p-Aminobenzamide supplier | CasNO.2835-68-9

Name
p-Aminobenzamide
EINECS 220-612-3
CAS No. 2835-68-9
Article Data186
CAS DataBase
Density 1.233 g/cm³
Solubility water: 9530 mg/L 25 °C
Melting Point 181-183 °C(lit.)
Formula C₇H₈N₂O
Boiling Point 349 °C at 760 mmHg
Molecular Weight 136.153
Flash Point 164.9 °C
Transport Information
Appearance off-white to beige crystalline powder
Safety 38-37/39-26-36
Risk Codes 20/22-36/38-36/37/38
Molecular Structure
Hazard Symbols Xn,Xi
Synonyms Benzamide,p-amino- (6CI,7CI,8CI);(4-(Aminocarbonyl)phenyl)amine;(4-Aminophenyl)carboxamide;4-Aminobenzamide;4-Carbamoylaniline;4-Carboxamidoaniline;NSC233920;NSC 36963;SR 4329;p-Aminobenzenecarboxamide;p-Carbamoylaniline;
PSA 69.11000
LogP 1.64920

Synthetic route

: 619-80-7
4-nitrobenzamide

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethanol	100%
With palladium on activated carbon; hydrogen In methanol at 20℃; under 750.075 Torr; for 3h;	100%
With hydrogen In ethyl acetate at 20℃; under 7600.51 Torr; for 2h; Autoclave;	99%

: 873-74-5
4-Aminobenzonitrile

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With C18H57O3P6Ru2(1+)C6H5O(1-)C6H6O; water In 1,4-dioxane for 48h; Time; Sealed tube; Inert atmosphere; Schlenk technique;	100%
With [RuH(tBu-PNP(-))(CO)]; water In tert-butyl alcohol at 80℃; for 16h;	99%
With Amberlyst A-26 (OH- form); dihydrogen peroxide In methanol at 20℃; for 3h; Hydrolysis;	97%

: 99-77-4
ethyl 4-nitrobenzoate

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With palladium on carbon; ammonia; hydrogen In methanol at 30 - 35℃; under 1500.15 - 2250.23 Torr; for 7h; Temperature; Solvent; Reagent/catalyst; Autoclave;	98.8%

: 556-18-3
4-aminobenzaldehyde

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With aluminum oxide; hydroxylamine hydrochloride; methanesulfonyl chloride; water at 100℃; for 1.5h;	97%
With hydroxylamine hydrochloride; methanesulfonyl chloride In neat (no solvent) at 70℃; for 3h;	88%
With tert.-butylhydroperoxide; titanium superoxide; saccharin In 1,4-dioxane; hexane at 90℃; for 1h; Green chemistry;	38%
Multi-step reaction with 2 steps 1: hydroxylamine hydrochloride; pyridine / methanol / 24 h / 20 °C 2: [RuCl2(η2-C6H6){P(NMe2)3}]; water / 7 h / 100 °C / Inert atmosphere; Sealed tube View Scheme

: 64-10-8
phenyl carbamate

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With aluminium trichloride for 0.0833333h; Fries rearrangement; microwave irradiation;	95%

: 27332-13-4
4,4'-dicarbamoylazobenzene

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With aminomethylpolystyrene-supported formate; palladium on activated charcoal In methanol at 20℃; for 4.5h;	95%
With aminomethyl polysterene resine formic acid salt; zinc In methanol at 20℃; for 0.333333h;	94%
With zinc In methanol at 25℃; for 0.2h; Inert atmosphere;	94%
With polystyrene-CH2-NH3(+)HCO2(-); magnesium In methanol at 20℃; for 0.233333h;	93%
With magnesium In methanol at 25℃; for 0.216667h; Inert atmosphere;	92%

: 698-67-9
p-bromobenzamide

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With copper(I) oxide; 1-D-O-Methyl-chiro-inositol; ammonia; sodium hydroxide In water at 100℃; for 12h;	95%
With C24H32N2*ClCu; ammonia; potassium carbonate In 1-methyl-pyrrolidin-2-one; methanol at 90℃; under 5171.62 Torr; for 24h; Inert atmosphere;	93%
With ammonium hydroxide; ethylenediaminetetraacetic acid; potassium carbonate; copper(II) oxide In water at 100℃; for 12h; Sealed tube;	59%

