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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-[(4-Chlorophenyl)-phenylmethyl]-1-piperazineethanol

Cas:109806-71-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

CHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis

High Purity 99% Pharmaceutical Intermediates 2-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethanol

Cas:109806-71-5

Min.Order:100 Gram

FOB Price: $3.0 / 4.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 109806-71-5 with competitive price

Cas:109806-71-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE CAS:109806-71-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical interm

4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE CAS:109806-71-5

Cas:109806-71-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-Piperazineethanol,4-[(4-chlorophenyl)phenylmethyl]-

Cas:109806-71-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

1-Piperazineethanol,4-[(4-chlorophenyl)phenylmethyl]-/ LIDE PHARMA- Factory supply / Best price

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE CAS: 109806-71-5

Cas:109806-71-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Piperazineethanol,4-[(4-chlorophenyl)phenylmethyl]-

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE

Cas:109806-71-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-[(4-Chlorophenyl)phenylmethyl]-1-piperazineethanol dihydrochloride

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-[(4-Chlorophenyl)-phenylmethyl]-1-piperazineethanol

Cas:109806-71-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

1-Piperazineethanol,4-[(4-chlorophenyl)phenylmethyl]-

Cas:109806-71-5

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE

Cas:109806-71-5

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE

Cas:109806-71-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE

Cas:109806-71-5

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE

Cas:109806-71-5

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethanol

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethanol

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Other

inquiry

BOC Sciences

BOC Sciences is committed to supplying cost-effective products and services. We provide Levocetirizine Impurity 6. 4-(p-Chloro-α-phenylbenzyl)-1-piperazineethanol is used in the synthesis of antifungal triazole and imidazole derivatives. Impu

Levocetirizine Impurity 6

Cas:109806-71-5

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethanol

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

1-Piperazineethanol,4-[(4-chlorophenyl)phenylmethyl]-

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

4-[(4-Chlorophenyl)phenylmethyl]-1-piperazineethanol diHCl

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

1-Piperazineethanol,4-[(4-chlorophenyl)phenylmethyl]-

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

1-Piperazineethanol,4-[(4-chlorophenyl)phenylmethyl]- CAS No.109806-71-5

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

best seller Application:API

4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

2-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethanolAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

2-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethanol

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Other

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

109806-71-5

Cas:109806-71-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol dihydrochloride

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol dihydrochloride

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Conditions
ConditionsYield
With sodium carbonate In water; toluene at 25℃; Heating / reflux;95%
With sodium hydroxide In water; toluene at 55 - 60℃;
With water In toluene
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

1-chloro-4-(chloro(phenyl)methyl)benzene
134-83-8

1-chloro-4-(chloro(phenyl)methyl)benzene

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Conditions
ConditionsYield
at 130℃;
N-(4-chlorobenzhydryl)piperazine
303-26-4

N-(4-chlorobenzhydryl)piperazine

2-bromoethanol
540-51-2

2-bromoethanol

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Conditions
ConditionsYield
With TEA In toluene Alkylation;
N-(4-chlorobenzhydryl)piperazine
303-26-4

N-(4-chlorobenzhydryl)piperazine

2-chloro-ethanol
107-07-3

2-chloro-ethanol

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Conditions
ConditionsYield
With triethylamine In toluene Heating / reflux;
With triethylamine at 110℃;
(4-chlorophenyl)phenylmethanol
119-56-2

(4-chlorophenyl)phenylmethanol

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / toluene / 1 h / 85 - 90 °C / Large scale reaction
2.1: toluene / 3 h / 80 °C / Large scale reaction
2.2: pH 1 / Large scale reaction
3.1: water / toluene
View Scheme
1-chloro-4-(chloro(phenyl)methyl)benzene
134-83-8

1-chloro-4-(chloro(phenyl)methyl)benzene

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene / 3 h / 80 °C / Large scale reaction
1.2: pH 1 / Large scale reaction
2.1: water / toluene
View Scheme
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol dihydrochloride

