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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Nelfinavir Manufacturer/High quality/Best price/In stock

Cas:159989-64-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

nelfinavir manufacturer/supplier

Cas:159989-64-7

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% NELFINAVIR 159989-64-7 GMP Manufacturer

Cas:159989-64-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

NELFINAVIR

Cas:159989-64-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 159989-64-7 with best quality

Cas:159989-64-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Nelfinavir/AG 1341 159989-64-7

Cas:159989-64-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

Nelfinavir

Cas:159989-64-7

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

159989-64-7 Nelfinavir product Name Nelfinavir Synonyms 3-isoquinolinecarboxamide,n-(1,1-dimethylethyl)decahydro-2-(2-hydroxy-3-((3-hy; 8a-bet

Nelfinavir,159989-64-7

Cas:159989-64-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Other

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Qingdao Beluga Import and Export Co., LTD

NELFINAVIR CAS:159989-64-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

NELFINAVIR CAS:159989-64-7

Cas:159989-64-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Nelfinavir

Cas:159989-64-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Nelfinavir

Cas:159989-64-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio

Nelfinavir

Cas:159989-64-7

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Nelfinavir

Cas:159989-64-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Nelfinavir

Cas:159989-64-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3-Isoquinolinecarboxamide

Cas:159989-64-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Nelfinavir

Cas:159989-64-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Nelfinavir

Cas:159989-64-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

NELFINAVIR

Cas:159989-64-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Nelfinavir

Cas:159989-64-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Nelfinavir

Cas:159989-64-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Nelfinavir

Cas:159989-64-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Nelfinavir

Cas:159989-64-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Nelfinavir

Cas:159989-64-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used for active pharmaceutical ingr

Nelfinavir

Cas:159989-64-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Nelfinavir

Cas:159989-64-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

Nelfinavir

Cas:159989-64-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Nelfinavir cas no. 159989-64-7 98%

Cas:159989-64-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment .5) We can do different t

99% up by HPLC NELFINAVIR 159989-64-7

Cas:159989-64-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Nelfinavir

Cas:159989-64-7

Min.Order:0

Negotiable

Type:Manufacturers

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Synthetic route

thiophenol
108-98-5

thiophenol

(3S,4aS,8aS)-N-tert-butyl-2-((R)-2-hydroxy-2-((S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)ethyl)-decahydroisoquinoline-3-carboxamide
188936-07-4

(3S,4aS,8aS)-N-tert-butyl-2-((R)-2-hydroxy-2-((S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)ethyl)-decahydroisoquinoline-3-carboxamide

A

nelfinavir
159989-64-7

nelfinavir

B

(3S,4aS,8aS)-2-[(2S,3S)-3-Hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-4-phenylsulfanyl-butyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide
1025935-06-1

(3S,4aS,8aS)-2-[(2S,3S)-3-Hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-4-phenylsulfanyl-butyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide

Conditions
ConditionsYield
With potassium hydrogencarbonate In various solvent(s) at 115℃; for 4h;A 84%
B 8 % Chromat.
With triethylamine In N,N-dimethyl-formamide at 80℃; for 10h; Product distribution; other base, other temperature, other solvents;A 84 % Chromat.
B 16 % Chromat.
In ethylene glycol at 120℃; for 20h;A 18 % Chromat.
B 82 % Chromat.
thiophenol
108-98-5

thiophenol

(3S,4aS,8aS)-N-tert-butyl-2-((R)-2-hydroxy-2-((S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)ethyl)-decahydroisoquinoline-3-carboxamide
188936-07-4

(3S,4aS,8aS)-N-tert-butyl-2-((R)-2-hydroxy-2-((S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)ethyl)-decahydroisoquinoline-3-carboxamide

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
82%
With potassium hydrogencarbonate at 140℃; for 5h; Sealed tube;78%
With potassium hydrogencarbonate In various solvent(s) Substitution;72%
With triethylamine In water; N,N-dimethyl-formamide; toluene; butanone65%
3-acetoxy-2-methylbenzoyl chloride
167678-46-8

