Trifluoroacetamide supplier

Name
Trifluoroacetamide
EINECS 206-559-9
CAS No. 354-38-1
Article Data67
CAS DataBase
Density 1.435 g/cm³
Solubility water: 460 g/L(20 °C)
Melting Point 65-70 °C(lit.)
Formula C₂H₂F₃NO
Boiling Point 162.5 °C at 760 mmHg
Molecular Weight 113.039
Flash Point 52.1 °C
Transport Information
Appearance White to pale yellow or beige crystalline powder
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2,2,2-Trifluoroacetamide;NSC 9449;
PSA 43.09000
LogP 0.73430

Synthetic route

: 383-63-1
ethyl trifluoroacetate,

: 354-38-1
2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With hydrogenchloride; triethylamine In ethanol; ethyl acetate	100%
With diethyl ether; ammonia
With methanol; ammonia

: 354-34-7
trifluoroacetyl fluoride

: 354-38-1
2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With methylamine at 150℃; under 750.075 Torr; for 10h; Gas phase;	99.1%

: 3888-00-4
nitropentafluoroacetone

A: 1493-05-6
difluoro-nitro-methane

B: 354-38-1
2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With ammonia in bomb tube;	A 14% B 99%
With NH3 in bomb tube;	A 14% B 99%

: 52225-57-7
2,2,2-trifluoro-N-{2,2,2-trifluoro-1-(trifluoromethyl) ethylidene}acetamide

: 103-69-5
N-ethyl-N-phenylamine

A: 65797-85-5
2-(4-(ethylamino)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

B: 677-71-4
hexafluoroacetone hydrate

C: 354-38-1
2,2,2-trifluoroacetamide

D: 106119-57-7
2,4,4-tris(trifluoromethyl)-1-ethyl-1,4-dihydroquinazoline

E: N-[1-(Ethyl-phenyl-amino)-2,2,2-trifluoro-1-trifluoromethyl-ethyl]-2,2,2-trifluoro-acetamide

Conditions

Conditions	Yield
In chloroform at 20℃; for 1440h; Mechanism;	A n/a B n/a C n/a D 87% E n/a

...Expand

: 89567-94-2
N-trifluoroacetyl-Se-(p-bromophenyl)-Se-methylselenimide

A: 354-38-1
2,2,2-trifluoroacetamide

B: 78238-44-5
methyl (p-bromophenyl)selenium dichloride

Conditions

Conditions	Yield
With acetyl chloride In chloroform at 20℃; for 3h;	A 55% B 85%

: 84353-59-3
1-(2,2,2-trifluoroacetyl)-3-(E)-styrylurea

A: 354-38-1
2,2,2-trifluoroacetamide

B: 84353-56-0
(E)-N-(2-phenylethenyl)-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
In trifluoroacetic acid at 230℃; for 0.333333h;	A 69% B 22%

: 84353-55-9
1-(2,2,2-trifluoroacetyl)-3-<2-(2,2,2-trifluoroacetyloxy)-2-phenylethyl>urea

A: 354-38-1
2,2,2-trifluoroacetamide

B: 84353-56-0
(E)-N-(2-phenylethenyl)-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
In neat (no solvent) at 230℃; for 0.5h;	A 69% B 19%

: 84353-59-3
1-(2,2,2-trifluoroacetyl)-3-(E)-styrylurea

: 354-38-1
2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
In neat (no solvent) at 230℃; for 0.333333h;	68%

: 126-81-8
dimedone

: 77571-23-4, 78780-20-8, 78780-21-9
N-(trifluoroacetyl)-di(p-methoxyphenyl)tellurimide

A: 354-38-1
2,2,2-trifluoroacetamide

B: 57857-72-4
di(p-metoxyphenyl)telluroniodimedonide

Conditions

Conditions	Yield
In chloroform Ambient temperature; overnight;	A 58% B 67%

...Expand

: 76-05-1
trifluoroacetic acid

: 354-38-1
2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With zirconium(IV) chloride; ammonium carbamate In toluene at 120℃; for 24h; Inert atmosphere; Molecular sieve;	67%

