CAS No.161552-03-0,CYCLO (ARG-GLY-ASP-D-PHE-LYS) Suppliers

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Cyclo (-RGDfK) manufacturer/supplier

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% CYCLO (ARG-GLY-ASP-D-PHE-LYS) 161552-03-0 GMP Manufacturer

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality CYCLO (ARG-GLY-ASP-D-PHE-LYS)

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production Cyromazine、lead diacetate trihydrate /Lead acetate trihydrateC、 2-phenylacetamide 、 4-Aminophenyl-1-phenethylpiperidine 、Citric acid monohydrate 、 Citric acid/c

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

Cyclo(-Arg-Gly-Asp-D-Phe-Lys)

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

CYCLO (ARG-GLY-ASP-D-PHE-LYS) 161552-03-0

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Qingdao Beluga Import and Export Co., LTD

CYCLO (ARG-GLY-ASP-D-PHE-LYS) CAS:161552-03-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality or

CYCLO (ARG-GLY-ASP-D-PHE-LYS) CAS:161552-03-0

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

c(RGDfK)

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

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Henan Tianfu Chemical Co., Ltd.

CYCLO (ARG-GLY-ASP-D-PHE-LYS) Basic information Product Name: CYCLO (ARG-GLY-ASP-D-PHE-LYS) Synonyms: CYCLO(-RGDFK);CYCLO (ARG-GLY-ASP-D-PHE-LYS);cyclo (Arg-Gly-Asp-Phe-Lys);c(RGDfK);Cyc

TIANFU-CHEM CAS:161552-03-0 CYCLO (ARG-GLY-ASP-D-PHE-LYS)

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

CYCLO (ARG-GLY-ASP-D-PHE-LYS)

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

cyclo (Arg-Gly-Asp-Phe-Lys)

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

cyclo (Arg-Gly-Asp-Phe-Lys)

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

cyclo (Arg-Gly-Asp-Phe-Lys)

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Cyclic RGDFK peptide

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists，engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

cyclo (Arg-Gly-Asp-Phe-Lys)

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Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

CYCLO (ARG-GLY-ASP-D-PHE-LYS)

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Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment .5) We can do different t

99% up by HPLC CYCLO (ARG-GLY-ASP-D-PHE-LYS) 161552-03-0

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

c(RGDfK)

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Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Cyclo(-Arg-Gly-Asp-D-Phe-Lys) 25mg

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

CYCLO (ARG-GLY-ASP-D-PHE-LYS)

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Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

CYCLO (ARG-GLY-ASP-D-PHE-LYS)

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BOC Sciences

BOC Sciences is committed to supplying cost-effective products and services. We provide Cyclo (-RGDfK). Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor.More information please visit:www.bocsci.com/cyclo-rgdfk-cas-161552-

Cyclo (-RGDfK)

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

CYCLO (ARG-GLY-ASP-D-PHE-LYS)

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

CYCLO (ARG-GLY-ASP-D-PHE-LYS)

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Hubei Langyou International Trading Co., Ltd

cyclo (Arg-Gly-Asp-Phe-Lys) Application:cyclo (Arg-Gly-Asp-Phe-Lys)

cyclo (Arg-Gly-Asp-Phe-Lys)

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Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Cyclic RGDFK peptide CAS No.161552-03-0

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Synthetic route

: C42H51ClN10O11

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol; acetic acid at 20℃; for 18h;	100%

: Fmoc-Asp(OAll)-Pol

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 86123-10-6
Fmoc-D-Phe-OH

: Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Stage #1: Fmoc-Asp(OAll)-Pol Stage #2: N-(fluoren-9-ylmethoxycarbonyl)glycine Stage #3: Fmoc-Lys(tert-butoxycarbonyl); Fmoc-D-Phe-OH; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine Further stages;	43%

...Expand

: 2-chlorotrityl resin

: Fmoc-dPhe-OH

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 111061-54-2
Nα-Fmoc-Nε-Trt-Lys

: Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Stage #1: H-Gly-(2-Cl)-Trt-pol; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine With N-ethyl-N,N-diisopropylamine; [ethyl cyano(hydroxyimino)acetato-O2]tri-1-pyrrolidinylphosphonium hexafluorophosphate at 20℃; for 1h; 2-CT Cl resin; Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.1h; Stage #3: Fmoc-dPhe-OH; Fmoc-(tBu)Asp-OH; Nα-Fmoc-Nε-Trt-Lys Further stages;	43%

