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Nantong Noatic Bio-Pharm Technology Co.,Ltd

We are manufacturer of this product and can supply good quality and competitive price , the purity over 99.0%, this product has been in massive production for years , so its process and quality always keep stable and its price is very competitive .

Exatecan mesylate intermediate B

Cas:110351-94-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

Cas:110351-94-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&D b

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione,4-ethyl-7,8-dihydro-4-hydroxy-, (4S)-

Cas:110351-94-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 110351-94-5 with competitive price

Cas:110351-94-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Qingdao Beluga Import and Export Co., LTD

(S)-4-Ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10(4h)-trione CAS:110351-94-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemic

(S)-4-Ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10(4h)-trione CAS:110351-94-5

Cas:110351-94-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione,4-ethyl-7,8-dihydro-4-hydroxy-, (4S)-

Cas:110351-94-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

(S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Cas:110351-94-5

Min.Order:1 Gram

FOB Price: $1035.0

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE,4-ETHYL-7,8-DIHYDRO-4-HYDROXY-, (4S)-

Cas:110351-94-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

Cas:110351-94-5

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

Melting Point:183-185℃ (decomposition) Boiling Point:666.634 °C at 760 mmHg PKA:11.20±0.20(Predicted) Flash Point:356.968 °C PSA:85.60000 Density:1.506 g/cm3 LogP:0.08910 Storage Temp.:2-8°C XLogP3:-0.8 Hydrogen

110351-94-5 (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-F]indolizine-3,6,10(4H)-trione

Cas:110351-94-5

Min.Order:1 Gram

FOB Price: $3.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(S)-4-hydroxy-4-propyl-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Cas:110351-94-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(4s)-4-ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10-trione

Cas:110351-94-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

Cas:110351-94-5

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: (S)-4-Ethyl-4-Hydroxy-7,8-Dihydro-1H-Pyrano[3,4-f]Indolizine-3,6,10(4H)-Trione CAS No.:110351-94-5 Molecule Formula:C13H13NO5 Molecule Weight:263.64 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture

High Quality (S)-4-Ethyl-4-Hydroxy-7,8-Dihydro-1H-Pyrano[3,4-f]Indolizine-3,6,10(4H)-Trione in stock

Cas:110351-94-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(S)-4-Ethyl-4-hydroxy-7,8-dihydro-1h-pyrano[3,4-f]indolizine-3,6,10(4h)-trione

Cas:110351-94-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

Cas:110351-94-5

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

Cas:110351-94-5

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

Cas:110351-94-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

Cas:110351-94-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

Cas:110351-94-5

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

(4S)-4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Cas:110351-94-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemvon Biotechnology Co. Ltd.

Chemvon Biotechnology Co. Ltd., established in the end of 2004, is a high-technology pharmaceutical and fine chemical company in R&D, manufacturing and sales of (S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE. With

Supply (S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

Cas:110351-94-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

Cas:110351-94-5

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Suzhou Sibian Chemical Technology Co., Ltd

The process is mature and can be mass produced to 100 kg, with good quality and purity up to 99%.The product has a large stock and can be supplied stably. Package:bottle Application:Drug R&D Transportation:Sealed drying(25℃) Port:ShangHai

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

Cas:110351-94-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

Cas:110351-94-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione,4-ethyl-7,8-dihydro-4-hydroxy-, (4S)-

Cas:110351-94-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

(S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

Cas:110351-94-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(S)-4′-ethyl-4′-hydroxy-7′,8′-dihydrospiro[[1,3]dioxolane-2,6′-pyrano[3,4-f]indolizine]-3′,10′(1′H,4′H)-dione
110351-93-4

(S)-4′-ethyl-4′-hydroxy-7′,8′-dihydrospiro[[1,3]dioxolane-2,6′-pyrano[3,4-f]indolizine]-3′,10′(1′H,4′H)-dione