: 233257-02-8
[(trifluoroacetyl)imino]tris-(2-methylphenyl)-λ(5)-bismuthane

A: 354-38-1
2,2,2-trifluoroacetamide

B: 10050-08-5
tri-o-tolylbismuth

Conditions

Conditions	Yield
In benzene 60°C, 48 h;	A n/a B 61%

: 1868-48-0
2,5-bis(trifluoromethyl)-1,3,4-oxadiazole

: 513-81-5
2,3-dimethyl-buta-1,3-diene

A: 4-(trifluoromethyl)-2-ethoxycarbonyl-1,6-dimethyl-3-oxatricyclo[2.2.1.02,6]heptane

B: 354-38-1
2,2,2-trifluoroacetamide

C: 100696-00-2
2-(trifluoromethyl)-4,5-dimethylpyridine

Conditions

Conditions	Yield
at 150℃; for 18h;	A 32% B 15% C 30%

...Expand

: 944903-98-4
2-trifluoromethyl-5-ethoxycarbonyl-1,3,4-oxadiazole

: 513-81-5
2,3-dimethyl-buta-1,3-diene

A: 4-(trifluoromethyl)-2-ethoxycarbonyl-1,6-dimethyl-3-oxatricyclo[2.2.1.02,6]-heptane

B: 354-38-1
2,2,2-trifluoroacetamide

C: 100696-00-2
2-(trifluoromethyl)-4,5-dimethylpyridine

Conditions

Conditions	Yield
at 150℃; for 14h;	A 27% B n/a C n/a

...Expand

: 359-45-5
N-bromo-trifluoroacetamide

A: 354-38-1
2,2,2-trifluoroacetamide

: 78162-82-0, 78174-04-6
(+/-)-trifluoroacetic acid-(trans-2-bromo-cyclohexylamide)

: 78162-82-0, 78174-04-6
N-((1R,2S)-2-Bromo-cyclohexyl)-2,2,2-trifluoro-acetamide

Conditions

Conditions	Yield
With cyclohexene In dichloromethane at 15 - 20℃; for 0.2h; Irradiation; Yields of byproduct given;	A 7% B n/a C n/a

...Expand

: 359-45-5
N-bromo-trifluoroacetamide

: 110-83-8
cyclohexene

A: 354-38-1
2,2,2-trifluoroacetamide

: 78162-82-0, 78174-04-6
(+/-)-trifluoroacetic acid-(trans-2-bromo-cyclohexylamide)

: 78162-82-0, 78174-04-6
N-((1R,2S)-2-Bromo-cyclohexyl)-2,2,2-trifluoro-acetamide

Conditions

Conditions	Yield
In dichloromethane at 15 - 20℃; for 0.2h; Irradiation; Yield given. Yields of byproduct given;	A 7% B n/a C n/a

...Expand

: 83643-84-9
methyl 4,4,4-trifluoroacetoacetate

A: 60-35-5
acetamide

B: 354-38-1
2,2,2-trifluoroacetamide

C: 107638-26-6
3-amino-4,4,4-trifluorobut-2-enoic acid

Conditions

Conditions	Yield
With ammonia In diethyl ether at 100℃; for 10h; Product distribution; NH3 amount dependence;	A n/a B n/a C 5%

...Expand

: 3888-00-4
nitropentafluoroacetone

: 354-38-1
2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With ammonia In diethyl ether

: 815-07-6
2,2,2-trifluoroacetimidic acid methyl ester

: 354-38-1
2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether

: 55982-15-5
N-(trimethylsilyl)trifluoroacetamide

: 354-38-1
2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With boron trifluoride

: 844-40-6
benzhydryl 2,2,2-trifluoroacetate

: 354-38-1
2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With ammonia In benzene