3-acetoxy-2-methylbenzoyl chloride

(2R,3R)-4-((3S,4aS,8aS)-3-(tertbutylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-aminium benzoate

(2R,3R)-4-((3S,4aS,8aS)-3-(tertbutylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-aminium benzoate

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Stage #1: 3-acetoxy-2-methylbenzoyl chloride; (2R,3R)-4-((3S,4aS,8aS)-3-(tertbutylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-aminium benzoate In ethanol
Stage #2: With sodium hydroxide
79%
active charcoal

active charcoal

thiophenol
108-98-5

thiophenol

butanone
78-93-3

butanone

(3S,4aS,8aS)-N-tert-butyl-2-((R)-2-hydroxy-2-((S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)ethyl)-decahydroisoquinoline-3-carboxamide
188936-07-4

(3S,4aS,8aS)-N-tert-butyl-2-((R)-2-hydroxy-2-((S)-2-(3-hydroxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)ethyl)-decahydroisoquinoline-3-carboxamide

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
In pyridine69%
(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide
128019-40-9, 149510-73-6, 136465-81-1

(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide

Acetic acid 3-((1R,2S)-2,3-dihydroxy-1-phenylsulfanylmethyl-propylcarbamoyl)-2-methyl-phenyl ester
767341-27-5

Acetic acid 3-((1R,2S)-2,3-dihydroxy-1-phenylsulfanylmethyl-propylcarbamoyl)-2-methyl-phenyl ester

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Stage #1: Acetic acid 3-((1R,2S)-2,3-dihydroxy-1-phenylsulfanylmethyl-propylcarbamoyl)-2-methyl-phenyl ester With triethylamine; p-toluenesulfonyl chloride
Stage #2: (3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide
59%
(3S,4AS,8AS)-2-[(2R,3R)-3-(3-acetoxy-2-methylbenzoylamino)-2-hydroxy-4-phenylthiobutyl]decahydroisoquinoline-3-carboxylic acid t-butylamide

(3S,4AS,8AS)-2-[(2R,3R)-3-(3-acetoxy-2-methylbenzoylamino)-2-hydroxy-4-phenylthiobutyl]decahydroisoquinoline-3-carboxylic acid t-butylamide

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
With ammonia; water In methanol at 20℃; for 1.5h;54%
With ammonia; water In methanol at 20℃; for 3h; Inert atmosphere;884 mg
Stage #1: (3S,4AS,8AS)-2-[(2R,3R)-3-(3-acetoxy-2-methylbenzoylamino)-2-hydroxy-4-phenylthiobutyl]decahydroisoquinoline-3-carboxylic acid t-butylamide With sodium hydroxide; water; benzyl alcohol at 20 - 82℃; for 0.583333h; pH=14;
Stage #2: With water; acetic acid In benzyl alcohol at 53℃; pH=7 - 7.5; Product distribution / selectivity;
(2R,3S)-3-(3-acetoxy-2-methylbenzamido)-1-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-4-hydroxybutan-2-yl-4-methoxybenzoate

(2R,3S)-3-(3-acetoxy-2-methylbenzamido)-1-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-4-hydroxybutan-2-yl-4-methoxybenzoate

thiophenol
108-98-5

thiophenol

A

nelfinavir
159989-64-7

nelfinavir

B

(3S,4aS,8aS)-2-[(2S,3S)-3-Hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-4-phenylsulfanyl-butyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide
1025935-06-1

(3S,4aS,8aS)-2-[(2S,3S)-3-Hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-4-phenylsulfanyl-butyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide

Conditions
ConditionsYield
Stage #1: (2R,3S)-3-(3-acetoxy-2-methylbenzamido)-1-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-4-hydroxybutan-2-yl-4-methoxybenzoate With methanesulfonyl chloride; triethylamine In N,N-dimethyl-formamide at 20℃;
Stage #2: thiophenol at 120℃;
Stage #3: With potassium carbonate In methanol at 40℃;
A 31%
B 41%
3-acetoxy-2-methylbenzoic acid
168899-58-9

