Good price, high purity, mature production technology, accept custom synthesis per customer's requirements Package:As per Customer‘ requirements
Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:1038915-60-4
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryNiraparib CAS No.:1038915-60-4 Name: Niraparib Synonyms 2-[4-((3S)-3-Piperidinyl)phenyl]-2H-indazole-7-carboxamide Molecular Structure Molecular Formula: C19H20N4O Molecular Weig
Cas:1038915-60-4
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Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:1038915-60-4
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inquiryHigh quality. Factory supply. In stock. Best price. 1.Quick response within 24 hours. 2.Best quality in your requirement. 3.We pay more attention on delivery time, and usually ship on time. 4.Free samples will be provided. 5.Ensure specifications an
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:1038915-60-4
Min.Order:1 Kilogram
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Chinese Name: Nilapani English Name: Niraparib CAS: 1038915-60-4 Molecular formula: C19H20N4O Molecular weight: 320.3883 Niraparib (trade name Zejula) is a polyadenosine diphosphate ribose polymerase inhibitor, which can inhibit DNA
Cas:1038915-60-4
Min.Order:25 Metric Ton
FOB Price: $3.0 / 5.0
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:1038915-60-4
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:1038915-60-4
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:1038915-60-4
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inquiryAppearance:White to off-white powder Storage:R.T Package:1kg/Bottle or at customers reqirement Application:Ovarian cancer treatment Transportation:Express/Sea/Air Port:Any port in China
Cas:1038915-60-4
Min.Order:100 Gram
Negotiable
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:1038915-60-4
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inquiryNiraparib is a selective inhibitor of PARP1/PARP2 (The poly(ADP-ribose) polymerase) with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It has been recently approved by FDA for the maintenance treatment of adult patients with recurrent
Niraparib Basic information Uses Product Name: Niraparib Synonyms: (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide;MK-4827,(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide;Niraparib;2-[4-((3S)-3-Piperidinyl)phenyl]-2H-indaz
Niraparib CAS:1038915-60-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
Cas:1038915-60-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful
Cas:1038915-60-4
Min.Order:0 Metric Ton
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Type:Trading Company
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:1038915-60-4
Min.Order:1 Gram
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Type:Trading Company
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:1038915-60-4
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryHebei Mojin Biotechnology Co., Ltd,Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all em
Cas:1038915-60-4
Min.Order:1 Gram
FOB Price: $95.0 / 100.0
Type:Trading Company
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product
Niraparib is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:Pale Yellow to Light Yellow Solid Storage:Room temperature, Keep in Dark Place. Package:Kilograms/MT Application:Pharmaceu
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:1038915-60-4
Min.Order:1 Kilogram
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Type:Trading Company
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:1038915-60-4
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as
1038915-60-4 C19H20N4O (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamideAppearance:white powder Storage:Normal temperature Package:according to customers' requirements Application:API;Anti-cancer&immunity Transportation:B
Cas:1038915-60-4
Min.Order:1 Gram
Negotiable
Type:Other
inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In 5,5-dimethyl-1,3-cyclohexadiene at 40℃; for 3h; | 95% |
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
With sodium hydroxide In water; ethyl acetate at 20℃; | 94.2% |
formaldehyd