: 93032-04-3
2,2-Dibromo-4,4,4-trifluoro-3-oxo-butyric acid methyl ester

A: 598-70-9
dibromoacetamide

B: 354-38-1
2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With ammonia In diethyl ether at -40 - -10℃; Yield given. Yields of byproduct given;

: (E)-2-Chloro-4,4,4-trifluoro-3-hydroxy-but-2-enoic acid methyl ester

A: 354-38-1
2,2,2-trifluoroacetamide

B: 79-07-2
Chloroacetamide

Conditions

Conditions	Yield
With ammonia In diethyl ether at -40 - -10℃; Yield given. Yields of byproduct given;

: 14565-32-3
2,2,2-trifluoroacetyl isocyanate

: 2925-25-9
trifluorothioacetic acid

A: 354-38-1
2,2,2-trifluoroacetamide

B: 407-24-9
bistrifluoroacetamide

Conditions

Conditions	Yield
Yield given;

...Expand

: 79-14-1
glycolic Acid

: 25561-30-2
N,O-bis(trimethylsilyl)trifluoroacetamide

A: 354-38-1
2,2,2-trifluoroacetamide

B: 33581-77-0
trimethylsilyl [(trimethylsilyl)oxy]acetate

C: 55982-15-5
N-(trimethylsilyl)trifluoroacetamide

Conditions

Conditions	Yield
In hexane; dichloromethane at 60℃; for 0.666667h; Substitution;

...Expand

: 849585-22-4
LACTIC ACID

: 25561-30-2
N,O-bis(trimethylsilyl)trifluoroacetamide

A: 354-38-1
2,2,2-trifluoroacetamide

B: 17596-96-2
propanoic acid,2-[(trimethylsilyl)oxy] trimethylsilyl ester

C: 55982-15-5
N-(trimethylsilyl)trifluoroacetamide

Conditions

Conditions	Yield
In hexane; dichloromethane at 60℃; for 0.666667h; Substitution;

...Expand

: 110-94-1
1,5-pentanedioic acid

: 25561-30-2
N,O-bis(trimethylsilyl)trifluoroacetamide

A: 354-38-1
2,2,2-trifluoroacetamide

B: 55494-07-0
bis-trimethylsilyl glutarate

C: 55982-15-5
N-(trimethylsilyl)trifluoroacetamide

Conditions

Conditions	Yield
In hexane; dichloromethane at 60℃; for 0.666667h; Substitution;

...Expand

: 124-04-9
Adipic acid

: 25561-30-2
N,O-bis(trimethylsilyl)trifluoroacetamide

A: 354-38-1
2,2,2-trifluoroacetamide

B: 18105-31-2
Bis(trimethylsilyl) adipate

C: 55982-15-5
N-(trimethylsilyl)trifluoroacetamide

Conditions

Conditions	Yield
In hexane; dichloromethane at 60℃; for 0.666667h; Substitution;

...Expand

: 111-14-8
oenanthic acid

: 25561-30-2
N,O-bis(trimethylsilyl)trifluoroacetamide

A: 354-38-1
2,2,2-trifluoroacetamide

B: 25435-96-5
l'heptanoate de trimethylsilyle

C: 55982-15-5
N-(trimethylsilyl)trifluoroacetamide

Conditions

Conditions	Yield
In hexane; dichloromethane at 60℃; for 0.666667h; Substitution;

...Expand

: 124-07-2
Octanoic acid

: 25561-30-2
N,O-bis(trimethylsilyl)trifluoroacetamide

A: 354-38-1
2,2,2-trifluoroacetamide

B: 55982-15-5
N-(trimethylsilyl)trifluoroacetamide

C: octanoic acid, trimethylsilyl ester

Conditions

Conditions	Yield
In hexane; dichloromethane at 60℃; for 0.666667h; Substitution;

