acid dibenzyl ester
1623-08-1

phosphoric acid dibenzyl ester

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

benzene
71-43-2

benzene

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

...Expand
pyridine
110-86-1

pyridine

phosphoric acid dibenzyl ester
1623-08-1

phosphoric acid dibenzyl ester

4-Nitrobenzenesulfonyl chloride
98-74-8

4-Nitrobenzenesulfonyl chloride

benzene
71-43-2

benzene

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

...Expand
tetrachloromethane
56-23-5

tetrachloromethane

Dibenzyl phosphite
17176-77-1

Dibenzyl phosphite

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

Conditions
ConditionsYield
With potassium hydroxide
Bromotrichloromethane
75-62-7

Bromotrichloromethane

Dibenzyl phosphite
17176-77-1

Dibenzyl phosphite

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

Conditions
ConditionsYield
With potassium hydroxide
dibenzyl phosphochloridate
538-37-4

dibenzyl phosphochloridate

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

Conditions
ConditionsYield
With potassium hydroxide
phosphoric acid dibenzyl ester
1623-08-1

phosphoric acid dibenzyl ester

triethylamine
121-44-8

triethylamine

acetonitrile
75-05-8

acetonitrile

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

...Expand
tetrachloromethane
56-23-5

tetrachloromethane

Dibenzyl phosphite
17176-77-1

Dibenzyl phosphite

aqueous KOH

aqueous KOH

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

...Expand
Bromotrichloromethane
75-62-7

Bromotrichloromethane

Dibenzyl phosphite
17176-77-1

Dibenzyl phosphite

aqueous KOH

aqueous KOH

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

...Expand
dibenzyl phosphochloridate
538-37-4

dibenzyl phosphochloridate

aqueous KOH

aqueous KOH

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

N,N-diethylaniline
91-66-7

N,N-diethylaniline

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzene; PCl3 / 5 °C / anschliessendes Behandeln mit Wasser
2: aqueous KOH
View Scheme
Multi-step reaction with 2 steps
1: benzene; PCl3 / 5 °C / anschliessendes Behandeln mit Wasser
2: aqueous KOH
View Scheme
benzyl alcohol
100-51-6

benzyl alcohol

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: benzene; PCl3 / 5 °C / anschliessendes Behandeln mit Wasser
2: aqueous KOH
View Scheme
Multi-step reaction with 2 steps
1: benzene; PCl3 / 5 °C / anschliessendes Behandeln mit Wasser
2: aqueous KOH
View Scheme
benzyl alcohol
100-51-6

benzyl alcohol

sodium

sodium

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H3PO4, Et3N, trichloroacetonitrile
2: DCC
View Scheme
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

1-O-(tert-butyldimethylsilyl)-3-(2-hydroxy-4,6-dimethylphenyl)-3,3-dimethylpropan-1-ol
134098-64-9

1-O-(tert-butyldimethylsilyl)-3-(2-hydroxy-4,6-dimethylphenyl)-3,3-dimethylpropan-1-ol

dibenzyl (2-(4-((tert-butyldimethylsilyl)oxy)-2-methylbutan-2-yl)-3,5-dimethylphenyl) phosphate
153910-63-5

dibenzyl (2-(4-((tert-butyldimethylsilyl)oxy)-2-methylbutan-2-yl)-3,5-dimethylphenyl) phosphate

Conditions
ConditionsYield
Stage #1: 1-O-(tert-butyldimethylsilyl)-3-(2-hydroxy-4,6-dimethylphenyl)-3,3-dimethylpropan-1-ol With potassium tert-butylate In tetrahydrofuran at 60℃; for 0.0833333h;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran at 60℃; for 1h;		100%
With potassium tert-butylate In tetrahydrofuran at 60℃; for 0.75h;87%
Stage #1: 1-O-(tert-butyldimethylsilyl)-3-(2-hydroxy-4,6-dimethylphenyl)-3,3-dimethylpropan-1-ol With potassium tert-butylate In tetrahydrofuran at 60℃; for 0.0833333h;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran for 1h; Reflux;		87.2%
With potassium tert-butylate In tetrahydrofuran at 60℃;43.8%
In N,N-dimethyl-formamide; mineral oil
1-O-benzyl-2,3-(2,3-dimethoxybut-2,3-diyl)-α-D-xylopyranoside
1032939-16-4

1-O-benzyl-2,3-(2,3-dimethoxybut-2,3-diyl)-α-D-xylopyranoside

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

1-O-benzyl-2,3-(2,3-dimethoxybut-2,3-diyl)-α-D-xylopyranoside-4-O-dibenzylphosphate
1032939-17-5