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 60℃; for 3h;100%
With trifluoroacetic acid at 20℃; for 6h;93%
With trifluoroacetic acid for 3h; Ambient temperature;88.9%
C17H21NO7
165674-36-2

C17H21NO7

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 60℃; for 3h;100%
(S,E)-6-benzylidene-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,10(4H,6H)-dione

(S,E)-6-benzylidene-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,10(4H,6H)-dione

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Stage #1: (S,E)-6-benzylidene-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,10(4H,6H)-dione With oxygen; ozone In dichloromethane at -40℃; for 0.75h;
Stage #2: With dimethylsulfide In dichloromethane at -40 - 20℃; for 2h;
96%
(S)-4′-ethyl-4′-hydroxy-7′,8′-dihydrospiro[[1,3]dioxolane-2,6′-pyrano[3,4-f]indolizine]-3′,10′(1′H,4′H)-dione
110351-93-4

(S)-4′-ethyl-4′-hydroxy-7′,8′-dihydrospiro[[1,3]dioxolane-2,6′-pyrano[3,4-f]indolizine]-3′,10′(1′H,4′H)-dione

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 60℃; for 3h;100%
With trifluoroacetic acid at 20℃; for 6h;93%
With trifluoroacetic acid for 3h; Ambient temperature;88.9%
C17H21NO7
165674-36-2

C17H21NO7

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 60℃; for 3h;100%
(S,E)-6-benzylidene-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,10(4H,6H)-dione

(S,E)-6-benzylidene-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,10(4H,6H)-dione

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Stage #1: (S,E)-6-benzylidene-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,10(4H,6H)-dione With oxygen; ozone In dichloromethane at -40℃; for 0.75h;
Stage #2: With dimethylsulfide In dichloromethane at -40 - 20℃; for 2h;
96%
1,1-dimethylethyl (S)-4-ethyl-3,4,8,10-tetrahydro-4,6-dihydroxy-3,10-dioxo-1H-pyrano[3,4 - f] indolidin-7-carboxylate
183434-04-0

1,1-dimethylethyl (S)-4-ethyl-3,4,8,10-tetrahydro-4,6-dihydroxy-3,10-dioxo-1H-pyrano[3,4 - f] indolidin-7-carboxylate

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
In toluene; trifluoroacetic acid at 110℃; for 2h;93.4%
With trifluoroacetic acid In toluene at 110℃; for 1.66667h;77%
(S)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetamide
110314-10-8

(S)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetamide

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
With trifluoroacetic acid for 3h; Ambient temperature;93%
With sulfuric acid In 1,2-dimethoxyethane
Multi-step reaction with 2 steps
1: acetic acid / 2 h / 70 °C
2: 2N aq. sulfuric acid / 1,2-dimethoxy-ethane / 8 h / 50 °C
View Scheme
4'-ethyl-1',4',7',8'-tetrahydro-4'-hydroxy-3'H,10'H-spiro[1,3-dioxolane-2,6'-pyrano[3,4-f]indolizine]-3',10'-dione
102978-41-6

4'-ethyl-1',4',7',8'-tetrahydro-4'-hydroxy-3'H,10'H-spiro[1,3-dioxolane-2,6'-pyrano[3,4-f]indolizine]-3',10'-dione

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 98.1 percent / DMAP / CH2Cl2 / 4 h / 40 °C
2: aq. K2CO3 / methanol / Ambient temperature
3: 88.9 percent / 80percent aq. CF3COOH / 3 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: 20 h / 75 °C
2: sulfuric acid / 1,2-dimethoxy-ethane
View Scheme
Multi-step reaction with 3 steps
1: 20 h / 75 °C
2: acetic acid / 2 h / 70 °C
3: 2N aq. sulfuric acid / 1,2-dimethoxy-ethane / 8 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: 20 h / 70 °C
2: p-toluenesulfonica acid / acetic acid / 7 h / 70 °C
3: 2N aq. sulfuric acid / 1,2-dimethoxy-ethane / 8 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1.1: copper(l) chloride / dichloromethane / 8 h / 20 °C
2.1: potassium hydroxide / methanol / 5 h / 67 °C
2.2: pH 2-3
3.1: trifluoroacetic acid / 6 h / 20 °C
View Scheme
1,1-ethylenedioxy-5-oxo-(5'-ethyl-2'H,5'H,6'H-6-oxopyran)-[3',4',f]-Δ6(8)-tetrahydroindolizine
127318-97-2

