Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:1268524-70-4
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inquiry(+)-JQ-1 CAS No.:1268524-70-4 Name: (+)-JQ-1 Synonyms: (S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetat
Cas:1268524-70-4
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FOB Price: $2.0
Type:Other
inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:1268524-70-4
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:1268524-70-4
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:1268524-70-4
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Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:1268524-70-4
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Negotiable
Type:Lab/Research institutions
inquiryS)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate CAS:1268524-70-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and deve
Cas:1268524-70-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:1268524-70-4
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater
Cas:1268524-70-4
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:1268524-70-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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Type:Lab/Research institutions
inquiry1. We can provide customers with "one-stop"packaging service,from research,development,production,export and so on 2. Powerful R&D strength let our technology in a leading level,forever,in turn,to provide customers with better service .
Cas:1268524-70-4
Min.Order:100 Gram
FOB Price: $10.0 / 100.0
Type:Trading Company
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:1268524-70-4
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be
Cas:1268524-70-4
Min.Order:1 Gram
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Type:Other
inquiryMulti-target purpose intermediate with wide usage Commercial production from grams to tons, with technical documents package support, and audit and inspection support. With high purity and optimized and stable process. Self Innovation Appeara
Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:1268524-70-4
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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Type:Trading Company
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:1268524-70-4
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:1268524-70-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Density 1.33 Storage Conditions 2-8 °C Solubility DMSO: soluble 20mg/mL, clear Morphology Powder Color white to Beige Appearance:Detailed see specifications Storage:keep sealed and keep from direct light Package:Accordi
Cas:1268524-70-4
Min.Order:1 Gram
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Type:Lab/Research institutions
inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
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Type:Lab/Research institutions
inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Cas:1268524-70-4
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Good price, high purity, mature production technology, in stock, accept custom synthesis per customer's requirements Storage:in stock Package:As per Customer‘ requirements Application:Pharmaceutical API
We produce carbomer by our own factory,carbomer 940 is our best seller.It is used for cosmetic and medical.And we also become agent for lubrizol.Our carbomer 940 get high viscosity and good transparency.The price will depond on the market,surely supp
Cas:1268524-70-4
Min.Order:0
Negotiable
Type:Trading Company
inquiryThe process is mature and can be mass produced to 100 kg, with good quality and purity up to 99%.The product has a large stock and can be supplied stably. Package:bottle Application:Drug R&D Transportation:Sealed drying(25℃) Port:ShangHai
Cas:1268524-70-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry(S)-tert-butyl 2-(5-(4-chlorophenyl)-6,7-dimethyl-2-oxo-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepin-3-yl)acetate
acetic acid hydrazide
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Stage #1: tert-butyl (S)-2-(5-(4-chlorophenyl)-6,7-dimethyl-2-oxo-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepin-3-yl)acetate With potassium tert-butylate In tetrahydrofuran at -78 - 23℃; for 0.5h; Stage #2: With diethyl chlorophosphate In tetrahydrofuran at -10℃; for 0.75h; Stage #3: acetic acid hydrazide In tetrahydrofuran; butan-1-ol at 23 - 90℃; for 2h; | 92% |
Stage #1: tert-butyl (S)-2-(5-(4-chlorophenyl)-6,7-dimethyl-2-oxo-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepin-3-yl)acetate With potassium tert-butylate In tetrahydrofuran at -78 - -10℃; for 0.5h; Stage #2: With chlorophosphoric acid diphenyl ester In tetrahydrofuran at -78 - -40℃; for 0.75h; Stage #3: acetic acid hydrazide Further stages; | 60.2% |
