Product Name

  • Name

    trifluperidol

  • EINECS
  • CAS No. 749-13-3
  • Article Data4
  • CAS DataBase
  • Density 1.26g/cm3
  • Solubility
  • Melting Point
  • Formula C22H23 F4 N O2
  • Boiling Point 535.7°C at 760 mmHg
  • Molecular Weight 409.424
  • Flash Point 277.8°C
  • Transport Information
  • Appearance
  • Safety Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F− and NOx. See also FLUORIDES and TRIFLUPERIDOL HYDROCHLORIDE.
  • Risk Codes
  • Molecular Structure Molecular Structure of 749-13-3 (trifluperidol)
  • Hazard Symbols
  • Synonyms Butyrophenone,4'-fluoro-4-[4-hydroxy-4-(a,a,a-trifluoro-m-tolyl)piperidino]- (6CI,7CI,8CI);4'-Fluoro-4-[4-hydroxy-4-(a,a,a-trifluoro-m-tolyl)piperidino]butyrophenone;Flumoperone; McN-JR 2498; NSC 170978; P 459; Psicoperidol; R 2498;Trifluoperidol; Trifluperidol; Trifluperol; Triperidol; Trisedil; p-Fluoro-g-[4-hydroxy-4-(3-trifluoromethylphenyl)piperidino]butyrophenone
  • PSA 40.54000
  • LogP 4.72890

Trifluperidol Chemical Properties

IUPAC Name: 1-(4-Fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidyl]butan-1-one
Synonyms of Trifluperidol (CAS NO.749-13-3) : 1-Butanone, 1-(4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)-1-piperidinyl)- ; 4'-Fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino butyrophenone ; Flumoperone ; Psicoperidol ; Trifluperidol ; Trisedil ; Butyrophenone, 4'-fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino)-
InChI:InChI=1/C22H23F4NO2/c23-19-8-6-16(7-9-19)20(28)5-2-12-27-13-10-21(29,11-14-27)17-3-1-4-18(15-17)22(24,25)26/h1,3-4,6-9,15,29H,2,5,10-14H2   
CAS NO:749-13-3
Molecular Formula:C22H23F4NO2                                                      
Molecular Weight :409.4171                                                              
Molecular Structure :
Index of Refraction:  1.534 
Surface Tension:  41.1 dyne/cm 
Density:  1.26 g/cm3 
Flash Point:  265.8 °C 
Enthalpy of Vaporization:  82.95 kJ/mol 
Boiling Point:  515.9 °C at 760 mmHg 
Vapour Pressure:  1.8E-11 mmHg at 25°C 

Trifluperidol Uses

 Trifluperidol (CAS NO.749-13-3) is a typical antipsychotic of the butyrophenone chemical class.It is used in the treatment of psychoses including mania and schizophrenia.

Trifluperidol Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 subcutaneous > 2500ug/kg (2.5mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
dog LD50 subcutaneous > 80mg/kg (80mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
monkey LD50 subcutaneous > 1250ug/kg (1.25mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse LD50 intravenous 26mg/kg (26mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse LD50 oral 110mg/kg (110mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT		 Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1248, 1974.
mouse LD50 subcutaneous 50mg/kg (50mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT		 Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 1248, 1974.
mouse LDLo intraperitoneal 150mg/kg (150mg/kg)   National Technical Information Service. Vol. AD691-490,
rat LD50 intravenous 14mg/kg (14mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
rat LD50 oral 140mg/kg (140mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
rat LD50 subcutaneous 70mg/kg (70mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

AUTONOMIC NERVOUS SYSTEM: CENTRAL SYMPATHOLYTIC

BEHAVIORAL: ALTERATION OF CLASSICAL CONDITIONING		 Medicinal Chemistry: A Series of Monographs. Vol. 4(2), Pg. 199, 1967.

Trifluperidol Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of F− and NOx. See also FLUORIDES and TRIFLUPERIDOL HYDROCHLORIDE.

Trifluperidol Specification

 Trifluperidol (CAS NO.749-13-3) has general properties similar to those of haloperidol, but is considerably more potent by weight, and causes relatively more severe side effects, especially tardive dyskinesia and other extrapyramidal effects.

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