1,1-ethylenedioxy-5-oxo-(5'-ethyl-2'H,5'H,6'H-6-oxopyran)-[3',4',f]-Δ6(8)-tetrahydroindolizine

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: O2, (EtO)3P, tBuONa / dimethylformamide / 2 h / -40 °C
2: 98.1 percent / DMAP / CH2Cl2 / 4 h / 40 °C
3: aq. K2CO3 / methanol / Ambient temperature
4: 88.9 percent / 80percent aq. CF3COOH / 3 h / Ambient temperature
View Scheme
Multi-step reaction with 8 steps
1: 94 percent / DIBAL-H / tetrahydrofuran / 2 h / -78 °C
2: 96 percent / MsCl, TEA / tetrahydrofuran / 24 h / Ambient temperature
3: (DHQD)2-PHAL, K3Fe(CN)6, K2CO3, K2OsO2, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 96 h / Ambient temperature
4: pyridine / 3 h / Ambient temperature
5: 93 percent / i-PrNEt / CH2Cl2 / 3 h / Ambient temperature
6: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature
7: 84 percent / pyridinium chlorochromate, AcONa, molecular sieves 4 Angstroem / 24 h / Ambient temperature
8: 100 percent / aq. HCl / tetrahydrofuran; H2O / 3 h / 60 °C
View Scheme
Multi-step reaction with 5 steps
1: 94 percent / DIBAL-H / tetrahydrofuran / 2 h / -78 °C
2: 96 percent / MsCl, TEA / tetrahydrofuran / 24 h / Ambient temperature
3: (DHQD)2-PHAL, K3Fe(CN)6, K2CO3, K2OsO2, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 96 h / Ambient temperature
4: I2, CaCO3 / methanol; H2O / 24 h / Ambient temperature
5: 100 percent / aq. HCl / tetrahydrofuran; H2O / 3 h / 60 °C
View Scheme
4-acetoxy-4-ethyl-6,6-(ethylenedioxy)-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,10(4H)-dione
144788-94-3

4-acetoxy-4-ethyl-6,6-(ethylenedioxy)-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,10(4H)-dione

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. K2CO3 / methanol / Ambient temperature
2: 88.9 percent / 80percent aq. CF3COOH / 3 h / Ambient temperature
View Scheme
citrazinic acid
99-11-6

citrazinic acid

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 17 steps
1: 78 percent / POPCl3, Me4NCl / 2 h / 130 - 142 °C
2: 84 percent / tetrahydrofuran / 1 h / 0 °C
3: 100 percent / TMSCl / 12 h / Ambient temperature
4: 89 percent / methanol / 20 h / Heating
5: 1.) n-BuLi / 1.) heptane, hexane, 0 deg C, 30 min, 2.) hexane, heptane, -30 deg C - 0 deg C, 1 h
6: 71 percent / NaBH4, n-Bu4NCl / H2O / 18 h
7: 99.3 percent / t-BuOK / tetrahydrofuran / 1 h / 20 - 30 °C
8: 89 percent / Pd(OAc)2, K2CO3, DPP / dimethylformamide / 16 h / 90 °C / 775.7 Torr
10: 92 percent / OsO4, Me3NO*2H2O / 2-methyl-propan-2-ol / 24 h / 40 °C
11: 76 percent / PS-30 catalyst / various solvent(s) / 48 h
12: 100 percent / NaOCl, 4-acetoxy-TEMPO, KBr, NaHCO3 / CH2Cl2; H2O / 0.67 h
13: 96 percent / H2 / Pd/C / methanol / 96 h / 775.7 Torr / Ambient temperature; other catalyst, reaction time, temperature
14: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h
15: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
16: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
17: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
2,6-dichloropyridine-4-carboxylic acid
5398-44-7