Yield

Stage #1: H-Gly-(2-Cl)-Trt-pol; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine With N-ethyl-N,N-diisopropylamine; [ethyl cyano(hydroxyimino)acetato-O2]tri-1-pyrrolidinylphosphonium hexafluorophosphate at 20℃; for 1h; 2-CT Cl resin;
Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.1h;
Stage #3: Fmoc-dPhe-OH; Fmoc-(tBu)Asp-OH; Nα-Fmoc-Nε-Trt-Lys Further stages;

43%

...Expand

: 2-chlorotrityl resin

: Fmoc-dPhe-OH

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 159766-56-0
Fmoc-Lys(OAc)-OH

: Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Stage #1: H-Gly-(2-Cl)-Trt-pol; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine With N-ethyl-N,N-diisopropylamine; [ethyl cyano(hydroxyimino)acetato-O2]tri-1-pyrrolidinylphosphonium hexafluorophosphate at 20℃; for 1h; 2-CT Cl resin; Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 0.1h; Stage #3: Fmoc-dPhe-OH; Fmoc-(tBu)Asp-OH; Fmoc-Lys(OAc)-OH Further stages;	43%

Yield

43%

...Expand

: 388633-54-3
C45H67N9O10S

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
With chlorotriisopropylsilane; water; trifluoroacetic acid for 2h;

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 86123-10-6
Fmoc-D-Phe-OH

: 186350-56-1
Alloc-L-Lys(N-Fmoc)-OH

R(Pmc)-G linear peptide bound to resin: R(Pmc)-G linear peptide bound to resin

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multistep reaction;

...Expand

: 71989-14-5
Fmoc-(tBu)Asp-OH

Fmoc-Asn-OHFmoc-Leu-OH: Fmoc-Asn-OHFmoc-Leu-OH

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Pd(PPh3)4; PhSiH3 2: TFA; triisopropylsilane; water / 2 h View Scheme

: 86123-10-6
Fmoc-D-Phe-OH

bis-1,4-aminomethylcyclohexane on chlorotrityl resin: bis-1,4-aminomethylcyclohexane on chlorotrityl resin

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Pd(PPh3)4; PhSiH3 2: TFA; triisopropylsilane; water / 2 h View Scheme

: 146982-27-6
(S)-6-allyloxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Pd(PPh3)4; PhSiH3 2: TFA; triisopropylsilane; water / 2 h View Scheme

: 343312-39-0
cyclo(-D(tBu)-f-K(Aloc)-R(Pmc)-G-)

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Pd(PPh3)4; PhSiH3 2: TFA; triisopropylsilane; water / 2 h View Scheme

: 1035105-00-0
C39H56N10O11

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
for 2h; UV-irradiation;

: C74H84N9O12PolS

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
With chlorotriisopropylsilane; trifluoroacetic acid In dichloromethane at 20℃; for 3h; solid phase reaction;	0.45 mg

: 1035105-00-0
C39H56N10O11

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
for 1.5h; Irradiation;	92 %Chromat.

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 86123-10-6
Fmoc-D-Phe-OH

: 146982-24-3
N-alpha-(9-fluorenylmethyloxycarbonyl)-L-aspartic acid beta-allyl ester

: Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Stage #1: N-alpha-(9-fluorenylmethyloxycarbonyl)-L-aspartic acid beta-allyl ester With N-ethyl-N,N-diisopropylamine In dichloromethane for 3h; 2-chlorotrityl chloride polystyrene resin; Stage #2: With piperidine In 1-methyl-pyrrolidin-2-one for 0.416667h; Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Lys(tert-butoxycarbonyl); Fmoc-D-Phe-OH; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine Further stages;

Yield

Stage #1: N-alpha-(9-fluorenylmethyloxycarbonyl)-L-aspartic acid beta-allyl ester With N-ethyl-N,N-diisopropylamine In dichloromethane for 3h; 2-chlorotrityl chloride polystyrene resin;
Stage #2: With piperidine In 1-methyl-pyrrolidin-2-one for 0.416667h;
Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Lys(tert-butoxycarbonyl); Fmoc-D-Phe-OH; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine Further stages;

...Expand

: c[R]GDfK

A: 54711-38-5
7-(diethylamino)-4-(hydroxymethyl)-2H-chromen-2-one

B: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
With water In aq. buffer pH=7.4; Irradiation;

: C21H29BrN8O8

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1.1: dichloromethane / 20 °C 2.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor 2.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor 3.1: hydrogenchloride / 1,4-dioxane / 20 °C 4.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor 4.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor 5.1: hydrogenchloride / 1,4-dioxane / 20 °C 6.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor 6.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor 7.1: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C 8.1: acetonitrile / 0.08 h / 20 °C / UV-irradiation; Flow reactor 9.1: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 18 h / 20 °C View Scheme

