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Hangzhou Think Chemical Co. Ltd

2-(4-Bromophenyl)malonic acid dimethyl ester CAS No.:149506-35-4 Name: 2-(4-Bromophenyl)malonic acid dimethyl ester Synonyms: Dimethyl (4-bromophenyl)malonate Molecular Structure Molec

High purity 2-(4-Bromophenyl)malonic acid dimethyl ester CAS No.:149506-35-4

Cas:149506-35-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

dimethyl 2-(4-bromophenyl)propanedioate Manufacturer/High quality/Best price/In stock

Cas:149506-35-4

Min.Order:1 Kilogram

FOB Price: $7.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-(4-Bromo-phenyl)-malonic acid dimethyl ester

Cas:149506-35-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

2-(4-Bromophenyl)-propanedioic acid, 1,3-mdiethyl ester CAS NO.149506-35-4

Cas:149506-35-4

Min.Order:10 Kilogram

FOB Price: $40.0 / 50.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Propanedioic acid,2-(4-bromophenyl)-, 1,3-dimethyl ester 149506-35-4

Cas:149506-35-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER CAS:149506-35-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, speci

2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER CAS:149506-35-4

Cas:149506-35-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Propanedioic acid,2-(4-bromophenyl)-, 1,3-dimethyl ester

Cas:149506-35-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Propanedioic acid,2-(4-bromophenyl)-, 1,3-dimethyl ester

Cas:149506-35-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

2-(4-Bromophenyl)-propanedioic acid, 1,3-mdiethyl ester CAS NO.149506-35-4

Cas:149506-35-4

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

BLOOM TECH Advanced API/Technology support Dimethyl 2-(4-bromophenyl)malonate CAS 149506-35-4

Cas:149506-35-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

diMethyl 2-(4-broMophenyl)Malonate.Appearance:powder Storage:dry Package:according to customers' requirements Application:Anabolic Steroid. Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or according to yo

diMethyl 2-(4-broMophenyl)Malonate.

Cas:149506-35-4

Min.Order:1 Gram

Negotiable

Type:Other

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

2-(4-Bromophenyl)-propanedioic acid, 1,3-mdiethyl ester CAS NO.149506-35-4

Cas:149506-35-4

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 2-(4-Bromo-phenyl)-Malonic Acid Dimethyl Ester CAS No.: 149506-35-4 Molecule Formula:C11H11BrO4 Molecule Weight:287.11 Purity: 99.0% Package: 25kg/drum Description:Light yellow crystalline powder Manufacture Standards:En

Lower Price 2-(4-Bromo-phenyl)-Malonic Acid Dimethyl Ester

Cas:149506-35-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-(4-Bromophenyl)-propanedioic acid, 1,3-mdiethyl ester CAS NO.149506-35-4

Cas:149506-35-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-(4-Bromophenyl)-propanedioic acid, 1,3-mdiethyl ester CAS NO.149506-35-4

Cas:149506-35-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2-(4-Bromophenyl)-propanedioic acid, 1,3-mdiethyl ester CAS NO.149506-35-4 CAS NO.149506-35-4

Cas:149506-35-4

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/2-(4-Bromophenyl)malonic acid dimethyl ester

Cas:149506-35-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-(4-Bromophenyl)malonic acid dimethyl ester

Cas:149506-35-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2-(4-Bromophenyl)-propanedioic acid, 1,3-mdiethyl ester CAS NO.149506-35-4

Cas:149506-35-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

Propanedioic acid,2-(4-bromophenyl)-, 1,3-dimethyl ester

Cas:149506-35-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

dimethyl 2-(4-bromophenyl)propanedioate

Cas:149506-35-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

Propanedioic acid, 2-(4-broMophenyl)-, 1,3-diMethyl ester

Cas:149506-35-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER

Cas:149506-35-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER

Cas:149506-35-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Propanedioic acid,2-(4-bromophenyl)-, 1,3-dimethyl ester

Cas:149506-35-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER

Cas:149506-35-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER

Cas:149506-35-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Propanedioic acid,2-(4-bromophenyl)-, 1,3-dimethyl ester

Cas:149506-35-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

2-(4-Bromophenyl)-propanedioic acid, 1,3-mdiethyl ester CAS NO.149506-35-4 Application:2-(4-Bromophenyl)-propanedioic acid, 1,3-mdiethyl ester CAS NO.149506-35-4

DB BIOTECH CO., LTD

best seller Application:API

2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER

Cas:149506-35-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(4-bromo-phenyl)-acetic acid methyl ester
41841-16-1

