2-(4-Bromophenyl)malonic acid dimethyl ester CAS No.:149506-35-4 Name: 2-(4-Bromophenyl)malonic acid dimethyl ester Synonyms: Dimethyl (4-bromophenyl)malonate Molecular Structure Molec
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inquiry2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER CAS:149506-35-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, speci
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inquiryProduct Detail Minimum Order Qty. 10 Gram
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inquirydiMethyl 2-(4-broMophenyl)Malonate.Appearance:powder Storage:dry Package:according to customers' requirements Application:Anabolic Steroid. Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or according to yo
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inquiryProduct name: 2-(4-Bromo-phenyl)-Malonic Acid Dimethyl Ester CAS No.: 149506-35-4 Molecule Formula:C11H11BrO4 Molecule Weight:287.11 Purity: 99.0% Package: 25kg/drum Description:Light yellow crystalline powder Manufacture Standards:En
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inquiry2-(4-Bromophenyl)-propanedioic acid, 1,3-mdiethyl ester CAS NO.149506-35-4 Application:2-(4-Bromophenyl)-propanedioic acid, 1,3-mdiethyl ester CAS NO.149506-35-4
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inquiry(4-bromo-phenyl)-acetic acid methyl ester
carbonic acid dimethyl ester
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
Stage #1: (4-bromo-phenyl)-acetic acid methyl ester With sodium hydride In tetrahydrofuran; mineral oil at 40 - 45℃; for 5h; Stage #2: carbonic acid dimethyl ester In tetrahydrofuran; mineral oil at 20 - 32℃; for 24h; | 79% |
Stage #1: (4-bromo-phenyl)-acetic acid methyl ester With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 1h; Stage #2: carbonic acid dimethyl ester In tetrahydrofuran; mineral oil at 20℃; for 72h; | 77% |
In toluene; paraffin oil |
dimethyl diazomalonate
4-Bromophenylboronic acid
B
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
With (pentamethylcyclopentadienyl)*Rh(OAc)2; potassium carbonate; N-fluorobis(benzenesulfon)imide In N,N-dimethyl acetamide at 40℃; for 16h; Reagent/catalyst; Solvent; Temperature; | A 40% B 13% |
With (pentamethylcyclopentadienyl)*Rh(OAc)2; potassium acetate; N-fluorobis(benzenesulfon)imide In N,N-dimethyl acetamide at 80℃; for 16h; Solvent; Temperature; | A 17% B 21% |
(4-bromo-phenyl)-acetic acid methyl ester
methyl chloroformate
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
With lithium diisopropyl amide 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 40 min; Yield given. Multistep reaction; |
2-(4-bromophenyl)acetyl chloride
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 2 h / Ambient temperature 2: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 40 min View Scheme |
2-(4-bromophenyl)-acetic acid
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: SOCl2, DMF / CH2Cl2 / Ambient temperature 2: Et3N / CH2Cl2 / 2 h / Ambient temperature 3: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 40 min View Scheme | |
Multi-step reaction with 2 steps 1.1: thionyl chloride / 0 - 20 °C 2.1: sodium hydride / tetrahydrofuran / 1.83 h / 40 °C 2.2: 22 h / 20 - 31 °C 2.3: -10 °C / pH 6 - 7 View Scheme | |
Multi-step reaction with 2 steps 1.1: thionyl chloride / 3 h / 0 - 20 °C 2.1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 40 - 45 °C 2.2: 24 h / 20 - 32 °C View Scheme |
carbonic acid dimethyl ester
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
Stage #1: (4-bromo-phenyl)-acetic acid methyl ester With sodium hydride In tetrahydrofuran at 27℃; for 1.83333h; Stage #2: carbonic acid dimethyl ester In tetrahydrofuran at 20 - 31℃; for 22h; |
formamidine hydrochloride
2-(4-bromophenyl)-malonic acid dimethyl ester
5-(4-bromophenyl)-4,6-dihydroxypyrimidine
Conditions | Yield |
---|---|
at 25℃; for 16h; Temperature; | 92.6% |
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium In methanol at 0 - 20℃; for 18h; Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h; | 91% |
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium methylate In methanol at 0℃; for 18h; Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h; | |
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium In methanol at 0 - 20℃; for 18h; Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h; Stage #3: With citric acid In water | |