2,6-dichloropyridine-4-carboxylic acid

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 16 steps
1: 84 percent / tetrahydrofuran / 1 h / 0 °C
2: 100 percent / TMSCl / 12 h / Ambient temperature
3: 89 percent / methanol / 20 h / Heating
4: 1.) n-BuLi / 1.) heptane, hexane, 0 deg C, 30 min, 2.) hexane, heptane, -30 deg C - 0 deg C, 1 h
5: 71 percent / NaBH4, n-Bu4NCl / H2O / 18 h
6: 99.3 percent / t-BuOK / tetrahydrofuran / 1 h / 20 - 30 °C
7: 89 percent / Pd(OAc)2, K2CO3, DPP / dimethylformamide / 16 h / 90 °C / 775.7 Torr
9: 92 percent / OsO4, Me3NO*2H2O / 2-methyl-propan-2-ol / 24 h / 40 °C
10: 76 percent / PS-30 catalyst / various solvent(s) / 48 h
11: 100 percent / NaOCl, 4-acetoxy-TEMPO, KBr, NaHCO3 / CH2Cl2; H2O / 0.67 h
12: 96 percent / H2 / Pd/C / methanol / 96 h / 775.7 Torr / Ambient temperature; other catalyst, reaction time, temperature
13: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h
14: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
15: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
16: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
1-(2,6-dichloropyridin-4-yl)propan-1-one
183433-62-7

1-(2,6-dichloropyridin-4-yl)propan-1-one

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 15 steps
1: 100 percent / TMSCl / 12 h / Ambient temperature
2: 89 percent / methanol / 20 h / Heating
3: 1.) n-BuLi / 1.) heptane, hexane, 0 deg C, 30 min, 2.) hexane, heptane, -30 deg C - 0 deg C, 1 h
4: 71 percent / NaBH4, n-Bu4NCl / H2O / 18 h
5: 99.3 percent / t-BuOK / tetrahydrofuran / 1 h / 20 - 30 °C
6: 89 percent / Pd(OAc)2, K2CO3, DPP / dimethylformamide / 16 h / 90 °C / 775.7 Torr
8: 92 percent / OsO4, Me3NO*2H2O / 2-methyl-propan-2-ol / 24 h / 40 °C
9: 76 percent / PS-30 catalyst / various solvent(s) / 48 h
10: 100 percent / NaOCl, 4-acetoxy-TEMPO, KBr, NaHCO3 / CH2Cl2; H2O / 0.67 h
11: 96 percent / H2 / Pd/C / methanol / 96 h / 775.7 Torr / Ambient temperature; other catalyst, reaction time, temperature
12: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h
13: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
14: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
15: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
5-Benzyloxymethyl-4-(1-hydroxy-1-hydroxymethyl-propyl)-6-methoxy-pyridine-2-carboxylic acid propyl ester
183433-74-1

5-Benzyloxymethyl-4-(1-hydroxy-1-hydroxymethyl-propyl)-6-methoxy-pyridine-2-carboxylic acid propyl ester

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 76 percent / PS-30 catalyst / various solvent(s) / 48 h
2: 100 percent / NaOCl, 4-acetoxy-TEMPO, KBr, NaHCO3 / CH2Cl2; H2O / 0.67 h
3: 96 percent / H2 / Pd/C / methanol / 96 h / 775.7 Torr / Ambient temperature; other catalyst, reaction time, temperature
4: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h
5: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
6: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
7: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
5-Benzyloxymethyl-4-((S)-1-hydroxy-1-hydroxymethyl-propyl)-6-methoxy-pyridine-2-carboxylic acid propyl ester
183433-75-2