(4-bromo-phenyl)-acetic acid methyl ester

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

Conditions
ConditionsYield
Stage #1: (4-bromo-phenyl)-acetic acid methyl ester With sodium hydride In tetrahydrofuran; mineral oil at 40 - 45℃; for 5h;
Stage #2: carbonic acid dimethyl ester In tetrahydrofuran; mineral oil at 20 - 32℃; for 24h;
79%
Stage #1: (4-bromo-phenyl)-acetic acid methyl ester With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 1h;
Stage #2: carbonic acid dimethyl ester In tetrahydrofuran; mineral oil at 20℃; for 72h;
77%
In toluene; paraffin oil
dimethyl diazomalonate
6773-29-1

dimethyl diazomalonate

4-Bromophenylboronic acid
5467-74-3

4-Bromophenylboronic acid

A

C11H10BrFO4

C11H10BrFO4

B

2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

Conditions
ConditionsYield
With (pentamethylcyclopentadienyl)*Rh(OAc)2; potassium carbonate; N-fluorobis(benzenesulfon)imide In N,N-dimethyl acetamide at 40℃; for 16h; Reagent/catalyst; Solvent; Temperature;A 40%
B 13%
With (pentamethylcyclopentadienyl)*Rh(OAc)2; potassium acetate; N-fluorobis(benzenesulfon)imide In N,N-dimethyl acetamide at 80℃; for 16h; Solvent; Temperature;A 17%
B 21%
(4-bromo-phenyl)-acetic acid methyl ester
41841-16-1

(4-bromo-phenyl)-acetic acid methyl ester

methyl chloroformate
79-22-1

methyl chloroformate

2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

Conditions
ConditionsYield
With lithium diisopropyl amide 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 40 min; Yield given. Multistep reaction;
2-(4-bromophenyl)acetyl chloride
37859-24-8

2-(4-bromophenyl)acetyl chloride

2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N / CH2Cl2 / 2 h / Ambient temperature
2: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 40 min
View Scheme
2-(4-bromophenyl)-acetic acid
1878-68-8

2-(4-bromophenyl)-acetic acid

2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: SOCl2, DMF / CH2Cl2 / Ambient temperature
2: Et3N / CH2Cl2 / 2 h / Ambient temperature
3: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 40 min
View Scheme
Multi-step reaction with 2 steps
1.1: thionyl chloride / 0 - 20 °C
2.1: sodium hydride / tetrahydrofuran / 1.83 h / 40 °C
2.2: 22 h / 20 - 31 °C
2.3: -10 °C / pH 6 - 7
View Scheme
Multi-step reaction with 2 steps
1.1: thionyl chloride / 3 h / 0 - 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 40 - 45 °C
2.2: 24 h / 20 - 32 °C
View Scheme
carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

Conditions
ConditionsYield
Stage #1: (4-bromo-phenyl)-acetic acid methyl ester With sodium hydride In tetrahydrofuran at 27℃; for 1.83333h;
Stage #2: carbonic acid dimethyl ester In tetrahydrofuran at 20 - 31℃; for 22h;
formamidine hydrochloride
6313-33-3

formamidine hydrochloride

2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

5-(4-bromophenyl)-4,6-dihydroxypyrimidine
706811-25-8

5-(4-bromophenyl)-4,6-dihydroxypyrimidine

Conditions
ConditionsYield
at 25℃; for 16h; Temperature;92.6%
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium In methanol at 0 - 20℃; for 18h;
Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h;
91%
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium methylate In methanol at 0℃; for 18h;
Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h;
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium In methanol at 0 - 20℃; for 18h;
Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h;
Stage #3: With citric acid In water
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium In methanol at 0 - 20℃; for 18h;
Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h;
Stage #3: With citric acid In water for 0.166667h;
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

5-(4-bromophenyl)-4,6-dihydroxypyrimidine
706811-25-8

5-(4-bromophenyl)-4,6-dihydroxypyrimidine

Conditions
ConditionsYield
With sodium methylate In methanol at 70℃;75.25%
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

methyl iodide
74-88-4

methyl iodide

dimethyl (4-bromophenyl)(methyl)malonate

dimethyl (4-bromophenyl)(methyl)malonate

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.5h;
Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 20℃; for 2h;
67%
acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

methyl 4-(4'-bromophenyl)-4,4-dimethoxycarbonylbutanoate
177845-96-4

methyl 4-(4'-bromophenyl)-4,4-dimethoxycarbonylbutanoate

Conditions
ConditionsYield
With sodium methylate In methanol for 6h; Ambient temperature;64%
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

6-bromo-1,2-dihydronaphthalene-1-carboxylic acid
177846-05-8

6-bromo-1,2-dihydronaphthalene-1-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature
2: 100 percent / aq. KOH / Heating
3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating
4: 46 percent / PPA / 4 h / 90 °C
5: 77 percent / H3PO4 / tetrahydrofuran / 4 h / 100 °C
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

7-bromo-4-hydroxycarbonyltetralone
177845-98-6

7-bromo-4-hydroxycarbonyltetralone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature
2: 100 percent / aq. KOH / Heating
3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating
4: 46 percent / PPA / 4 h / 90 °C
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