With potassium tert-butylate; diethyl chlorophosphate In tetrahydrofuran | |
Stage #1: tert-butyl (S)-2-(5-(4-chlorophenyl)-6,7-dimethyl-2-oxo-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepin-3-yl)acetate In tetrahydrofuran; toluene at -40℃; for 1h; Stage #2: With chlorophosphoric acid diphenyl ester In tetrahydrofuran; toluene at -10℃; for 2.3h; Stage #3: acetic acid hydrazide In tetrahydrofuran; toluene at 20 - 80℃; for 2.5h; Reagent/catalyst; Temperature; Solvent; |
Trimethyl orthoacetate
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Stage #1: C21H23ClN2O2S2 With hydrazine hydrate In tetrahydrofuran at 23℃; for 1h; Stage #2: Trimethyl orthoacetate In toluene at 120℃; for 2h; | 85% |
(2-amino-4,5-dimethylthiophen-3-yl)(4-chlorophenyl)methanone
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / N,N-dimethyl-formamide / 16 h / 23 °C 2.1: piperidine / N,N-dimethyl-formamide / 0.5 h / 23 °C 3.1: silica gel / ethanol / 3 h / 90 °C 4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 - 23 °C 4.2: 0.75 h / -10 °C 4.3: 2 h / 23 - 90 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / N,N-dimethyl-formamide / 16 h / 23 °C 2.1: piperidine / N,N-dimethyl-formamide / 0.5 h / 23 °C 3.1: silica gel / ethanol / 3 h / 90 °C 4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 - 23 °C 4.2: 0.75 h / -10 °C 4.3: 2 h / 23 - 90 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 23 °C 1.2: 16 h / 23 °C 2.1: piperidine / N,N-dimethyl-formamide / 0.5 h / 23 °C 3.1: acetic acid / ethanol / 0.5 h / 85 °C 4.1: tetraphosphorus decasulfide; sodium hydrogencarbonate / tetrahydrofuran / 16 h / 90 °C 5.1: hydrazine hydrate / tetrahydrofuran / 1 h / 23 °C 5.2: 2 h / 120 °C View Scheme |
p-chlorobenzoylacetonitrile
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: morpholine; sulfur / ethanol / 12 h / 23 - 70 °C 2.1: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / N,N-dimethyl-formamide / 16 h / 23 °C 3.1: piperidine / N,N-dimethyl-formamide / 0.5 h / 23 °C 4.1: silica gel / ethanol / 3 h / 90 °C 5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 - 23 °C 5.2: 0.75 h / -10 °C 5.3: 2 h / 23 - 90 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: morpholine; sulfur / ethanol / 12 h / 23 - 70 °C 2.1: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / N,N-dimethyl-formamide / 16 h / 23 °C 3.1: piperidine / N,N-dimethyl-formamide / 0.5 h / 23 °C 4.1: silica gel / ethanol / 3 h / 90 °C 5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 - 23 °C 5.2: 0.75 h / -10 °C 5.3: 2 h / 23 - 90 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: morpholine; sulfur / ethanol / 12 h / 25 °C 2.1: 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 23 °C 2.2: 16 h / 23 °C 3.1: piperidine / N,N-dimethyl-formamide / 0.5 h / 23 °C 4.1: acetic acid / ethanol / 0.5 h / 85 °C 5.1: tetraphosphorus decasulfide; sodium hydrogencarbonate / tetrahydrofuran / 16 h / 90 °C 6.1: hydrazine hydrate / tetrahydrofuran / 1 h / 23 °C 6.2: 2 h / 120 °C View Scheme |
(S)-tert-butyl-3-amino-4-((3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2-yl)amino)-4-oxobutanoate
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: silica gel / ethanol / 3 h / 90 °C 2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 - 23 °C 2.2: 0.75 h / -10 °C 2.3: 2 h / 23 - 90 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid / ethanol / 0.5 h / 85 °C 2.1: tetraphosphorus decasulfide; sodium hydrogencarbonate / tetrahydrofuran / 16 h / 90 °C 3.1: hydrazine hydrate / tetrahydrofuran / 1 h / 23 °C 3.2: 2 h / 120 °C View Scheme | |
Multi-step reaction with 2 steps 1: silica gel / toluene 2: potassium tert-butylate; diethyl chlorophosphate / tetrahydrofuran View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: acetic acid / ethanol / 0.5 h / 85 °C 2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 - 23 °C 2.2: 0.75 h / -10 °C 2.3: 2 h / 23 - 90 °C View Scheme |
(S)-tert-butyl 2-(5-(4-chlorophenyl)-6,7-dimethyl-2-oxo-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepin-3-yl)acetate
A
(-)-JQ1
B
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / -78 - -10 °C 1.2: 0.75 h / -78 - -10 °C 2.1: tetrahydrofuran; butan-1-ol / 2 h / 20 - 90 °C View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: tetraphosphorus decasulfide; sodium hydrogencarbonate / tetrahydrofuran / 16 h / 90 °C 2.1: hydrazine hydrate / tetrahydrofuran / 1 h / 23 °C 2.2: 2 h / 120 °C View Scheme |
para-Chlorobenzyl alcohol