5-Benzyloxymethyl-4-((S)-1-hydroxy-1-hydroxymethyl-propyl)-6-methoxy-pyridine-2-carboxylic acid propyl ester

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 100 percent / NaOCl, 4-acetoxy-TEMPO, KBr, NaHCO3 / CH2Cl2; H2O / 0.67 h
2: 96 percent / H2 / Pd/C / methanol / 96 h / 775.7 Torr / Ambient temperature; other catalyst, reaction time, temperature
3: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h
4: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
5: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
6: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
2,6-dichloro-4-(2-ethyl-1,3-dioxolan-2-yl)pyridine
183433-63-8

2,6-dichloro-4-(2-ethyl-1,3-dioxolan-2-yl)pyridine

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 14 steps
1: 89 percent / methanol / 20 h / Heating
2: 1.) n-BuLi / 1.) heptane, hexane, 0 deg C, 30 min, 2.) hexane, heptane, -30 deg C - 0 deg C, 1 h
3: 71 percent / NaBH4, n-Bu4NCl / H2O / 18 h
4: 99.3 percent / t-BuOK / tetrahydrofuran / 1 h / 20 - 30 °C
5: 89 percent / Pd(OAc)2, K2CO3, DPP / dimethylformamide / 16 h / 90 °C / 775.7 Torr
7: 92 percent / OsO4, Me3NO*2H2O / 2-methyl-propan-2-ol / 24 h / 40 °C
8: 76 percent / PS-30 catalyst / various solvent(s) / 48 h
9: 100 percent / NaOCl, 4-acetoxy-TEMPO, KBr, NaHCO3 / CH2Cl2; H2O / 0.67 h
10: 96 percent / H2 / Pd/C / methanol / 96 h / 775.7 Torr / Ambient temperature; other catalyst, reaction time, temperature
11: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h
12: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
13: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
14: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
6-chloro-4-(2-ethyl-1,3-dioxolan-2-yl)-2-methoxypyridine
183433-64-9

6-chloro-4-(2-ethyl-1,3-dioxolan-2-yl)-2-methoxypyridine

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1: 1.) n-BuLi / 1.) heptane, hexane, 0 deg C, 30 min, 2.) hexane, heptane, -30 deg C - 0 deg C, 1 h
2: 71 percent / NaBH4, n-Bu4NCl / H2O / 18 h
3: 99.3 percent / t-BuOK / tetrahydrofuran / 1 h / 20 - 30 °C
4: 89 percent / Pd(OAc)2, K2CO3, DPP / dimethylformamide / 16 h / 90 °C / 775.7 Torr
6: 92 percent / OsO4, Me3NO*2H2O / 2-methyl-propan-2-ol / 24 h / 40 °C
7: 76 percent / PS-30 catalyst / various solvent(s) / 48 h
8: 100 percent / NaOCl, 4-acetoxy-TEMPO, KBr, NaHCO3 / CH2Cl2; H2O / 0.67 h
9: 96 percent / H2 / Pd/C / methanol / 96 h / 775.7 Torr / Ambient temperature; other catalyst, reaction time, temperature
10: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h
11: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
12: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
13: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
6-Chloro-4-(2-ethyl-[1,3]dioxolan-2-yl)-2-methoxy-pyridine-3-carbaldehyde
183433-65-0