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium In methanol at 0 - 20℃; for 18h; Stage #2: formamidine hydrochloride In methanol at 20℃; for 4h; Stage #3: With citric acid In water for 0.166667h; |
formamide
2-(4-bromophenyl)-malonic acid dimethyl ester
5-(4-bromophenyl)-4,6-dihydroxypyrimidine
Conditions | Yield |
---|---|
With sodium methylate In methanol at 70℃; | 75.25% |
2-(4-bromophenyl)-malonic acid dimethyl ester
methyl iodide
Conditions | Yield |
---|---|
Stage #1: 2-(4-bromophenyl)-malonic acid dimethyl ester With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.5h; Stage #2: methyl iodide In tetrahydrofuran; mineral oil at 20℃; for 2h; | 67% |
acrylic acid methyl ester
2-(4-bromophenyl)-malonic acid dimethyl ester
methyl 4-(4'-bromophenyl)-4,4-dimethoxycarbonylbutanoate
Conditions | Yield |
---|---|
With sodium methylate In methanol for 6h; Ambient temperature; | 64% |
2-(4-bromophenyl)-malonic acid dimethyl ester
6-bromo-1,2-dihydronaphthalene-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature 2: 100 percent / aq. KOH / Heating 3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating 4: 46 percent / PPA / 4 h / 90 °C 5: 77 percent / H3PO4 / tetrahydrofuran / 4 h / 100 °C View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
7-bromo-4-hydroxycarbonyltetralone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature 2: 100 percent / aq. KOH / Heating 3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating 4: 46 percent / PPA / 4 h / 90 °C View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature 2: 100 percent / aq. KOH / Heating 3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating 4: 46 percent / PPA / 4 h / 90 °C 5: 0.62 g / NaBH4 / propan-2-ol 6: 74 percent / p-TSA / CH2Cl2 / 3 h / Ambient temperature View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
4-(4'-bromophenyl)-4-hydroxycarbonylbutanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature 2: 100 percent / aq. KOH / Heating 3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
6-Bromo-4-hydroxy-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature 2: 100 percent / aq. KOH / Heating 3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating 4: 46 percent / PPA / 4 h / 90 °C 5: 0.62 g / NaBH4 / propan-2-ol View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature 2: 100 percent / aq. KOH / Heating View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature 2: 100 percent / aq. KOH / Heating 3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating 4: 46 percent / PPA / 4 h / 90 °C 5: 77 percent / H3PO4 / tetrahydrofuran / 4 h / 100 °C 6: 1.) DCC, HOBT*H2O / 1.) CH3CN, RT, 0.5 h, 2.) CH3CN, 48 h 7: 3H2, Et3N / 10percent Pd/C / ethyl acetate / 24 h 8: BH3*SMe2 / tetrahydrofuran / 8 h / Heating View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature 2: 100 percent / aq. KOH / Heating 3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating 4: 46 percent / PPA / 4 h / 90 °C 5: 77 percent / H3PO4 / tetrahydrofuran / 4 h / 100 °C 6: 1.) DCC, HOBT*H2O / 1.) CH3CN, RT, 0.5 h, 2.) CH3CN, 48 h 7: 3H2, Et3N / 10percent Pd/C / ethyl acetate / 24 h View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
C18H21BrN2O
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature 2: 100 percent / aq. KOH / Heating 3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating 4: 46 percent / PPA / 4 h / 90 °C 5: 77 percent / H3PO4 / tetrahydrofuran / 4 h / 100 °C 6: 1.) DCC, HOBT*H2O / 1.) CH3CN, RT, 0.5 h, 2.) CH3CN, 48 h View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 64 percent / NaOMe / methanol / 6 h / Ambient temperature 2: 100 percent / aq. KOH / Heating 3: 100 percent / conc. H2SO4 / H2O / 2 h / Heating 4: 46 percent / PPA / 4 h / 90 °C 5: 77 percent / H3PO4 / tetrahydrofuran / 4 h / 100 °C 6: 1.) DCC, HOBT*H2O / 1.) CH3CN, RT, 0.5 h, 2.) CH3CN, 48 h View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
2-(4-bromophenyl)-1,3-propanediol
Conditions | Yield |
---|---|
With sulfuric acid In tetrahydrofuran; diethyl ether; water |
2-(4-bromophenyl)-malonic acid dimethyl ester
5-(4-bromophenyl)-4,6-dichloropyrimidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium / methanol / 18 h / 0 - 20 °C 1.2: 4 h / 20 °C 1.3: 0.17 h 2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 130 °C 2.2: 0.33 h / Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium / methanol / 18 h / 0 - 20 °C 1.2: 4 h / 20 °C 2.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium methylate; methanol / 1.25 h / 0 - 5 °C / Inert atmosphere 1.2: 6 h / 0 - 30 °C 1.3: 1.5 h / 25 - 30 °C 2.1: triethylamine; trichlorophosphate / acetonitrile / 5 h / 25 - 85 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: sodium methylate / methanol / 70 °C 2: trichlorophosphate / 90 °C View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