7-bromo-1,2,3,4-tetrahydro-1,4-(epoxymethano)-naphthalen-9-one

7-bromo-1,2,3,4-tetrahydro-1,4-(epoxymethano)-naphthalen-9-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature
2: 100 percent / aq. KOH / Heating
3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating
4: 46 percent / PPA / 4 h / 90 °C
5: 0.62 g / NaBH4 / propan-2-ol
6: 74 percent / p-TSA / CH2Cl2 / 3 h / Ambient temperature
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

4-(4'-bromophenyl)-4-hydroxycarbonylbutanoic acid
177845-97-5

4-(4'-bromophenyl)-4-hydroxycarbonylbutanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature
2: 100 percent / aq. KOH / Heating
3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

6-Bromo-4-hydroxy-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid
177846-03-6

6-Bromo-4-hydroxy-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature
2: 100 percent / aq. KOH / Heating
3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating
4: 46 percent / PPA / 4 h / 90 °C
5: 0.62 g / NaBH4 / propan-2-ol
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

2-(4-Bromo-phenyl)-2-carboxy-pentanedioic acid

2-(4-Bromo-phenyl)-2-carboxy-pentanedioic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature
2: 100 percent / aq. KOH / Heating
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

C18H23(3)H3N2

C18H23(3)H3N2

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature
2: 100 percent / aq. KOH / Heating
3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating
4: 46 percent / PPA / 4 h / 90 °C
5: 77 percent / H3PO4 / tetrahydrofuran / 4 h / 100 °C
6: 1.) DCC, HOBT*H2O / 1.) CH3CN, RT, 0.5 h, 2.) CH3CN, 48 h
7: 3H2, Et3N / 10percent Pd/C / ethyl acetate / 24 h
8: BH3*SMe2 / tetrahydrofuran / 8 h / Heating
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

C18H21(3)H3N2O

C18H21(3)H3N2O

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature
2: 100 percent / aq. KOH / Heating
3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating
4: 46 percent / PPA / 4 h / 90 °C
5: 77 percent / H3PO4 / tetrahydrofuran / 4 h / 100 °C
6: 1.) DCC, HOBT*H2O / 1.) CH3CN, RT, 0.5 h, 2.) CH3CN, 48 h
7: 3H2, Et3N / 10percent Pd/C / ethyl acetate / 24 h
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

C18H21BrN2O
177845-99-7

C18H21BrN2O

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature
2: 100 percent / aq. KOH / Heating
3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating
4: 46 percent / PPA / 4 h / 90 °C
5: 77 percent / H3PO4 / tetrahydrofuran / 4 h / 100 °C
6: 1.) DCC, HOBT*H2O / 1.) CH3CN, RT, 0.5 h, 2.) CH3CN, 48 h
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

C18H21BrN2O

C18H21BrN2O

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature
2: 100 percent / aq. KOH / Heating
3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating
4: 46 percent / PPA / 4 h / 90 °C
5: 77 percent / H3PO4 / tetrahydrofuran / 4 h / 100 °C
6: 1.) DCC, HOBT*H2O / 1.) CH3CN, RT, 0.5 h, 2.) CH3CN, 48 h
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

2-(4-bromophenyl)-1,3-propanediol
149506-34-3

2-(4-bromophenyl)-1,3-propanediol

Conditions
ConditionsYield
With sulfuric acid In tetrahydrofuran; diethyl ether; water
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

5-(4-bromophenyl)-4,6-dichloropyrimidine
146533-41-7

5-(4-bromophenyl)-4,6-dichloropyrimidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium / methanol / 18 h / 0 - 20 °C
1.2: 4 h / 20 °C
1.3: 0.17 h
2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 130 °C
2.2: 0.33 h / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1.1: sodium / methanol / 18 h / 0 - 20 °C
1.2: 4 h / 20 °C
2.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium methylate; methanol / 1.25 h / 0 - 5 °C / Inert atmosphere
1.2: 6 h / 0 - 30 °C
1.3: 1.5 h / 25 - 30 °C
2.1: triethylamine; trichlorophosphate / acetonitrile / 5 h / 25 - 85 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: sodium methylate / methanol / 70 °C
2: trichlorophosphate / 90 °C
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

N-[5-(4-bromophenyl)-6-chloro-4-pyrimidinyl]-N'-benzyl-sulfamide
441797-42-8

N-[5-(4-bromophenyl)-6-chloro-4-pyrimidinyl]-N'-benzyl-sulfamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium / methanol / 18 h / 0 - 20 °C
1.2: 4 h / 20 °C
1.3: 0.17 h
2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 130 °C
2.2: 0.33 h / Cooling with ice
3.1: dimethyl sulfoxide / 24 h / 20 °C
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide
441796-08-3

