IUPAC Name: (2S,3R,5S)-2-[(1S)-1-[(3S,6aR,11aS,11bR)-3-hydroxy-10,11b-dimethyl-1,2,3,4,6,6a,11,11a-octahydrobenzo[a]fluoren-9-yl]ethyl]-5-methylpiperidin-3-ol
Synonyms: Veratramine ; Vreaframine ; (3b,23b)-14,15,16,17-Teradehydroveratraman-3,23-diol ; (3,23)-14,15,16,17-Teradehydroveratraman-3,23-diol
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
Molecular Formula of Veratramine (CAS NO.60-70-8) : C27H39NO2
Molecular Weight: 409.6041 g/mol
Structure of Veratramine (CAS NO.60-70-8) :
Index of Refraction: 1.601
Surface Tension: 50.5 dyne/cm
Density: 1.14 g/cm3
Flash Point: 86.2 °C
Enthalpy of Vaporization: 89.29 kJ/mol
Boiling Point: 565 °C at 760 mmHg
Vapour Pressure: 1.33E-13 mmHg at 25°C
Melting point: 122-1240°C
Appearance: White Solid
Veratramine (CAS NO.60-70-8) is useful as signal transduction inhibitor for treating tumors.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 3100ug/kg (3.1mg/kg) | Cesko-Slovenska Farmacie. Vol. 2, Pg. 418, 1953. | |
mouse | LD50 | subcutaneous | 4500ug/kg (4.5mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 89, 1955. |
rabbit | LDLo | oral | 33mg/kg (33mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR | Teratology, The International Journal of Abnormal Development. Vol. 3, Pg. 175, 1970. |
Poison by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. When heated to decomposition Veratramine (CAS NO.60-70-8) emits toxic fumes of NOx.
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