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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

3-Bromoisonicotinic acid

Cas:13959-02-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Vitamin E 50% supplier in China

Cas:13959-02-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum Application:pharmaceutic

3-Bromoisonicotinic acid Cas 13959-02-9

Cas:13959-02-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

3-bromoisonicotinic Acid

Cas:13959-02-9

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

3-Bromoisonicotinic acid

Cas:13959-02-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Vitamin E 50%

Cas:13959-02-9

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Vitamin E 13959-02-9 GMP manufacturer

Cas:13959-02-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Bromoisonicotinic acid

Cas:13959-02-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1965.html Product Name 3-Bromoisonicotinic acid CAS No. 13959-02-9

3-Bromoisonicotinic acid

Cas:13959-02-9

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

3-Bromoisonicotinic acid

Cas:13959-02-9

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--13959-02-9--High purity 3-Bromoisonicotinic acid factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established sta

TIANFUCHEM--13959-02-9--High purity 3-Bromoisonicotinic acid factory price

Cas:13959-02-9

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 13959-02-9 with competitive price

Cas:13959-02-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-Pyridinecarboxylicacid, 3-bromo- 13959-02-9

Cas:13959-02-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:light yellow powder Storage:Refer to COA / MSDS

3-Bromoisonicotinic acid 98% Natural 25% 50% 70% 90% Oil Ready stock CAS 13959-02-9 Vitamin E

Cas:13959-02-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

3-Bromoisonicotinic acid CAS:13959-02-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

3-Bromoisonicotinic acid CAS:13959-02-9

Cas:13959-02-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Pyridinecarboxylicacid, 3-bromo-

Cas:13959-02-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Pyridinecarboxylicacid, 3-bromo-

Cas:13959-02-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

3-Bromoisonicotinic acid

Cas:13959-02-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality, moderate price & quick delivery Our product quality and property receive very good reputations both domestically and abroad. the products are well sold to over 10 provinces in China, and to Asia, Europe, the Americas, Af

3-Bromoisonicotinic acid

Cas:13959-02-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-Bromoisonicotinic acid

Cas:13959-02-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

3-Bromoisonicotinic acid

Cas:13959-02-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Pyridinecarboxylicacid, 3-bromo-

Cas:13959-02-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-Bromoisonicotinic acid/High quality/Best price

Cas:13959-02-9

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Vitamin E

Cas:13959-02-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

3-Bromoisonicotinic acid

Cas:13959-02-9

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

3-Bromoisonicotinicacid

Cas:13959-02-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

3-Bromoisonicotinic acid Chemical Properties Melting point 237-238 Boiling point 403.1±30.0 °C(Predicted) density 1.813±0.06 g/cm3(Predicted) Fp 197. pka 0.60±0.10(Predicted) InChIKey AVXWWBFBRTXBRM-UHFF

3-Bromoisonicotinic acid

Cas:13959-02-9

Min.Order:1 Metric Ton

FOB Price: $66.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3-Bromoisonicotinic acid

Cas:13959-02-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

3-Bromoisonicotinic acid

Cas:13959-02-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3-Bromoisonicotinic acid

Cas:13959-02-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

pyridine-4-carboxylic acid
55-22-1

pyridine-4-carboxylic acid

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

Conditions
ConditionsYield
With bromine In methanol at 30 - 45℃; for 5h; Temperature;96.3%
3-Bromo-4-methylpyridin
3430-22-6

3-Bromo-4-methylpyridin

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

Conditions
ConditionsYield
Stage #1: 3-Bromo-4-methylpyridin With Co0.27CuO3; water
Stage #2: With oxygen at 90℃;
90%
With potassium permanganate In water Heating / reflux;32%
With hydrogenchloride; potassium permanganate In water
3-Bromopyridine
626-55-1

