Thioridazine hydrochloride supplier

Name
Thioridazine hydrochloride
EINECS 204-992-8
CAS No. 130-61-0
Article Data2
CAS DataBase
Density 1.1227 (rough estimate)
Solubility Soluble in water (75 mM), DMSO (100 mM), chloroform, ethanol, and methanol.
Melting Point 158-160 °C
Formula C₂₁H₂₇ClN₂S₂
Boiling Point 515.7 °C at 760 mmHg
Molecular Weight 407.044
Flash Point 265.7 °C
Transport Information UN 3077 9/PG 3
Appearance Pale yellow solid
Safety 26-36-60-61
Risk Codes 22-36/37/38-50/53
Molecular Structure
Hazard Symbols Xn, N
Synonyms 10H-Phenothiazine,10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, monohydrochloride (9CI);Phenothiazine, 10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylthio)-,hydrochloride (6CI,7CI);Phenothiazine,10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylthio)-, monohydrochloride (8CI);10-[3-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)phenothiazine hydrochloride;2-Methylmercapto-10-[2-(N-methyl-2-piperidyl)ethyl]phenothiazine hydrochloride;Aldazine;Mallorol;Mellaril;Mellaril hydrochloride;Melleretten;Melleril (tablet);NSC 186060;Novoridazine;Orsanil;Stalleril;10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride;10H-Phenothiazine,10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, hydrochloride (1:1);
PSA 57.08000
LogP 6.69050

Synthetic route

: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-{2-[2-(methylthio)-10H-phenothiazin-10-yl]ethyl}piperidine-1-carboxylate

: 130-61-0
thioridazine Hydrochloride

Conditions

Conditions	Yield
Stage #1: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-{2-[2-(methylthio)-10H-phenothiazin-10-yl]ethyl}piperidine-1-carboxylate With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 50℃; for 18h; Inert atmosphere; Stage #2: With hydrogenchloride In ethanol; water	100%
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 0 - 50 °C / Inert atmosphere 2: hydrogenchloride / ethanol; water View Scheme

: 50-52-2, 52496-67-0, 57129-06-3, 114488-10-7
thioridazine

: 130-61-0
thioridazine Hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol; water	100%

: 130-61-0
thioridazine Hydrochloride

: 969-99-3
chlorpromazine sulfoxide

Conditions

Conditions	Yield
With dihydrogen peroxide In water for 72h; Ambient temperature;	93%

: 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester

: 130-61-0
thioridazine Hydrochloride

: 1-chloroethyl 2-(2-(2-(methylthio)-10hphenothiazin-10-yl)ethyl)piperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: thioridazine Hydrochloride With triethylamine In 1,2-dichloro-ethane at 20℃; for 0.333333h; Inert atmosphere; Stage #2: carbonochloridic acid 1-chloro-ethyl ester In 1,2-dichloro-ethane for 12h; Inert atmosphere; Reflux;	84%

: 513-53-1
1-methyl-1-propanethiol

: 130-61-0
thioridazine Hydrochloride

: 96457-89-5
2-(sec-butylthio)-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine

Conditions

Conditions	Yield
With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube;	71%

: 1569-69-3
Cyclohexanethiol

: 130-61-0
thioridazine Hydrochloride

: 2-(cyclohexylthio)-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine

Conditions

Conditions	Yield
With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube;	62%

: 34301-54-7
1-Adamantanethiol

: 130-61-0
thioridazine Hydrochloride

: 2-((adamantan-1-yl)thio)-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine

Conditions

Conditions	Yield
With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube;	61%

: 130-61-0
thioridazine Hydrochloride

: 100-53-8
phenylmethanethiol

: 97013-68-8
2-(benzylthio)-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine

Conditions

Conditions	Yield
With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube;	56%

: 110-53-2
1-Bromopentane

: 130-61-0
thioridazine Hydrochloride

: 1-methyl-2-(2-(2-(methylthio)-10H-phenothiazin-10-yl)ethyl)-1-pentylpiperidin-1-ium bromide

Conditions

Conditions	Yield
In acetonitrile for 24h; Reflux; Inert atmosphere;	51%

: 111-88-6
Octanethiol

: 130-61-0
thioridazine Hydrochloride

: 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(octylthio)-10H-phenothiazine