Yield

Multi-step reaction with 9 steps
1.1: dichloromethane / 20 °C
2.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor
2.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor
3.1: hydrogenchloride / 1,4-dioxane / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor
4.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor
5.1: hydrogenchloride / 1,4-dioxane / 20 °C
6.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor
6.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor
7.1: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C
8.1: acetonitrile / 0.08 h / 20 °C / UV-irradiation; Flow reactor
9.1: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 18 h / 20 °C
View Scheme

: C16H21BrN8O6*C2HF3O2

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor 1.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor 2.1: hydrogenchloride / 1,4-dioxane / 20 °C 3.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor 3.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor 4.1: hydrogenchloride / 1,4-dioxane / 20 °C 5.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor 5.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor 6.1: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C 7.1: acetonitrile / 0.08 h / 20 °C / UV-irradiation; Flow reactor 8.1: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 18 h / 20 °C View Scheme

Yield

Multi-step reaction with 8 steps
1.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor
1.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor
2.1: hydrogenchloride / 1,4-dioxane / 20 °C
3.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor
3.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor
4.1: hydrogenchloride / 1,4-dioxane / 20 °C
5.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor
5.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor
6.1: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C
7.1: acetonitrile / 0.08 h / 20 °C / UV-irradiation; Flow reactor
8.1: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 18 h / 20 °C
View Scheme

: C35H46BrClN10O11

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: hydrogenchloride / 1,4-dioxane / 20 °C 2.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor 2.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor 3.1: hydrogenchloride / 1,4-dioxane / 20 °C 4.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor 4.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor 5.1: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C 6.1: acetonitrile / 0.08 h / 20 °C / UV-irradiation; Flow reactor 7.1: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 18 h / 20 °C View Scheme

Yield

Multi-step reaction with 7 steps
1.1: hydrogenchloride / 1,4-dioxane / 20 °C
2.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor
2.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor
3.1: hydrogenchloride / 1,4-dioxane / 20 °C
4.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor
4.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor
5.1: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C
6.1: acetonitrile / 0.08 h / 20 °C / UV-irradiation; Flow reactor
7.1: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 18 h / 20 °C
View Scheme

: C30H38BrClN10O9*ClH

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor 1.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor 2.1: hydrogenchloride / 1,4-dioxane / 20 °C 3.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor 3.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor 4.1: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C 5.1: acetonitrile / 0.08 h / 20 °C / UV-irradiation; Flow reactor 6.1: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 18 h / 20 °C View Scheme

Yield

Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor
1.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor
2.1: hydrogenchloride / 1,4-dioxane / 20 °C
3.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor
3.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor
4.1: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C
5.1: acetonitrile / 0.08 h / 20 °C / UV-irradiation; Flow reactor
6.1: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 18 h / 20 °C
View Scheme

: C44H55BrClN11O12

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: hydrogenchloride / 1,4-dioxane / 20 °C 2.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor 2.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor 3.1: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C 4.1: acetonitrile / 0.08 h / 20 °C / UV-irradiation; Flow reactor 5.1: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 18 h / 20 °C View Scheme

Yield

Multi-step reaction with 5 steps
1.1: hydrogenchloride / 1,4-dioxane / 20 °C
2.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor
2.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor
3.1: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C
4.1: acetonitrile / 0.08 h / 20 °C / UV-irradiation; Flow reactor
5.1: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 18 h / 20 °C
View Scheme

: C39H47BrClN11O10*ClH

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor 1.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor 2.1: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C 3.1: acetonitrile / 0.08 h / 20 °C / UV-irradiation; Flow reactor 4.1: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 18 h / 20 °C View Scheme

Yield

Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine; bis(trichloromethyl) carbonate / N,N-dimethyl-formamide; acetonitrile / 0 h / 20 °C / Flow reactor
1.2: 0 h / 20 °C / pH 8 - 9 / Flow reactor
2.1: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C
3.1: acetonitrile / 0.08 h / 20 °C / UV-irradiation; Flow reactor
4.1: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 18 h / 20 °C
View Scheme

: C55H66BrClN12O15

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride / 1,4-dioxane / 0.67 h / 20 °C 2: acetonitrile / 0.08 h / 20 °C / UV-irradiation; Flow reactor 3: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 18 h / 20 °C View Scheme

: C50H58BrClN12O13

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetonitrile / 0.08 h / 20 °C / UV-irradiation; Flow reactor 2: hydrogen; palladium 10% on activated carbon / methanol; acetic acid / 18 h / 20 °C View Scheme