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol dihydrochloride

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Conditions
ConditionsYield
With sodium carbonate In water; toluene at 25℃; Heating / reflux;95%
With sodium hydroxide In water; toluene at 55 - 60℃;
With water In toluene
1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

1-chloro-4-(chloro(phenyl)methyl)benzene
134-83-8

1-chloro-4-(chloro(phenyl)methyl)benzene

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Conditions
ConditionsYield
at 130℃;
N-(4-chlorobenzhydryl)piperazine
303-26-4

N-(4-chlorobenzhydryl)piperazine

2-bromoethanol
540-51-2

2-bromoethanol

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Conditions
ConditionsYield
With TEA In toluene Alkylation;
N-(4-chlorobenzhydryl)piperazine
303-26-4

N-(4-chlorobenzhydryl)piperazine

2-chloro-ethanol
107-07-3

2-chloro-ethanol

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Conditions
ConditionsYield
With triethylamine In toluene Heating / reflux;
With triethylamine at 110℃;
(4-chlorophenyl)phenylmethanol
119-56-2

(4-chlorophenyl)phenylmethanol

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / toluene / 1 h / 85 - 90 °C / Large scale reaction
2.1: toluene / 3 h / 80 °C / Large scale reaction
2.2: pH 1 / Large scale reaction
3.1: water / toluene
View Scheme
1-chloro-4-(chloro(phenyl)methyl)benzene
134-83-8

1-chloro-4-(chloro(phenyl)methyl)benzene

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene / 3 h / 80 °C / Large scale reaction
1.2: pH 1 / Large scale reaction
2.1: water / toluene
View Scheme
4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: water; Aliquat 336 / toluene / 20 °C / Large scale reaction
1.2: 5 h / 50 °C / Large scale reaction
2.1: thionyl chloride / toluene / 1 h / 85 - 90 °C / Large scale reaction
3.1: toluene / 3 h / 80 °C / Large scale reaction
3.2: pH 1 / Large scale reaction
4.1: water / toluene
View Scheme
cetirizine dihydrochloride
83881-52-1

cetirizine dihydrochloride

A

2-(piperazin-1-yl)acetaldehyde
1247549-57-0

2-(piperazin-1-yl)acetaldehyde

B

4-chlorophenyl(phenyl)methane
831-81-2

4-chlorophenyl(phenyl)methane

C

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Conditions
ConditionsYield
With laccase from Aspergillus oryzae In aq. phosphate buffer at 60℃; pH=6; pH-value; Temperature; Sonication; Enzymatic reaction;
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Bromoacetaldehyde diethyl acetal
2032-35-1

Bromoacetaldehyde diethyl acetal

2-{2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy}acetaldehyde diethylacetal
290362-10-6

2-{2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy}acetaldehyde diethylacetal

Conditions
ConditionsYield
Stage #1: 2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol With sodium hydride In tetrahydrofuran at 50℃; for 0.333333h;
Stage #2: Bromoacetaldehyde diethyl acetal In tetrahydrofuran at 50 - 90℃; for 10h;
Stage #3: With water In tetrahydrofuran
96.7%
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

sodium monochloroacetic acid
3926-62-3

sodium monochloroacetic acid

cetirizine dihydrochloride
83881-52-1

cetirizine dihydrochloride

Conditions
ConditionsYield
Stage #1: 2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol; sodium monochloroacetic acid With sodium hydroxide In water; dimethyl sulfoxide; toluene at 30 - 35℃; for 14 - 18h;
Stage #2: With hydrogenchloride In water; acetone at 20℃;
87.4%
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

1-(2-chloroethyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine
102163-64-4

1-(2-chloroethyl)-4-[(4-chlorophenyl)(phenyl)methyl]piperazine

Conditions
ConditionsYield
With pyridine; thionyl chloride for 16h; Reflux;30%
With thionyl chloride at 60℃;
With thionyl chloride for 6h; Reflux;
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

