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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

4-Bromo-2-fluorobenzoic acid Manufacturer/High quality/Best price/In stock

Cas:112704-79-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Bromo-2-Fluorobenzoic Acid supplier in China

Cas:112704-79-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Our Services 1. Certificate Of Analysis (COA) 2. Material Safety Data Sheet (MSDS) 3. Route of synthesis (ROS) 4. Method of Aanlysis (MOA)

4-Bromo-2-fluorobenzoic acid

Cas:112704-79-7

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:shanghai

4-Bromo-2-fluorobenzoic acid

Cas:112704-79-7

Min.Order:1 Kilogram

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Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Bromo-2-Fluorobenzoic Acid

Cas:112704-79-7

Min.Order:1

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Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 112704-79-7 4-Bromo-2-fluorobenzoic Acid Manufacturer

Cas:112704-79-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Name 4-Bromo-2-fluorobenzoic acid Molecular Structure Molecular Formula C7H4BrFO2 Molecular Weight

4-Bromo-2-fluorobenzoic acid

Cas:112704-79-7

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

4-Bromo-2-fluorobenzoic acid

Cas:112704-79-7

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Bromo-2-fluorobenzoic acid

Cas:112704-79-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

CAS NO.:112704-79-7 4-Bromo-2-fluorobenzoic acid 1.Large qty in stock 2.High quality 3.Lowest price 4.Best service Our Advantage 1. Risk-free guarantee,15days refund 2. Most of the products in stock,can ship within 7days after the o

CAS NO.:112704-79-7 4-Bromo-2-fluorobenzoic acid

Cas:112704-79-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 112704-79-7 with best quality

Cas:112704-79-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name: 4-Bromo-2-fluorobenzoic acid Synonyms: 2-FLUORO-4-BROMOBENZOIC ACID;4-BROMO-2-FLUOROBENZOIC ACID;BUTTPARK 18\02-86;RARECHEM AL BO 0754;4-Bromo-2-Fluorobenzoic Acid 2-Fluoro-4-Bromobenzoic Acid

4-Bromo-2-fluorobenzoic acid CAS: 112704-79-7

Cas:112704-79-7

Min.Order:5 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Powder Storage:Store in sealed containers at cool & dry pla

4-Bromo-2-fluorobenzoic acid cas no 112704-79-7

Cas:112704-79-7

Min.Order:100 Gram

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Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Bromo-2-fluorobenzoic acid 112704-79-7

Cas:112704-79-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

4-Bromo-2-fluorobenzoic acid

Cas:112704-79-7

Min.Order:5 Gram

FOB Price: $331.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

4-Bromo-2-fluorobenzoic acid CAS:112704-79-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality org

4-Bromo-2-fluorobenzoic acid CAS:112704-79-7

Cas:112704-79-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Bromo-2-fluorobenzoic acid

Cas:112704-79-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

4-Bromo-2-fluorobenzoic acid/ LIDE PHARMA- Factory supply / Best price

Cas:112704-79-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

4-Bromo-2-fluorobenzoic acid CAS:112704-79-7

Cas:112704-79-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Bromo-2-fluorobenzoic acid

Cas:112704-79-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Bromo-2-Fluorobenzoic Acid

Cas:112704-79-7

Min.Order:0

Negotiable

Type:Manufacturers

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

4-Bromo-2-fluorobenzoic acid

Cas:112704-79-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-Bromo-2-fluorobenzoic Acid

Cas:112704-79-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Bromo-2-fluorobenzoic acid

Cas:112704-79-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 4-Bromo-2-fluorobenzoic acid

Cas:112704-79-7

Min.Order:100 Gram

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Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

CAS:112704-79-7 MW:219.01 MF:C7H4BrFO2 Melting point:208-213℃ Boiling point:244.5°C at 760 mmHg Density:1.571g/cm3 Appearance:White crystalline powder Package:25kg/drum Transportation:by sea/air/courier Port:Shanghai