3-acetoxy-2-methylbenzoic acid

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 72 percent / EDCI; HOBt
2: 100 percent / HCl / methanol / 3 h / 40 °C
3: 59 percent / TsCl; Et3N
View Scheme
1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-phenylsulfanyl-ethylamine

1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-phenylsulfanyl-ethylamine

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 72 percent / EDCI; HOBt
2: 100 percent / HCl / methanol / 3 h / 40 °C
3: 59 percent / TsCl; Et3N
View Scheme
2-Benzenesulfinyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethylamine

2-Benzenesulfinyl-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethylamine

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 71 percent / BF3*Et2O; NaI
2: 72 percent / EDCI; HOBt
3: 100 percent / HCl / methanol / 3 h / 40 °C
4: 59 percent / TsCl; Et3N
View Scheme
Acetic acid 3-[(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenylsulfanyl-ethylcarbamoyl]-2-methyl-phenyl ester
767341-31-1

Acetic acid 3-[(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-phenylsulfanyl-ethylcarbamoyl]-2-methyl-phenyl ester

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / HCl / methanol / 3 h / 40 °C
2: 59 percent / TsCl; Et3N
View Scheme
(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide
128019-40-9, 149510-73-6, 136465-81-1

(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: K2CO3 / propan-2-ol / Heating
View Scheme
Multi-step reaction with 2 steps
1: K2CO3 / methanol; H2O / 5 h / 50 °C
2: 72 percent / KHCO3 / various solvent(s)
View Scheme
Multi-step reaction with 7 steps
1.1: sodium carbonate / N,N-dimethyl-formamide / 30 h / 120 °C
2.1: hydrogenchloride / tetrahydrofuran; water / 3.5 h / 20 °C
3.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
4.1: hydrogenchloride; ozone; oxygen / dichloromethane; ethyl acetate / 0.58 h / -78 °C
4.2: 3 h / -78 - 0 °C
5.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 0.33 h / 20 °C
5.2: 3 h / 50 °C
6.1: potassium carbonate / methanol / 2 h / 100 °C / Sealed tube
7.1: potassium hydrogencarbonate / 5 h / 140 °C / Sealed tube
View Scheme
Acetic acid 3-{(S)-4-[(S)-1-hydroxy-2-(toluene-4-sulfonyloxy)-ethyl]-4,5-dihydro-oxazol-2-yl}-2-methyl-phenyl ester
201402-95-1

Acetic acid 3-{(S)-4-[(S)-1-hydroxy-2-(toluene-4-sulfonyloxy)-ethyl]-4,5-dihydro-oxazol-2-yl}-2-methyl-phenyl ester

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: K2CO3 / propan-2-ol / Heating
View Scheme
3-acetoxy-2-methylbenzoyl chloride
167678-46-8

3-acetoxy-2-methylbenzoyl chloride

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: Et3N / ethyl acetate / 1.75 h / 20 °C
1.2: H2SO4 (98 percent) / ethyl acetate / 17 h / 20 °C
2.1: K2CO3 / methanol; H2O / 5 h / 50 °C
3.1: 72 percent / KHCO3 / various solvent(s)
View Scheme
Multi-step reaction with 5 steps
1: NaHCO3 / CH2Cl2; H2O
2: Et3N / CH2Cl2
3: 1.) BF3*Et2O / 1.) CH2Cl2
4: K2CO3 / methanol; H2O
5: 18 percent Chromat. / ethane-1,2-diol / 20 h / 120 °C
View Scheme
(2R)-1-acetoxy-2-((4S)-2-(3-acetoxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)-2-methanesulfonyloxyethane
188936-06-3