CH3CH2CH(halide)-CO2H

CH3CH2CH(halide)-CO2H

2-(2-{4-[(4-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxy)-butyric acid

2-(2-{4-[(4-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxy)-butyric acid

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol Etherification;
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

(m-OCH3)-C6H4-CH2-halide

(m-OCH3)-C6H4-CH2-halide

1-[(4-chloro-phenyl)-phenyl-methyl]-4-[2-(3-methoxy-benzyloxy)-ethyl]-piperazine

1-[(4-chloro-phenyl)-phenyl-methyl]-4-[2-(3-methoxy-benzyloxy)-ethyl]-piperazine

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol Etherification;
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

(p-OCH3)-C6H4-CH2-halide

(p-OCH3)-C6H4-CH2-halide

1-[(4-chloro-phenyl)-phenyl-methyl]-4-[2-(4-methoxy-benzyloxy)-ethyl]-piperazine

1-[(4-chloro-phenyl)-phenyl-methyl]-4-[2-(4-methoxy-benzyloxy)-ethyl]-piperazine

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol Etherification;
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

(p-isopropyl)-C6H4-CH2-halide

(p-isopropyl)-C6H4-CH2-halide

1-[(4-chloro-phenyl)-phenyl-methyl]-4-[2-(4-isopropyl-benzyloxy)-ethyl]-piperazine

1-[(4-chloro-phenyl)-phenyl-methyl]-4-[2-(4-isopropyl-benzyloxy)-ethyl]-piperazine

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol Etherification;
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

halide-CH(Ph)-CO2H

halide-CH(Ph)-CO2H

2-(2-{4-[(4-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxy)-3-phenyl-propionic acid

2-(2-{4-[(4-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxy)-3-phenyl-propionic acid

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol Etherification;
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

(2-naphthyl)-CH2-halide

(2-naphthyl)-CH2-halide

1-[(4-chloro-phenyl)-phenyl-methyl]-4-[2-(naphthalen-2-ylmethoxy)-ethyl]-piperazine

1-[(4-chloro-phenyl)-phenyl-methyl]-4-[2-(naphthalen-2-ylmethoxy)-ethyl]-piperazine

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol Etherification;
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

(1-naphthyl)-CH2-halide

(1-naphthyl)-CH2-halide

1-[(4-chloro-phenyl)-phenyl-methyl]-4-[2-(naphthalen-1-ylmethoxy)-ethyl]-piperazine

1-[(4-chloro-phenyl)-phenyl-methyl]-4-[2-(naphthalen-1-ylmethoxy)-ethyl]-piperazine

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol Etherification;
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

halide-CH2-p-C6H4-CH2CO2H

halide-CH2-p-C6H4-CH2CO2H

[4-(2-{4-[(4-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxymethyl)-phenyl]-acetic acid

[4-(2-{4-[(4-chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxymethyl)-phenyl]-acetic acid

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol Etherification;
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

(+)-[2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]]ethanol
705289-61-8

(+)-[2-[4-[(4-chlorophenyl)-phenyl methyl]-1-piperazinyl]]ethanol

Conditions
ConditionsYield
at 25℃; Resolution of racemate;n/a
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

sodium monochloroacetic acid
3926-62-3

sodium monochloroacetic acid

cetirizine
83881-51-0

cetirizine

Conditions
ConditionsYield
Stage #1: 2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol; sodium monochloroacetic acid With potassium hydroxide In DMF (N,N-dimethyl-formamide) at 153℃; for 4 - 5h;
Stage #2: With hydrogenchloride In DMF (N,N-dimethyl-formamide); water pH=4.0 - 4.5;
Stage #1: 2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol; sodium monochloroacetic acid With potassium hydroxide In DMF (N,N-dimethyl-formamide) at 25 - 35℃; for 10 - 12h;
Stage #2: With hydrogenchloride; water at 25 - 35℃; pH=5 - 5.5;
With sodium hydroxide In dimethyl sulfoxide at 20 - 40℃; for 20h; Product distribution / selectivity;
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

chloroacetic acid
79-11-8

chloroacetic acid

cetirizine
83881-51-0

cetirizine

Conditions
ConditionsYield
With sodium hydroxide In water; dimethyl sulfoxide; toluene at 30 - 35℃; for 20h; Product distribution / selectivity;
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

