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Nanjing Fred Technology Co.,Ltd.

Taizhou FremChem Co. Ltd. is a high-tech enterprise located in China Medical City specializing in R&D, manufacturing, sales of new APIS, pharmaceutical intermediates and fine chemicals. All of our company is committed to provide high quality ch

2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2,3-Difluoropyridine Manufacturer/High quality/Best price/In stock

Cas:1513-66-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:1 Kilogram

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Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Factory supply 2,3-Difluoropyridine CAS 1513-66-2 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed

Factory supply 2,3-Difluoropyridine CAS 1513-66-2 with fast delivery

Cas:1513-66-2

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

2,3-difluoropyridine

Cas:1513-66-2

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 1513-66-2 with best quality

Cas:1513-66-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: 2,3-Difluorpyridin Molecular Formula:C5H3F2N Molecular Weight:115.08 CAS No.:1513-66-2 Appearance:Colorless To Slight Yellow Liquid Appearance:Colorless To Slight Yellow Liquid Storage:Preserve in well-closed, light-resistant and airtight c

2,3-Difluorpyridin

Cas:1513-66-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Pyridine,2,3-difluoro- 1513-66-2

Cas:1513-66-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

2,3-Difluoropyridine CAS:1513-66-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte

2,3-Difluoropyridine CAS:1513-66-2

Cas:1513-66-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Pyridine,2,3-difluoro-/ LIDE PHARMA- Factory supply / Best price

Cas:1513-66-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:1 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2,3-Difluoropyridine /High quality/Best price

Cas:1513-66-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2,3-Difluoropyridine CAS NO.1513-66-2

Cas:1513-66-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality moderate price & quick delivery Appearance:powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used to make other chemic

Pyridine,2,3-difluoro-

Cas:1513-66-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply 2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:0

Negotiable

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

1513-66-2---2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...)

2,3-Difluoropyridine CAS NO.: 1513-66-2

Cas:1513-66-2

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

2,3-Difluoropyridine Chemical Properties Boiling point 125-126°C density 1.265 g/mL at 25 °C refractive index n20/D 1.427 Fp 125-126°C pka -2.85±0.10(Predicted) CAS DataBase Reference 1513-66-2(CAS DataBase Re

2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:200 Kilogram

FOB Price: $65.0

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:100 Gram

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/2,3-Difluoropyridine

Cas:1513-66-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

5-chloro-2,3-difluoropyridine
89402-43-7

5-chloro-2,3-difluoropyridine

2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

Conditions
ConditionsYield
With ammonium formate; acetic acid; palladium on activated charcoal at 25℃; for 6h;75%
palladium-carbon
palladium-carbon
pyridine
110-86-1

pyridine

A

perfluoro-N-ethylpyrrolidine
2344-10-7

perfluoro-N-ethylpyrrolidine

B

2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

C

Pentafluoropyridine
700-16-3

Pentafluoropyridine

D

N,N-Bis(trifluoromethyl)amine
371-77-7

N,N-Bis(trifluoromethyl)amine

Conditions
ConditionsYield
With caesium tetrafluorocobaltate(III) In gaseous matrix at 310℃; for 3.5h; Further byproducts given;A 35.3%
B 2.2%
C 13.6%
D 8.2%
pyridine
110-86-1

pyridine

A

2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

B

4H,5H-heptafluoro-2-azahex-2(Z),4(E)-diene
54471-09-9

4H,5H-heptafluoro-2-azahex-2(Z),4(E)-diene

C

5H-decafluoro-2-azahex-2(Z)-ene
54471-08-8

5H-decafluoro-2-azahex-2(Z)-ene

D

undecafluoro-2-azahex-2(Z)-ene
54471-05-5

undecafluoro-2-azahex-2(Z)-ene

Conditions
ConditionsYield
With potassium tetrafluorocobaltate In gaseous matrix at 215 - 225℃; 1.) 3.5-4 h; 2.) 2 h; Further byproducts given;
2-chloro-3-aminopyridine
6298-19-7

2-chloro-3-aminopyridine

2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

Conditions
ConditionsYield
Stage #1: 2-chloro-3-aminopyridine With hexafluorophosphoric acid; sodium nitrite In water at 0℃;
Stage #2: In xylene at 85℃; for 3h;
Stage #3: With sodium hydrogencarbonate; triethylamine In water; xylene
3-Fluoropyridine
372-47-4