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: copper dichloride; potassium hydroxide; oxygen / N,N-dimethyl acetamide / 12 h / 25 °C 2.1: morpholine; sulfur / ethanol / 12 h / 25 °C 3.1: 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 23 °C 3.2: 16 h / 23 °C 4.1: piperidine / N,N-dimethyl-formamide / 0.5 h / 23 °C 5.1: acetic acid / ethanol / 0.5 h / 85 °C 6.1: tetraphosphorus decasulfide; sodium hydrogencarbonate / tetrahydrofuran / 16 h / 90 °C 7.1: hydrazine hydrate / tetrahydrofuran / 1 h / 23 °C 7.2: 2 h / 120 °C View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: morpholine; sulfur / ethanol 2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide 3: piperidine / N,N-dimethyl-formamide 4: silica gel / toluene 5: potassium tert-butylate; diethyl chlorophosphate / tetrahydrofuran View Scheme |
Fmoc-(tBu)Asp-OH
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide 2: piperidine / N,N-dimethyl-formamide 3: silica gel / toluene 4: potassium tert-butylate; diethyl chlorophosphate / tetrahydrofuran View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / Isopropyl acetate; water / 2 h / 25 °C 2.1: potassium amylate / tetrahydrofuran; toluene / 1 h / -40 °C 2.2: 2.3 h / -10 °C 2.3: 2.5 h / 20 - 80 °C View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / Isopropyl acetate; water / 2 h / 25 °C 2.1: potassium amylate / tetrahydrofuran; toluene / 1 h / -40 °C 2.2: 2.3 h / -10 °C 2.3: 2.5 h / 20 - 80 °C View Scheme |
4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
bromoacetic acid tert-butyl ester
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Stage #1: 4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine With lithium hexamethyldisilazane In tetrahydrofuran at -70℃; for 1h; Stage #2: bromoacetic acid tert-butyl ester In tetrahydrofuran at -70 - 20℃; for 5h; |
C15H13Cl2NO2S
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: sodium iodide / tetrahydrofuran / 2 h / 60 °C 2.1: ammonia / tetrahydrofuran / 3.5 h / -60 - 20 °C 3.1: acetic acid / isopropyl alcohol / 3 h / 90 °C 4.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 5 h / 65 °C 5.1: hydrazine hydrate / methanol / 1 h / 0 °C 6.1: toluene / 1 h / 80 °C 7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -70 °C 7.2: 5 h / -70 - 20 °C View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: ammonia / tetrahydrofuran / 3.5 h / -60 - 20 °C 2.1: acetic acid / isopropyl alcohol / 3 h / 90 °C 3.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 5 h / 65 °C 4.1: hydrazine hydrate / methanol / 1 h / 0 °C 5.1: toluene / 1 h / 80 °C 6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -70 °C 6.2: 5 h / -70 - 20 °C View Scheme |
glycine 3-(4-chloro-benzoyl)-4,5-dimethyl-thiophen-2-ylamide
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: acetic acid / isopropyl alcohol / 3 h / 90 °C 2.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 5 h / 65 °C 3.1: hydrazine hydrate / methanol / 1 h / 0 °C 4.1: toluene / 1 h / 80 °C 5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -70 °C 5.2: 5 h / -70 - 20 °C View Scheme |
5-(4-chloro-phenyl)-6,7-dimethyl-1,3-dihydro-thieno[2,3-e][1,4]diazepin-2-one
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 5 h / 65 °C 2.1: hydrazine hydrate / methanol / 1 h / 0 °C 3.1: toluene / 1 h / 80 °C 4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -70 °C 4.2: 5 h / -70 - 20 °C View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrazine hydrate / methanol / 1 h / 0 °C 2.1: toluene / 1 h / 80 °C 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -70 °C 3.2: 5 h / -70 - 20 °C View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: toluene / 1 h / 80 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -70 °C 2.2: 5 h / -70 - 20 °C View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
With formic acid at 20℃; for 75h; | 100% |
With formic acid at 20℃; for 75h; | 100% |
With trifluoroacetic acid In dichloromethane at 20℃; for 5h; | 100% |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
trifluoroacetic acid
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 2h; | 100% |
In dichloromethane at 20℃; for 3h; | 100% |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
chloroacetyl chloride
Conditions | Yield |
---|---|
With formic acid at 45℃; | 99.8% |
3-phthalimido-1-propene
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); N-Methyldicyclohexylamine; tri tert-butylphosphoniumtetrafluoroborate In 1-methyl-pyrrolidin-2-one at 160℃; for 0.333333h; Microwave irradiation; | 99.2% |
Benzophenone imine
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate In toluene at 110℃; for 16h; Inert atmosphere; | 98.5% |
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate In toluene at 110℃; for 16h; Inert atmosphere; | 60% |
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate In toluene at 110℃; for 16h; Inert atmosphere; | 60% |