: Fmoc-Asp(OtBu)-D-Phe-Lys(Boc)-Arg(Pbf)-Gly-OH

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: piperidine / N,N-dimethyl-formamide / 3 h / 0 - 20 °C 2: sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C / pH 8 3: trifluoroacetic acid; methyl-phenyl-thioether; chlorotriisopropylsilane; phenol / 3 h / 20 °C View Scheme

: 942132-29-8
H-Asp(OtBu)-D-Phe-Lys(Boc)-Arg(Pbf)-Gly-OH

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol / N,N-dimethyl-formamide / 24 h / 20 °C / pH 8 2: trifluoroacetic acid; methyl-phenyl-thioether; chlorotriisopropylsilane; phenol / 3 h / 20 °C View Scheme

: 545376-68-9
cyclized H2N-Asp(OtBu)-D-Phe-Lys(Boc)-Arg(Pbf)-Gly-OH

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
With chlorotriisopropylsilane; methyl-phenyl-thioether; trifluoroacetic acid; phenol at 20℃; for 3h;
With chlorotriisopropylsilane; water; trifluoroacetic acid at 20℃; for 24h;

: Gly-Arg(Pbf)-Lys(Boc)-D-Phe-Asp(OtBu)-OH

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 24 h / 20 °C 2: trifluoroacetic acid; water; chlorotriisopropylsilane / 24 h / 20 °C View Scheme

: C45H67N9O13S

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate; diphenyl phosphoryl azide / N,N-dimethyl-formamide 2: trifluoroacetic acid; chlorotriisopropylsilane / water / 2 h / 20 °C View Scheme

: C45H65N9O12S

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
With chlorotriisopropylsilane; trifluoroacetic acid In water at 20℃; for 2h;

: C56H67ClN11O8Pol

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

Conditions

Conditions	Yield
Stage #1: C56H67ClN11O8Pol With hydrazine hydrate In N,N-dimethyl-formamide for 0.0833333h; CTC-resin; Stage #2: With methyl-phenyl-thioether; ethane-1,2-dithiol; methoxybenzene; trifluoroacetic acid CTC-resin;

: 1145938-00-6
C14H21N5O7

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: 1145938-02-8
C37H57N13O11

Conditions

Conditions	Yield
In dimethyl sulfoxide; acetonitrile	99%

: 1378531-80-6
ADIBO-PEG5-N-succinimidyl ester

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: 1415001-59-0
C59H79N11O15

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 20℃;	90%

: 1422540-83-7
C26H39NO13

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: 1422541-06-7
C47H75N9O17

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 15h; Inert atmosphere;	86%

: 1,3-bis[4, 10-bis(carboxymethyl)-1,4,10-triaza-7-oxacyclododec-1-ylmethyl]-5-isothiocyanatobenzene hydrochloride salt

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C60H92N16O17S

Conditions

Conditions	Yield
In aq. buffer at 20℃; for 24h; pH=9;	84%

: 2,5-dioxopyrrolidin-1-yl (E)-3-(2-(2-(4-(dicyanomethylene)-6-methyl-4H-pyran-2-yl)vinyl)-7-(diphenylamino)-9-(2-(2-ethoxyethoxy)ethyl)-9H-fluoren-9-yl)propanoate

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C72H80N12O11

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere;	82%

: 6-[(2-ethylcarbamothioyl)hydrazinyl]-3-pyridinecarboxylic acid

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C36H51N13O8S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	80%

: C52H50N12O10Si

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C79H89N21O16Si

Conditions

Conditions	Yield
Stage #1: C52H50N12O10Si With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 4h; Stage #2: [(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	78%

: cholesterol-tetraethylene glycol-DSC

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: cholesterol-cRGDfK

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 16h;	74%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 16h;	74%

: 132178-37-1
2,5-dioxopyrrolidin-1-yl pent-4-ynoate

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: 1076242-17-5
cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-N6-pent-4-ynoyl-L-lysyl)

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide	70%

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: 541-88-8
Chloroacetic anhydride

: cyclo[Lys(ClAc)-Arg-Gly-Asp-D-Phe]

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 10h;	65%

: 55750-63-5
6-maleimidohexanoic acid N-hydroxylsuccinimide ester

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C37H52N10O10

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 4h;	64.1%

: C48H60N5O8S(1+)*I(1-)*Na(1+)

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C75H99N14O14S(1+)*I(1-)*Na(1+)

Conditions

Conditions	Yield
Stage #1: C48H60N5O8S(1+)I(1-)Na(1+) With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere; Stage #2: With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In N,N-dimethyl-formamide for 3h; Inert atmosphere; Stage #3: [(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 18h;	60%