1-[(4-chlorophenyl)(phenyl)methyl]-4-[2-(1H-1,2,4-triazole-1-yl)ethyl]piperazine
1275578-39-6

1-[(4-chlorophenyl)(phenyl)methyl]-4-[2-(1H-1,2,4-triazole-1-yl)ethyl]piperazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine; thionyl chloride / 16 h / Reflux
2: tetraethylammonium iodide; potassium carbonate; sodium hydroxide / acetonitrile / 24 h / Reflux
View Scheme
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

1-[(4-chlorophenyl)(phenyl)methyl]-4-[2-(1H-imidazol-1-yl)ethyl]piperazine
1345892-34-3

1-[(4-chlorophenyl)(phenyl)methyl]-4-[2-(1H-imidazol-1-yl)ethyl]piperazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: pyridine; thionyl chloride / 16 h / Reflux
2: tetraethylammonium iodide; potassium carbonate; sodium hydroxide / acetonitrile / 38 h / Reflux
View Scheme
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

cetirizine dihydrochloride
83881-52-1

cetirizine dihydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate / toluene / 10 - 15 °C / Inert atmosphere; Large scale reaction
1.2: 2 h / 50 - 60 °C / Large scale reaction
2.1: water; sodium hydroxide / 3 h / Reflux; Large scale reaction
View Scheme
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

2-chloro-N,N-dimethylacetamide
2675-89-0

2-chloro-N,N-dimethylacetamide

2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)-N,N-dimethylacetamide dihydrochloride

2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)-N,N-dimethylacetamide dihydrochloride

Conditions
ConditionsYield
Stage #1: 2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol With sodium methylate In toluene at 10 - 15℃; Inert atmosphere; Large scale reaction;
Stage #2: 2-chloro-N,N-dimethylacetamide at 50 - 60℃; for 2h; Large scale reaction;
Stage #3: With hydrogenchloride In water
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

1-((4-chlorophenyl)(phenyl)methyl)-4-(2-(piperazin-1-yl)ethyl)piperazine

1-((4-chlorophenyl)(phenyl)methyl)-4-(2-(piperazin-1-yl)ethyl)piperazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: thionyl chloride / 60 °C
2: potassium carbonate / N,N-dimethyl-formamide / 80 °C
3: hydrogenchloride / methanol / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: thionyl chloride / 6 h / Reflux
2: potassium carbonate / 4 h / Reflux
3: hydrogenchloride / water / 2 h / 20 °C
View Scheme
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

(Z)-5-((4-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethyl)piperazin-1-yl)methylene)thiazolidine-2,4-dione

(Z)-5-((4-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethyl)piperazin-1-yl)methylene)thiazolidine-2,4-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: thionyl chloride / 60 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C
3.1: hydrogenchloride / methanol / 50 °C
4.1: triethylamine / acetonitrile
4.2: 45 °C
View Scheme
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

C28H39ClN4O2

C28H39ClN4O2

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride / 60 °C
2: potassium carbonate / N,N-dimethyl-formamide / 80 °C
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride / 6 h / Reflux
2: potassium carbonate / 4 h / Reflux
View Scheme
2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol
109806-71-5

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

C25H35ClN4O

C25H35ClN4O

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: thionyl chloride / 6 h / Reflux
2: potassium carbonate / 4 h / Reflux
3: hydrogenchloride / water / 2 h / 20 °C
4: triethylamine / toluene / 8 h / Reflux
View Scheme

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