4-Bromo-2-fluorobenzoic acid

Cas:112704-79-7

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-Bromom-2-fluoro-benzoic acid/Manufacturer/High quality/Best price

Cas:112704-79-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 4-Bromo-2-Fluorobenzoic Acid

Cas:112704-79-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 4-Bromo-2-Fluorobenzoic Acid CAS No.:112704-79-7 Molecule Formula:C7H4BrFO2 Molecule Weight:219.00 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard T

High Quality 4-Bromo-2-Fluorobenzoic Acid on stock

Cas:112704-79-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-Bromo-2-fluorobenzoic acid

Cas:112704-79-7

Min.Order:1 Gram

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Type:Lab/Research institutions

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Synthetic route

sodium chlorite
7758-19-2

sodium chlorite

Na2HPO4.12H2O

Na2HPO4.12H2O

4-bromo-2-fluorobenzaldehyde
57848-46-1

4-bromo-2-fluorobenzaldehyde

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

Conditions
ConditionsYield
With dihydrogen peroxide In water; acetonitrile96%
2-fluoro-4-bromotoluene
51436-99-8

2-fluoro-4-bromotoluene

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); oxygen; sodium bromide; cobalt(II) acetate; acetic acid In various solvent(s) at 110℃; under 760.051 Torr; for 4.5h;91%
With 2,2'-azobis(isobutyronitrile); oxygen; cobalt(II) diacetate tetrahydrate; acetic acid; sodium bromide at 130℃; under 9000.9 Torr; for 1.5h; Green chemistry;88%
carbon dioxide
124-38-9

carbon dioxide

2,5-dibromofluorobenzene
1435-52-5

2,5-dibromofluorobenzene

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

Conditions
ConditionsYield
With n-butyllithium; butyl magnesium bromide In tetrahydrofuran; hexane at 0℃;90%
4-bromo-2-fluoroacetophenone
625446-22-2

4-bromo-2-fluoroacetophenone

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

Conditions
ConditionsYield
With copper (II) nitrate tetrahydrate; oxygen In acetonitrile at 180℃; under 18751.9 Torr; for 1.5h; Green chemistry;79%
4-bromo-2-fluoro-3-triethylsilanyl-benzoic acid

4-bromo-2-fluoro-3-triethylsilanyl-benzoic acid

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 155℃;
4-bromo-2-fluorobenzaldehyde
57848-46-1

4-bromo-2-fluorobenzaldehyde

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

Conditions
ConditionsYield
With sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide In water; acetonitrile at 20℃;
(2-bromo-6-fluorophenyl)triethylsilane
872545-52-3

(2-bromo-6-fluorophenyl)triethylsilane

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: BuLi / hexane; tetrahydrofuran / -75 °C
2: tetrabutylammonium fluoride trihydrate / dimethylformamide / 155 °C
View Scheme
3-fluorobromobenzene
1073-06-9

3-fluorobromobenzene

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / BuLi / hexane; tetrahydrofuran / 2.75 h / -75 °C
2: BuLi / hexane; tetrahydrofuran / -75 °C
3: tetrabutylammonium fluoride trihydrate / dimethylformamide / 155 °C
View Scheme
C10H12BrFO2Si

C10H12BrFO2Si

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

Conditions
ConditionsYield
With methanol; sodium hydroxide In water at 20 - 50℃; for 6h; Inert atmosphere;5.6 g
2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

4-bromo-2-fluorobenzoyl chloride
151982-51-3

4-bromo-2-fluorobenzoyl chloride

Conditions
ConditionsYield
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere; Cooling with ice;100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 1h;100%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 22h;100%
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