(2R)-1-acetoxy-2-((4S)-2-(3-acetoxy-2-methylphenyl)-4,5-dihydrooxazol-4-yl)-2-methanesulfonyloxyethane

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: K2CO3 / methanol; H2O / 5 h / 50 °C
2: 72 percent / KHCO3 / various solvent(s)
View Scheme
Multi-step reaction with 2 steps
1: K2CO3 / methanol; H2O
2: 18 percent Chromat. / ethane-1,2-diol / 20 h / 120 °C
View Scheme
Acetic acid 3-((5S,6R)-6-hydroxy-2,2-dimethyl-[1,3]dioxepan-5-ylcarbamoyl)-2-methyl-phenyl ester
188936-02-9

Acetic acid 3-((5S,6R)-6-hydroxy-2,2-dimethyl-[1,3]dioxepan-5-ylcarbamoyl)-2-methyl-phenyl ester

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Et3N / CH2Cl2
2: 1.) BF3*Et2O / 1.) CH2Cl2
3: K2CO3 / methanol; H2O
4: 18 percent Chromat. / ethane-1,2-diol / 20 h / 120 °C
View Scheme
Acetic acid 3-((5S,6R)-6-methanesulfonyloxy-2,2-dimethyl-[1,3]dioxepan-5-ylcarbamoyl)-2-methyl-phenyl ester
188936-03-0

Acetic acid 3-((5S,6R)-6-methanesulfonyloxy-2,2-dimethyl-[1,3]dioxepan-5-ylcarbamoyl)-2-methyl-phenyl ester

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) BF3*Et2O / 1.) CH2Cl2
2: K2CO3 / methanol; H2O
3: 18 percent Chromat. / ethane-1,2-diol / 20 h / 120 °C
View Scheme
3-acetoxy-2-methylbenzoyl chloride
167678-46-8

3-acetoxy-2-methylbenzoyl chloride

(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-(phenylthio)butyl]decahydroisoquinoline-3-carboxamide
159878-04-3

(3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-(phenylthio)butyl]decahydroisoquinoline-3-carboxamide

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Stage #1: (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-(phenylthio)butyl]decahydroisoquinoline-3-carboxamide Alkaline aqueous solution; Heating / reflux;
Stage #2: 3-acetoxy-2-methylbenzoyl chloride In water Alkaline aqueous solution;
3-hydroxy 2-methylbenzoic acid
603-80-5

3-hydroxy 2-methylbenzoic acid

(2R,3R)-4-((3S,4aS,8aS)-3-(tertbutylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-aminium benzoate

(2R,3R)-4-((3S,4aS,8aS)-3-(tertbutylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-aminium benzoate

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Stage #1: 3-hydroxy 2-methylbenzoic acid; (2R,3R)-4-((3S,4aS,8aS)-3-(tertbutylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-aminium benzoate In methanol
Stage #2: With sodium hydroxide
(3S,4aS,8aS)-N-tert-butyl-2-(((4S,5R)-2-(4-methoxyphenyl)-4-vinyl-4,5-dihydrooxazol-5-yl)methyl)decahydroisoquinoline-3-carboxamide

(3S,4aS,8aS)-N-tert-butyl-2-(((4S,5R)-2-(4-methoxyphenyl)-4-vinyl-4,5-dihydrooxazol-5-yl)methyl)decahydroisoquinoline-3-carboxamide

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: hydrogenchloride / tetrahydrofuran; water / 3.5 h / 20 °C
2.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
3.1: hydrogenchloride; ozone; oxygen / dichloromethane; ethyl acetate / 0.58 h / -78 °C
3.2: 3 h / -78 - 0 °C
4.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 0.33 h / 20 °C
4.2: 3 h / 50 °C
5.1: potassium carbonate / methanol / 2 h / 100 °C / Sealed tube
6.1: potassium hydrogencarbonate / 5 h / 140 °C / Sealed tube
View Scheme
(3S,4aS,8aS)-N-tert-butyl-2-(((4S,5R)-2-(4-methoxyphenyl)-4-vinyl-4,5-dihydrooxazol-5-yl)methyl)decahydroisoquinoline-3-carboxamide