...Expand

: 141-82-2
malonic acid

: 25561-30-2
N,O-bis(trimethylsilyl)trifluoroacetamide

A: 354-38-1
2,2,2-trifluoroacetamide

B: 18457-04-0
bis(trimethylsilyl) malonate

C: 55982-15-5
N-(trimethylsilyl)trifluoroacetamide

Conditions

Conditions	Yield
In hexane; dichloromethane at 60℃; for 0.666667h; Substitution;

...Expand

: trimethylstannyl hydroxide

: 354-38-1
2,2,2-trifluoroacetamide

: 152071-56-2
N-(trimethylstannyl)-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
In benzene byproducts: water; absence of moisture; equimolar amts., refluxing for 3 h (distn. off of water); solvent removal (vac.);	100%

: 354-38-1
2,2,2-trifluoroacetamide

: 286367-11-1
2-(4-(trifluoromethyl)phenyl)-4,5-dihydrooxazole

: C12H8F6N2O2

Conditions

Conditions	Yield
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; [bis(acetoxy)iodo]benzene In dichloromethane at 40℃; for 16h; Inert atmosphere; regioselective reaction;	100%

: 354-38-1
2,2,2-trifluoroacetamide

: 7465-63-6
2-(4-Nitrophenyl)-4,5-dihydrooxazole

: C11H8F3N3O4

Conditions

Conditions	Yield
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; [bis(acetoxy)iodo]benzene In dichloromethane at 40℃; for 16h; Inert atmosphere; regioselective reaction;	100%

: 13676-94-3
2-(4-methoxyphenyl)-4,5-dihydrooxazole

: 354-38-1
2,2,2-trifluoroacetamide

: 2,2,2-trifluoro-N-[2-(4-methoxyphenyl)-4,5-dihydrooxazole]acetamide

Conditions

Conditions	Yield
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; [bis(acetoxy)iodo]benzene In dichloromethane at 40℃; for 16h; Inert atmosphere; regioselective reaction;	100%
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; [bis(acetoxy)iodo]benzene In dichloromethane at 40℃; for 16h; Schlenk technique; Inert atmosphere; Sealed tube;	100%

: 354-38-1
2,2,2-trifluoroacetamide

: tert-butyl 2-thia-6-azaspiro[3.3]heptane-6-carboxylate 2-oxide

: tert-butyl 2-((2,2,2-trifluoroacetyl)imino)-2λ6-thia-6-azaspiro[3.3]heptane-6-carboxylate 2-oxide

Conditions

Conditions	Yield
With dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; magnesium oxide In dichloromethane for 3h; Reflux;	100%

: 354-38-1
2,2,2-trifluoroacetamide

: 4-bromo-N-isopropyl-N-(4-methoxy-2-methylphenyl)-3-methylsulfanylbenzenesulfonamide

: (E)-N-((2-bromo-5-(N-isopropyl-N-(4-methoxy-2-methylphenyl)sulfamoyl)phenyl)(methyl)-λ4-sulfanylidene)-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sodium hydride In tetrahydrofuran at 20℃; for 2h;	100%

: (S)-2-methyl-1-[(2-nitrophenyl)sulfonyl]aziridine

: 354-38-1
2,2,2-trifluoroacetamide

: (S)-2,2,2-trifluoro-N-{2-[(2-nitrophenyl)sulfonamido]propyl}acetamide

Conditions

Conditions	Yield
Stage #1: 2,2,2-trifluoroacetamide With potassium hexamethylsilazane In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: (S)-2-methyl-1-[(2-nitrophenyl)sulfonyl]aziridine In tetrahydrofuran; dichloromethane at 20℃; for 18h; Inert atmosphere;	100%