Conditions

Conditions	Yield
With Singacycle A1; lithium hexamethyldisilazane In o-xylene at 160℃; for 12h; Glovebox; Sealed tube;	49%

: zinc acetate hydrate

: 130-61-0
thioridazine Hydrochloride

: ZnC6H4SN((CH2)2C5H9NHCH3)C6H3(SCH3)Cl(2+)*2CH3COO(1-)=[ZnC6H4SN((CH2)2C5H9NHCH3)C6H3(SCH3)Cl](CH3COO)2

Conditions

Conditions	Yield
In methanol slow addn. of soln. of ZnCl2 to soln. of ligand (room temp.), stirring (1 h), conctg. (reduced pressure), storing (overnight at 4°C); decanting viscous liq., redissolving in methanol with stirring at 60°C, suction filtn., washing (2-3 times, cold methanol), drying (air),drying (vac.), recrystn. (hot methanol), elem. anal.;	48.5%

: 14602-86-9
(1R,2S,5R)-menthyl chloroformate

: 130-61-0
thioridazine Hydrochloride

A: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-{(2S)-[2-(methylthio)-10H-phenothiazin-10-yl]ethyl}piperidine-1-carboxylate

B: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-{(2R)-[2-(methylthio)-10H-phenothiazin-10-yl]ethyl}piperidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;	A 43% B 38%

...Expand

: 130-61-0
thioridazine Hydrochloride

: 7646-85-7
zinc(II) chloride

: Zn(C6H4SN((CH2)2C5H9NHCH3)C6H3(SCH3))2Cl2(2+)*2Cl(1-)*CH3OH=[Zn(C6H4SN((CH2)2C5H9NHCH3)C6H3(SCH3))2Cl2]Cl2*CH3OH

Conditions

Conditions	Yield
In methanol slow addn. of soln. of ZnCl2 to soln. of ligand (room temp.), refluxing (60°C, 1.5-2 h), cooling (overnight to 4°C); decanting oily product, redissolving in methanol with stirring at 60°C, suction filtn., washing (2-3 times, cold methanol), drying (air),drying (vac.), recrystn. (hot methanol), elem. anal.;	35.1%

: 7647-01-0
hydrogenchloride

: 130-61-0
thioridazine Hydrochloride

: palladium dichloride

: ((C6H4)(C6H3SCH3)N(CH2CH2C5H9NHCH3)S)Pd2Cl5*2H2O

Conditions

Conditions	Yield
In methanol dissolving ligand in methanol, slow addn. with stirring to conctd. methanolic soln. of PdCl2 contg. HCl (room temp.), stirring (1 h), cooling (overnight to 4°C); suction filtn., washing (several times, cold water, cold methanol), air drying, drying in vac. over anhydrous CaSO4, recrystn. from hot methanol, elem. anal.;	30%

...Expand

: 130-61-0
thioridazine Hydrochloride

: C21H27N2S2

Conditions

Conditions	Yield
With potassium metaperiodate; phosphoric acid; sulfuric acid In water

: 130-61-0
thioridazine Hydrochloride

: 7776-05-8
Thioridazine 5-sulfoxide

Conditions

Conditions	Yield
With potassium dichromate In water at 25℃; for 1h;

: 130-61-0
thioridazine Hydrochloride

: thioridazine cation-radical

Conditions

Conditions	Yield
With iron(III) chloride In water at 25℃; Product distribution; Further Variations:; Temperatures; Reagents;

: 10025-99-7
potassium tetrachloroplatinate(II)

: 130-61-0
thioridazine Hydrochloride

: 82489-48-3
Pt(C6H4SN(CH2CH2C5H9NH(CH3))C6H3SCH3)Cl3

Conditions

Conditions	Yield
In water byproducts: KCl; aq. soln. of ligand mixed with Pt complex; filtered off, washed with H2O, dried in vac. at 100 °C; elem. anal.;

: 10025-98-6
potassium tetrachloropalladate(II)

: 130-61-0
thioridazine Hydrochloride

: 82489-46-1
Pd(C6H4SN(CH2CH2C5H9NH(CH3))C6H3SCH3)Cl3

Conditions

Conditions	Yield
In water byproducts: KCl; aq. soln. of ligand mixed with Pd complex; filtered off, washed with H2O, dried in vac. at 100 °C; elem. anal.;