(3S,4aS,8aS)-N-tert-butyl-2-(((4S,5R)-2-(4-methoxyphenyl)-4-vinyl-4,5-dihydrooxazol-5-yl)methyl)decahydroisoquinoline-3-carboxamide

A

nelfinavir
159989-64-7

nelfinavir

B

(3S,4aS,8aS)-2-[(2S,3S)-3-Hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-4-phenylsulfanyl-butyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide
1025935-06-1

(3S,4aS,8aS)-2-[(2S,3S)-3-Hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-4-phenylsulfanyl-butyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogenchloride / tetrahydrofuran; water / 3.5 h / 20 °C
2.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
3.1: hydrogenchloride; ozone; oxygen / dichloromethane; ethyl acetate / 0.58 h / -78 °C
3.2: 3 h / -78 - 0 °C
4.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 20 °C
4.2: 120 °C
4.3: 40 °C
View Scheme
(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide
128019-40-9, 149510-73-6, 136465-81-1

(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide

A

nelfinavir
159989-64-7

nelfinavir

B

(3S,4aS,8aS)-2-[(2S,3S)-3-Hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-4-phenylsulfanyl-butyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide
1025935-06-1

(3S,4aS,8aS)-2-[(2S,3S)-3-Hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-4-phenylsulfanyl-butyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium carbonate / N,N-dimethyl-formamide / 30 h / 120 °C
2.1: hydrogenchloride / tetrahydrofuran; water / 3.5 h / 20 °C
3.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
4.1: hydrogenchloride; ozone; oxygen / dichloromethane; ethyl acetate / 0.58 h / -78 °C
4.2: 3 h / -78 - 0 °C
5.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 20 °C
5.2: 120 °C
5.3: 40 °C
View Scheme
(2R,3S)-3-(3-acetoxy-2-methylbenzamido)-1-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)pent-4-en-2-yl-4-methoxybenzoate

(2R,3S)-3-(3-acetoxy-2-methylbenzamido)-1-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)pent-4-en-2-yl-4-methoxybenzoate

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogenchloride; ozone; oxygen / dichloromethane; ethyl acetate / 0.58 h / -78 °C
1.2: 3 h / -78 - 0 °C
2.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 0.33 h / 20 °C
2.2: 3 h / 50 °C
3.1: potassium carbonate / methanol / 2 h / 100 °C / Sealed tube
4.1: potassium hydrogencarbonate / 5 h / 140 °C / Sealed tube
View Scheme
(2R,3S)-3-(3-acetoxy-2-methylbenzamido)-1-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)pent-4-en-2-yl-4-methoxybenzoate

(2R,3S)-3-(3-acetoxy-2-methylbenzamido)-1-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)pent-4-en-2-yl-4-methoxybenzoate

A

nelfinavir
159989-64-7

nelfinavir

B

(3S,4aS,8aS)-2-[(2S,3S)-3-Hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-4-phenylsulfanyl-butyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide
1025935-06-1

(3S,4aS,8aS)-2-[(2S,3S)-3-Hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-4-phenylsulfanyl-butyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride; ozone; oxygen / dichloromethane; ethyl acetate / 0.58 h / -78 °C
1.2: 3 h / -78 - 0 °C
2.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 20 °C
2.2: 120 °C
2.3: 40 °C
View Scheme
C27H41N3O4

C27H41N3O4

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
2.1: hydrogenchloride; ozone; oxygen / dichloromethane; ethyl acetate / 0.58 h / -78 °C
2.2: 3 h / -78 - 0 °C
3.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 0.33 h / 20 °C
3.2: 3 h / 50 °C
4.1: potassium carbonate / methanol / 2 h / 100 °C / Sealed tube
5.1: potassium hydrogencarbonate / 5 h / 140 °C / Sealed tube
View Scheme
C27H41N3O4

