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HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of 7,10-Dimethoxy 10-DAB III from Wuhan, Hubei, China. It is made obtaina

7,10-Dimethoxy 10-DAB III CAS 183133-94-0

Cas:114915-14-9

Min.Order:1 Kilogram

FOB Price: $4.8 / 5.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Docetaxel intermediate

Cas:114915-14-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of Docetaxel intermediate Cas 114915-14-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:Cool dry place Package:100g,1kg/foil bag

High quality Docetaxel intermediate Cas 114915-14-9 with best price and fast delivery

Cas:114915-14-9

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Product Name: Docetaxel intermediate Synonyms: DOCETAXEL INTERMEDIATE;INTERMEDIATE FOR DOCETAXEL;IntermediateIIIforDocetaxel;INTERMEDIATEOFDOCETAXEL;N-1 Step intermediate;(aR,bS)-beta-[[(1,1-Dimethylethoxy)carbonyl]amino]-alpha-hydroxy

114915-14-9 Docetaxel intermediate

Cas:114915-14-9

Min.Order:1 Gram

FOB Price: $8900.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Discount price CAS 114915-14-9 with best price

Cas:114915-14-9

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Docetaxel intermediate/ LIDE PHARMA- Factory supply / Best price

Cas:114915-14-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Docetaxel intermediate CAS114915-14-9

Cas:114915-14-9

Min.Order:1 Kilogram

FOB Price: $289.0 / 499.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Docetaxel intermediate

Cas:114915-14-9

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Shanghai Minstar Chemical Co., Ltd

Product Name: Docetaxel intermediate Synonyms: 7,10-Di Troc Docetaxel;Docetaxel InterMediate (N-1);Benzenepropanoic acid, b-[[(1,1-diMethylethoxy)carbonyl]aMino]-a-hydroxy-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a

Docetaxel intermediate

Cas:114915-14-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Docetaxel intermediate CAS:114915-14-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic i

Docetaxel intermediate CAS:114915-14-9

Cas:114915-14-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Leader Biochemical Group

PRODUCT DETAILS

China Largest Factory Manufacturer sales 7,10-di-Troc-Docetaxel CAS 114915-14-9

Cas:114915-14-9

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

Docetaxel intermediate

Cas:114915-14-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Docetaxel intermediate 114915-14-9

Cas:114915-14-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

7,10-DI-TROC-DOCETAXEL

Cas:114915-14-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Binbo Biological Co., Ltd

1.high purity 2.consistent quality 3.competitive price 4.fast shipping Binbo Biological Products Co. Ltd., is a professional high-tech enterprise which engaged in Biological products raw materials. Binbo is engaged in R&D with perfect equipm

High Quality Docetaxel intermediate

Cas:114915-14-9

Min.Order:1 Kilogram

FOB Price: $0.1 / 0.2

Type:Lab/Research institutions

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Shanghai Send Pharmaceutical Technology Co., Ltd.

stocks High quaiity Appearance:White Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:API Transportation:shipping,land,air Port:Shanghai

7,10-O-Ditroc docetaxel;114915-14-9

Cas:114915-14-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Levetiracetam

Cas:114915-14-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply Docetaxel intermediate

Cas:114915-14-9

Min.Order:0

Negotiable

Type:Other

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used in organic synthesis

7,10-Di Troc Docetaxel

Cas:114915-14-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Lyander (Xiamen) Medical Technology Co., LTD

Lyander’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Lyander can provide different quantities of cu

Docetaxel intermediate

Cas:114915-14-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Docetaxel Protective Matter CAS No.:114915-14-9 Molecule Formula:C49H55Cl6NO18 Molecule Weight:1158.67 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

Best Quality Docetaxel Protective Matter

Cas:114915-14-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Docetaxel intermediate

Cas:114915-14-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Docetaxel intermediate

Cas:114915-14-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

Docetaxel intermediate

Cas:114915-14-9

Min.Order:100 Gram

Negotiable

Type:Manufacturers

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

intermediate for Docetaxel

Cas:114915-14-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

SAGECHEM/ 7,10-O-Ditroc docetaxel /Manufacturer in China

Cas:114915-14-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

13-[(2'R,4'S,5'R)-3'-t-butoxycarbonyl-2'-(1'''-naphthyl)-4'-phenyl-1,3-oxazolidine-5-carbonyl]-7,10-(di-2'',2'',2''-trichloroethoxy carbonyl)-10-deacetylbaccatin III
1033962-64-9