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; cobalt(III) acetylacetonate In 1,4-dioxane at 100℃; for 0.333333h; Temperature; Reagent/catalyst; Solvent; Microwave irradiation; | 93% |
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
With N-Ac-Leu In methanol at 70℃; for 1h; | 91.2% |
2-[4-((3S)-3-piperidinyl)phenyl]-2H-indazole-7-carboxamide p-toluenesulfonic acid salt
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
With sodium hydroxide In 2-methyltetrahydrofuran at 20℃; for 0.5h; | 75.9% |
With sodium hydroxide In 2-methyltetrahydrofuran; water at 20℃; for 0.5h; | 75.9% |
racemic 3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}piperidinium chloride
A
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
B
2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
Conditions | Yield |
---|---|
With diethylamine In isopropyl alcohol at 35℃; under 75007.5 Torr; Purification / work up; Resolution of racemate; | |
With carbon dioxide Resolution of racemate; Supercritical conditions; optical yield given as %ee; |
tert-butyl 3-[4-({[3-(methoxycarbonyl)-2-nitrophenyl]methylene}amino)phenyl]piperidine-1-carboxylate
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethyl phosphite / 24 h / 92 °C 2: formamide; sodium methylate / N,N-dimethyl-formamide / 3.5 h / 0 - 40 °C 3: trifluoroacetic acid / dichloromethane / 20 h 4: N-Ac-Leu / methanol / 1 h / 70 °C View Scheme |
methyl 2-{4-[1-(tert-butoxycarbonyl)piperidin-3-yl]phenyl}-2H-indazole-7-carboxylate
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: formamide; sodium methylate / N,N-dimethyl-formamide / 3.5 h / 0 - 40 °C 2: trifluoroacetic acid / dichloromethane / 20 h 3: N-Ac-Leu / methanol / 1 h / 70 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium methylate / N,N-dimethyl-formamide / 3.5 h / 40 °C 2: trifluorormethanesulfonic acid / dichloromethane 3: ethanol / 0.5 h / Reflux 4: sodium hydroxide / water; ethyl acetate / 20 °C View Scheme |
3-methyl-2-nitrobenzoic acid
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: sulfuric acid / 58 °C 2: manganese(IV) oxide; nitric acid / 40 °C 3: sodium hydrogencarbonate; acetic acid / 2 h / 40 °C 4: triethyl phosphite / 24 h / 92 °C 5: formamide; sodium methylate / N,N-dimethyl-formamide / 3.5 h / 0 - 40 °C 6: trifluoroacetic acid / dichloromethane / 20 h 7: N-Ac-Leu / methanol / 1 h / 70 °C View Scheme |
methyl 3-methyl-2-nitrobenzoate
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: manganese(IV) oxide; nitric acid / 40 °C 2: sodium hydrogencarbonate; acetic acid / 2 h / 40 °C 3: triethyl phosphite / 24 h / 92 °C 4: formamide; sodium methylate / N,N-dimethyl-formamide / 3.5 h / 0 - 40 °C 5: trifluoroacetic acid / dichloromethane / 20 h 6: N-Ac-Leu / methanol / 1 h / 70 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: N,N-dimethyl-formamide / 18 h / 130 °C 2.1: sodium periodate / N,N-dimethyl-formamide / 3.5 h / 20 °C 3.1: hexane / 18 h / Reflux 4.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 5.1: ammonium bicarbonate / methanol / 12 h / 100 °C 5.2: 3 h / 20 °C / pH Ca. 3 View Scheme | |
Multi-step reaction with 5 steps 1.1: N,N-dimethyl-formamide / 18 h / 130 °C 2.1: sodium periodate / N,N-dimethyl-formamide / 3.5 h / 20 °C 3.1: hexane / 18 h / Reflux 4.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 5.1: ammonium bicarbonate / methanol / 12 h / 100 °C 5.2: 3 h / 20 °C / pH Ca.3 View Scheme |
3-formyl-2-nitrobenzoic acid methyl ester
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium hydrogencarbonate; acetic acid / 2 h / 40 °C 2: triethyl phosphite / 24 h / 92 °C 3: formamide; sodium methylate / N,N-dimethyl-formamide / 3.5 h / 0 - 40 °C 4: trifluoroacetic acid / dichloromethane / 20 h 5: N-Ac-Leu / methanol / 1 h / 70 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: hexane / 18 h / Reflux 2.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 3.1: ammonium bicarbonate / methanol / 12 h / 100 °C 3.2: 3 h / 20 °C / pH Ca. 3 View Scheme | |
Multi-step reaction with 3 steps 1.1: hexane / 18 h / Reflux 2.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 3.1: ammonium bicarbonate / methanol / 12 h / 100 °C 3.2: 3 h / 20 °C / pH Ca.3 View Scheme |
β-(dimethylamino)-3-carbomethoxy-2-nitrostyrene
