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Jinan Finer Chemical Co., Ltd

Product informations Product Name 3,3-Tetramethyleneglutarimide CAS No. 1075-89-4

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

3,3-TetraMethyleneglutariMide

Cas:1075-89-4

Min.Order:1 Gram

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 8-azaspiro[4.5]decane-7,9-dione

Cas:1075-89-4

Min.Order:1

Negotiable

Type:Other

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

3, 3-Tetramethyleneglutarimide CAS 1075-89-4

Cas:1075-89-4

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

3,3-Tetramethyleneglutarimide 1075-89-4

Cas:1075-89-4

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 1075-89-4 with best price

Cas:1075-89-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

3,3-Tetramethyleneglutarimide CAS1075-89-4

Cas:1075-89-4

Min.Order:1 Kilogram

FOB Price: $289.0 / 499.0

Type:Trading Company

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:White to Almost white powder Storage:room temperature Package:25kg/drum Application:chemicals Transportation:Express/Sea/Air Port:any port in china

3,3-Tetramethyleneglutarimide factory price

Cas:1075-89-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

3,3-Tetramethyleneglutarimide/ LIDE PHARMA- Factory supply / Best price

Cas:1075-89-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

3,3-Tetramethyleneglutarimide CAS NO.1075-89-4

Cas:1075-89-4

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS1075-89-4 3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

1)quick response within 12 hours; 2)quality guarantee: all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. 3) oem/odm available; 4) rea

3,3-TetramethyleneglutarimideCAS NO.: 1075-89-4

Cas:1075-89-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:0

Negotiable

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3,3-Tetramethyleneglutarimide Cas no.1075-89-4 98%

Cas:1075-89-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:0

Negotiable

Type:Other

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Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

3,3-Tetramethyleneglutarimide CAS 1075-89-4

Cas:1075-89-4

Min.Order:0

Negotiable

Type:Other

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

3,3-Tetramethyleneglutarimide

Cas:1075-89-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

3,3-tetramethylene glutaric anhydride
5662-95-3

3,3-tetramethylene glutaric anhydride

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

Conditions
ConditionsYield
With ammonium hydroxide In tetrahydrofuran at 190℃;92%
ammonium salt of/the/ cyclopentane-diacetic acid-(1.1)

ammonium salt of/the/ cyclopentane-diacetic acid-(1.1)

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

cyclopentane-dimalonic acid-(1.1)-monoamide

cyclopentane-dimalonic acid-(1.1)-monoamide

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

Conditions
ConditionsYield
ueber den Schmelzpunkt;
tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

propargyl bromide
106-96-7

propargyl bromide

8-Propargyl-8-azaspiro<4.5>decane-7,9-dione
25032-23-9

8-Propargyl-8-azaspiro<4.5>decane-7,9-dione

Conditions
ConditionsYield
With potassium carbonate In acetone for 10h; Heating;100%
With potassium carbonate In acetone Heating;100%
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

N-(2-pyridinyl)piperazine
20980-22-7

N-(2-pyridinyl)piperazine

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

BUSPIRONE
36505-84-7

BUSPIRONE

Conditions
ConditionsYield
With potassium carbonate; benzyltriethylammonium bromide Product distribution; 1.) xylene, reflux, 3 h, 2.) reflux, 5 h; other imides and catalysts, variation of reaction time, also in toluene; also 1-(2-quinolinyl)piperazine;97%
With potassium carbonate; benzyltriethylammonium bromide 1.) xylene, reflux, 3 h, 2.) reflux, 5 h; Yield given. Multistep reaction;
4-chlorobutanal dimethyl acetal
29882-07-3

4-chlorobutanal dimethyl acetal

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-(4,4-dimethoxybutyl)-8-azaspiro[4.5]decane-7,9-dione
1359159-58-2

8-(4,4-dimethoxybutyl)-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In dimethyl sulfoxide at 80℃; for 4h;96%
tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

benzyl bromide
100-39-0

benzyl bromide

8-benzyl-8-azaspiro[4.5]decane-7,9-dione
77261-38-2

8-benzyl-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
Stage #1: tetramethylene glutarimide With potassium carbonate for 1h;
Stage #2: benzyl bromide In acetone for 2h; Reflux; Inert atmosphere;
96%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-(tert-butoxycarbonyl)-7,9-dioxo-8-azaspiro[4.5]decane
854280-06-1

8-(tert-butoxycarbonyl)-7,9-dioxo-8-azaspiro[4.5]decane

Conditions
ConditionsYield
With dmap In acetonitrile at 20℃; for 15h;95%
tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

3-azaspiro[5.5]undecane
180-44-9

3-azaspiro[5.5]undecane

Conditions
ConditionsYield
In tetrahydrofuran94%
tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

benzoyl chloride
98-88-4

benzoyl chloride

8-benzoyl-8-azaspiro[4.5]decane-7,9-dione

8-benzoyl-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 15h; Schlenk technique; Inert atmosphere;94%
4-chlorobutyl bromide
6940-78-9