: 354-38-1
2,2,2-trifluoroacetamide

: 353-85-5
trifluoroacetonitrile

Conditions

Conditions	Yield
With copper(II) oxide at 400℃; under 750.075 Torr; for 10h; Gas phase;	99.1%
With pyridine; pivaloyl chloride; trifluoroacetic acid at 20℃; for 5h; Product distribution / selectivity;	92%
With phosphorus pentoxide Heating;	90%

: 354-38-1
2,2,2-trifluoroacetamide

: 91043-70-8
N-Methoxymethylmonoaza-15-crown-5 ether

: 127846-31-5
2,2,2-Trifluoro-N-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-ylmethyl)-acetamide

Conditions

Conditions	Yield
In tetrachloromethane Heating;	99%

: 354-38-1
2,2,2-trifluoroacetamide

: 586-77-6
4-bromo-N,N-dimethylaniline

: 41116-22-7
2,2,2-trifluoro-(4-N,N-dimethyphenyl)acetamide

Conditions

Conditions	Yield
With potassium carbonate; N,N`-dimethylethylenediamine; copper(l) iodide In 1,4-dioxane at 75℃;	99%

: 354-38-1
2,2,2-trifluoroacetamide

: 1072123-51-3
C16H11NO

: 1152309-94-8
C18H13F3N2O2

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 1,1'-bis(diphenylphosphino)ferrocene In toluene at 100℃; for 3h; Inert atmosphere; optical yield given as %de; stereoselective reaction;	99%

: 354-38-1
2,2,2-trifluoroacetamide

: 1152309-83-5
C15H8BrNO

: 1152309-97-1
C17H10BrF3N2O2

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 1,1'-bis(diphenylphosphino)ferrocene In toluene at 100℃; for 3h; Inert atmosphere; optical yield given as %de; stereoselective reaction;	99%

: 354-38-1
2,2,2-trifluoroacetamide

: 220466-11-5
1-isocyanato-2-(2-phenylethynyl)benzene

: 1152309-90-4
C17H11F3N2O2

Conditions

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 1,1'-bis(diphenylphosphino)ferrocene In toluene at 100℃; for 3h; Inert atmosphere; optical yield given as %de; stereoselective reaction;	99%

: 4117-09-3
7-bromo-hept-1-ene

: 354-38-1
2,2,2-trifluoroacetamide

: 1268372-73-1
2,2,2-trifluoro-N-(hept-6-en-1-yl)acetamide

Conditions

Conditions	Yield
Stage #1: 2,2,2-trifluoroacetamide With sodium hydride In N,N-dimethyl-formamide at 0℃; Inert atmosphere; Stage #2: 7-bromo-hept-1-ene In N,N-dimethyl-formamide at 50℃; for 3h; Inert atmosphere;	99%

: 354-38-1
2,2,2-trifluoroacetamide

: 1119-51-3
bromopentene

: 2,2,2-trifluoro-N-(pent-4-en-1-yl)acetamide

Conditions

Conditions	Yield
Stage #1: 2,2,2-trifluoroacetamide With sodium hydride In N,N-dimethyl-formamide at 0℃; Inert atmosphere; Stage #2: bromopentene In N,N-dimethyl-formamide at 50℃; for 3h; Inert atmosphere;	99%
Stage #1: 2,2,2-trifluoroacetamide With sodium hydride In N,N-dimethyl-formamide; paraffin oil at 20℃; for 2h; Stage #2: bromopentene In N,N-dimethyl-formamide; paraffin oil at 50℃; for 21h;	63%

: 354-38-1
2,2,2-trifluoroacetamide

: (S)-2-benzyl-1-((2-nitrophenyl)sulfonyl)aziridine

: (S)-2,2,2-trifluoro-N-{2-[(2-nitrophenyl)sulfonamido]-3-phenylpropyl}acetamide

Conditions

Conditions	Yield
Stage #1: 2,2,2-trifluoroacetamide With potassium hexamethylsilazane In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: (S)-2-benzyl-1-((2-nitrophenyl)sulfonyl)aziridine In tetrahydrofuran; dichloromethane at 20℃; for 18h; Inert atmosphere;	99%