2-fluoro-4-bromo-N-methoxy-N-methylbenzamide
801303-33-3

2-fluoro-4-bromo-N-methoxy-N-methylbenzamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20 - 40℃; for 47h;100%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In water at 0 - 5℃;99%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; Reagent/catalyst;85%
methanol
67-56-1

methanol

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

methyl 4-bromo-2-fluorobenzoate
179232-29-2

methyl 4-bromo-2-fluorobenzoate

Conditions
ConditionsYield
With sulfuric acid for 20h; Heating / reflux;100%
Stage #1: 2-fluoro-4-bromobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane
Stage #2: methanol In dichloromethane at 20℃; for 0.5h;
97%
With thionyl chloride at 0 - 20℃; for 12h;96%
2,2'-dipyridyldisulphide
2127-03-9

2,2'-dipyridyldisulphide

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

4-Bromo-2-fluoro-thiobenzoic acid S-pyridin-2-yl ester
625446-21-1

4-Bromo-2-fluoro-thiobenzoic acid S-pyridin-2-yl ester

Conditions
ConditionsYield
With triphenylphosphine In dichloromethane at 0 - 20℃; for 4h;100%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

4-bromo-2-fluoro-N-(1-methylpiperidin-4-yl)benzamide
893420-55-8

4-bromo-2-fluoro-N-(1-methylpiperidin-4-yl)benzamide

Conditions
ConditionsYield
Stage #1: 4-Amino-1-methylpiperidine; 2-fluoro-4-bromobenzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h;
Stage #2: With sodium hydroxide In water at 20℃;
100%
With triethylamine; HATU In N,N-dimethyl-formamide
2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

methyl 4-bromo-2-fluorobenzoate
179232-29-2

methyl 4-bromo-2-fluorobenzoate

Conditions
ConditionsYield
In tetrahydrofuran; methanol; hexanes at 0 - 20℃; for 1h;100%
In tetrahydrofuran; methanol at 0 - 20℃; for 1h;88%
In methanol; diethyl ether; ethyl acetate at 20℃;
2,4-dimethyl-3-pentanol
600-36-2

2,4-dimethyl-3-pentanol

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

2,4-dimethylpentan-3-yl 4-bromo-2-fluorobenzoate

2,4-dimethylpentan-3-yl 4-bromo-2-fluorobenzoate

Conditions
ConditionsYield
With dmap; camphor-10-sulfonic acid; dicyclohexyl-carbodiimide In dichloromethane at 20℃;97%
2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

4-bromo-N-tert-butyl-2-fluorobenzamide

4-bromo-N-tert-butyl-2-fluorobenzamide

Conditions
ConditionsYield
96%
(S)-6,6'-bis[4-(trans-4-n-propylcyclohexyl)phenyl]-1,1'-bi-2-naphthol

(S)-6,6'-bis[4-(trans-4-n-propylcyclohexyl)phenyl]-1,1'-bi-2-naphthol

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

(S)-6,6'-bis[4-(trans-4-n-propylcyclohexyl)phenyl]-1,1'-binaphthyl-2,2'-diyl bis(4-bromo-2-fluoro)benzoate

(S)-6,6'-bis[4-(trans-4-n-propylcyclohexyl)phenyl]-1,1'-binaphthyl-2,2'-diyl bis(4-bromo-2-fluoro)benzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 17h;96%
2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

tert-butyl alcohol
75-65-0

tert-butyl alcohol

4-bromo-2-fluoro-benzoic acid tert-butyl ester
889858-12-2

4-bromo-2-fluoro-benzoic acid tert-butyl ester

Conditions
ConditionsYield
With dmap; di-tert-butyl dicarbonate In tetrahydrofuran at 80℃; for 13h;95.5%
Stage #1: 2-fluoro-4-bromobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In tetrahydrofuran at 0 - 20℃; for 1.5h;
Stage #2: tert-butyl alcohol With pyridine In dichloromethane at 20℃; for 64h;
80%
Stage #1: 2-fluoro-4-bromobenzoic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 5h;
Stage #2: tert-butyl alcohol With pyridine In tetrahydrofuran at 0 - 50℃; for 23h;
74%
ethylamine
75-04-7

