• Name

  Tulobuterol

• EINECS
• CAS No. 41570-61-0
• Article Data11
• CAS DataBase
• Density 1.098 g/cm³
• Solubility
• Melting Point 89-91 °C
• Formula C₁₂H₁₈ClNO
• Boiling Point 338.2 °C at 760 mmHg
• Molecular Weight 227.734
• Flash Point 158.3 °C
• Transport Information
• Appearance Crystalline Solid
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms HN 078;o-Chloro-a-[(tert-butylamino)methyl]benzyl alcohol;
• PSA 32.26000
• LogP 3.15240

Synthetic route

27993-71-1

1-(2-chlorophenyl)-2-hydroxyethanone

75-64-9

tert-butylamine

41570-61-0

tulobuterol

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate at 15 - 20℃;	94.1%
Stage #1: 1-(2-chlorophenyl)-2-hydroxyethanone; tert-butylamine In 1,2-dichloro-ethane at 25℃; for 2h; Stage #2: With sodium tetrahydroborate In 1,2-dichloro-ethane at 0℃; for 2h;	73%

62717-50-4

o-chlorostyrene oxide

75-64-9

tert-butylamine

41570-61-0

tulobuterol

Conditions

Conditions	Yield
In methanol at 40 - 50℃; for 9h; Concentration;	93%
In water at 20℃; for 48h;	59%
In ethanol; toluene at 150℃; under 6000.6 - 6750.68 Torr; for 0.833333h; Flow reactor; regioselective reaction;	162 mg

72702-57-9

2-Bromo-1-(2-chlorophenyl)ethan-1-ol

75-64-9

tert-butylamine

41570-61-0

tulobuterol

Conditions

Conditions	Yield
In ethanol for 6h; Reflux; Large scale;	89%
In ethanol at 20 - 80℃; for 3h; Temperature;	85%
for 8h; Reflux; Inert atmosphere;	68%

2142-68-9

1-(2-chlorophenyl)ethanone

75-64-9

tert-butylamine

41570-61-0

tulobuterol

Conditions

Conditions	Yield
Stage #1: 1-(2-chlorophenyl)ethanone With N-Bromosuccinimide; toluene-4-sulfonic acid In dichloromethane for 6h; Reflux; Stage #2: tert-butylamine With magnesium sulfate In methanol at 30℃; for 4h; Inert atmosphere; Stage #3: With potassium borohydride In ethanol at -10 - 10℃; for 6.5h; Solvent; Reagent/catalyst; Temperature; Reflux;	79%

17849-38-6

2-Chlorobenzyl alcohol

41570-61-0

tulobuterol

Conditions

Conditions

Yield

Multi-step reaction with 3 steps 1: sodium hypochlorite; potassium bromide; sodium hydrogencarbonate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; toluene / 0 °C / Flow reactor 2: sodium hydroxide; tetra-(n-butyl)ammonium iodide / water; toluene / 0.4 h / 90 °C / 750.08 - 1500.15 Torr / Flow reactor 3: ethanol; toluene / 0.83 h / 150 °C / 6000.6 - 6750.68 Torr / Flow reactor View Scheme

13524-04-4

2'-chloro-sec-phenethyl alcohol

41570-61-0

tulobuterol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium hydrogensulfate; hydroquinone / 3 h / 200 - 205 °C 2: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / Reflux 3: methanol / 9 h / 40 - 50 °C View Scheme

2142-68-9

1-(2-chlorophenyl)ethanone

41570-61-0

tulobuterol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: iodine; dimethyl sulfoxide / 120 °C 2.1: 1,2-dichloro-ethane / 2 h / 25 °C 2.2: 2 h / 0 °C View Scheme
Multi-step reaction with 3 steps 1: bromine / water / 0.75 h / 20 °C / Large scale 2: potassium borohydride / water; ethanol / 0.25 h / 20 °C / Cooling with ice; Large scale 3: ethanol / 6 h / Reflux; Large scale View Scheme

89-98-5

2-chloro-benzaldehyde

41570-61-0

tulobuterol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 5 - 20 °C 2: water / 48 h / 20 °C View Scheme

3303-84-2

3-(tert-butyloxycarbonylamino)propionic acid

41570-61-0

tulobuterol

C20H31ClN2O4

Conditions

Conditions	Yield
With dmap In dichloromethane at 0 - 20℃; for 3h;	98%

41570-61-0

tulobuterol

56776-01-3

Tulobuterol hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether; isopropyl alcohol	91%

41570-61-0

tulobuterol

β-alanyl-tulobuterol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dmap / dichloromethane / 3 h / 0 - 20 °C 2: hydrogenchloride / tetrahydrofuran; ethyl acetate / 2 h / 0 - 20 °C View Scheme

41570-61-0

tulobuterol

A

tulobuterol

B

tulobuterol

Conditions

Conditions	Yield
With ammonium acetate; triethylamine In water; acetonitrile pH=5;