3-Bromopyridine

carbon dioxide
124-38-9

carbon dioxide

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

Conditions
ConditionsYield
Stage #1: 3-Bromopyridine With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere;
Stage #2: carbon dioxide In tetrahydrofuran at 20℃; Inert atmosphere;
10%
Stage #1: 3-Bromopyridine With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -60℃; for 0.5h; Cooling with acetone-dry ice;
Stage #2: carbon dioxide In tetrahydrofuran; hexane
Stage #1: 3-Bromopyridine With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -60℃; for 0.5h;
Stage #2: carbon dioxide In tetrahydrofuran; hexane at 20℃;
Stage #3: With hydrogenchloride In tert-butyl methyl ether; water pH=3;
3-bromo-N-phenylpyridine-4-carboxamide
71541-34-9

3-bromo-N-phenylpyridine-4-carboxamide

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

Conditions
ConditionsYield
With hydrogenchloride for 15h; Heating;
N-phenylisonicotinamide
3034-31-9

N-phenylisonicotinamide

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) n-BuLi, 2.) 1,2-dibromoethane / 1.) THF, -78 deg C - 0.5 h, room temperature - 1 h, 2.) THF, -78 deg C - 1 h, room temperature - 2 h
2: aq. HCl / 15 h / Heating
View Scheme
3-Bromopyridine
626-55-1

3-Bromopyridine

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

Conditions
ConditionsYield
Stage #1: With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -40℃; for 0.5h; Cooling with acetone-dry ice;
Stage #2: 3-Bromopyridine In tetrahydrofuran; hexane at -60℃; for 0.5h;
Stage #3: With hydrogenchloride In water for 1h; pH=3; Cooling with ice;
2-aminopyridine-5-boronic acid pinacol ester
827614-64-2

2-aminopyridine-5-boronic acid pinacol ester

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

6'-amino-[3,3'-bipyridine]-4-carboxylic acid

6'-amino-[3,3'-bipyridine]-4-carboxylic acid

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane; water at 120℃; for 16h; Inert atmosphere;100%
3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

pinacol vinylboronate
75927-49-0

pinacol vinylboronate

3-vinyl-4-picolinic acid

3-vinyl-4-picolinic acid

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 100℃; Inert atmosphere;100%
3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

3-Aminopyridine-4-carboxylic acid
7579-20-6

3-Aminopyridine-4-carboxylic acid

Conditions
ConditionsYield
With ammonium hydroxide; copper(l) iodide at 100 - 105℃; for 8h; Time; Autoclave;95.2%
ethanol
64-17-5

ethanol

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

ethyl 3-bromopyridine-4-carboxylate
13959-01-8

ethyl 3-bromopyridine-4-carboxylate

Conditions
ConditionsYield
With sulfuric acid for 12h; Reflux;95%
With sulfuric acid for 12h; Reflux;88%
With sulfuric acid Reflux; Inert atmosphere;78%
3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

methyl 3-bromoisonicotinate
59786-31-1

methyl 3-bromoisonicotinate

Conditions
ConditionsYield
In methanol; diethyl ether; toluene for 2h; Inert atmosphere; Schlenk technique;94%
In methanol; diethyl ether; toluene at 20℃; for 2h;
4-amino-5-(2,3,5-trichlorophenyl)-4H-[1,2,4]triazole-3-thiol
1029491-80-2

4-amino-5-(2,3,5-trichlorophenyl)-4H-[1,2,4]triazole-3-thiol

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

6-(3-bromopyridin-4-yl)-3-(2,3,5-trichlorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

6-(3-bromopyridin-4-yl)-3-(2,3,5-trichlorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

Conditions
ConditionsYield
With trichlorophosphate Heating;84%
2-isopropyliodobenzene
19099-54-8

2-isopropyliodobenzene

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

diphenyl acetylene
501-65-5

diphenyl acetylene

7-isopropyl-5,6-diphenylbenzo[h]isoquinoline

7-isopropyl-5,6-diphenylbenzo[h]isoquinoline

Conditions
ConditionsYield
With norborn-2-ene; palladium diacetate; potassium carbonate; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 130℃; for 20h; Schlenk technique; Inert atmosphere; Sealed tube; regioselective reaction;80%
3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

aniline
62-53-3

aniline

3-bromo-N-phenylpyridine-4-carboxamide
71541-34-9

3-bromo-N-phenylpyridine-4-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;79%
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