C27H41N3O4

A

nelfinavir
159989-64-7

nelfinavir

B

(3S,4aS,8aS)-2-[(2S,3S)-3-Hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-4-phenylsulfanyl-butyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide
1025935-06-1

(3S,4aS,8aS)-2-[(2S,3S)-3-Hydroxy-2-(3-hydroxy-2-methyl-benzoylamino)-4-phenylsulfanyl-butyl]-decahydro-isoquinoline-3-carboxylic acid tert-butylamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
2.1: hydrogenchloride; ozone; oxygen / dichloromethane; ethyl acetate / 0.58 h / -78 °C
2.2: 3 h / -78 - 0 °C
3.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 20 °C
3.2: 120 °C
3.3: 40 °C
View Scheme
(2R,3S)-3-(3-acetoxy-2-methylbenzamido)-1-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-4-hydroxybutan-2-yl-4-methoxybenzoate

(2R,3S)-3-(3-acetoxy-2-methylbenzamido)-1-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-4-hydroxybutan-2-yl-4-methoxybenzoate

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine; methanesulfonyl chloride / N,N-dimethyl-formamide / 0.33 h / 20 °C
1.2: 3 h / 50 °C
2.1: potassium carbonate / methanol / 2 h / 100 °C / Sealed tube
3.1: potassium hydrogencarbonate / 5 h / 140 °C / Sealed tube
View Scheme
C36H47N3O7

C36H47N3O7

nelfinavir
159989-64-7

nelfinavir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / methanol / 2 h / 100 °C / Sealed tube
2: potassium hydrogencarbonate / 5 h / 140 °C / Sealed tube
View Scheme
methanesulfonic acid
75-75-2

methanesulfonic acid

nelfinavir
159989-64-7

nelfinavir

nelfinavir mesylate
159989-65-8

nelfinavir mesylate

Conditions
ConditionsYield
In acetone at 20 - 35℃; for 2h; Product distribution / selectivity;98%
Stage #1: methanesulfonic acid; nelfinavir In methanol at 25 - 30℃; for 0.166667h;
Stage #2: In methanol at 25 - 30℃; for 0.25h; Carbon;
Stage #3: at 40 - 55℃; under 10 - 150 Torr; for 1h; Product distribution / selectivity;
92%
In ethanol Product distribution / selectivity;80%
methyltertbutyl ether
67000-01-5

methyltertbutyl ether

nelfinavir
159989-64-7

nelfinavir

nelfinavir mesylate
159989-65-8

nelfinavir mesylate

Conditions
ConditionsYield
With methanesulfonic acid In tetrahydrofuran95%
nelfinavir
159989-64-7

nelfinavir

1,2:5,6-di-O-isopropylidene-3-O-(4-izocyanatobutyl)-α-D-glucofuranose

1,2:5,6-di-O-isopropylidene-3-O-(4-izocyanatobutyl)-α-D-glucofuranose

[4-[3-O-(1,2:5,6-di-O-isopropylidene-α-D-glucofuranose)]-butyl]carbamic acid 1(R)-[3(S)-tert-butylcarbamoyloctahydro-4a(S),8a(S)-isoquinolin-2-ylmethyl]-2(S)-(3-hydroxy-2-methylbenzoylamino)-3-phenylsulfanylpropyl ester

[4-[3-O-(1,2:5,6-di-O-isopropylidene-α-D-glucofuranose)]-butyl]carbamic acid 1(R)-[3(S)-tert-butylcarbamoyloctahydro-4a(S),8a(S)-isoquinolin-2-ylmethyl]-2(S)-(3-hydroxy-2-methylbenzoylamino)-3-phenylsulfanylpropyl ester

Conditions
ConditionsYield
With copper(l) chloride In dichloromethane; N,N-dimethyl-formamide at 20℃;63.5%
C22H30N6O4S2