13-[(2'R,4'S,5'R)-3'-t-butoxycarbonyl-2'-(1'''-naphthyl)-4'-phenyl-1,3-oxazolidine-5-carbonyl]-7,10-(di-2'',2'',2''-trichloroethoxy carbonyl)-10-deacetylbaccatin III

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Stage #1: 13-[(2'R,4'S,5'R)-3'-t-butoxycarbonyl-2'-(1'''-naphthyl)-4'-phenyl-1,3-oxazolidine-5-carbonyl]-7,10-(di-2'',2'',2''-trichloroethoxy carbonyl)-10-deacetylbaccatin III With toluene-4-sulfonic acid In chloroform at 20℃; for 3h;
Stage #2: With water; sodium hydrogencarbonate In chloroform
88%
With methanol; toluene-4-sulfonic acid In chloroform at 20℃; for 3h;88%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

10-deacetyl-7,10-diTroc-baccatin III
114915-16-1

10-deacetyl-7,10-diTroc-baccatin III

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran at 20℃;87%
In water; ethyl acetate at 25 - 30℃; for 1h;
With sodium hydrogencarbonate In water at 55 - 65℃; for 2h;737.4 g
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

C44H45Cl6N3O16
174729-13-6

C44H45Cl6N3O16

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
With potassium hydrogencarbonate; triphenylphosphine In dichloromethane; water for 19h; Ambient temperature;63%
N-chloro-N-sodio-tert-butylcarbamate
73210-14-7

N-chloro-N-sodio-tert-butylcarbamate

A

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

B

C49H55Cl6NO18
114977-25-2

C49H55Cl6NO18

Conditions
ConditionsYield
With osmium(VIII) oxide; silver nitrate In acetonitrile; tert-butyl alcohol for 24h; Ambient temperature; var. solvents and temp.; Further byproducts given;A 25%
B 22%
C 21.5%
D 16.5%
C57H61Cl6NO19
859498-31-0

C57H61Cl6NO19

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
With APTS In methanol at 20℃; for 16h;25%
With toluene-4-sulfonic acid In methanol at 20℃;
With hydrogenchloride In water; ethyl acetate at 20 - 24℃; Solvent; Temperature;
N-chloro-N-sodio-tert-butylcarbamate
73210-14-7

N-chloro-N-sodio-tert-butylcarbamate

B

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

C

C49H55Cl6NO18
114977-25-2

C49H55Cl6NO18

Conditions
ConditionsYield
With osmium(VIII) oxide; silver nitrate In toluene; tert-butyl alcohol at 4℃; for 24h; var. solvents and temp.; Further byproducts given;A 12%
B 20%
C 17%
D 18%
methyl (2S,3R)-3-phenyl-2,3-dihydroxypropanoate
124649-67-8

methyl (2S,3R)-3-phenyl-2,3-dihydroxypropanoate

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: triethylamine / CH2Cl2 / 38 h / 0 °C
2: K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature
3: 80 percent / LiOH*H2O / methanol; H2O / 1 h / Ambient temperature
4: 91 percent / dicyclohexylcarbodiimide, 4-N,N-dimethylaminopyridine / toluene / 1 h / 80 °C
5: 78 percent / sodium azide, methyl formate / methanol; H2O / 40 h / 50 °C / other reagent: tri-n-butyltinazide/ZnI2
6: 63 percent / KHCO3, PPh3 / CH2Cl2; H2O / 19 h / Ambient temperature
View Scheme
(2S,3R)-(-)-methyl 3-hydroxy-3-phenyl-2-((p-tolylsulfonyl)oxy)propionate
124605-43-2

(2S,3R)-(-)-methyl 3-hydroxy-3-phenyl-2-((p-tolylsulfonyl)oxy)propionate

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature
2: 80 percent / LiOH*H2O / methanol; H2O / 1 h / Ambient temperature
3: 91 percent / dicyclohexylcarbodiimide, 4-N,N-dimethylaminopyridine / toluene / 1 h / 80 °C
4: 78 percent / sodium azide, methyl formate / methanol; H2O / 40 h / 50 °C / other reagent: tri-n-butyltinazide/ZnI2
5: 63 percent / KHCO3, PPh3 / CH2Cl2; H2O / 19 h / Ambient temperature
View Scheme
(2R,3R)-(+)-methyl 3-phenyloxiranecarboxylate
99528-65-1