N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium / methanol / 18 h / 0 - 20 °C
1.2: 4 h / 20 °C
1.3: 0.17 h
2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 130 °C
2.2: 0.33 h / Cooling with ice
3.1: dimethyl sulfoxide / 24 h / 20 °C
4.1: potassium tert-butylate / 1,2-dimethoxyethane / 24 h / 95 °C
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

benzylsulfamic acid {5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yloxy)-ethoxy]-pyrimidine-4-yl}-amide
441796-09-4

benzylsulfamic acid {5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yloxy)-ethoxy]-pyrimidine-4-yl}-amide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium / methanol / 18 h / 0 - 20 °C
1.2: 4 h / 20 °C
1.3: 0.17 h
2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 130 °C
2.2: 0.33 h / Cooling with ice
3.1: dimethyl sulfoxide / 24 h / 20 °C
4.1: potassium tert-butylate / 1,2-dimethoxyethane / 24 h / 95 °C
5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h
5.2: 3.33 h / 20 - 60 °C
5.3: 20 °C
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

ACT-132577
1103522-45-7

ACT-132577

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium / methanol / 18 h / 0 - 20 °C
1.2: 4 h / 20 °C
1.3: 0.17 h
2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 130 °C
2.2: 0.33 h / Cooling with ice
3.1: dimethyl sulfoxide / 24 h / 20 °C
4.1: potassium tert-butylate / 1,2-dimethoxyethane / 24 h / 95 °C
5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h
5.2: 3.33 h / 20 - 60 °C
5.3: 20 °C
6.1: boron tribromide / dichloromethane; chloroform / 35 h / 20 °C
6.2: 20 °C
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

N-5-(4-bromophenyl)-6-chloro-4-pyrimidinyl-N‘-propylsulfamide
1393813-42-7

N-5-(4-bromophenyl)-6-chloro-4-pyrimidinyl-N‘-propylsulfamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium / methanol / 18 h / 0 - 20 °C
1.2: 4 h / 20 °C
2.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C
3.1: dimethyl sulfoxide / 48 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium methylate; methanol / 1.25 h / 0 - 5 °C / Inert atmosphere
1.2: 6 h / 0 - 30 °C
1.3: 1.5 h / 25 - 30 °C
2.1: triethylamine; trichlorophosphate / acetonitrile / 5 h / 25 - 85 °C / Inert atmosphere
3.1: sodium amide / dimethyl sulfoxide / 10 h / 25 - 30 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: sodium methylate / methanol / 70 °C
2: trichlorophosphate / 90 °C
3: lithium amide / dimethyl sulfoxide / 2 h / 20 - 25 °C
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

N‐[5‐(4‐bromophenyl)‐6‐[2‐hydroxyethoxy]‐4‐pyrimidinyl]‐N‐propylsulfamide
1393813-43-8

N‐[5‐(4‐bromophenyl)‐6‐[2‐hydroxyethoxy]‐4‐pyrimidinyl]‐N‐propylsulfamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium / methanol / 18 h / 0 - 20 °C
1.2: 4 h / 20 °C
2.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C
3.1: dimethyl sulfoxide / 48 h / 20 °C
4.1: potassium tert-butylate / 1,2-dimethoxyethane / 0.17 h / 40 °C
4.2: 70 h / 100 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium methylate; methanol / 1.25 h / 0 - 5 °C / Inert atmosphere
1.2: 6 h / 0 - 30 °C
1.3: 1.5 h / 25 - 30 °C
2.1: triethylamine; trichlorophosphate / acetonitrile / 5 h / 25 - 85 °C / Inert atmosphere
3.1: sodium amide / dimethyl sulfoxide / 10 h / 25 - 30 °C / Inert atmosphere
4.1: potassium tert-butylate / 10 h / 25 - 90 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: sodium methylate / methanol / 70 °C
2: trichlorophosphate / 90 °C
3: lithium amide / dimethyl sulfoxide / 2 h / 20 - 25 °C
4: lithium amide / 18 h / 100 - 105 °C / Green chemistry
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

C11H10BrClN4O2S

C11H10BrClN4O2S

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium / methanol / 18 h / 0 - 20 °C
1.2: 4 h / 20 °C
2.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C
3.1: dimethyl sulfoxide / 48 h / 20 °C
View Scheme
2-(4-bromophenyl)-malonic acid dimethyl ester
149506-35-4

2-(4-bromophenyl)-malonic acid dimethyl ester

C12H12BrClN4O2S
441797-83-7

C12H12BrClN4O2S

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium / methanol / 18 h / 0 - 20 °C
1.2: 4 h / 20 °C
2.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C
3.1: dimethyl sulfoxide / 48 h / 20 °C
View Scheme

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