N-[5-(4-bromophenyl)-6-chloro-4-pyrimidinyl]-N'-benzyl-sulfamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium / methanol / 18 h / 0 - 20 °C 1.2: 4 h / 20 °C 1.3: 0.17 h 2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 130 °C 2.2: 0.33 h / Cooling with ice 3.1: dimethyl sulfoxide / 24 h / 20 °C View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
N-[5-(4-bromophenyl)-6-(2-hydroxyethoxy)-4-pyrimidinyl]-N'-benzyl-sulfamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium / methanol / 18 h / 0 - 20 °C 1.2: 4 h / 20 °C 1.3: 0.17 h 2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 130 °C 2.2: 0.33 h / Cooling with ice 3.1: dimethyl sulfoxide / 24 h / 20 °C 4.1: potassium tert-butylate / 1,2-dimethoxyethane / 24 h / 95 °C View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
benzylsulfamic acid {5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yloxy)-ethoxy]-pyrimidine-4-yl}-amide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium / methanol / 18 h / 0 - 20 °C 1.2: 4 h / 20 °C 1.3: 0.17 h 2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 130 °C 2.2: 0.33 h / Cooling with ice 3.1: dimethyl sulfoxide / 24 h / 20 °C 4.1: potassium tert-butylate / 1,2-dimethoxyethane / 24 h / 95 °C 5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h 5.2: 3.33 h / 20 - 60 °C 5.3: 20 °C View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
ACT-132577
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium / methanol / 18 h / 0 - 20 °C 1.2: 4 h / 20 °C 1.3: 0.17 h 2.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 130 °C 2.2: 0.33 h / Cooling with ice 3.1: dimethyl sulfoxide / 24 h / 20 °C 4.1: potassium tert-butylate / 1,2-dimethoxyethane / 24 h / 95 °C 5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h 5.2: 3.33 h / 20 - 60 °C 5.3: 20 °C 6.1: boron tribromide / dichloromethane; chloroform / 35 h / 20 °C 6.2: 20 °C View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
N-5-(4-bromophenyl)-6-chloro-4-pyrimidinyl-N‘-propylsulfamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium / methanol / 18 h / 0 - 20 °C 1.2: 4 h / 20 °C 2.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C 3.1: dimethyl sulfoxide / 48 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium methylate; methanol / 1.25 h / 0 - 5 °C / Inert atmosphere 1.2: 6 h / 0 - 30 °C 1.3: 1.5 h / 25 - 30 °C 2.1: triethylamine; trichlorophosphate / acetonitrile / 5 h / 25 - 85 °C / Inert atmosphere 3.1: sodium amide / dimethyl sulfoxide / 10 h / 25 - 30 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: sodium methylate / methanol / 70 °C 2: trichlorophosphate / 90 °C 3: lithium amide / dimethyl sulfoxide / 2 h / 20 - 25 °C View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
N‐[5‐(4‐bromophenyl)‐6‐[2‐hydroxyethoxy]‐4‐pyrimidinyl]‐N‐propylsulfamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium / methanol / 18 h / 0 - 20 °C 1.2: 4 h / 20 °C 2.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C 3.1: dimethyl sulfoxide / 48 h / 20 °C 4.1: potassium tert-butylate / 1,2-dimethoxyethane / 0.17 h / 40 °C 4.2: 70 h / 100 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium methylate; methanol / 1.25 h / 0 - 5 °C / Inert atmosphere 1.2: 6 h / 0 - 30 °C 1.3: 1.5 h / 25 - 30 °C 2.1: triethylamine; trichlorophosphate / acetonitrile / 5 h / 25 - 85 °C / Inert atmosphere 3.1: sodium amide / dimethyl sulfoxide / 10 h / 25 - 30 °C / Inert atmosphere 4.1: potassium tert-butylate / 10 h / 25 - 90 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: sodium methylate / methanol / 70 °C 2: trichlorophosphate / 90 °C 3: lithium amide / dimethyl sulfoxide / 2 h / 20 - 25 °C 4: lithium amide / 18 h / 100 - 105 °C / Green chemistry View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium / methanol / 18 h / 0 - 20 °C 1.2: 4 h / 20 °C 2.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C 3.1: dimethyl sulfoxide / 48 h / 20 °C View Scheme |
2-(4-bromophenyl)-malonic acid dimethyl ester
C12H12BrClN4O2S
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium / methanol / 18 h / 0 - 20 °C 1.2: 4 h / 20 °C 2.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C 3.1: dimethyl sulfoxide / 48 h / 20 °C View Scheme |
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