: 873-74-5
4-Aminobenzonitrile

A: 2835-68-9
4-aminobenzamide

B: 150-13-0
4-amino-benzoic acid

Conditions

Conditions	Yield
With water at 140℃; for 6h; Sealed tube;	A 94% B 6%
With potassium phosphate buffer at 30℃; for 9h; Rhodococcus sp. AJ270 cells;	A 63.7% B 9.7%
With phosphate buffer at 30℃; for 48h; rhodococcus rhodocrous AJ270, pH 7.0;	A 30% B 38%
With potassium phosphate buffer at 30℃; for 48h; Rhodococcus sp. AJ270 cells;	A 30.1% B 37.5%

: 62-23-7
4-nitro-benzoic acid

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
Multistep reaction;	94%
Multistep reaction;
Multi-step reaction with 3 steps 1: pyridine; triethylamine / toluene / 20 h / 0 - 20 °C 2: ammonia; cetyltrimethylammonium chloride / toluene; water / 3 h / 40 °C 3: hydrogen; 5%-palladium/activated carbon / toluene; water / 60 °C / Autoclave View Scheme
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide; thionyl chloride / 3 h / 50 - 60 °C / 750.08 Torr / Green chemistry 2: ammonium hydroxide / 4 h / 50 - 60 °C / 1500.15 Torr / Green chemistry 3: hydrazine hydrate / ethanol; water / 3 h / 50 - 60 °C / Green chemistry View Scheme
Multi-step reaction with 3 steps 1: sulfuric acid / 15 h / Reflux 2: ammonia / methanol / 70 °C 3: hydrogen; palladium on activated charcoal / methanol / 20 °C View Scheme

: 88609-06-7
4-azidobenzamide

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With zinc In methanol at 20℃; for 3h;	94%
With D-glucose; potassium hydroxide In water at 85℃; for 0.166667h; Green chemistry; chemoselective reaction;	94%
With ammonium hydroxide at 90℃; for 4.16667h;	93%

: 16106-38-0
4-aminobenzoyl chloride

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With formamide at 100 - 120℃; Neat (no solvent);	93%
With ammonia In tetrahydrofuran; water at 0 - 20℃; for 12h;	30%
With ammonium hydroxide In tetrahydrofuran at 20℃; for 2h;

: 99-92-3
4-Aminoacetophenone

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With ammonia; water; iodine In tetrahydrofuran at 20℃; for 24h; Haller-Bauer reaction;	90%
With tert.-butylhydroperoxide; ammonia; tetra-(n-butyl)ammonium iodide In water at 100℃; for 16h; Green chemistry;	29%

: C8H7N2O3(1-)*K(1+)

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
In water; acetonitrile at 110℃; for 3.5h; Reflux;	88%

: 500545-36-8
4-(benzyloxycarbonylamino)benzamide

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate at 20℃; for 0.25h; chemoselective reaction;	85%

: 94-09-7
p-aminoethylbenzoate

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With ammonia In methanol at 20 - 25℃; under 1500.15 Torr; for 24h; Autoclave; Inert atmosphere;	85%

: 3419-18-9
4-aminobenzaldehyde oxime

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With [RuCl2(η2-C6H6){P(NMe2)3}]; water at 100℃; for 7h; Inert atmosphere; Sealed tube;	84%

: 55-21-0
benzamide

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With ammonia; dihydrogen peroxide In water; tert-butyl alcohol at 80℃; for 3h; Reagent/catalyst; Molecular sieve;	79%

: 636-97-5
N-amino-(4-nitrophenyl)carboxamide

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With tin; phosphoric acid; boric acid; oxalic acid; pyrographite; acetic acid In ethanol; water at 70℃; Electrolysis;	71%

: 623-00-7
4-bromobenzenecarbonitrile

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With diethylenetriaminopentaacetic acid; ammonia; copper(II) oxide; potassium hydroxide In water at 100℃; for 12h;	59%