6-Chloro-4-(2-ethyl-[1,3]dioxolan-2-yl)-2-methoxy-pyridine-3-carbaldehyde

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1: 71 percent / NaBH4, n-Bu4NCl / H2O / 18 h
2: 99.3 percent / t-BuOK / tetrahydrofuran / 1 h / 20 - 30 °C
3: 89 percent / Pd(OAc)2, K2CO3, DPP / dimethylformamide / 16 h / 90 °C / 775.7 Torr
5: 92 percent / OsO4, Me3NO*2H2O / 2-methyl-propan-2-ol / 24 h / 40 °C
6: 76 percent / PS-30 catalyst / various solvent(s) / 48 h
7: 100 percent / NaOCl, 4-acetoxy-TEMPO, KBr, NaHCO3 / CH2Cl2; H2O / 0.67 h
8: 96 percent / H2 / Pd/C / methanol / 96 h / 775.7 Torr / Ambient temperature; other catalyst, reaction time, temperature
9: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h
10: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
11: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
12: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
[6-Chloro-4-(2-ethyl-[1,3]dioxolan-2-yl)-2-methoxy-pyridin-3-yl]-methanol
183433-66-1

[6-Chloro-4-(2-ethyl-[1,3]dioxolan-2-yl)-2-methoxy-pyridin-3-yl]-methanol

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: 99.3 percent / t-BuOK / tetrahydrofuran / 1 h / 20 - 30 °C
2: 89 percent / Pd(OAc)2, K2CO3, DPP / dimethylformamide / 16 h / 90 °C / 775.7 Torr
4: 92 percent / OsO4, Me3NO*2H2O / 2-methyl-propan-2-ol / 24 h / 40 °C
5: 76 percent / PS-30 catalyst / various solvent(s) / 48 h
6: 100 percent / NaOCl, 4-acetoxy-TEMPO, KBr, NaHCO3 / CH2Cl2; H2O / 0.67 h
7: 96 percent / H2 / Pd/C / methanol / 96 h / 775.7 Torr / Ambient temperature; other catalyst, reaction time, temperature
8: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h
9: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
10: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
11: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
(S)-4-Ethyl-3,4-dihydroxy-8-methoxy-3,4-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxylic acid propyl ester
194999-55-8

(S)-4-Ethyl-3,4-dihydroxy-8-methoxy-3,4-dihydro-1H-pyrano[3,4-c]pyridine-6-carboxylic acid propyl ester

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h
2: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
3: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
4: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
propyl (S)-4-ethyl-3,4,7,8-tetrahydro-4-hydroxy-3,8-dioxo-1H-pyrano[3,4-c] pyridine-6-carboxylate
183434-02-8

propyl (S)-4-ethyl-3,4,7,8-tetrahydro-4-hydroxy-3,8-dioxo-1H-pyrano[3,4-c] pyridine-6-carboxylate

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
2: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
propyl (S)-4-ethyl-3,4-dihydro-4-hydroxy-8-methoxy-3-oxo-1H-pyrano[3,4-c]pyridine-6-carboxylate
183434-00-6

propyl (S)-4-ethyl-3,4-dihydro-4-hydroxy-8-methoxy-3-oxo-1H-pyrano[3,4-c]pyridine-6-carboxylate

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
2: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
3: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
3-Benzyloxymethyl-6-chloro-4-(2-ethyl-[1,3]dioxolan-2-yl)-2-methoxy-pyridine
183433-67-2

3-Benzyloxymethyl-6-chloro-4-(2-ethyl-[1,3]dioxolan-2-yl)-2-methoxy-pyridine

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 89 percent / Pd(OAc)2, K2CO3, DPP / dimethylformamide / 16 h / 90 °C / 775.7 Torr
3: 92 percent / OsO4, Me3NO*2H2O / 2-methyl-propan-2-ol / 24 h / 40 °C
4: 76 percent / PS-30 catalyst / various solvent(s) / 48 h
5: 100 percent / NaOCl, 4-acetoxy-TEMPO, KBr, NaHCO3 / CH2Cl2; H2O / 0.67 h
6: 96 percent / H2 / Pd/C / methanol / 96 h / 775.7 Torr / Ambient temperature; other catalyst, reaction time, temperature
7: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h
8: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
9: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
10: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
5-Benzyloxymethyl-6-methoxy-4-(1-methylene-propyl)-pyridine-2-carboxylic acid propyl ester
183433-72-9