(2R,3R)-(+)-methyl 3-phenyloxiranecarboxylate

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 80 percent / LiOH*H2O / methanol; H2O / 1 h / Ambient temperature
2: 91 percent / dicyclohexylcarbodiimide, 4-N,N-dimethylaminopyridine / toluene / 1 h / 80 °C
3: 78 percent / sodium azide, methyl formate / methanol; H2O / 40 h / 50 °C / other reagent: tri-n-butyltinazide/ZnI2
4: 63 percent / KHCO3, PPh3 / CH2Cl2; H2O / 19 h / Ambient temperature
View Scheme
methyl (2R,3S)-3-phenylglycidate
115794-67-7

methyl (2R,3S)-3-phenylglycidate

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: NaOH / tetrahydrofuran; H2O / 0.33 h / Ambient temperature
2: 5.55 g / dicyclohexylcarbodiimide, 4-N,N-dimethylaminopyridine / toluene / 0.17 h / Ambient temperature
3: 76 percent / hexamethylphosphoramide, TiBr4 / CH2Cl2 / 18 h / 0 °C
4: 71 percent / sodium azide, 15-crown-5 / dimethylformamide / 18 h / 0 °C
5: 63 percent / KHCO3, PPh3 / CH2Cl2; H2O / 19 h / Ambient temperature
View Scheme
Methyl cinnamate
103-26-4

Methyl cinnamate

XCH2CO2Et

XCH2CO2Et

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 65 percent / AD-mix-β / 2-methyl-propan-2-ol; H2O / 18 h / Ambient temperature
2: triethylamine / CH2Cl2 / 38 h / 0 °C
3: K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature
4: 80 percent / LiOH*H2O / methanol; H2O / 1 h / Ambient temperature
5: 91 percent / dicyclohexylcarbodiimide, 4-N,N-dimethylaminopyridine / toluene / 1 h / 80 °C
6: 78 percent / sodium azide, methyl formate / methanol; H2O / 40 h / 50 °C / other reagent: tri-n-butyltinazide/ZnI2
7: 63 percent / KHCO3, PPh3 / CH2Cl2; H2O / 19 h / Ambient temperature
View Scheme
cis-2,3-epoxy-3-phenyl-1-propanoic acid
99528-64-0

cis-2,3-epoxy-3-phenyl-1-propanoic acid

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 91 percent / dicyclohexylcarbodiimide, 4-N,N-dimethylaminopyridine / toluene / 1 h / 80 °C
2: 78 percent / sodium azide, methyl formate / methanol; H2O / 40 h / 50 °C / other reagent: tri-n-butyltinazide/ZnI2
3: 63 percent / KHCO3, PPh3 / CH2Cl2; H2O / 19 h / Ambient temperature
View Scheme
C44H44Cl6O16
174847-58-6

C44H44Cl6O16

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 76 percent / hexamethylphosphoramide, TiBr4 / CH2Cl2 / 18 h / 0 °C
2: 71 percent / sodium azide, 15-crown-5 / dimethylformamide / 18 h / 0 °C
3: 63 percent / KHCO3, PPh3 / CH2Cl2; H2O / 19 h / Ambient temperature
View Scheme
13-O-((2R,3R)-3-phenylglycidoyl)-7,10-O,O'-bis(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin
174729-12-5

13-O-((2R,3R)-3-phenylglycidoyl)-7,10-O,O'-bis(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 78 percent / sodium azide, methyl formate / methanol; H2O / 40 h / 50 °C / other reagent: tri-n-butyltinazide/ZnI2
2: 63 percent / KHCO3, PPh3 / CH2Cl2; H2O / 19 h / Ambient temperature
View Scheme
13-O-((2S,3R)-3-bromo-2-hydroxy-3-phenylpropionyl)-7,10-O,O'-bis(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin
174729-14-7

13-O-((2S,3R)-3-bromo-2-hydroxy-3-phenylpropionyl)-7,10-O,O'-bis(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 71 percent / sodium azide, 15-crown-5 / dimethylformamide / 18 h / 0 °C
2: 63 percent / KHCO3, PPh3 / CH2Cl2; H2O / 19 h / Ambient temperature
View Scheme
(2R,3S)-3-phenyloxiranecarboxylic acid
79898-19-4