1-O-benzyl-2,3-(2,3-dimethoxybut-2,3-diyl)-α-D-xylopyranoside-4-O-dibenzylphosphate

Conditions
ConditionsYield
Stage #1: 1-O-benzyl-2,3-(2,3-dimethoxybut-2,3-diyl)-α-D-xylopyranoside With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.333333h; Inert atmosphere;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran at -40 - 20℃; for 3.33333h;		100%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

benzyl 2,3-O-[(2R,3R)-2,3-dimethoxybutane-2,3-dioxy]-β-L-arabinopyranoside
550346-02-6

benzyl 2,3-O-[(2R,3R)-2,3-dimethoxybutane-2,3-dioxy]-β-L-arabinopyranoside

1-O-benzyl-2,3-(2,3-dimethoxybut-2,3-diyl)-β-L-arabinopyranoside-4-O-dibenzylphosphate
1032939-14-2

1-O-benzyl-2,3-(2,3-dimethoxybut-2,3-diyl)-β-L-arabinopyranoside-4-O-dibenzylphosphate

Conditions
ConditionsYield
Stage #1: benzyl 2,3-O-[(2R,3R)-2,3-dimethoxybutane-2,3-dioxy]-β-L-arabinopyranoside With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.333333h; Inert atmosphere;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran at -40 - 20℃; for 3.33333h;		100%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

Glycerinaldehyd-diethylacetal-3-triphenylmethylether
81429-51-8

Glycerinaldehyd-diethylacetal-3-triphenylmethylether

2-dibenzylphosphoryl-3-triphenylmethylglyceraldehyde diethyl acetal
1032939-18-6

2-dibenzylphosphoryl-3-triphenylmethylglyceraldehyde diethyl acetal

Conditions
ConditionsYield
Stage #1: Glycerinaldehyd-diethylacetal-3-triphenylmethylether With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.333333h; Inert atmosphere;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran at -40 - 20℃;		99%
methanol-CH2Cl2

methanol-CH2Cl2

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

dibenzyl (4-formylphenyl) phosphate
156745-33-4

dibenzyl (4-formylphenyl) phosphate

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran98%
...Expand
2-acetamido-3-O-acetyl-2-deoxy-4,6-O-(di-tert-butylsilandiyl)-D-glucopyranose

2-acetamido-3-O-acetyl-2-deoxy-4,6-O-(di-tert-butylsilandiyl)-D-glucopyranose

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

C32H46NO10PSi
1092110-69-4

C32H46NO10PSi

Conditions
ConditionsYield
Stage #1: 2-acetamido-3-O-acetyl-2-deoxy-4,6-O-(di-tert-butylsilandiyl)-D-glucopyranose With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.0833333h;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran at -78 - 20℃; stereoselective reaction;		98%
3-(4-hydroxyphenyl)propan-1-ol
10210-17-0

3-(4-hydroxyphenyl)propan-1-ol

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

3-[4-(dibenzyl)phosphoryloxy]phenyl-1-propanol

3-[4-(dibenzyl)phosphoryloxy]phenyl-1-propanol

Conditions
ConditionsYield
With tetrahexylammonium iodide; silver(l) oxide In dichloromethane at 20℃; for 20h;97%
4-phenyl-butan-1-ol
3360-41-6

4-phenyl-butan-1-ol

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

4-phenylbutyl-dibenzylphosphate
136025-58-6

4-phenylbutyl-dibenzylphosphate

Conditions
ConditionsYield
With titanium(IV) tetrabutoxide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h; Inert atmosphere;97%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

(1,1-bis-(hydroxymethyl)propyl)carbamic acid benzyl ester
1346041-88-0

(1,1-bis-(hydroxymethyl)propyl)carbamic acid benzyl ester

2-(benzyloxycarbonyl)amino-2-ethyl-3-hydroxylpropyl dibenzyl phosphate

2-(benzyloxycarbonyl)amino-2-ethyl-3-hydroxylpropyl dibenzyl phosphate

Conditions
ConditionsYield
With titanium(IV) tetrabutoxide; N-ethyl-N,N-diisopropylamine In toluene at 20℃; for 16h; Time; Inert atmosphere; chemoselective reaction;97%
With titanium(IV) tetrabutoxide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h; Solvent; Inert atmosphere;96%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

dibenzyl (4-formylphenyl) phosphate
156745-33-4

dibenzyl (4-formylphenyl) phosphate

Conditions
ConditionsYield
Stage #1: 4-hydroxy-benzaldehyde With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran at 70℃; for 1.16667h;		96%
1-O-benzyl-2,3-isopropylidene-β-L-ribopyranose
1032939-22-2