5-Benzyloxymethyl-6-methoxy-4-(1-methylene-propyl)-pyridine-2-carboxylic acid propyl ester

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 92 percent / OsO4, Me3NO*2H2O / 2-methyl-propan-2-ol / 24 h / 40 °C
2: 76 percent / PS-30 catalyst / various solvent(s) / 48 h
3: 100 percent / NaOCl, 4-acetoxy-TEMPO, KBr, NaHCO3 / CH2Cl2; H2O / 0.67 h
4: 96 percent / H2 / Pd/C / methanol / 96 h / 775.7 Torr / Ambient temperature; other catalyst, reaction time, temperature
5: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h
6: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
7: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
8: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
5-Benzyloxymethyl-4-((S)-1-formyl-1-hydroxy-propyl)-6-methoxy-pyridine-2-carboxylic acid propyl ester
183433-96-7

5-Benzyloxymethyl-4-((S)-1-formyl-1-hydroxy-propyl)-6-methoxy-pyridine-2-carboxylic acid propyl ester

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 96 percent / H2 / Pd/C / methanol / 96 h / 775.7 Torr / Ambient temperature; other catalyst, reaction time, temperature
2: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h
3: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
4: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
5: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
5-Benzyloxymethyl-4-(2-ethyl-[1,3]dioxolan-2-yl)-6-methoxy-pyridine-2-carboxylic acid propyl ester
183433-68-3

5-Benzyloxymethyl-4-(2-ethyl-[1,3]dioxolan-2-yl)-6-methoxy-pyridine-2-carboxylic acid propyl ester

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 9 steps
2: 92 percent / OsO4, Me3NO*2H2O / 2-methyl-propan-2-ol / 24 h / 40 °C
3: 76 percent / PS-30 catalyst / various solvent(s) / 48 h
4: 100 percent / NaOCl, 4-acetoxy-TEMPO, KBr, NaHCO3 / CH2Cl2; H2O / 0.67 h
5: 96 percent / H2 / Pd/C / methanol / 96 h / 775.7 Torr / Ambient temperature; other catalyst, reaction time, temperature
6: 99 percent / TEMPO, KBr, NaHCO3, NaOCl / CH2Cl2; H2O / 0.5 h
7: 89 percent / TMSCl, NaI / acetonitrile / 6 h / 0 - 20 °C
8: 74 percent / Cs2CO3 / dimethylsulfoxide / 21 h / 47 - 50 °C
9: 93.4 percent / trifluoroacetic acid; toluene / 2 h / 110 °C
View Scheme
C15H17NO4
165674-31-7

C15H17NO4

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: (DHQD)2-PHAL, K3Fe(CN)6, K2CO3, K2OsO2, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 96 h / Ambient temperature
2: pyridine / 3 h / Ambient temperature
3: 93 percent / i-PrNEt / CH2Cl2 / 3 h / Ambient temperature
4: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature
5: 84 percent / pyridinium chlorochromate, AcONa, molecular sieves 4 Angstroem / 24 h / Ambient temperature
6: 100 percent / aq. HCl / tetrahydrofuran; H2O / 3 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1: (DHQD)2-PHAL, K3Fe(CN)6, K2CO3, K2OsO2, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 96 h / Ambient temperature
2: I2, CaCO3 / methanol; H2O / 24 h / Ambient temperature
3: 100 percent / aq. HCl / tetrahydrofuran; H2O / 3 h / 60 °C
View Scheme
C15H19NO5
165674-30-6