(2R,3S)-3-phenyloxiranecarboxylic acid

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 5.55 g / dicyclohexylcarbodiimide, 4-N,N-dimethylaminopyridine / toluene / 0.17 h / Ambient temperature
2: 76 percent / hexamethylphosphoramide, TiBr4 / CH2Cl2 / 18 h / 0 °C
3: 71 percent / sodium azide, 15-crown-5 / dimethylformamide / 18 h / 0 °C
4: 63 percent / KHCO3, PPh3 / CH2Cl2; H2O / 19 h / Ambient temperature
View Scheme
(2R,3S)-3-amino-2-hydroxy-3-phenylpropionic acid ethyl ester
143615-00-3

(2R,3S)-3-amino-2-hydroxy-3-phenylpropionic acid ethyl ester

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 76 percent / NaHCO3 / CH2Cl2 / 20 °C
2: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C
3: 100 percent / LiOH, H2O / ethanol / 20 °C
4: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C
5: 78 percent / HCOOH / 4 h / 20 °C
6: 87 percent / NaHCO3 / tetrahydrofuran / 20 °C
View Scheme
(2R,3S)-3-azido-2-hydroxy-benzenepropanoic acid ethyl ester
144787-20-2

(2R,3S)-3-azido-2-hydroxy-benzenepropanoic acid ethyl ester

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr
2: 76 percent / NaHCO3 / CH2Cl2 / 20 °C
3: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C
4: 100 percent / LiOH, H2O / ethanol / 20 °C
5: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C
6: 78 percent / HCOOH / 4 h / 20 °C
7: 87 percent / NaHCO3 / tetrahydrofuran / 20 °C
View Scheme
benzaldehyde
100-52-7

benzaldehyde

aminoguanidine salt

aminoguanidine salt

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 1.) Et3N, Bu2BOTf / 1.) CH2Cl2, -70 to 20 deg C, 2 h, 2.) -78 to 0 deg C, 1 h
2: 81 percent / tetrahydrofuran / 0.25 h / -75 - 15 °C
3: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C
4: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr
5: 76 percent / NaHCO3 / CH2Cl2 / 20 °C
6: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C
7: 100 percent / LiOH, H2O / ethanol / 20 °C
8: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C
9: 78 percent / HCOOH / 4 h / 20 °C
10: 87 percent / NaHCO3 / tetrahydrofuran / 20 °C
View Scheme
7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III
95603-44-4

7,10-di-(2,2,2-trichloroethyloxycarbonyl)-10-deacetylbaccatin III

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C
2: 78 percent / HCOOH / 4 h / 20 °C
3: 87 percent / NaHCO3 / tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: dmap; dicyclohexyl-carbodiimide / toluene / 50 °C
2: sodium carbonate; dihydrogen peroxide / water; tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: dmap; dicyclohexyl-carbodiimide / toluene / 50 °C
2: sodium carbonate; dihydrogen peroxide / water; tetrahydrofuran / 20 °C
3: triphenylphosphine; diethylazodicarboxylate; 4-nitro-benzoic acid / tetrahydrofuran
View Scheme
ethyl (2R,3R)-3-phenyl-2,3-oxiranepropanoate
126060-73-9

ethyl (2R,3R)-3-phenyl-2,3-oxiranepropanoate

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C
2: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr
3: 76 percent / NaHCO3 / CH2Cl2 / 20 °C
4: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C
5: 100 percent / LiOH, H2O / ethanol / 20 °C
6: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C
7: 78 percent / HCOOH / 4 h / 20 °C
8: 87 percent / NaHCO3 / tetrahydrofuran / 20 °C
View Scheme
(2R,3S) ethyl N-(t-butoxycarbonyl)-3-phenylisoserine
143527-75-7

(2R,3S) ethyl N-(t-butoxycarbonyl)-3-phenylisoserine

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C
2: 100 percent / LiOH, H2O / ethanol / 20 °C
3: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C
4: 78 percent / HCOOH / 4 h / 20 °C
5: 87 percent / NaHCO3 / tetrahydrofuran / 20 °C
View Scheme
(4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid
143615-03-6, 143527-70-2

(4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C
2: 78 percent / HCOOH / 4 h / 20 °C
3: 87 percent / NaHCO3 / tetrahydrofuran / 20 °C
View Scheme
ethyl (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylate
143527-74-6

ethyl (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylate

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 100 percent / LiOH, H2O / ethanol / 20 °C
2: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C
3: 78 percent / HCOOH / 4 h / 20 °C
4: 87 percent / NaHCO3 / tetrahydrofuran / 20 °C
View Scheme
(4S,5R)-3-((2S,3R)-2-Bromo-3-hydroxy-3-phenyl-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one
144704-63-2