1-O-benzyl-2,3-isopropylidene-β-L-ribopyranose

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

1-O-benzyl-2,3-isopropylidene-β-L-ribopyranoside-4-O-dibenzylphosphate
1032939-23-3

1-O-benzyl-2,3-isopropylidene-β-L-ribopyranoside-4-O-dibenzylphosphate

Conditions
ConditionsYield
Stage #1: 1-O-benzyl-2,3-isopropylidene-β-L-ribopyranose With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.333333h; Inert atmosphere;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran at -40 - 20℃; for 5.66667h;		96%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

(S)-1-(3,4,5-trimethoxyphenyl)-4-(3-hydroxy-4-methoxyphenyl)-3-methyleneazetidine-2-one

(S)-1-(3,4,5-trimethoxyphenyl)-4-(3-hydroxy-4-methoxyphenyl)-3-methyleneazetidine-2-one

C34H34NO9P

C34H34NO9P

Conditions
ConditionsYield
With sodium hydride In dichloromethane at 0 - 20℃; for 0.25h; Schlenk technique;96%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

(1S,2S,3R,4S,5S,6R)-3-Benzyloxy-5-(1-ethoxy-ethoxy)-6-fluoro-cyclohexane-1,2,4-triol
129365-65-7

(1S,2S,3R,4S,5S,6R)-3-Benzyloxy-5-(1-ethoxy-ethoxy)-6-fluoro-cyclohexane-1,2,4-triol

Phosphoric acid dibenzyl ester (1S,2S,3R,4S,5S,6S)-2-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-(1-ethoxy-ethoxy)-5-fluoro-cyclohexyl ester
129365-66-8

Phosphoric acid dibenzyl ester (1S,2S,3R,4S,5S,6S)-2-benzyloxy-3,4-bis-(bis-benzyloxy-phosphoryloxy)-6-(1-ethoxy-ethoxy)-5-fluoro-cyclohexyl ester

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0℃; for 8h;95%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

2,3,4,6-tetra-O-benzyl-D-mannopyranose
4132-28-9, 4291-69-4, 6386-24-9, 6564-72-3, 59531-24-7, 69257-52-9, 78184-89-1, 78609-16-2, 78609-17-3, 78609-18-4, 96553-53-6, 104111-61-7, 131347-08-5

2,3,4,6-tetra-O-benzyl-D-mannopyranose

dibenzyl 2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl phosphate
90357-98-5

dibenzyl 2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl phosphate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; hexane; ethylbenzene at -78℃; for 3h;95%
N6-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine
691409-52-6

N6-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

N6-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine-3',5'-bis(dibenzylphosphate)
691409-55-9

N6-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine-3',5'-bis(dibenzylphosphate)

Conditions
ConditionsYield
Stage #1: N6-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine With potassium tert-butylate In tetrahydrofuran at -40℃; for 0.0833333h;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran at -40℃; for 0.5h;		95%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

2-(3-fluorophenyl)-5-hydroxy-6-methoxyquinolin-4-one
1256037-41-8

2-(3-fluorophenyl)-5-hydroxy-6-methoxyquinolin-4-one

2-(3-fluorophenyl)-6-methoxyquinoline-4,5-diyl bis(dibenzylphosphate)
1256037-56-5

2-(3-fluorophenyl)-6-methoxyquinoline-4,5-diyl bis(dibenzylphosphate)

Conditions
ConditionsYield
Stage #1: 2-(3-fluorophenyl)-5-hydroxy-6-methoxyquinolin-4-one With sodium hydride In tetrahydrofuran at 0℃;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran for 0.416667h;		95%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

2-azido-4,6-di-O-benzyl-2,3-dideoxy-3-fluoro-α/β-D-glucopyranose

2-azido-4,6-di-O-benzyl-2,3-dideoxy-3-fluoro-α/β-D-glucopyranose

(2-azido-4,6-di-O-benzyl-2,3-dideoxy-3-fluoro-α-D-glucopyranosyl)-1-dibenzylphosphate
1334530-12-9

(2-azido-4,6-di-O-benzyl-2,3-dideoxy-3-fluoro-α-D-glucopyranosyl)-1-dibenzylphosphate

Conditions
ConditionsYield
Stage #1: 2-azido-4,6-di-O-benzyl-2,3-dideoxy-3-fluoro-α/β-D-glucopyranose With ethylbenzene; lithium diisopropyl amide In tetrahydrofuran; n-heptane at -78℃; for 0.25h; Inert atmosphere;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran; n-heptane at -78 - 0℃; for 3h; Inert atmosphere;		95%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