methanol
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
methyl 2-((6S,Z)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f] [1,2,4]triazolo[4,3-a] [1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
With sulfuric acid Reflux; | 95% |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
tert-Butyldimethyl(prop-2-ynyloxy)silane
Conditions | Yield |
---|---|
With bis[dicyclohexyl(2,4,6-triisopropyl-[1,1':3',1''-terphenyl]-2-yl)phosphane]palladium(II) dichloride; caesium carbonate In acetonitrile at 100℃; for 1.5h; Inert atmosphere; | 70% |
trifluoromethylsulfonic anhydride
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Stage #1: trifluoromethylsulfonic anhydride; C18H27N3O7 With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -78℃; for 0.833333h; Inert atmosphere; Stage #2: (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate In tetrahydrofuran at -78℃; for 1.33333h; Inert atmosphere; | 52% |
N-methylpropargylamine
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
With bis[dicyclohexyl(2,4,6-triisopropyl-[1,1':3',1''-terphenyl]-2-yl)phosphane]palladium(II) dichloride; caesium carbonate In acetonitrile at 90℃; for 1h; Microwave irradiation; | 50% |
trifluoromethylsulfonic anhydride
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Stage #1: trifluoromethylsulfonic anhydride; C13H17N3O3 With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -78℃; for 0.833333h; Inert atmosphere; Stage #2: (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate In tetrahydrofuran at -78℃; for 1.33333h; Inert atmosphere; | 43% |
trifluoromethylsulfonic anhydride
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Stage #1: trifluoromethylsulfonic anhydride; C14H19N3O4 With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at -78℃; for 0.833333h; Inert atmosphere; Stage #2: (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate In tetrahydrofuran at -78℃; for 1.33333h; Inert atmosphere; | 40% |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
1,1-dimethylprop-3-ynylamine
Conditions | Yield |
---|---|
With bis[dicyclohexyl(2,4,6-triisopropyl-[1,1':3',1''-terphenyl]-2-yl)phosphane]palladium(II) dichloride; caesium carbonate In acetonitrile at 95℃; for 1.5h; Microwave irradiation; | 38% |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
but-3-yn-2-amine
Conditions | Yield |
---|---|
With bis[dicyclohexyl(2,4,6-triisopropyl-[1,1':3',1''-terphenyl]-2-yl)phosphane]palladium(II) dichloride; caesium carbonate In acetonitrile at 95℃; for 1.5h; Microwave irradiation; | 32% |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Propargylamine
Conditions | Yield |
---|---|
With Pd(Cy*Phine)2Cl2 ; caesium carbonate In N,N-dimethyl-formamide at 120℃; for 1h; Microwave irradiation; Inert atmosphere; | 24% |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
but-3-yn-1-amine
Conditions | Yield |
---|---|
With bis[dicyclohexyl(2,4,6-triisopropyl-[1,1':3',1''-terphenyl]-2-yl)phosphane]palladium(II) dichloride; caesium carbonate In acetonitrile at 90℃; for 2h; Microwave irradiation; | 10% |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; Inert atmosphere; | |
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
8-{2-[(S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetyl}-8-azabicyclo[3.2.1]octan-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / 1,4-dioxane / 20 °C 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
2-[(S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethan-1-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / 1,4-dioxane / 20 °C 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / 1,4-dioxane / 20 °C 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / 1,4-dioxane / 20 °C 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C 3: trifluoroacetic acid / dichloromethane / 20 °C View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
2-[(S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)ethan-1-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / 1,4-dioxane / 20 °C 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
2-[(S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1-(2-oxa-6-azaspiro[3.4]oct-6-yl)ethan-1-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / 1,4-dioxane / 20 °C 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C View Scheme |
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
2-[(S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1-(2-oxa-7-azaspiro[3.5]non-6-yl)ethan-1-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / 1,4-dioxane / 20 °C 2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C View Scheme |
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