: 619-45-4
4-methoxycarbonyl aniline

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With ammonium hydroxide In water at 60℃; for 18h;	58%

: 4-amino-N-phenyl-N-tosylbenzamide

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With ammonium carbonate In dimethyl sulfoxide at 40℃; for 16h;	55%

: 1520-21-4
4-vinyl benzylamine

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; ammonia In water at 105℃; for 16h;	51%

: 619-57-8
p-hydroxybenzamide

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With sodium tetrahydroborate; 5%-palladium/activated carbon; hydrazine hydrate In 1,4-dioxane at 170℃; for 16h; Molecular sieve; Inert atmosphere;	46%

: 1197-55-3
4-aminophenylacetic acid

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With copper(I) oxide; ammonium hydroxide; oxygen In water at 130℃; for 19h;	36%

: 89677-75-8
2-iodo-4-nitrobenzamide

: 2835-68-9
4-aminobenzamide

Conditions

Conditions	Yield
With ammonium formate; nickel In methanol for 60h; Ambient temperature;	31%

: 84781-99-7
C10H12N4O2

A: 79-16-3
N-methyl-acetamide

B: 2835-68-9
4-aminobenzamide

C: 1,3-bis(4-benzamido)triazene

Conditions

Conditions	Yield
With sulfuric acid at 25℃; Rate constant;

...Expand

: 110-85-0
piperazine

: 2835-68-9
4-aminobenzamide

: C18H20N8O2

Conditions

Conditions	Yield
Stage #1: 4-aminobenzamide With hydrogenchloride; sodium nitrite In water for 0.5h; cooling; Stage #2: piperazine In water for 0.5h;	100%

: 50-00-0
formaldehyd

: 2835-68-9
4-aminobenzamide

: 110-60-1
1,4-diaminobutane

: 4-(2-{3-[(3-{2-[4-(aminocarbonyl)phenyl]-1-diazenyl}-1,3-diazepan-1-yl)methyl]-1,3-diazepan-1-yl}-1-diazenyl)benzamide

Conditions

Conditions	Yield
Stage #1: 4-aminobenzamide With hydrogenchloride; sodium nitrite at 0 - 5℃; for 0.5h; Stage #2: formaldehyd; 1,4-diaminobutane With sodium hydrogencarbonate In water for 0.5h; cooling;	100%

...Expand

: 10009-70-8
R-(+)-2-bromopropionic acid

: 2835-68-9
4-aminobenzamide

: 4-{[(2R)-2-bromopropanoyl]amino}benzamide

Conditions

Conditions	Yield
With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In tetrahydrofuran; ethyl acetate at 20℃; for 0.5h; Inert atmosphere;	100%
With pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In tetrahydrofuran; ethyl acetate at 20℃; for 0.5h; Inert atmosphere;	100%

: 120-43-4
4-ethoxycarbonylpiperazine

: 2835-68-9
4-aminobenzamide

: 4-(4-carbamoyl-phenyl-diazenyl)-piperazine-1-carboxylic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: 4-aminobenzamide With hydrogenchloride; sodium nitrite In water for 0.5h; cooling; Stage #2: 4-ethoxycarbonylpiperazine In water for 0.5h;	99%

: 2835-68-9
4-aminobenzamide

: 610-14-0
2-nitrobenzyl chloride

: 331240-86-9
N-[4-(aminocarbonyl)phenyl]-3-nitrobenzamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 1h;	99%

: 92-74-0
N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide

: 2835-68-9
4-aminobenzamide

: C.I. Pigment Red 170

Conditions

Conditions	Yield
Stage #1: 4-aminobenzamide With hydrogenchloride; acetic acid; sodium nitrite In water at 3 - 5℃; for 1.16667h; Stage #2: N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide With phenol AS-OL; sodium hydroxide In ethanol at 30 - 80℃; for 0.166667h; Stage #3: at 15 - 20℃; for 0.833333h;	99%
Stage #1: 4-aminobenzamide With hydrogenchloride; acetic acid In water for 1h; Stage #2: With sodium nitrite In water at 0℃; for 1h; Stage #3: N-(2-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide With sodium hydroxide In water at 100℃; for 2h;