A

ethyl 3-bromopyridine-4-carboxylate
13959-01-8

ethyl 3-bromopyridine-4-carboxylate

B

3-bromopyridine-4-carboxamide
13958-99-1

3-bromopyridine-4-carboxamide

Conditions
ConditionsYield
Stage #1: chloroformic acid ethyl ester; 3-bromoisonicotinic acid With triethylamine In tetrahydrofuran at 0℃; for 1h;
Stage #2: With ammonia In tetrahydrofuran for 0.25h;
A 5%
B 78%
6-amino-4-methylquinolin-2-ol
90914-95-7

6-amino-4-methylquinolin-2-ol

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

3-bromo-N-(2-hydroxy-4-methyl-6-quinolyl)pyridine-4-carboxamide

3-bromo-N-(2-hydroxy-4-methyl-6-quinolyl)pyridine-4-carboxamide

Conditions
ConditionsYield
With dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 80℃; for 1h;78%
4-[4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1,2,3-triazol-1-yl]piperidine

4-[4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1,2,3-triazol-1-yl]piperidine

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

(3-bromopyridin-4-yl)-{4-[4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1H-1,2,3-triazol-1-yl]piperidin-1-yl}methanone

(3-bromopyridin-4-yl)-{4-[4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1H-1,2,3-triazol-1-yl]piperidin-1-yl}methanone

Conditions
ConditionsYield
Stage #1: 3-bromoisonicotinic acid With 1,1'-carbonyldiimidazole In 1,4-dioxane at 80℃; for 0.5h;
Stage #2: 4-[4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-1,2,3-triazol-1-yl]piperidine In 1,4-dioxane at 100℃; for 3h;
75%
2-isopropyliodobenzene
19099-54-8

2-isopropyliodobenzene

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

bicyclo[2.2.1]hepta-2,5-diene
121-46-0

bicyclo[2.2.1]hepta-2,5-diene

7-isopropylbenzo[h]isoquinoline

7-isopropylbenzo[h]isoquinoline

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; tricyclohexylphosphine In 1,4-dioxane at 130℃; for 18h; Schlenk technique; Sealed tube; Inert atmosphere;72%
3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

N-[(diphenylphosphinoyl)methyl]-N-methylamine
122365-23-5

N-[(diphenylphosphinoyl)methyl]-N-methylamine

3-chloro-N-(diphenylphosphinoylmethyl)-N-methylisonicotinamide
380227-43-0

3-chloro-N-(diphenylphosphinoylmethyl)-N-methylisonicotinamide

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 2h; Ambient temperature;69%
pyrrolidine
123-75-1

pyrrolidine

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

(3-bromopyridin-4-yl)(pyrrolidin-1-yl)methanone
1357094-61-1

(3-bromopyridin-4-yl)(pyrrolidin-1-yl)methanone

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h;68.7%
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

3-bromo-N-methyl-N-(methyloxy)-4-pyridinecarboxamide
909532-61-2

3-bromo-N-methyl-N-(methyloxy)-4-pyridinecarboxamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; water at 20℃; for 16h;67%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 16h;67%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; Schlenk technique;
3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

diethyl malonate
105-53-3

diethyl malonate

3-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyI]isonicotinic acid
929301-89-3

3-[2-ethoxy-1-(ethoxycarbonyl)-2-oxoethyI]isonicotinic acid

Conditions
ConditionsYield
Stage #1: 3-bromoisonicotinic acid; diethyl malonate With sodium hydride; copper(I) bromide at 80℃; for 2h;
Stage #2: With hydrogenchloride In water pH=4;
66%
3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

methyl 3-bromoisonicotinate
59786-31-1

methyl 3-bromoisonicotinate

Conditions
ConditionsYield
In tetrahydrofuran; methanol at 0 - 20℃; for 1h; Inert atmosphere;66%
4-methoxy-aniline
104-94-9

4-methoxy-aniline

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

3-bromo-N-(4-methoxyphenyl)pyridine-4-carboxamide

3-bromo-N-(4-methoxyphenyl)pyridine-4-carboxamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;64%
methanol
67-56-1

methanol

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

methyl 3-bromoisonicotinate
59786-31-1

methyl 3-bromoisonicotinate

Conditions
ConditionsYield
With sulfuric acid Heating / reflux;62%
Stage #1: methanol; 3-bromoisonicotinic acid With sulfuric acid Reflux;
Stage #2: With sodium hydrogencarbonate; sodium hydroxide In water at 0℃; pH=7 - 8;
With sulfuric acid for 14h; Reflux;
With sulfuric acid Cooling with ice; Reflux;335.3 mg
5-iodoquinoline
1006-50-4