4-chlorobutyl bromide

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-(4-chlorobutyl)-8-azaspiro<4.5>decane-7,9-dione
21098-11-3

8-(4-chlorobutyl)-8-azaspiro<4.5>decane-7,9-dione

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃;93%
In N-methyl-acetamide
tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

4-bromobutanenitrile
5332-06-9

4-bromobutanenitrile

4-(7,9-dioxo-8-aza-spiro[4.5]dec-8-yl)butyronitrile
1236066-79-7

4-(7,9-dioxo-8-aza-spiro[4.5]dec-8-yl)butyronitrile

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 60℃; for 20h; Inert atmosphere;93%
tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-(2-quinolinyl)-8-aza-5-azoniaspiro<4.5>decane bromide
142415-01-8

8-(2-quinolinyl)-8-aza-5-azoniaspiro<4.5>decane bromide

Kaspar
142336-21-8

Kaspar

Conditions
ConditionsYield
With potassium carbonate; 18-crown-6 ether In xylene for 6h; Heating;89%
tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-(1,2-benzisothiazol-3-yl)-8-aza-5-azoniaspiro[4.5]decane bromide
87691-94-9

8-(1,2-benzisothiazol-3-yl)-8-aza-5-azoniaspiro[4.5]decane bromide

tiospirone
87691-91-6

tiospirone

Conditions
ConditionsYield
With 18-crown-6 ether; potassium carbonate In toluene for 22h; Heating;88%
bromopropionitrile
2417-90-5

bromopropionitrile

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

3-(7,9-dioxo-8-aza-spiro[4.5]dec-8-yl)propionitrile
1236066-78-6

3-(7,9-dioxo-8-aza-spiro[4.5]dec-8-yl)propionitrile

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 60℃; for 20h; Inert atmosphere;87%
(E)-1,1-Difluorodec-3-en-2-yl Diethyl Phosphate

(E)-1,1-Difluorodec-3-en-2-yl Diethyl Phosphate

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

(E)-8-(1,1-difluorodec-2-en-4-yl)-8-azaspiro[4.5]decane-7,9-dione

(E)-8-(1,1-difluorodec-2-en-4-yl)-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
With bis(η3-allyl-μ-chloropalladium(II)); caesium carbonate In dimethyl sulfoxide at 30℃; for 1h; Inert atmosphere;87%
tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

6-methyl-4-bromomethylcoumarin
79344-41-5

6-methyl-4-bromomethylcoumarin

8-[(6-methyl-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

8-[(6-methyl-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
Stage #1: tetramethylene glutarimide With potassium carbonate In acetone at 20℃; for 0.666667h;
Stage #2: 6-methyl-4-bromomethylcoumarin In acetone at 55 - 60℃; for 10h;
85%
tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

6-chloro-4-bromomethylcoumarin
79344-40-4

6-chloro-4-bromomethylcoumarin

8-[(6-chloro-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

8-[(6-chloro-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
Stage #1: tetramethylene glutarimide With potassium carbonate In acetone at 20℃; for 0.666667h;
Stage #2: 6-chloro-4-bromomethylcoumarin In acetone at 55 - 60℃; for 10h;
85%
tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

4-(bromomethyl)-7-chloro-2H-chromen-2-one
79344-39-1

4-(bromomethyl)-7-chloro-2H-chromen-2-one

8-[(7-chloro-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

8-[(7-chloro-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
Stage #1: tetramethylene glutarimide With potassium carbonate In acetone at 20℃; for 0.666667h;
Stage #2: 4-(bromomethyl)-7-chloro-2H-chromen-2-one In acetone at 55 - 60℃; for 10h;
85%
4-(bromomethyl)-7,8-dimethyl-2H-chromen-2-one
1252026-46-2

4-(bromomethyl)-7,8-dimethyl-2H-chromen-2-one

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-[(7,8-dimethyl-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

8-[(7,8-dimethyl-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
Stage #1: tetramethylene glutarimide With potassium carbonate In acetone at 20℃; for 0.666667h;
Stage #2: 4-(bromomethyl)-7,8-dimethyl-2H-chromen-2-one In acetone at 55 - 60℃; for 10h;
85%
tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

4-bromomethyl-6-methoxycoumarin
82156-57-8

4-bromomethyl-6-methoxycoumarin

8-[(6-methoxy-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

8-[(6-methoxy-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
Stage #1: tetramethylene glutarimide With potassium carbonate In acetone at 20℃; for 0.666667h;
Stage #2: 4-bromomethyl-6-methoxycoumarin In acetone at 55 - 60℃; for 10h;
85%
4-(bromomethyl)-7-methoxycoumarin
35231-44-8

4-(bromomethyl)-7-methoxycoumarin

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-[(7-methoxy-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

8-[(7-methoxy-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
Stage #1: tetramethylene glutarimide With potassium carbonate In acetone at 20℃; for 0.666667h;
Stage #2: 4-(bromomethyl)-7-methoxycoumarin In acetone at 55 - 60℃; for 10h;
85%
6-bromo-4-(bromomethyl)–2H-chromen-2-one