C15H19NO5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 96 percent / MsCl, TEA / tetrahydrofuran / 24 h / Ambient temperature
2: (DHQD)2-PHAL, K3Fe(CN)6, K2CO3, K2OsO2, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 96 h / Ambient temperature
3: pyridine / 3 h / Ambient temperature
4: 93 percent / i-PrNEt / CH2Cl2 / 3 h / Ambient temperature
5: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature
6: 84 percent / pyridinium chlorochromate, AcONa, molecular sieves 4 Angstroem / 24 h / Ambient temperature
7: 100 percent / aq. HCl / tetrahydrofuran; H2O / 3 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: 96 percent / MsCl, TEA / tetrahydrofuran / 24 h / Ambient temperature
2: (DHQD)2-PHAL, K3Fe(CN)6, K2CO3, K2OsO2, CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 96 h / Ambient temperature
3: I2, CaCO3 / methanol; H2O / 24 h / Ambient temperature
4: 100 percent / aq. HCl / tetrahydrofuran; H2O / 3 h / 60 °C
View Scheme
C17H23NO7

C17H23NO7

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / pyridinium chlorochromate, AcONa, molecular sieves 4 Angstroem / 24 h / Ambient temperature
2: 100 percent / aq. HCl / tetrahydrofuran; H2O / 3 h / 60 °C
View Scheme
C17H21NO7

C17H21NO7

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 93 percent / i-PrNEt / CH2Cl2 / 3 h / Ambient temperature
2: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature
3: 84 percent / pyridinium chlorochromate, AcONa, molecular sieves 4 Angstroem / 24 h / Ambient temperature
4: 100 percent / aq. HCl / tetrahydrofuran; H2O / 3 h / 60 °C
View Scheme
C19H25NO8

C19H25NO8

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature
2: 84 percent / pyridinium chlorochromate, AcONa, molecular sieves 4 Angstroem / 24 h / Ambient temperature
3: 100 percent / aq. HCl / tetrahydrofuran; H2O / 3 h / 60 °C
View Scheme
C15H19NO6

C15H19NO6

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: pyridine / 3 h / Ambient temperature
2: 93 percent / i-PrNEt / CH2Cl2 / 3 h / Ambient temperature
3: 92 percent / aq. K2CO3 / methanol / 2 h / Ambient temperature
4: 84 percent / pyridinium chlorochromate, AcONa, molecular sieves 4 Angstroem / 24 h / Ambient temperature
5: 100 percent / aq. HCl / tetrahydrofuran; H2O / 3 h / 60 °C
View Scheme
Multi-step reaction with 2 steps
1: I2, CaCO3 / methanol; H2O / 24 h / Ambient temperature
2: 100 percent / aq. HCl / tetrahydrofuran; H2O / 3 h / 60 °C
View Scheme
(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

2-amino-5-methylthiopropiophenone
124623-17-2

2-amino-5-methylthiopropiophenone

(S)-4,11-Diethyl-4-hydroxy-9-methylsulfanyl-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

(S)-4,11-Diethyl-4-hydroxy-9-methylsulfanyl-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 24h; Heating;99%
1-(2-amino-phenyl)-3-trimethylsilanyl-propan-1-one
1609324-12-0

1-(2-amino-phenyl)-3-trimethylsilanyl-propan-1-one

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

(4S)-4-ethyl-4-hydroxy-11-[2-(trimethylsilyl)ethyl]-1H-pyrano[3':4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

(4S)-4-ethyl-4-hydroxy-11-[2-(trimethylsilyl)ethyl]-1H-pyrano[3':4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Conditions
ConditionsYield
With toluene-4-sulfonic acid; acetic acid In toluene at 100℃; for 20h;98%
2-(3'-trimethylsilylpropionyl)-N-Boc-aniline
1609257-42-2

2-(3'-trimethylsilylpropionyl)-N-Boc-aniline

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
110351-94-5

(4S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione

(4S)-4-ethyl-4-hydroxy-11-[2-(trimethylsilyl)ethyl]-1H-pyrano[3':4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

(4S)-4-ethyl-4-hydroxy-11-[2-(trimethylsilyl)ethyl]-1H-pyrano[3':4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Conditions
ConditionsYield
With toluene-4-sulfonic acid; acetic acid In toluene at 100℃; for 24h;96%

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