ethylamine

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

4-bromo-2-fluoro-N-ethylbenzamide

4-bromo-2-fluoro-N-ethylbenzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 2h;95%
Stage #1: 2-fluoro-4-bromobenzoic acid With thionyl chloride at 80℃; for 1.33333h;
Stage #2: ethylamine In tetrahydrofuran; dichloromethane at 20℃; for 2h;
90%
Stage #1: 2-fluoro-4-bromobenzoic acid With thionyl chloride at 80℃; for 1.33333h;
Stage #2: ethylamine In dichloromethane
849 mg
2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

methylamine
74-89-5

methylamine

4-bromo-2-fluoro-N-methylbenzanamide
749927-69-3

4-bromo-2-fluoro-N-methylbenzanamide

Conditions
ConditionsYield
Stage #1: 2-fluoro-4-bromobenzoic acid With thionyl chloride; N,N-dimethyl-formamide In Isopropyl acetate at 55℃; for 3h;
Stage #2: methylamine With water In Isopropyl acetate at 0 - 35℃; for 12h;
94.4%
Stage #1: 2-fluoro-4-bromobenzoic acid With thionyl chloride In 1,2-dimethoxyethane at 0 - 50℃;
Stage #2: methylamine In 1,2-dimethoxyethane at 35℃; for 0.5h; Solvent; Reagent/catalyst; Temperature;
93%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;74%
(S)-dibenzyl 2-aminosuccinate 4-methylbenzenesulphonic acid salt

(S)-dibenzyl 2-aminosuccinate 4-methylbenzenesulphonic acid salt

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

(S)-dibenzyl 2-(4-bromo-2-fluorobenzamido)succinate

(S)-dibenzyl 2-(4-bromo-2-fluorobenzamido)succinate

Conditions
ConditionsYield
Stage #1: 2-fluoro-4-bromobenzoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane for 0.0833333h;
Stage #2: (S)-dibenzyl 2-aminosuccinate 4-methylbenzenesulphonic acid salt In dichloromethane at 20℃; for 24h;
94%
2-(2-Hydroxyethyl)pyridine
103-74-2

2-(2-Hydroxyethyl)pyridine

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

2-(2-pyridyl)ethyl 4-bromo-2-fluorobenzoate
920270-28-6

2-(2-pyridyl)ethyl 4-bromo-2-fluorobenzoate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; Product distribution / selectivity;93%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 16h; Inert atmosphere;93%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; Product distribution / selectivity;80%
2-fluoro-5-(trifluoromethyl)phenylboronic acid
352535-96-7

2-fluoro-5-(trifluoromethyl)phenylboronic acid

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

2',3-difluoro-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid

2',3-difluoro-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid

Conditions
ConditionsYield
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine In 1,4-dioxane at 100℃; for 1h; Microwave irradiation;93%
With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine In 1,4-dioxane at 120℃; for 1h; Microwave irradiation;93%
phenylmethanethiol
100-53-8

phenylmethanethiol

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

2-(benzylthio)-4-bromobenzoic acid

2-(benzylthio)-4-bromobenzoic acid

Conditions
ConditionsYield
Stage #1: 2-fluoro-4-bromobenzoic acid With caesium carbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 0.05h;
Stage #2: phenylmethanethiol In 1-methyl-pyrrolidin-2-one at 20 - 120℃; for 3h;
93%
benzyl bromide
100-39-0

benzyl bromide

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

benzyl 4-bromo-2-fluorobenzoate
437764-46-0

benzyl 4-bromo-2-fluorobenzoate

Conditions
ConditionsYield
With sodium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 24h;92%
With sodium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 16h;89%
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 3h;
ethanol
64-17-5

ethanol

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

4-bromo-2-fluorobenzoic acid ethyl ester
474709-71-2

4-bromo-2-fluorobenzoic acid ethyl ester

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 20h;90%
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide at 40 - 45℃; for 24h; Inert atmosphere;90%
With sulfuric acid for 16h; Heating / reflux;

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