: 130-61-0
thioridazine Hydrochloride

: 10538-32-6, 114991-17-2, 114991-18-3
Northioridazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: triethylamine / 1,2-dichloro-ethane / 0.33 h / 20 °C / Inert atmosphere 1.2: 12 h / Inert atmosphere; Reflux 2.1: water / methanol / 12 h / Reflux; Inert atmosphere View Scheme

: 130-61-0
thioridazine Hydrochloride

: 10-(2-(1-benzylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: triethylamine / 1,2-dichloro-ethane / 0.33 h / 20 °C / Inert atmosphere 1.2: 12 h / Inert atmosphere; Reflux 2.1: water / methanol / 12 h / Reflux; Inert atmosphere 3.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 3.2: 24 h / 20 °C / Inert atmosphere View Scheme

: 130-61-0
thioridazine Hydrochloride

: 2-(methylthio)-10-(2-(1-propylpiperidin-2-yl)ethyl)-10H-phenothiazine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: triethylamine / 1,2-dichloro-ethane / 0.33 h / 20 °C / Inert atmosphere 1.2: 12 h / Inert atmosphere; Reflux 2.1: water / methanol / 12 h / Reflux; Inert atmosphere 3.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 3.2: 24 h / 20 °C / Inert atmosphere View Scheme

: 130-61-0
thioridazine Hydrochloride

: 10-(2-(1-isopropylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: triethylamine / 1,2-dichloro-ethane / 0.33 h / 20 °C / Inert atmosphere 1.2: 12 h / Inert atmosphere; Reflux 2.1: water / methanol / 12 h / Reflux; Inert atmosphere 3.1: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 3.2: 24 h / 20 °C / Inert atmosphere View Scheme

: 130-61-0
thioridazine Hydrochloride

: (+)-Thioridazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere View Scheme

: 130-61-0
thioridazine Hydrochloride

: (-)-Thioridazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere View Scheme

: 130-61-0
thioridazine Hydrochloride

: (R)-northioridazine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere 3.1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere 3.2: 4 h / Reflux; Inert atmosphere View Scheme

: 130-61-0
thioridazine Hydrochloride

: (R)-nosyl-northioridazine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2: chlorotriisopropylsilane; trifluoroacetic acid / water / 72 h / 110 °C / Sealed tube 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere View Scheme
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere 3.1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere 3.2: 4 h / Reflux; Inert atmosphere 4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2: chlorotriisopropylsilane; trifluoroacetic acid / water / 72 h / 110 °C / Sealed tube
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere
View Scheme

Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere
3.1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere
3.2: 4 h / Reflux; Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere
View Scheme

: 130-61-0
thioridazine Hydrochloride

: C50H51Cl2N9O6S3

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2.1: chlorotriisopropylsilane; trifluoroacetic acid / water / 72 h / 110 °C / Sealed tube 3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 3.2: 16 h / 20 °C 4.1: water; tert-butyl alcohol / 20 °C 4.2: 33 °C View Scheme
Multi-step reaction with 5 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere 3.1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere 3.2: 4 h / Reflux; Inert atmosphere 4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 4.2: 16 h / 20 °C 5.1: water; tert-butyl alcohol / 20 °C 5.2: 33 °C View Scheme

Yield

Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: chlorotriisopropylsilane; trifluoroacetic acid / water / 72 h / 110 °C / Sealed tube
3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
3.2: 16 h / 20 °C
4.1: water; tert-butyl alcohol / 20 °C
4.2: 33 °C
View Scheme

Multi-step reaction with 5 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere
3.1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere
3.2: 4 h / Reflux; Inert atmosphere
4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
4.2: 16 h / 20 °C
5.1: water; tert-butyl alcohol / 20 °C
5.2: 33 °C
View Scheme

: 130-61-0
thioridazine Hydrochloride

: C49H49Cl2N9O6S3

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2.1: chlorotriisopropylsilane; trifluoroacetic acid / water / 72 h / 110 °C / Sealed tube 3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 3.2: 16 h / 20 °C 4.1: water; tert-butyl alcohol / 20 °C 4.2: 58 h / 33 °C View Scheme
Multi-step reaction with 5 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere 3.1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere 3.2: 4 h / Reflux; Inert atmosphere 4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 4.2: 16 h / 20 °C 5.1: water; tert-butyl alcohol / 20 °C 5.2: 58 h / 33 °C View Scheme