: 22445-41-6
3,5-dimethylphenyl iodide

: 2835-68-9
4-aminobenzamide

: 97042-52-9
4-amino-N-(3,5-dimethylphenyl)benzamide

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; (S,S)-1,2-diaminocyclohexane In 1,4-dioxane at 110℃; for 23h;	98%
With potassium phosphate; copper(l) iodide; (S,S)-1,2-diaminocyclohexane In 1,4-dioxane; dodecane at 110℃; for 23h;	98%

: 2835-68-9
4-aminobenzamide

: 538-75-0
dicyclohexyl-carbodiimide

: 1383815-21-1
4-((bis(cyclohexylamino)methylene)amino)benzamide

Conditions

Conditions	Yield
With zinc(II) oxide In toluene at 80℃; for 8h;	98%

: 2835-68-9
4-aminobenzamide

: 501-53-1
benzyl chloroformate

: 500545-36-8
4-(benzyloxycarbonylamino)benzamide

Conditions

Conditions	Yield
With sodium carbonate In tetrahydrofuran at 0℃;	97%

: 2835-68-9
4-aminobenzamide

: 504-02-9
1,3-cylohexanedione

: 100-52-7
benzaldehyde

: 4-(1,2,3,4,5,6,7,8-octahydro-1,8-dioxo-9-phenylacridin-10(9H)-yl)benzamide

Conditions

Conditions	Yield
With hydrogenchloride In N,N-dimethyl-formamide for 1.5h; Reflux;	97%

...Expand

: 2835-68-9
4-aminobenzamide

: 504-02-9
1,3-cylohexanedione

: 555-16-8
4-nitrobenzaldehdye

: 4-(1,2,3,4,5,6,7,8-octahydro-9-(4-nitrophenyl)-1,8-dioxoacridin-10(9H)-yl)benzamide

Conditions

Conditions	Yield
With hydrogenchloride In N,N-dimethyl-formamide for 1.5h; Reflux;	97%

...Expand

: 2835-68-9
4-aminobenzamide

: 61019-00-9
3,5-dimethylphenyl benzenesulfonate

: 4-((3,5-dimethylphenyl)amino)benzamide

Conditions

Conditions	Yield
With palladium diacetate; potassium carbonate; XPhos In tert-butyl alcohol at 110℃; for 3h;	96%
	115 mg (96%)

: 2835-68-9
4-aminobenzamide

: 100-52-7
benzaldehyde

: 4-(N-benzylamino)benzamide

Conditions

Conditions	Yield
With (2,6-dichlorophenyl)bis(2,3,5,6-tetrafluorophenyl)borane; hydrogen In tetrahydrofuran at 100℃; under 60804.1 Torr; for 15h; Sealed tube; Molecular sieve; Autoclave; Green chemistry;	96%
With cobalt(II) phthalocyanine; diphenylsilane In ethanol at 70℃; for 12h; chemoselective reaction;	85%

: 769-54-0
3-fluoro-4-nitropyridine N-oxide

: 2835-68-9
4-aminobenzamide

: 3-((4-carbamoylphenyl)amino)4-nitropyridine 1-oxide

Conditions

Conditions	Yield
In ethanol for 8h; Reflux;	96%

: 2835-68-9
4-aminobenzamide

: 131805-94-2
2-bromo-1-[3,5-di(trifluoromethyl)phenyl]ethan-1-one

: 4-(4-[3,5-bis(trifluoromethyl)phenyl]oxazol-2-yl)aniline

Conditions

Conditions	Yield
In ethanol for 0.166667h; Microwave irradiation;	96%

: 50-00-0
formaldehyd

: 2835-68-9
4-aminobenzamide

: 589-37-7
1,3-diaminopentane

: C27H38N10O2

Conditions

Conditions	Yield
Stage #1: 4-aminobenzamide With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.5h; Stage #2: formaldehyd; 1,3-diaminopentane With sodium hydrogencarbonate In water for 0.5h; pH=7; cooling;	95%