2-(3-fluorophenyl)-5-hydroxy-6-methoxyquinolin-4-one
1256037-41-8

2-(3-fluorophenyl)-5-hydroxy-6-methoxyquinolin-4-one

2-(3-fluorophenyl)-6-methoxyquinoline-4,5-diyl bis(dibenzylphosphate)
1256037-56-5

2-(3-fluorophenyl)-6-methoxyquinoline-4,5-diyl bis(dibenzylphosphate)

Conditions
ConditionsYield
Stage #1: 2-(3-fluorophenyl)-5-hydroxy-6-methoxyquinolin-4-one With sodium hydride In tetrahydrofuran at -1 - 1℃; for 1h;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran for 0.416667h; Product distribution / selectivity;		95%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

1,5-anhydro-3,4-di-O-benzyl-2-deoxy-5a-carba-D-arabino-hex-1-enitol
207564-31-6

1,5-anhydro-3,4-di-O-benzyl-2-deoxy-5a-carba-D-arabino-hex-1-enitol

C35H37O6P

C35H37O6P

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃;95%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

2-chloro-9-[(diethanolamino)carboxymethyl]-6-methylamino-purine
262863-48-9

2-chloro-9-[(diethanolamino)carboxymethyl]-6-methylamino-purine

9-bis(2-dibenzylphosphatoethylamino)-acetyl-2-chloro-6-methylamino-purine
262863-49-0

9-bis(2-dibenzylphosphatoethylamino)-acetyl-2-chloro-6-methylamino-purine

Conditions
ConditionsYield
Stage #1: 2-chloro-9-[(diethanolamino)carboxymethyl]-6-methylamino-purine With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.25h; deprotonation;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran at 0 - 25℃; for 12h; phosphorylation; Further stages.;		94%

Tetrabenzyl pyrophosphate Specification

The CAS register number of Tetrabenzyl pyrophosphate is 990-91-0. It also can be called as Pyrophosphoric acid tetrabenzyl ester and the IUPAC name about this chemical is dibenzyl bis(phenylmethoxy)phosphoryl phosphate. It belongs to the following product categories, such as Biochemistry, Nucleosides, Nucleotides & Related Reagents, Phosphorylating and Phosphorothioating Agents, Phosphorylation, Protecting Agents, Phosphorylating Agents & Condensing Agents, Synthetic Organic Chemistry and so on.

Physical properties about Tetrabenzyl pyrophosphate are: (1)ACD/LogP: 6.01; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): 6.01; (4)ACD/LogD (pH 7.4): 6.01; (5)ACD/BCF (pH 5.5): 21756.89; (6)ACD/BCF (pH 7.4): 21756.89; (7)ACD/KOC (pH 5.5): 44303.46; (8)ACD/KOC (pH 7.4): 44303.46; (9)#H bond acceptors: 7; (10)#Freely Rotating Bonds: 14; (11)Polar Surface Area: 99.91Å2; (12)Index of Refraction: 1.59; (13)Molar Refractivity: 141 cm3; (14)Molar Volume: 417.4 cm3; (15)Polarizability: 55.89x10-24cm3; (16)Surface Tension: 52.2 dyne/cm; (17)Enthalpy of Vaporization: 86.23 kJ/mol; (18)Boiling Point: 601.6 °C at 760 mmHg; (19)Vapour Pressure: 8.62E-14 mmHg at 25°C.

Uses of Tetrabenzyl pyrophosphate: it can be used to produce dibenzyl phosphorofluoridate at Ambient temperature. This reaction will need reagent CsF and solvent acetonitrile. The yield is about 80%.

When you are using this chemical, please be cautious about it as the following:
This chemical can causes burns. When you are using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice and in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

You can still convert the following datas into molecular structure:
(1)SMILES: O=P(OCc1ccccc1)(OCc2ccccc2)OP(=O)(OCc3ccccc3)OCc4ccccc4
(2)InChI: InChI=1/C28H28O7P2/c29-36(31-21-25-13-5-1-6-14-25,32-22-26-15-7-2-8-16-26)35-37(30,33-23-27-17-9-3-10-18-27)34-24-28-19-11-4-12-20-28/h1-20H,21-24H2
(3)InChIKey: NSBNXCZCLRBQTA-UHFFFAOYAE
(4)Std. InChI: InChI=1S/C28H28O7P2/c29-36(31-21-25-13-5-1-6-14-25,32-22-26-15-7-2-8-16-26)35-37(30,33-23-27-17-9-3-10-18-27)34-24-28-19-11-4-12-20-28/h1-20H,21-24H2
(5)Std. InChIKey: NSBNXCZCLRBQTA-UHFFFAOYSA-N

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