Yield

: 130-61-0
thioridazine Hydrochloride

: C49H49Cl2N9O6S3

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2.1: chlorotriisopropylsilane; trifluoroacetic acid / water / 72 h / 110 °C / Sealed tube 3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 3.2: 16 h / 20 °C 4.1: water; tert-butyl alcohol / 20 °C 4.2: 58 h / 33 °C View Scheme
Multi-step reaction with 5 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux; Inert atmosphere 3.1: carbonochloridic acid 1-chloro-ethyl ester; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere 3.2: 4 h / Reflux; Inert atmosphere 4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 4.2: 16 h / 20 °C 5.1: water; tert-butyl alcohol / 20 °C 5.2: 58 h / 33 °C View Scheme

Yield

Thioridazine hydrochloride Chemical Properties

IUPAC NAME: 10-[2-(1-Methylpiperidin-2-yl)ethyl]-2-methylsulfanylphenothiazine hydrochloride
EINECS: 204-992-8
Molecular Formula: C₂₁H₂₇ClN₂S₂
Molecular Weight: 407.04 g/mol
Flash Point: 265.7 °C
Boiling Point: 515.7 °C at 760 mmHg
Enthalpy of Vaporization: 78.76 kJ/mol
Vapour Pressure: 9.65E-11 mmHg at 25 °C
Appearance: Pale Yellow Solid
Melting Point: 158-160 °C
Product Categories: Miscellaneous ; Intermediates & Fine Chemicals ; Pharmaceuticals ; Dopamine receptor
Classification Code of 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride (CAS NO.130-61-0): Antipsychotic; Drug / Therapeutic Agent; Human Data; Mutation data; Sedative-hypnotic

Thioridazine hydrochloride Uses

10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride (CAS NO.130-61-0) is used for acute schizophrenia, bipolar disorder, menopause, mental illness, nervous depression.

Thioridazine hydrochloride Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	160mg/kg (160mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
mouse	LD50	intraperitoneal	100mg/kg (100mg/kg)		National Technical Information Service. Vol. AD277-689,
mouse	LD50	intravenous	33mg/kg (33mg/kg)		Therapie. Vol. 14, Pg. 793, 1959.
mouse	LD50	oral	360mg/kg (360mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
rabbit	LD50	intravenous	26mg/kg (26mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
rabbit	LD50	oral	1100mg/kg (1100mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
rat	LD50	intravenous	71mg/kg (71mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
rat	LD50	oral	1060mg/kg (1060mg/kg)		Drugs in Japan Vol. 6, Pg. 458, 1982.
women	TDLo	oral	864mg/kg/18D- (864mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP ENDOCRINE: EVIDENCE OF THYROID HYPERFUNCTION	Postgraduate Medical Journal. Vol. 60, Pg. 445, 1984.

Thioridazine hydrochloride Consensus Reports

EPA Genetic Toxicology Program.

Thioridazine hydrochloride Safety Profile

Poison by ingestion and intravenous routes. Human systemic effects: evidence of thyroid hyperfunction, increased body temperature, pulse rate increase. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO_x, SO_x, and HCl.
Hazard Codes: Harmful Xn, Dangerous N
Risk Statements:
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R50/53: Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S60: This material and its container must be disposed of as hazardous waste.
S61: Avoid release to the environment. Refer to special instructions / safety data sheets.

Thioridazine hydrochloride Specification

10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride (CAS NO.130-61-0), its Synonyms are Thioridazine hydrochloride ; 10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)-, monohydrochloride ; 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine hydrochloride ; Mellaril ; Mellaril hydrochloride ; Melleril (tablet) ; Melzine ; Sonapax hydrochloride ; Thioridazine HCl ; Thioridazine chloride .

Product Name

Thioridazine hydrochloride

Synthetic route

Thioridazine hydrochloride Chemical Properties

Thioridazine hydrochloride Uses

Thioridazine hydrochloride Toxicity Data With Reference

Thioridazine hydrochloride Consensus Reports

Thioridazine hydrochloride Safety Profile

Thioridazine hydrochloride Specification

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