3-Fluoropyridine

2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

Conditions
ConditionsYield
With silver(II) fluoride In acetonitrile at 20℃; for 1h; Mechanism;55 %Spectr.
2-chloro-3-fluoropyridine
17282-04-1

2-chloro-3-fluoropyridine

2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

Conditions
ConditionsYield
With tetramethylammonium fluoride In dimethyl sulfoxide at 80℃; for 24h; Inert atmosphere; Sealed tube;65 %Spectr.
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

3-fluoro-2-hydrazinylpyridine
887266-57-1

3-fluoro-2-hydrazinylpyridine

Conditions
ConditionsYield
With hydrazine hydrate at 120℃; for 1h;93%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

ethyl (ethoxymethylene)cyanoacetate
94-05-3

ethyl (ethoxymethylene)cyanoacetate

ethyl 5-amino-1-(3-fluoropyridin-2-yl)-1H-pyrazole-4-carboxylate

ethyl 5-amino-1-(3-fluoropyridin-2-yl)-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
Stage #1: 2,3-difluoropyridine With hydrazine hydrate In ethanol for 3h; Reflux;
Stage #2: ethyl (ethoxymethylene)cyanoacetate In ethanol Reflux;
91%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

9H-carbazole
86-74-8

9H-carbazole

2,3-di(9H-carbazol-9-yl)pyridine

2,3-di(9H-carbazol-9-yl)pyridine

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 150℃; for 12h; Inert atmosphere;90%
With potassium carbonate In dimethyl sulfoxide at 150℃; for 12h; Inert atmosphere;85%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

3,3'-difluoro-2H-[1,2'-bipyridin]-2-one

3,3'-difluoro-2H-[1,2'-bipyridin]-2-one

Conditions
ConditionsYield
With water; caesium carbonate In dimethyl sulfoxide at 110℃; for 12h;90%
With water; caesium carbonate In dimethyl sulfoxide at 110℃; for 12h;90%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

acetamidine hydrochloride
124-42-5

acetamidine hydrochloride

C7H7FN2O

C7H7FN2O

Conditions
ConditionsYield
With water; caesium carbonate In dimethyl sulfoxide at 90℃; for 18h; Schlenk technique; chemoselective reaction;89%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

tert-butyl (2S)-2-{[N-methoxy(N-methyl)amino]carbonyl}pyrrolidine-1-carboxylate
115186-37-3

tert-butyl (2S)-2-{[N-methoxy(N-methyl)amino]carbonyl}pyrrolidine-1-carboxylate

C15H18F2N2O3

C15H18F2N2O3

Conditions
ConditionsYield
Stage #1: 2,3-difluoropyridine With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;
Stage #2: tert-butyl (2S)-2-{[N-methoxy(N-methyl)amino]carbonyl}pyrrolidine-1-carboxylate In tetrahydrofuran at -78℃; for 2h; Inert atmosphere;
85%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

4-chloro-2,3-difluoropyridine
851178-99-9

4-chloro-2,3-difluoropyridine

Conditions
ConditionsYield
Stage #1: 2,3-difluoropyridine With n-butyllithium In tetrahydrofuran; hexane
Stage #2: With 1,1,2-Trichloro-1,2,2-trifluoroethane In tetrahydrofuran; hexane
81%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

(E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone oxime
1224432-92-1

(E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone oxime

(E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-3-fluoropyridin-2-yl oxime
1224433-00-4

(E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-3-fluoropyridin-2-yl oxime

Conditions
ConditionsYield
Stage #1: (E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone oxime With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 2,3-difluoropyridine In N,N-dimethyl-formamide; mineral oil at 20℃; for 1.5h; Inert atmosphere;
81%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

3-fluoropyridin-2-amine
21717-95-3

3-fluoropyridin-2-amine

Conditions
ConditionsYield
With acetamidine hydrochloride; sodium hydroxide In water; dimethyl sulfoxide at 130℃; for 24h; Schlenk technique; chemoselective reaction;81%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