C22H30N6O4S2

nelfinavir
159989-64-7

nelfinavir

A

C54H73N9O7S3

C54H73N9O7S3

B

C54H73N9O7S3

C54H73N9O7S3

C

C76H101N15O10S5

C76H101N15O10S5

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; Inert atmosphere; Molecular sieve;A 62%
B 3%
C 2%
nelfinavir
159989-64-7

nelfinavir

1,2:5,6-di-O-isopropylidene-3-O-(3-carboxypropanoyl)-α-D-glucofuranose

1,2:5,6-di-O-isopropylidene-3-O-(3-carboxypropanoyl)-α-D-glucofuranose

succinic acid 3-[3-[3(S)-tert-butylcarbamoyloctahydro-4a(S),8a(S)-isoquinolin-2-yl]-2(R)-hydroxy-1(S)-phenylsulfanylmethylpropylcarbamoyl]-2-methylphenyl ester 4-[3-O-(1,2:5,6-di-O-isopropylidene-α-D-glucofuranose)] ester

succinic acid 3-[3-[3(S)-tert-butylcarbamoyloctahydro-4a(S),8a(S)-isoquinolin-2-yl]-2(R)-hydroxy-1(S)-phenylsulfanylmethylpropylcarbamoyl]-2-methylphenyl ester 4-[3-O-(1,2:5,6-di-O-isopropylidene-α-D-glucofuranose)] ester

Conditions
ConditionsYield
With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 0 - 20℃;16%
nelfinavir
159989-64-7

nelfinavir

[4-[3-O-D-glucose]-butyl]carbamic acid 1(R)-[3(S)-tert-butylcarbamoyloctahydro-4a(S),8a(S)-isoquinolin-2-ylmethyl]-2(S)-(3-hydroxy-2-methylbenzoylamino)-3-phenylsulfanylpropyl ester (bis trifluoroacatic acid salt)

[4-[3-O-D-glucose]-butyl]carbamic acid 1(R)-[3(S)-tert-butylcarbamoyloctahydro-4a(S),8a(S)-isoquinolin-2-ylmethyl]-2(S)-(3-hydroxy-2-methylbenzoylamino)-3-phenylsulfanylpropyl ester (bis trifluoroacatic acid salt)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 63.5 percent / CuCl / CH2Cl2; dimethylformamide / 20 °C
2: 97 percent / H2O; acetonitrile / 0 - 20 °C
View Scheme
7-(3-benzyl-1-ethyl-(1H)-pyrazol-5-yl)-3-azabicyclo[3.3.0]octane

7-(3-benzyl-1-ethyl-(1H)-pyrazol-5-yl)-3-azabicyclo[3.3.0]octane

nelfinavir
159989-64-7

nelfinavir

1-(((3S,4S)-3-((7-(3-Benzyl-1-ethyl-(1H)-pyrazol-5-yl)-3-azabicyclo[3.3.0]octan-3-yl)methyl]-4-(3-fluorophenyl)pyrrolidin-1-yl)methyl) cyclohexanecarboxylic Acid

1-(((3S,4S)-3-((7-(3-Benzyl-1-ethyl-(1H)-pyrazol-5-yl)-3-azabicyclo[3.3.0]octan-3-yl)methyl]-4-(3-fluorophenyl)pyrrolidin-1-yl)methyl) cyclohexanecarboxylic Acid

nelfinavir
159989-64-7

nelfinavir

3-({3-[3-(tert-butylaminomethyl)octahydroisoquinolin-2-yl]-2-hydroxy-1-phenylsulfanylmethylpropylamino}methyl)-2-methylphenol

3-({3-[3-(tert-butylaminomethyl)octahydroisoquinolin-2-yl]-2-hydroxy-1-phenylsulfanylmethylpropylamino}methyl)-2-methylphenol

Conditions
ConditionsYield
Stage #1: nelfinavir With borane-THF In tetrahydrofuran at 65℃; Inert atmosphere;
Stage #2: With piperidine In methanol at 65℃; Inert atmosphere;

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