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium periodate / N,N-dimethyl-formamide / 3.5 h / 20 °C 2.1: hexane / 18 h / Reflux 3.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 4.1: ammonium bicarbonate / methanol / 12 h / 100 °C 4.2: 3 h / 20 °C / pH Ca. 3 View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium periodate / N,N-dimethyl-formamide / 3.5 h / 20 °C 2.1: hexane / 18 h / Reflux 3.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 4.1: ammonium bicarbonate / methanol / 12 h / 100 °C 4.2: 3 h / 20 °C / pH Ca.3 View Scheme |
18-(nitrobenzylideneamino)phenylpiperidine-1-carboxylate
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 2.1: ammonium bicarbonate / methanol / 12 h / 100 °C 2.2: 3 h / 20 °C / pH Ca. 3 View Scheme |
2-[4-((3S)-(tertbutoxycarbonyl)piperidin-3-yl)phenyl]-2H-indazole-7-carboxylic acid methyl ester
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Stage #1: 2-[4-((3S)-(tertbutoxycarbonyl)piperidin-3-yl)phenyl]-2H-indazole-7-carboxylic acid methyl ester With ammonium bicarbonate In methanol at 100℃; for 12h; Stage #2: With hydrogenchloride In methanol; water at 20℃; for 3h; pH=Ca. 3; | 8.2 g |
Stage #1: 2-[4-((3S)-(tertbutoxycarbonyl)piperidin-3-yl)phenyl]-2H-indazole-7-carboxylic acid methyl ester With ammonium bicarbonate In methanol at 100℃; for 12h; Stage #2: With hydrogenchloride In water at 20℃; for 3h; pH=Ca.3; | 8.2 g |
3-(4'-nitrophenyl)pyridine
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: 10 h / 110 °C 2.1: sodium tetrahydroborate; methanol / 8.5 h / 3 - 20 °C 2.2: 24 h / 9120.61 Torr / Autoclave 3.1: L-Tartaric acid / acetonitrile / 10 °C / Reflux 4.1: sodium hydroxide; triethylamine; dmap / dichloromethane / 8 h / 20 °C 5.1: hexane / 18 h / Reflux 6.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 7.1: ammonium bicarbonate / methanol / 12 h / 100 °C 7.2: 3 h / 20 °C / pH Ca. 3 View Scheme |
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium tetrahydroborate; methanol / 8.5 h / 3 - 20 °C 1.2: 24 h / 9120.61 Torr / Autoclave 2.1: L-Tartaric acid / acetonitrile / 10 °C / Reflux 3.1: sodium hydroxide; triethylamine; dmap / dichloromethane / 8 h / 20 °C 4.1: hexane / 18 h / Reflux 5.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 6.1: ammonium bicarbonate / methanol / 12 h / 100 °C 6.2: 3 h / 20 °C / pH Ca. 3 View Scheme |
(3S)-3-(4-aminophenyl)piperidine
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium hydroxide; triethylamine; dmap / dichloromethane / 8 h / 20 °C 2.1: hexane / 18 h / Reflux 3.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 4.1: ammonium bicarbonate / methanol / 12 h / 100 °C 4.2: 3 h / 20 °C / pH Ca. 3 View Scheme |
3-(4-aminophenyl)piperidine
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: L-Tartaric acid / acetonitrile / 10 °C / Reflux 2.1: sodium hydroxide; triethylamine; dmap / dichloromethane / 8 h / 20 °C 3.1: hexane / 18 h / Reflux 4.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 5.1: ammonium bicarbonate / methanol / 12 h / 100 °C 5.2: 3 h / 20 °C / pH Ca. 3 View Scheme | |
Multi-step reaction with 4 steps 1.1: acetonitrile / 10 °C / Reflux 1.2: 0.33 h 1.3: 8 h / 20 °C 2.1: hexane / 18 h / Reflux 3.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 4.1: ammonium bicarbonate / methanol / 12 h / 100 °C 4.2: 3 h / 20 °C / pH Ca.3 View Scheme |
(3S)-3-(4-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hexane / 18 h / Reflux 2.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 3.1: ammonium bicarbonate / methanol / 12 h / 100 °C 3.2: 3 h / 20 °C / pH Ca. 3 View Scheme | |
Multi-step reaction with 3 steps 1.1: hexane / 18 h / Reflux 2.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 3.1: ammonium bicarbonate / methanol / 12 h / 100 °C 3.2: 3 h / 20 °C / pH Ca.3 View Scheme |
tert-butyl 3-{4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl}-piperidine-1-carboxylate
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: trifluorormethanesulfonic acid / dichloromethane 2: ethanol / 0.5 h / Reflux 3: sodium hydroxide / water; ethyl acetate / 20 °C View Scheme |
1-benzyl-3-piperidone