4-benzyl-3-ethoxy-5-methyl-1H-pyrazole
1116655-96-9

4-benzyl-3-ethoxy-5-methyl-1H-pyrazole

2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)-3-fluoropyridine

2-(4-benzyl-3-ethoxy-5-methyl-1H-pyrazol-1-yl)-3-fluoropyridine

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 180℃; for 2h; Microwave irradiation;74%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

cyclopropropanecarbonitrile
5500-21-0

cyclopropropanecarbonitrile

1-(3-fluoropyridin-2-yl)cyclopropane-1-carbonitrile

1-(3-fluoropyridin-2-yl)cyclopropane-1-carbonitrile

Conditions
ConditionsYield
Stage #1: cyclopropropanecarbonitrile With lithium hexamethyldisilazane In 2-methyltetrahydrofuran; hexane at 0℃; for 0.166667h;
Stage #2: 2,3-difluoropyridine In 2-methyltetrahydrofuran; hexane at 0 - 20℃; for 3h;
72%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

1,2-dicarba-closo-dodecaborane(12)
16872-09-6

1,2-dicarba-closo-dodecaborane(12)

C7H14B10FN

C7H14B10FN

Conditions
ConditionsYield
Stage #1: 1,2-dicarba-closo-dodecaborane(12) With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 0.5h; Inert atmosphere; Schlenk technique;
Stage #2: 2,3-difluoropyridine In tetrahydrofuran; hexane at 70℃; for 3h; Inert atmosphere; Schlenk technique;
69%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

2,3-difluoro-4-iodopyridine
851386-34-0

2,3-difluoro-4-iodopyridine

Conditions
ConditionsYield
Stage #1: 2,3-difluoropyridine With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 1h;
Stage #2: With iodine In tetrahydrofuran; hexane at -78℃; for 1h;
63%
With iodine; lithium diisopropyl amide In tetrahydrofuran at -78℃; regioselective reaction;
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

1-(4-methyl-4-piperidyl)pyrazole-4-carbaldehyde

1-(4-methyl-4-piperidyl)pyrazole-4-carbaldehyde

1-[1-(3-fluoro-2-pyridyl)-4-methyl-4-piperidyl]pyrazole-4-carbaldehyde

1-[1-(3-fluoro-2-pyridyl)-4-methyl-4-piperidyl]pyrazole-4-carbaldehyde

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 135℃; for 12h; Sealed tube;61.25%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

diethyl malonate
105-53-3

diethyl malonate

diethyl 2-(3-fluoropyridin-2-yl)malonate
940933-39-1

diethyl 2-(3-fluoropyridin-2-yl)malonate

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide at 100℃; for 4.5h;60%
With caesium carbonate In dimethyl sulfoxide at 100℃; for 4.5h;60%
With caesium carbonate In dimethyl sulfoxide at 100℃; for 3h;
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

C14H21N3O2

C14H21N3O2

C19H23FN4O2

C19H23FN4O2

Conditions
ConditionsYield
at 130℃; for 48h;52%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

3-amino-2-pyridone
33630-99-8

3-amino-2-pyridone

3-amino-3‘-fluoro-2H-[1,2’-bipyridin]-2-one

3-amino-3‘-fluoro-2H-[1,2’-bipyridin]-2-one

Conditions
ConditionsYield
With potassium phosphate In 1-methyl-pyrrolidin-2-one at 90 - 100℃; for 22h;49.37%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

3-methyl-1H-pyrazole-4-carbaldehyde
112758-40-4

3-methyl-1H-pyrazole-4-carbaldehyde

1-(3-fluoro-2-pyridyl)-3-methylpyrazole-4-carbaldehyde
1307248-77-6

1-(3-fluoro-2-pyridyl)-3-methylpyrazole-4-carbaldehyde

Conditions
ConditionsYield
Stage #1: 3-methyl-1H-pyrazole-4-carbaldehyde With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: 2,3-difluoropyridine In N,N-dimethyl-formamide at 20℃; for 20h;
43%
Stage #1: 3-methyl-1H-pyrazole-4-carbaldehyde With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: 2,3-difluoropyridine In N,N-dimethyl-formamide at 20℃; for 20h;
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