: 354-38-1
2,2,2-trifluoroacetamide

: 89384-43-0
[1-(1-Cyano-3-methyl-butylcarbamoyl)-2-phenyl-ethyl]-carbamic acid methyl ester

: 89384-44-1
{1-[4-Isobutyl-5-(2,2,2-trifluoro-acetylamino)-oxazol-2-yl]-2-phenyl-ethyl}-carbamic acid methyl ester

Conditions

Conditions	Yield
trifluoroacetic acid	98%

: 354-38-1
2,2,2-trifluoroacetamide

: 89384-49-6, 150957-49-6
Cbz-l-Leu-dl-Phe-N-benzyl amide

: 87783-99-1
2-<1(S)-(carbobenzyloxyamino)-3-methylbutyl>-4-benzyl-5-(N-benzyltrifluoroacetamido)oxazole

Conditions

Conditions	Yield
trifluoroacetic acid In dichloromethane	98%

: 354-38-1
2,2,2-trifluoroacetamide

: 2695-47-8
6-Bromo-1-hexene

: 183439-11-4
2,2,2-trifluoro-N-(hex-5-en-1-yl)acetamide

Conditions

Conditions	Yield
Stage #1: 2,2,2-trifluoroacetamide With sodium hydride In N,N-dimethyl-formamide at 0℃; Inert atmosphere; Stage #2: 6-Bromo-1-hexene In N,N-dimethyl-formamide at 50℃; for 3h; Inert atmosphere;	98%
With sodium hydride 1) DMF, 0.5 h; 2) DMF, 80 deg C, 10 h; Yield given. Multistep reaction;

: 354-38-1
2,2,2-trifluoroacetamide

: 139-66-2
diphenyl sulfide

: 87446-53-5
S,S-diphenyl-N-(trifluoroacetyl)sulfilimine

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; magnesium oxide; dirhodium tetraacetate In dichloromethane at 20℃; for 6h;	98%
With rhodium(II) acetate dimer; [bis(acetoxy)iodo]benzene; magnesium oxide In dichloromethane at 20℃; for 18h; Inert atmosphere;

: 354-38-1
2,2,2-trifluoroacetamide

: 92-66-0
4-bromo-1,1'-biphenyl

: 347-37-5
2,2,2-trifluoro-4'-phenylacetanilide

Conditions

Conditions	Yield
With potassium carbonate; N,N`-dimethylethylenediamine; copper(l) iodide In 1,4-dioxane at 75℃;	98%

: 354-38-1
2,2,2-trifluoroacetamide

: 1352227-18-9
(3R)-4-(2-chloro-6-[(methylsulfinyl)methyl]-4-pyrimidinyl)-3-methylmorpholine

: N-[({2-chloro-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-4-yl}methyl)(methyl)oxido-λ6-sulfanylidene]-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With rhodium(II) acetate; [bis(acetoxy)iodo]benzene; magnesium oxide In dichloromethane at 20℃; for 16h; Inert atmosphere;	98%
With [bis(acetoxy)iodo]benzene; magnesium oxide; dirhodium tetraacetate In dichloromethane at 20℃; for 96h;	82%
With dirhodium tetraacetate; [bis(acetoxy)iodo]benzene; magnesium oxide In dichloromethane at 20℃; for 96h;	82%
With rhodium(II) acetate dimer; [bis(acetoxy)iodo]benzene In dichloromethane at 20℃; for 36h; Reagent/catalyst;	64.82%

: 354-38-1
2,2,2-trifluoroacetamide

: C3H13B10I

: C6H16B10F3NO

Conditions

Conditions	Yield
With potassium phosphate; [methanesulfonato2-dicyclohexylphosphino-2-(N,N-dimethylamino)biphenyl(2′-amino-1,1′-biphenyl-2-yl)palladium(II)] In toluene at 100℃; for 12h; Inert atmosphere; Sealed tube; Schlenk technique;	98%