6-bromo-4-(bromomethyl)–2H-chromen-2-one

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-[(6-bromo-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decan-7,9-dione

8-[(6-bromo-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decan-7,9-dione

Conditions
ConditionsYield
Stage #1: tetramethylene glutarimide With potassium carbonate In acetone at 20℃; for 0.666667h;
Stage #2: 6-bromo-4-(bromomethyl)–2H-chromen-2-one In acetone at 55 - 60℃; for 10h;
85%
4-(bromomethyl)-2H-naphthol[1,2-b]pyran-2-one
87317-83-7

4-(bromomethyl)-2H-naphthol[1,2-b]pyran-2-one

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-[(2-oxo-2H-benzo[h]chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

8-[(2-oxo-2H-benzo[h]chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
Stage #1: tetramethylene glutarimide With potassium carbonate In acetone at 20℃; for 0.666667h;
Stage #2: 4-(bromomethyl)-2H-naphthol[1,2-b]pyran-2-one In acetone at 55 - 60℃; for 10h;
85%
(4aS,8aR)-2-(1-(2-chloroacetyl)azetidin-3-yl)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one

(4aS,8aR)-2-(1-(2-chloroacetyl)azetidin-3-yl)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-(2-(3-((4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,8,8a-tetrahydrophthalazin-2(1H)-yl)azetidin-1-yl)-2-oxoethyl)-8-azaspiro[4.5]decane-7,9-dione

8-(2-(3-((4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-4a,5,8,8a-tetrahydrophthalazin-2(1H)-yl)azetidin-1-yl)-2-oxoethyl)-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 3h;80%
4-bromomethyl-7-methyl-coumarin
41321-75-9

4-bromomethyl-7-methyl-coumarin

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-[(7-methyl-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

8-[(7-methyl-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
Stage #1: tetramethylene glutarimide With potassium carbonate In acetone at 20℃; for 0.666667h;
Stage #2: 4-bromomethyl-7-methyl-coumarin In acetone at 55 - 60℃; for 10h;
80%
4-(bromomethyl)-5,7-dimethyl-2H-chromen-2-one
41295-53-8

4-(bromomethyl)-5,7-dimethyl-2H-chromen-2-one

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-[(5,7-dimethyl-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

8-[(5,7-dimethyl-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
Stage #1: tetramethylene glutarimide With potassium carbonate In acetone at 20℃; for 0.666667h;
Stage #2: 4-(bromomethyl)-5,7-dimethyl-2H-chromen-2-one In acetone at 55 - 60℃; for 10h;
80%
6-tert-butyl-4-(bromomethyl)-2H-chromen-2-one

6-tert-butyl-4-(bromomethyl)-2H-chromen-2-one

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-[(6-tert-butyl-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

8-[(6-tert-butyl-2-oxo-2H-chromen-4-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
Stage #1: tetramethylene glutarimide With potassium carbonate In acetone at 20℃; for 0.666667h;
Stage #2: 6-tert-butyl-4-(bromomethyl)-2H-chromen-2-one In acetone at 55 - 60℃; for 10h;
80%
5,6-benzo-4-bromomethylcoumarin
101553-94-0

5,6-benzo-4-bromomethylcoumarin

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-[(3-oxo-3H-benzo[f]chromen-1-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

8-[(3-oxo-3H-benzo[f]chromen-1-yl)methyl]-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
Stage #1: tetramethylene glutarimide With potassium carbonate In acetone at 20℃; for 0.666667h;
Stage #2: 5,6-benzo-4-bromomethylcoumarin In acetone at 55 - 60℃; for 10h;
80%
1,4-dibromo-2,2,3,3-tetradeuteriobutane
52089-63-1

1,4-dibromo-2,2,3,3-tetradeuteriobutane

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-(4-bromobutyl-2,2,3,3-d4)-8-azaspiro[4,5]decane-7,9-dione

8-(4-bromobutyl-2,2,3,3-d4)-8-azaspiro[4,5]decane-7,9-dione

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 14h; Alkylation; Heating;77.92%
1,4-dibromo-butane
110-52-1

1,4-dibromo-butane

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-(4-bromobutyl)-8-azaspiro[4.5]decane-7,9-dione
80827-62-9

8-(4-bromobutyl)-8-azaspiro[4.5]decane-7,9-dione

Conditions
ConditionsYield
With 18-crown-6 ether; potassium carbonate In toluene at 111℃; for 24h; Inert atmosphere;75%
With potassium carbonate; potassium iodide In acetonitrile at 60℃; for 6h;69%
1-bromo-4-butene
5162-44-7

1-bromo-4-butene

tetramethylene glutarimide
1075-89-4

tetramethylene glutarimide

8-(3-butenyl)-8-azaspiro<4.5>decane-7,9-dione
131779-51-6

8-(3-butenyl)-8-azaspiro<4.5>decane-7,9-dione

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide Heating;74%

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