4,6-dimethoxypyrimidin-2-ylacetonitrile
128276-52-8

4,6-dimethoxypyrimidin-2-ylacetonitrile

4,6-dimethoxy-2-(3-fluoro-2-pyridyl)formylpyrimidine

4,6-dimethoxy-2-(3-fluoro-2-pyridyl)formylpyrimidine

Conditions
ConditionsYield
Stage #1: 4,6-dimethoxypyrimidin-2-ylacetonitrile With sodium hydride In N,N-dimethyl acetamide at 0℃; for 0.5h;
Stage #2: 2,3-difluoropyridine In N,N-dimethyl acetamide at 20℃; for 8h;
Stage #3: With dihydrogen peroxide In N,N-dimethyl acetamide at 0 - 20℃;
42.7%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

ethyl 1-methyl-5-(4-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1H-pyrazole-3-carboxylate

ethyl 1-methyl-5-(4-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1H-pyrazole-3-carboxylate

C18H21FN4O2

C18H21FN4O2

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 100℃; for 24h;40%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

methyl 3-[(6-hydroxy-1-methyl-1H-benzimidazol-2-yl)methoxy]benzoate
1242328-95-5

methyl 3-[(6-hydroxy-1-methyl-1H-benzimidazol-2-yl)methoxy]benzoate

methyl 3-({6-[(3-fluoropyridin-2-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoate

methyl 3-({6-[(3-fluoropyridin-2-yl)oxy]-1-methyl-1H-benzimidazol-2-yl}methoxy)benzoate

Conditions
ConditionsYield
With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate In N,N-dimethyl-formamide at 80℃; for 2h; Inert atmosphere;28%
3-bromo-pyridin-2-ol
13466-43-8

3-bromo-pyridin-2-ol

2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

3-bromo-3‘-fluoro-2H-[1,2’-bipyridin]-2-one

3-bromo-3‘-fluoro-2H-[1,2’-bipyridin]-2-one

Conditions
ConditionsYield
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 110℃; for 15h;21.47%
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 110℃; for 15h;21%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

3-hydroxy-2,2-dimethyl-N-(1-methylpiperidin-4-yl)propanamide

3-hydroxy-2,2-dimethyl-N-(1-methylpiperidin-4-yl)propanamide

3-((3-fluoropyridin-2-yl)oxy)-2,2-dimethyl-N-(1-methylpiperidin-4-yl)propanamide

3-((3-fluoropyridin-2-yl)oxy)-2,2-dimethyl-N-(1-methylpiperidin-4-yl)propanamide

Conditions
ConditionsYield
Stage #1: 3-hydroxy-2,2-dimethyl-N-(1-methylpiperidin-4-yl)propanamide With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 2,3-difluoropyridine In N,N-dimethyl-formamide at 20℃;
19%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

3-bromopyridin-2(1H)-one
13466-43-8

3-bromopyridin-2(1H)-one

3-bromo-3‘-fluoro-2H-[1,2’-bipyridin]-2-one

3-bromo-3‘-fluoro-2H-[1,2’-bipyridin]-2-one

Conditions
ConditionsYield
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 110℃; for 15h;16.81%
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 110℃; for 15h; Time;16.81%
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

3,4-difluoropyridine

3,4-difluoropyridine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: BuLi / tetrahydrofuran; hexane
1.2: 81 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane
2.1: 75 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 2 h / 150 °C
3.1: i-Pr2NH; BuLi / tetrahydrofuran; hexane / 2 h / -75 °C
3.2: 82 percent / tetrahydrofuran; hexane / 1 h / -75 °C
4.1: 96 percent / hydrazine monohydrate / tetrahydrofuran / 20 h / 50 °C
5.1: 72 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 25 °C
6.1: 60 percent / MnO2 / octan-1-ol / 15 - 25 °C
View Scheme
2,3-difluoropyridine
1513-66-2

2,3-difluoropyridine

3,4-difluoro-2-hydrazinopyridine
874907-81-0

3,4-difluoro-2-hydrazinopyridine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: BuLi / tetrahydrofuran; hexane
1.2: 81 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane
2.1: 75 percent / KF; tetramethylammonium chloride / dimethylsulfoxide / 2 h / 150 °C
3.1: i-Pr2NH; BuLi / tetrahydrofuran; hexane / 2 h / -75 °C
3.2: 82 percent / tetrahydrofuran; hexane / 1 h / -75 °C
4.1: 96 percent / hydrazine monohydrate / tetrahydrofuran / 20 h / 50 °C
5.1: 72 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 2 h / 25 °C
View Scheme

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