Product Name

  • Name

    Thiamine nitrate

  • EINECS 208-537-4
  • CAS No. 532-43-4
  • Article Data6
  • CAS DataBase
  • Density
  • Solubility
  • Melting Point 196-200 °C
  • Formula C12H17N5O4S
  • Boiling Point
  • Molecular Weight 327.364
  • Flash Point
  • Transport Information
  • Appearance white crystal powder
  • Safety 22-24/25
  • Risk Codes
  • Molecular Structure Molecular Structure of 532-43-4 (Thiamine nitrate)
  • Hazard Symbols
  • Synonyms Thiaminenitrate (6CI);Thiamine nitrate (salt) (7CI,8CI);Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-,nitrate (salt) (9CI);3-(4-Amino-2-methylpyrimidyl-5-methyl)-4-methyl-5,b-hydroxyethylthiazolium nitrate;Aneurine mononitrate;Aneurine-nitrate;Betabion mononitrate;Vitamin B1mononitrate;Vitamin B1 nitrate;Vitamin B1 mononitrate;Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-,nitrate (1:1);Thiamine mononitrate;
  • PSA 173.03000
  • LogP 1.47300

Synthetic route

thiamine sulfate

thiamine sulfate

vitamin B1 mononitrate
532-43-4

vitamin B1 mononitrate

Conditions
ConditionsYield
With ammonium hydroxide; nitric acid at 10℃; for 3.5h; pH=7 - 8; Temperature; pH-value;94.56%
3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-3H-thiazole-2-thione
299-35-4

3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-3H-thiazole-2-thione

vitamin B1 mononitrate
532-43-4

vitamin B1 mononitrate

Conditions
ConditionsYield
With dihydrogen peroxide; nitric acid
Thiamine hydrochloride
67-03-8

Thiamine hydrochloride

vitamin B1 mononitrate
532-43-4

vitamin B1 mononitrate

Conditions
ConditionsYield
With sodium hydroxide; silver nitrate In water
Aneurin
70-16-6

Aneurin

vitamin B1 mononitrate
532-43-4

vitamin B1 mononitrate

Conditions
ConditionsYield
With dihydrogen peroxide; nitric acid In water at 20℃; pH=3.5;
thiamine sulfate
2380-61-2

thiamine sulfate

vitamin B1 mononitrate
532-43-4

vitamin B1 mononitrate

Conditions
ConditionsYield
With ammonium nitrate; ammonium hydroxide for 0.25h; pH=7.3; Reagent/catalyst; pH-value;47.92 g
vitamin B1 mononitrate
532-43-4

vitamin B1 mononitrate

CYTIDINE
65-46-3

CYTIDINE

2-methyl-8-ribosylcytosichrome

2-methyl-8-ribosylcytosichrome

Conditions
ConditionsYield
In methanol for 3h; Heating;40%
vitamin B1 mononitrate
532-43-4

vitamin B1 mononitrate

<5,12,19,26,33,40-hexaamino-3,10,17,24,31,38-hexamethyl<1.6>(1,5)pyrimidiniophane> hexanitrate

<5,12,19,26,33,40-hexaamino-3,10,17,24,31,38-hexamethyl<1.6>(1,5)pyrimidiniophane> hexanitrate

Conditions
ConditionsYield
In methanol for 2h; Heating;34%
In methanol for 2h; Heating;
phosgene
75-44-5

phosgene

vitamin B1 mononitrate
532-43-4

vitamin B1 mononitrate

3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-chlorocarbonyloxy-ethyl)-4-methyl-thiazolium; chloride
96793-20-3

3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-chlorocarbonyloxy-ethyl)-4-methyl-thiazolium; chloride

Conditions
ConditionsYield
In acetic acid at -10℃;
vitamin B1 mononitrate
532-43-4

vitamin B1 mononitrate

methyl iodide
74-88-4

methyl iodide

N1'-methylthiaminium diiodide

N1'-methylthiaminium diiodide

Conditions
ConditionsYield
In methanol

Thiamine nitrate Chemical Properties

Molecular Structure of Thiamine mononitrate (CAS NO.532-43-4):

Molecular Formula: C12H17N5O4S
Molecular Weight: 327.3595
IUPAC Name: 2-[3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol nitrate 
EINECS: 208-537-4
Classification Code: Vitamin [enzyme co-factor]
Melting point: 196-200 °C
H bond acceptors: 5
H bond donors: 3
Freely Rotating Bonds: 5 
Product Categories: Biochemistry; Vitamins; Vitamins and derivatives 
Stability: Stable. Incompatible with strong oxidizing agents.

Thiamine nitrate Uses

  Thiamine mononitrate (CAS NO.532-43-4) is applicable to vitamin B1 deficiency, maintain normal metabolism and nerve conduction function. It is also used in adjuvant therapy for indigestion, neuropathy, etc.

Thiamine nitrate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 350mg/kg (350mg/kg)   Drugs in Japan Vol. 6, Pg. 449, 1982.
mouse LD oral > 5gm/kg (5000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 42, Pg. 114, 1992.
mouse LD50 intraperitoneal 387mg/kg (387mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Proceedings of the Society for Experimental Biology and Medicine. Vol. 68, Pg. 153, 1948.
mouse LD50 intravenous 84mg/kg (84mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: CYANOSIS		 Proceedings of the Society for Experimental Biology and Medicine. Vol. 68, Pg. 153, 1948.
rabbit LD50 intravenous 113mg/kg (113mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Proceedings of the Society for Experimental Biology and Medicine. Vol. 68, Pg. 153, 1948.
rabbit LD50 intravenous 300mg/kg (300mg/kg)   Drugs in Japan Vol. 6, Pg. 449, 1982.

Thiamine nitrate Consensus Reports

Reported in EPA TSCA Inventory.

Thiamine nitrate Safety Profile

Poison by intravenous and intraperitoneal routes. A powerful oxidizer. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Safety Statements of Thiamine mononitrate (CAS NO.532-43-4): 22-24/25
S22: Do not breathe dust. 
S24/25: Avoid contact with skin and eyes.

Thiamine nitrate Specification

 Synonyms of Thiamine mononitrate (CAS NO.532-43-4) are Stuartinic ; 3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium nitrate ; 3-(4-Amino-2-methylpyrimidyl-5-methyl)-4-methyl-5,beta-hydroxyethylthiazolium nitrate ; Aneurine mononitrate ; Aneurine nitrate ; Betabion mononitrate ; Thiamine nitrate ; Thiamine nitrate (salt) ; Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, nitrate (salt) ; Vitamin B(sub 1) nitrate ; Vitamin B1 mononitrate ; Vitamin B1 nitrate ; Thiamine nitrate (salt) (8CI) ; Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, nitrate (1:1) .

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