Product Name

  • Name

    trimethylcolchicinic acid methyl ether

  • EINECS
  • CAS No. 3476-50-4
  • Article Data2
  • CAS DataBase
  • Density 1.25g/cm3
  • Solubility
  • Melting Point
  • Formula C20H23 N O5
  • Boiling Point 626.6°Cat760mmHg
  • Molecular Weight 357.406
  • Flash Point 287°C
  • Transport Information
  • Appearance
  • Safety Poison by intraperitoneal and intramuscular routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also COLCHICINE and ETHERS.
  • Risk Codes
  • Molecular Structure Molecular Structure of 3476-50-4 (trimethylcolchicinic acid methyl ether)
  • Hazard Symbols
  • Synonyms Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (S)-; Colchicine, N-deacetyl-(7CI,8CI); Colchicine, deacetyl- (6CI); (-)-7-Deacetylcolchicine;(-)-Deacetylcolchicine; Deacetylcolchicine; Desacetylcolchicine;N-Deacetylcolchicine; N-Desacetylcolchicine; NSC 201400
  • PSA 80.01000
  • LogP 3.39450

Trimethylcolchicinic acid methyl ether Chemical Properties

IUPAC Name: (7S)-7-Amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one 
Molecular Formula: C20H23NO5
Molecular Weight: 357.44g/mol
Density: 1.25g/cm3
Boiling Point: 626.6°C at 760mmHg
Flash Point: 287°C 
Freely Rotating Bonds: 5
Polar Surface Area: 57.23 Å2
Index of Refraction: 1.597
Molar Refractivity: 97.19 cm3
Molar Volume: 284.9 cm3
Polarizability: 38.53 ×10-24 cm3
Surface Tension: 51.7 dyne/cm
Enthalpy of Vaporization: 92.74 kJ/mol
Vapour Pressure: 1.29E-15 mmHg at 25°C
The Cas Register Number  of Trimethylcolchicinic acid methyl ether is 3476-50-4.The chemical synonyms of Trimethylcolchicinic acid methyl ether (CAS NO.3476-50-4) are (7S)-7-Amino-1,2,3,10-tetramethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one ; Benzo[a]heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (7S)- ; (S)-7-Amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo(a)heptalen-9(5H)-one ; 7-Amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one ; Benzo(a)heptalen-9(5H)-one, 7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (S)- (9CI) ; Colchicine analog ; Colchicine, N-deacetyl- ; Colchinic acid trimethyl ; Deacetylcolchicine ; N-Deacetylcolchicine ; Tmca methyl ether ; Trimethylcolchicinic acid methyl ether .The molecular structure of Trimethylcolchicinic acid methyl ether (CAS NO.3476-50-4) is.

Trimethylcolchicinic acid methyl ether Uses

  Trimethylcolchicinic acid methyl ether (CAS NO.3476-50-4) is used as organic intermediate.

Trimethylcolchicinic acid methyl ether Toxicity Data With Reference

1.    

oms-mus-par 46 mg/kg

     CANCAR    Cancer. 3 (1950),134.
2.    

spm-mus-par 46 mg/kg

     CANCAR    Cancer. 3 (1950),134.
3.    

ipr-mus LD50:46 mg/kg

     MDREP*    U.S. Army, Chemical Corps Medical Division Reports .(Army Chemical Center, MD.: )1949,204.
4.    

ims-mus LD50:49 mg/kg

     JMCMAR    Journal of Medicinal Chemistry. 24 (1981),257.

Trimethylcolchicinic acid methyl ether Safety Profile

Poison by intraperitoneal and intramuscular routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also COLCHICINE and ETHERS.
Safety Statements: 22-24/25 
S22: Do not breathe dust. 
S24/25: Avoid contact with skin and eyes.
WGK Germany: 3

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