5-iodoquinoline

4,4'-dimethoxydiphenylacetylene
2132-62-9

4,4'-dimethoxydiphenylacetylene

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

5,6-bis(4-methoxyphenyl)isoquinolino[7,8-f]quinoline

5,6-bis(4-methoxyphenyl)isoquinolino[7,8-f]quinoline

Conditions
ConditionsYield
With norborn-2-ene; palladium diacetate; potassium carbonate; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 130℃; for 20h; Schlenk technique; Inert atmosphere; Sealed tube; regioselective reaction;55%
3,3-difluoroazetidine hydrochloride
288315-03-7

3,3-difluoroazetidine hydrochloride

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

(3-bromopyridin-4-yl)(3,3-difluoroazetidin-1-yl)methanone

(3-bromopyridin-4-yl)(3,3-difluoroazetidin-1-yl)methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 48h;55%
3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

3-bromo-4-(hydroxymethyl)pyridine
146679-66-5

3-bromo-4-(hydroxymethyl)pyridine

Conditions
ConditionsYield
Stage #1: 3-bromoisonicotinic acid With triethylamine; methyl chloroformate In tetrahydrofuran at 0℃; for 0.166667h;
Stage #2: With sodium tetrahydroborate In water at 0℃; for 1h;
52%
3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

methyl chloroformate
79-22-1

methyl chloroformate

3-bromo-4-(hydroxymethyl)pyridine
146679-66-5

3-bromo-4-(hydroxymethyl)pyridine

Conditions
ConditionsYield
Stage #1: 3-bromoisonicotinic acid; methyl chloroformate With triethylamine In tetrahydrofuran at 0℃; for 0.166667h;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; water at 0℃; for 1h;
52%
azetidine
503-29-7

azetidine

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

Azetidin-1-yl(3-bromopyridin-4-yl)methanone

Azetidin-1-yl(3-bromopyridin-4-yl)methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 48h;52%
3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

beta-Naltrexamine dihydrochloride
63463-07-0

beta-Naltrexamine dihydrochloride

C26H28BrN3O4*2ClH

C26H28BrN3O4*2ClH

Conditions
ConditionsYield
Stage #1: 3-bromoisonicotinic acid; beta-Naltrexamine dihydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere; Molecular sieve;
Stage #2: With potassium carbonate In methanol; N,N-dimethyl-formamide at 20℃; Inert atmosphere;
Stage #3: With hydrogenchloride In methanol at 20℃; for 0.5h;
51.4%
3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

3,4,5-trifluoro aniline
163733-96-8

3,4,5-trifluoro aniline

2-bromo-N-(3,4,5-trifluorophenyl)isonicotinamide

2-bromo-N-(3,4,5-trifluorophenyl)isonicotinamide

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; Inert atmosphere;50%
5-iodoquinoline
1006-50-4

5-iodoquinoline

bis(4-chlorophenyl)acetylene
1820-42-4

bis(4-chlorophenyl)acetylene

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

5,6-bis(4-chlorophenyl)isoquinolino[7,8-f]quinoline

5,6-bis(4-chlorophenyl)isoquinolino[7,8-f]quinoline

Conditions
ConditionsYield
With norborn-2-ene; palladium diacetate; potassium carbonate; tris-(o-tolyl)phosphine In N,N-dimethyl-formamide at 130℃; for 20h; Schlenk technique; Inert atmosphere; Sealed tube; regioselective reaction;42%
2-amino-4-methoxyacetophenone hydrochloride
335104-63-7

2-amino-4-methoxyacetophenone hydrochloride

3-bromoisonicotinic acid
13959-02-9

3-bromoisonicotinic acid

Conditions
ConditionsYield
With 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine In dichloromethane at 22℃; for 18h;41.7%

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