-
Name
VALERENIC ACID
- EINECS
- CAS No. 3569-10-6
- Article Data4
- CAS DataBase
- Density 1.06 g/cm3
- Solubility Soluble in Ethanol
- Melting Point 134-139°C
- Formula C15H22 O2
- Boiling Point 374.5 °C at 760 mmHg
- Molecular Weight 234.338
- Flash Point 274.2 °C
- Transport Information
- Appearance brown-yellow powder
- Safety A poison by intraperitoneal route. When heated to decomposition it emits acrid smoke and irritating vapors.
- Risk Codes
-
Molecular Structure
- Hazard Symbols A poison.
- Synonyms 2-Propenoicacid, 3-(2,4,5,6,7,7a-hexahydro-3,7-dimethyl-1H-inden-4-yl)-2-methyl-, [4S-[4a(E),7b,7aa]]-;Indene-4-acrylic acid, 2,4,5,6,7,7a-hexahydro-a,3,7-trimethyl- (7CI,8CI);Valerenic acid (6CI);Valerenic acid;64130-69-4;
- PSA 37.30000
- LogP 3.78990
VALERENIC ACID Chemical Properties
Chemical Name: VALERENIC ACID
CBNumber: CB3449648
Molecular Formula: C15H22O2
Formula Weight: 234.33
CAS No.: 3569-10-6
molecular structure:
Synonyms:VALERENIC ACID;VALERENIC ACID SNAP-N-SHOOT 0.1mg/mL(P);VALERENIC ACID(AHP);VALERENIC ACID WITH HPLC;(E)-3-[(4S)-2,4,5,6,7,7aα-Hexahydro-3,7β-dimethyl-1H-inden-4-yl]-2-methylpropenoic acid
mp :134-139°C
storage temp:-20°C
Valerian is used as a herbal sedative which may be helpful in the treatment of insomnia. While the precise mechanism of this action has not been established and it is likely that several different components of the plant contribute to the effect, valerenic acid is thought to be at least partly responsible for the sedative effects.
Valerenic acid is a sesquiterpenoid constituent of the essential oil of the Valerian plant.
Valerenic acid has been demonstrated to be both a subtype-selective GABAA agonist acting mainly at α1β2 and α1β3 subtypes, and also a 5HT5A partial agonist. Both of these actions are likely to play a role in the sedative effects of this compound, as other GABAA agonists such as benzodiazepines are commonly used as sedative drugs, and while no selective 5HT5A agonists are currently used medically, the 5HT5A receptor is known to be highly expressed in the suprachiasmatic nucleus of the brain, which is believed to be involved in the sleep-wake cycle.
Valerenic acid has also been reported to be an NF-κB inhibitor, and may be partly responsible for the reported anti-inflammatory action of the valerian plant.
VALERENIC ACID Toxicity Data With Reference
| 1. | ipr-mus TDLo:50 mg/kg | TCPHP* Toxicology and Clinical Pharmacology of Herbal Products Melanie Johns Cupp ed.,Humana press,2000,56. | ||
| 2. | ipr-mus TDLo:100 mg/kg | TCPHP* Toxicology and Clinical Pharmacology of Herbal Products Melanie Johns Cupp ed.,Humana press,2000,57. | ||
| 3. | ipr-mus TDLo:150 mg/kg | TCPHP* Toxicology and Clinical Pharmacology of Herbal Products Melanie Johns Cupp ed.,Humana press,2000,57. |
VALERENIC ACID Safety Profile
VALERENIC ACID Specification
F 9 Keep under nitrogen.
F 10 Keep under argon
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