: 354-38-1
2,2,2-trifluoroacetamide

: (S)-2-isobutyl-1-[(2-nitrophenyl)sulfonyl]aziridine

: (S)-2,2,2-trifluoro-N-{4-methyl-2-[(2-nitrophenyl)sulfonamido]pentyl}acetamide

Conditions

Conditions	Yield
Stage #1: 2,2,2-trifluoroacetamide With potassium hexamethylsilazane In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #2: (S)-2-isobutyl-1-[(2-nitrophenyl)sulfonyl]aziridine In tetrahydrofuran; dichloromethane at 20℃; for 18h; Inert atmosphere;	98%

: 354-38-1
2,2,2-trifluoroacetamide

: C17H16O2

: N-((6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzofuran-2-yl)(phenyl)methyl)-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With tris(2,2'-bipyridyl)ruthenium dichloride; sodium carbonate In 1,2-dichloro-ethane at 20℃; for 8h; Irradiation;	98%

: 354-38-1
2,2,2-trifluoroacetamide

: 67082-95-5
3-(3-phenylpropyl-2-yn-1-ylidene)-2,4-pentanedione

: N-((4-acetyl-5-methylfuran-2-yl)(phenyl)methyl)-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With tris(2,2'-bipyridyl)ruthenium dichloride; sodium carbonate In 1,2-dichloro-ethane at 20℃; for 8h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Irradiation;	98%

: 354-38-1
2,2,2-trifluoroacetamide

: 120758-24-9
1-benzyloxy-3-tosyloxypropane

: 185854-00-6
N-(3-Benzyloxypropyl)-2,2,2-trifluoroacetamide

Conditions

Conditions	Yield
With potassium tert-butylate; sodium iodide In tetrahydrofuran for 4h;	97%

Trifluoroacetamide Chemical Properties

IUPAC Name: 2,2,2-Trifluoroacetamide
Following is the structure of Trifluoroacetamide (CAS NO.354-38-1):

Molecular Formula: C₂H₂F₃NO
Molecular Weight: 113.04g/mol
Mol File: 354-38-1.mol
EINECS: 206-559-9
Melting Point: 65-70 °C(lit.)
Boiling point: 162.5 °C(lit.)
Storage Temperature: Store at RT.
Flash Point: 162-164 °C
Water Solubility: 460 g/L (20 °C)
Surface Tension: 21.4 dyne/cm
Enthalpy of Vaporization: 39.91 kJ/mol
Vapour Pressure: 2.16 mmHg at 25°C
XLogP3-AA: 0.1
H-Bond Donor: 1
H-Bond Acceptor: 4
Appearance of Trifluoroacetamide (CAS NO.354-38-1): White to pale yellow or beige crystalline powder
Product Categories of Trifluoroacetamide (CAS NO.354-38-1): Amides; Carbonyl Compounds; Organic Building Blocks
Canonical SMILES: C(=O)(C(F)(F)F)N
InChI: InChI=1S/C2H2F3NO/c3-2(4,5)1(6)7/h(H2,6,7)
InChIKey: NRKYWOKHZRQRJR-UHFFFAOYSA-N

Trifluoroacetamide Safety Profile

Safety Information of Trifluoroacetamide (CAS NO.354-38-1):
Hazard Codes: Xi Irritant
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
S37/39:Wear suitable gloves and eye/face protection.

Trifluoroacetamide Specification

Trifluoroacetamide , its CAS NO. is 354-38-1, the synonyms are 2,2,2-Trifluoroacetamide ; Acetamide, 2,2,2-trifluoro- ; 2,2,2-Trifluoro-acetamide .

Product Name

Trifluoroacetamide

Synthetic route

Trifluoroacetamide Chemical Properties

Trifluoroacetamide Safety Profile

Trifluoroacetamide Specification

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