(4S,5R)-3-((2S,3R)-2-Bromo-3-hydroxy-3-phenyl-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 81 percent / tetrahydrofuran / 0.25 h / -75 - 15 °C
2: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C
3: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr
4: 76 percent / NaHCO3 / CH2Cl2 / 20 °C
5: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C
6: 100 percent / LiOH, H2O / ethanol / 20 °C
7: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C
8: 78 percent / HCOOH / 4 h / 20 °C
9: 87 percent / NaHCO3 / tetrahydrofuran / 20 °C
View Scheme
4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-9-oxo-7β,10β-bis[(2,2,2-tri-chloroethoxy)carbonyloxy]-11-taxen-13α-yl (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylate
143527-76-8

4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-9-oxo-7β,10β-bis[(2,2,2-tri-chloroethoxy)carbonyloxy]-11-taxen-13α-yl (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylate

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 78 percent / HCOOH / 4 h / 20 °C
2: 87 percent / NaHCO3 / tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: formic acid / 1 h / 25 - 35 °C
2: sodium hydrogencarbonate / water / 2 h / 55 - 65 °C
View Scheme
(3'S)-7,10-di-Troc-docetaxel

(3'S)-7,10-di-Troc-docetaxel

A

(2'R,3'S)-7,10-di-Troc-docetaxel
151636-78-1

(2'R,3'S)-7,10-di-Troc-docetaxel

B

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
With silica gel column (20 μM, 0.45*90 cm) In methanol; dichloromethane Purification / work up; Resolution of diastereomeric mixture;
(2'R,3'S)-7,10-di-Troc-docetaxel
151636-78-1

(2'R,3'S)-7,10-di-Troc-docetaxel

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Stage #1: (2'R,3'S)-7,10-di-Troc-docetaxel With triphenylphosphine; diethylazodicarboxylate; 4-nitro-benzoic acid In tetrahydrofuran
Stage #2: With potassium hydroxide In tetrahydrofuran
Stage #1: (2'R,3'S)-7,10-di-Troc-docetaxel With triphenylphosphine; diethylazodicarboxylate; 4-nitro-benzoic acid In tetrahydrofuran
Stage #2: With potassium hydroxide In tetrahydrofuran
(3'S)-2'-Ac-7,10-di-Troc-docetaxel

(3'S)-2'-Ac-7,10-di-Troc-docetaxel

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate; dihydrogen peroxide / water; tetrahydrofuran / 20 °C
2: triphenylphosphine; diethylazodicarboxylate; 4-nitro-benzoic acid / tetrahydrofuran
View Scheme
(3'S)-2'-Ac-7,10-di-Troc-docetaxel

(3'S)-2'-Ac-7,10-di-Troc-docetaxel

A

(2'R,3'S)-7,10-di-Troc-docetaxel
151636-78-1

(2'R,3'S)-7,10-di-Troc-docetaxel

B

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
With dihydrogen peroxide; sodium carbonate In tetrahydrofuran; water at 20℃;
7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

N,N'-dimethyl-N-benzyl-[4-(2,3,4-tri-O-tert-butyldimethylsilyl-β-D-glucopyranosyl)uronate-3-nitrobenzoyloxycarbonyl]ethylenediamine carbamoyl chloride
637330-41-7

N,N'-dimethyl-N-benzyl-[4-(2,3,4-tri-O-tert-butyldimethylsilyl-β-D-glucopyranosyl)uronate-3-nitrobenzoyloxycarbonyl]ethylenediamine carbamoyl chloride

C93H126Cl6N4O30Si3

C93H126Cl6N4O30Si3

Conditions
ConditionsYield
With dmap In dichloromethane for 2h;93%
7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

Conditions
ConditionsYield
With acetic acid; zinc In methanol at 60℃; for 2h;90%
With acetic acid; zinc In methanol at 60℃; for 1h;90%
Product distribution / selectivity;90%
7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

10-deacetyl-7,10-diTroc-baccatin III
114915-16-1

10-deacetyl-7,10-diTroc-baccatin III

Conditions
ConditionsYield
With trimethylsilyl iodide In acetonitrile at 0℃; for 0.5h;75%
With formic acid at 18℃; for 1.5h; Temperature;25.3 g
glutaric anhydride,
108-55-4

glutaric anhydride,

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel
114915-14-9

7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel

C54H61Cl6NO21

C54H61Cl6NO21

Conditions
ConditionsYield
With pyridine at -20 - 25℃;60%

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