Product Name

  • Name

    Tetryzoline

  • EINECS 201-522-3
  • CAS No. 84-22-0
  • Article Data3
  • CAS DataBase
  • Density 1.2 g/cm3
  • Solubility
  • Melting Point 117-119 °C(Solv: heptane (142-82-5); ethanol (64-17-5))
  • Formula C13H16 N2
  • Boiling Point 393.5 °C at 760 mmHg
  • Molecular Weight 200.283
  • Flash Point 191.8 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 84-22-0 (Tetryzoline)
  • Hazard Symbols
  • Synonyms 2-Imidazoline,2-(1,2,3,4-tetrahydro-1-naphthyl)- (6CI,7CI,8CI); (?à)-Tetrahydrozoline; 2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline;Ocuzolin; Tetrahydrozoline; Tetryvil; Tetryzolin; Tetryzoline;dl-Tetrahydrozoline
  • PSA 24.39000
  • LogP 1.87260

Tetryzoline Chemical Properties

Molecular Structure of Tetryzoline (CAS NO.84-22-0):

IUPAC Name: 2-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole 
Molecular Formula: C13H16N2
Molecular Weight: 200.28
EINECS: 201-522-3 
Index of Refraction: 1.656
Molar Refractivity: 60.91 cm3
Molar Volume: 165.7 cm3
Surface Tension: 45.9 dyne/cm
Density: 1.2 g/cm3
Flash Point: 191.8 °C
Enthalpy of Vaporization: 61.83 kJ/mol
Boiling Point: 393.5 °C at 760 mmHg
Vapour Pressure: 4.8E-06 mmHg at 25 °C
Classification Code: Autonomic Agents; Cardiovascular Agents; Drug / Therapeutic Agent; Human Data; Nasal decongestants; Peripheral Nervous System Agents; Respiratory System Agents; Sympathomimetics; Vasoconstrictor Agents

Tetryzoline Uses

 Tetryzoline (CAS NO.84-22-0) is used as nasal decongestant; Visine is a form of eye drops. It is an alpha agonist and its main mechanism of action is the constriction of conjunctival blood vessels. This serves to relieve the redness of the eye caused by minor ocular irritants.

Tetryzoline Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 150ug/kg (0.15mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: IRRITABILITY		 Annals of Emergency Medicine. Vol. 20, Pg. 655, 1991.
child TDLo oral 186nL/kg (186mL/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) American Journal of Emergency Medicine. Vol. 2, Pg. 217, 1984.
child TDLo oral 375nL/kg (375mL/kg) BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 American Journal of Emergency Medicine. Vol. 2, Pg. 217, 1984.
child TDLo oral 1049nL/kg (1049mL/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

KIDNEY, URETER, AND BLADDER: INCONTINENCE		 Pediatric Emergency Care. Vol. 15, Pg. 193, 1999.
infant TCLo inhalation 60mg/kg (60mg/kg) SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE

BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION		 "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 580, 1969.
mouse LD50 intraperitoneal 116mg/kg (116mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 971, 1962.
mouse LD50 intravenous 48100ug/kg (48.1mg/kg)   Drugs in Japan Vol. -, Pg. 699, 1990.
mouse LD50 oral 335mg/kg (335mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 971, 1962.
mouse LD50 subcutaneous 252mg/kg (252mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 12, Pg. 971, 1962.

Tetryzoline Specification

 Tetryzoline (CAS NO.84-22-0), its Synonyms are Tetrahydrozoline ; 1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)- ; Tetrahydrozolinum ; Tetrizolina ; Tetryzolin ; Tetryzolinum ; Tyzanol ; 2-Imidazoline, 2-(1,2,3,4-tetrahydro-1-naphthyl)- . Tetryzoline is found in over-the-counter eye drops and nasal sprays which is a derivative of imidazoline.
 Excessive use it can lead to poisoning. It can cause severe nausea and vomiting to seizures or a coma and violent diarrhea.

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