Yield

Stage #1: C48H60N5O8S(1+)*I(1-)*Na(1+) With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Inert atmosphere;
Stage #2: With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In N,N-dimethyl-formamide for 3h; Inert atmosphere;
Stage #3: [(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 18h;

60%

: 91487-18-2
2,5-dioxopyrrolidin-1-yl 3-iodobenzoate

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C34H44IN9O8

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide for 3h;	59%

: C18H18N6O5

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C41H54N14O9

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.5h;	57%

: 60444-78-2
succinimidyl 4-formylbenzoate

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: 1261036-91-2
C35H45N9O9

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 1h; pH=7.5; aq. phosphate buffer;	56%

: 6-[2-(phenylcarbamothioyl)hydrazinyl]-3-pyridinecarboxylic acid

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C40H51N13O8S

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;	55%

: rel-(1R-4E-pS)-cyclooct-4-ene-1-yl (4-nitrophenyl) carbonate

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C36H53N9O9

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 6h;	52%

: C42H48N6O10Pd

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: palladium 31-oxo-15-methoxycarbonylmethyl-rhodobacteriochlorin 131-(2,3-dihydroxypropyl)amide-173-(cycloRGDfK)amide

Conditions

Conditions	Yield
With triethylamine In 1-methyl-pyrrolidin-2-one for 1.25h;	50%

: 1338496-56-2
2,5-dioxopyrrolidin-1-yl-6-(4-(dimethylamino)phenoxy)hexanoate

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: 1338496-53-9
C41H60N10O9

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In water; N,N-dimethyl-formamide at 20℃;	50%

: [Ru(2,2′:6′,2″-terpyridine)(2,2′-bipyridine)(D-biotin)](Cl)2

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C62H74N16O9RuS(2+)*2Cl(1-)

Conditions

Conditions	Yield
Stage #1: [Ru(2,2′:6′,2″-terpyridine)(2,2′-bipyridine)(D-biotin)](Cl)2 With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxy-2,5-dioxopyrrolidine-3-sulfonic acid In dimethyl sulfoxide at 20℃; for 24h; Darkness; Stage #2: [(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid With triethylamine pH=7; Darkness;	50%

Yield

Stage #1: [Ru(2,2′:6′,2″-terpyridine)(2,2′-bipyridine)(D-biotin)](Cl)2 With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxy-2,5-dioxopyrrolidine-3-sulfonic acid In dimethyl sulfoxide at 20℃; for 24h; Darkness;
Stage #2: [(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid With triethylamine pH=7; Darkness;

50%

: 172531-37-2
11-azido-3,6,9-trioxaundecanoic acid

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: 2-((2S,5R,8S,11S)-8-(1-azido-11-oxo-3,6,9-trioxa-12-azahexadecan-16-yl)-5-benzyl-11-(3-guanidinopropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid

Conditions

Conditions	Yield
Stage #1: 11-azido-3,6,9-trioxaundecanoic acid With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20℃; Stage #2: [(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid In dimethyl sulfoxide at 20℃;	48.3%

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: 655246-28-9
(3R,4R,5R,6S)-6-((((9H-fluoren-9-yl)methoxy)carbonylamino)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

: C49H62N10O14

Conditions

Yield

Stage #1: (3R,4R,5R,6S)-6-((((9H-fluoren-9-yl)methoxy)carbonylamino)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: [(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 6h;

43%

: 5,5′,5″-(((1,4,7-triazonane-1,4,7-triyl)tris(methylene))tris(1H-imidazole-2,1-diyl))tripentanoic acid

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C114H168N36O24

Conditions

Yield

Stage #1: 5,5′,5″-(((1,4,7-triazonane-1,4,7-triyl)tris(methylene))tris(1H-imidazole-2,1-diyl))tripentanoic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: [(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid In N,N-dimethyl-formamide for 2h;

41%

: 1542144-06-8
C16H22Cl2N4O12Pt

: C54H61N9O11Si

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C89H114Cl2N20O24PtSi

Conditions

Conditions	Yield
Stage #1: C54H61N9O11Si; [(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 20℃; for 0.166667h; Stage #2: C16H22Cl2N4O12Pt In dimethyl sulfoxide at 20℃; for 24h;	40%

...Expand

: C49H49N3O10S2*2H3N

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C72H85N11O14S2

Conditions

Conditions	Yield
Stage #1: [(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.00833333h; Stage #2: C49H49N3O10S2*2H3N In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;	36%

: N-succinimidyl 3-bromobenzoate

: 161552-03-0
[(2S,5R,8S,11S)-8-(4-Amino-butyl)-5-benzyl-11-(3-guanidino-propyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid

: C34H44BrN9O8

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide for 3h;	35%

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