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -60 °C / Inert atmosphere 1.2: 8 h / Inert atmosphere; Reflux 2.1: acetonitrile / 10 °C / Reflux 2.2: 0.33 h 2.3: 8 h / 20 °C 3.1: hexane / 18 h / Reflux 4.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 5.1: ammonium bicarbonate / methanol / 12 h / 100 °C 5.2: 3 h / 20 °C / pH Ca.3 View Scheme |
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nitrobenzene
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -60 °C / Inert atmosphere 1.2: 8 h / Inert atmosphere; Reflux 2.1: acetonitrile / 10 °C / Reflux 2.2: 0.33 h 2.3: 8 h / 20 °C 3.1: hexane / 18 h / Reflux 4.1: sodium azide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 24 h / 120 °C 5.1: ammonium bicarbonate / methanol / 12 h / 100 °C 5.2: 3 h / 20 °C / pH Ca.3 View Scheme |
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 2: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere 3: ammonia / acetonitrile / 2 h / 105 °C 4: sodium hydroxide / water / 20 - 35 °C 5: potassium carbonate; copper(I) bromide; 8-quinolinol; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl acetamide / 24 h / 110 °C / Inert atmosphere 6: methanesulfonic acid / o-xylene / 3 h / 40 °C View Scheme |
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: ammonia / acetonitrile / 2 h / 105 °C 2: sodium hydroxide / water / 20 - 35 °C 3: potassium carbonate; copper(I) bromide; 8-quinolinol; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl acetamide / 24 h / 110 °C / Inert atmosphere 4: methanesulfonic acid / o-xylene / 3 h / 40 °C View Scheme |
4-(3S-piperidine-3-yl)bromobenzene
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / water / 20 - 35 °C 2: potassium carbonate; copper(I) bromide; 8-quinolinol; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl acetamide / 24 h / 110 °C / Inert atmosphere 3: methanesulfonic acid / o-xylene / 3 h / 40 °C View Scheme |
(S)-3-(4-bromophenyl)piperidine-1-carboxylic acid tert-butyl ester
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate; copper(I) bromide; 8-quinolinol; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl acetamide / 24 h / 110 °C / Inert atmosphere 2: methanesulfonic acid / o-xylene / 3 h / 40 °C View Scheme |
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.5 h / 20 - 35 °C 1.2: 3 h / 45 °C 2.1: potassium carbonate; copper(I) bromide; 8-quinolinol; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl acetamide / 24 h / 110 °C / Inert atmosphere 3.1: methanesulfonic acid / o-xylene / 3 h / 40 °C View Scheme |
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate; copper(I) bromide; 8-quinolinol; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl acetamide / 24 h / 110 °C / Inert atmosphere 2: methanesulfonic acid / o-xylene / 3 h / 40 °C View Scheme |
(S)-tert-butyl 3-(4-(7-(tert-butylcarbamoyl)-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
With methanesulfonic acid In o-xylene at 40℃; for 3h; |
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere 2: ammonia / acetonitrile / 2 h / 105 °C 3: sodium hydroxide / water / 20 - 35 °C 4: potassium carbonate; copper(I) bromide; 8-quinolinol; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl acetamide / 24 h / 110 °C / Inert atmosphere 5: methanesulfonic acid / o-xylene / 3 h / 40 °C View Scheme |
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
toluene-4-sulfonic acid
2-[4-((3S)-3-piperidinyl)phenyl]-2H-indazole-7-carboxamide p-toluenesulfonic acid salt
Conditions | Yield |
---|---|
In Isopropyl acetate; dimethyl sulfoxide; isopropyl alcohol at 5 - 70℃; Inert atmosphere; | 85% |
In water at 20 - 30℃; for 4h; Inert atmosphere; | 110 g |
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
D-(+)-camphoric acid
Conditions | Yield |
---|---|
In tetrahydrofuran; methanol at 20 - 40℃; for 72h; | 75% |
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
(R)-Mandelic Acid
Conditions | Yield |
---|---|
In tetrahydrofuran; acetonitrile at 20 - 40℃; for 80h; | 50.6% |
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
(1S)-10-camphorsulfonic acid
Conditions | Yield |
---|---|
In tetrahydrofuran; acetonitrile at 20 - 40℃; | 37% |
(3S)-3-[4-{7-(aminocarbonyl)-2H-indazol-2-yl}phenyl]piperidine
(3S)-3-[4-[7-(aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidinium chloride
Conditions | Yield |
---|---|
With hydrogenchloride In water for 0.25h; |
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