...Expand

: 2835-68-9
4-aminobenzamide

: 555-16-8
4-nitrobenzaldehdye

: 126-81-8
dimedone

: 4-(1,2,3,4,5,6,7,8-octahydro-3,3,6,6-tetramethyl-1,8-dioxo-9-[(4-nitrophenylacridine-10(9H)-yl)])benzamide

Conditions

Conditions	Yield
With hydrogenchloride In N,N-dimethyl-formamide for 1.5h; Reflux;	95%

...Expand

: 576-26-1
2.6-dimethylphenol

: 2835-68-9
4-aminobenzamide

: (E)‑4‑((4‑hydroxy‑3,5‑dimethylphenyl)diazenyl)benzamide

Conditions

Conditions	Yield
Stage #1: 4-aminobenzamide With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.75h; Stage #2: 2.6-dimethylphenol With sodium hydroxide In water at 0 - 5℃; for 1.25h; Alkaline conditions;	95%

: 51-80-9
bis-(dimethylamino)methane

: 2835-68-9
4-aminobenzamide

: 540-63-6
ethane-1,2-dithiol

: 4-(1,5,3-dithiazepan-3-yl)benzamide

Conditions

Conditions	Yield
Stage #1: bis-(dimethylamino)methane; ethane-1,2-dithiol In ethanol; chloroform for 0.5h; Stage #2: 4-aminobenzamide With samarium(III) nitrate hexahydrate In ethanol; chloroform at 70℃; for 24h;	95%

...Expand

p-Aminobenzamide Chemical Properties

IUPAC Name: 4-Aminobenzamide
Following is the structure of Benzamide,4-amino- (CAS NO.2835-68-9):

Empirical Formula: C₇H₈N₂O
Molecular Weight: 136.1512
EINECS: 220-612-3
Index of Refraction: 1.632
Molar Refractivity: 39.41 cm³
Molar Volume: 110.4 cm³
Density: 1.233 g/cm³
Flash Point: 164.9 °C
Surface Tension: 60.1 dyne/cm
Melting point: 181-183 °C(lit.)
Water Solubility: 9530 mg/L 25 °C
Enthalpy of Vaporization: 59.35 kJ/mol
Boiling Point: 349 °C at 760 mmHg
Vapour Pressure: 4.84E-05 mmHg at 25 °C
Appearance of Benzamide,4-amino- (CAS NO.2835-68-9): off-white to beige crystalline powder
Product Categories of Benzamide,4-amino- (CAS NO.2835-68-9): AMIDE;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Amides; Carbonyl Compounds; Organic Building Blocks
Canonical SMILES: C1=CC(=CC=C1C(=O)N)N
InChI: InChI=1S/C7H8N2O/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H2,9,10)
InChIKey: QIKYZXDTTPVVAC-UHFFFAOYSA-N

p-Aminobenzamide Toxicity Data With Reference

Benzamide,4-amino- (CAS NO.2835-68-9) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated.

p-Aminobenzamide Safety Profile

Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 20/22-36/38-36/37/38
R20/22:Harmful by inhalation and if swallowed.
R36/38:Irritating to eyes and skin.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 38-37/39-26-36
S38:In case of insufficient ventilation, wear suitable respiratory equipment.
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 1

p-Aminobenzamide Specification

Benzamide,4-amino-, its cas register number 2835-68-9. It also can be called p-Aminobenzamide ; and 4-Aminobenzamide .
Benzamide,4-amino- (CAS NO.2835-68-9) could be stable. It should avoid the condition like incompatible materials, exposure to moist air or water. It is not compatible with strong oxidizing agents, strong acids. And also prevent it to broken down into hazardous decomposition products: hydrogen cyanide, carbon monoxide, oxides of nitrogen, carbon dioxide, nitric acid. However, its hazardous polymerization will not occur.

Product Name

p-Aminobenzamide

Synthetic route

p-Aminobenzamide Chemical Properties

p-Aminobenzamide Toxicity Data With Reference

p-Aminobenzamide Safety Profile

p-Aminobenzamide Specification

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