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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Estrone 3-methyl ether Manufacturer/High quality/Best price/In stock

Cas:1624-62-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Estrone 3-Methyl Ether supplier in China

Cas:1624-62-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

Basic Information Product Name 3-methylether-estrone Appearance White Powder Odor &Taste Charac

CAS:1624-62-0 Estrone 3-methyl ether

Cas:1624-62-0

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hangzhou Think Chemical Co. Ltd

Estrone 3-methyl ether CAS No.:1624-62-0 Name: Estrone 3-methyl ether Synonyms: 3-Methoxy-1,3,5(10)-estratrien-17-one Molecular Structure Molecular Formula: C19H24O2 Molecular

High purity Estrone 3-methyl ether CAS No.:1624-62-0

Cas:1624-62-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-methoxyoestra-1,3,5(10)-trien-17-one

Cas:1624-62-0

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Estrone 3-methyl ether

Cas:1624-62-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Estrone3-methylether The alias:NSC88911 CAS NO:1624-62-0 EINECS NO:216-613-3 Molecular formula:C19H24O2 Molecular weight:284.39 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Da

Estrone 3-methyl ether/CAS:1624-62-0/with favorable price

Cas:1624-62-0

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

CAS No.1624-62-0 Estrone 3-methyl ether Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business

CAS No.1624-62-0 Estrone 3-methyl ether

Cas:1624-62-0

Min.Order:1 Liter

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 1624-62-0 with best quality

Cas:1624-62-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Estrone 3-methyl ether/ LIDE PHARMA- Factory supply / Best price

Cas:1624-62-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Estrone 3-methyl ether

Cas:1624-62-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Estra-1,3,5(10)-trien-17-one,3-methoxy- 1624-62-0

Cas:1624-62-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Estrone 3-methyl ether CAS:1624-62-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic in

Estrone 3-methyl ether CAS:1624-62-0

Cas:1624-62-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Estra-1,3,5(10)-trien-17-one,3-methoxy-

Cas:1624-62-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Estra-1,3,5(10)-trien-17-one,3-methoxy-

Cas:1624-62-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Product name: sodium metabisulfite / sodium metabisulphite Molecular weight: 190.10 Specification: 25Kg woven bag Quality guarantee period: 6 months Appearance:white powder/crystal Storage:Store in a cool,dry place and keep away fr

Estrone 3-Methyl Ether

Cas:1624-62-0

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Estrone 3-methyl ether 1624-62-0

Cas:1624-62-0

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

ESTORONE 3-METHYL ETHER

Cas:1624-62-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Estra-1,3,5(10)-trien-17-one,3-methoxy-

Cas:1624-62-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Estrone 3-Methyl Ether

Cas:1624-62-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Estrone3-methylether

Cas:1624-62-0

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

1624-62-0 CAS NO.1624-62-0

Cas:1624-62-0

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3–methylether–estrone

Cas:1624-62-0

Min.Order:0

Negotiable

Type:Manufacturers

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SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

Estrone-3-methylether

Cas:1624-62-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

3-METHOXYESTRONE

Cas:1624-62-0

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

3-Methoxy-1,3,5(10)-estratrien-17-one

Cas:1624-62-0

Min.Order:0

Negotiable

Type:Manufacturers

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Estrone 3-methyl ether

Cas:1624-62-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

with high qualityAppearance:white powder Storage:Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Package:25kg/drum Application:to formulate preparations Transportation:by courier, air or sea Port:At any port fro

Estrone 3-methyl ether 1624-62-0 API

Cas:1624-62-0

Min.Order:0

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

stable supply&competitive price Storage:Available Package:25KG Or as client requirement Application:Important pharm intermediate Transportation:By air or By sea

3–methylether–estrone

Cas:1624-62-0

Min.Order:0

Negotiable

Type:Trading Company

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HANGZHOU CLAKE BIOTECH CO.,LTD

1. ISO AVALIABLE ; 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE EP/USP both ok Appearance:WHITE POWDER Storage:in cool Package:25kg/drum Application:active pharmaceutical ingredient Transportation:as request Port:any

Estrone 3-methyl-ether

Cas:1624-62-0

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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Synthetic route

17α-cyano-3-methoxy-17β-(methoxycarbonyloxy)estra-1,3,5(10)-triene

17α-cyano-3-methoxy-17β-(methoxycarbonyloxy)estra-1,3,5(10)-triene

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With water; potassium carbonate In methanol at 20℃; for 4h; Hydrolysis;100%
With potassium carbonate In methanol; water at 20℃; for 18h; Product distribution; Further Variations:; Reagents; Solvents; pH-values; Hydrolysis;92%
Estrone
53-16-7

Estrone

methyl iodide
74-88-4

methyl iodide

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; sodium hydroxide In dichloromethane at 70℃; for 3h;99%
With potassium carbonate In N,N-dimethyl-formamide Heating;98%
With potassium carbonate In N,N-dimethyl-formamide 1) reflux, 2 h, 2) r.t., 5 d;97%
Estrone
53-16-7

Estrone

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 16h;99%
17,17-ethylenedioxy-3-methoxyoestra-1,3,5(10)-triene
28336-29-0

17,17-ethylenedioxy-3-methoxyoestra-1,3,5(10)-triene

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 2h;98.3%
With hydrogenchloride In water; acetone
Estrone
53-16-7

Estrone

dimethyl sulfate
77-78-1

dimethyl sulfate

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With sodium hydroxide In water; acetone for 2h; Reflux;98%
With sodium hydride In tetrahydrofuran at 0 - 20℃;97%
With sodium hydride In tetrahydrofuran at 20℃; for 2h;97%
3-O-methyl-17β-oestradiol
1035-77-4

3-O-methyl-17β-oestradiol

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In N,N-dimethyl-formamide at 23 - 25℃; for 4h;98%
With 1-hydroxy-1.oxo-1H-1λ5-benzo[d][1,2]iodoxol-3-one pyridinium salt In tetrahydrofuran at 24 - 28℃; for 24h;95%
With oxone; C18H17IN2O7PolS(1-)*Na(1+); tetra(n-butyl)ammonium hydrogensulfate In acetonitrile at 70℃; for 18h; Sealed tube; Green chemistry;61%
Multi-step reaction with 2 steps
1: 96 percent / pyridine / 24 h
2: 28 percent / KOAc / dimethylsulfoxide / 6 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / benzene / 12 h / Ambient temperature
2: NaN3, water / acetone / 1 h / Heating
3: 35 percent / CCl4 / 6 h / 100 °C
View Scheme
Conditions
ConditionsYield
With diisopropyl-carbodiimide In toluene at 120℃; for 24h; Inert atmosphere; Sealed tube;96%
With Dess-Martin periodane In dichloromethane at 20℃; for 3h; Inert atmosphere;1.26 g
17-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene-17-β-ol

17-hydroxymethyl-3-methoxyestra-1,3,5(10)-triene-17-β-ol

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With oxygen; sodium methylate; silver trifluoromethanesulfonate In tetrahydrofuran; methanol at 37℃; for 12h;94%
3-O-methyl-estra-1,3,5(10),6-tetraen-17-one
17253-36-0

3-O-methyl-estra-1,3,5(10),6-tetraen-17-one

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With hydrogen In tetrahydrofuran at 20℃; for 1.5h; Catalytic behavior; Solvent; Time;93%
Estrone
53-16-7

Estrone

tetramethlyammonium chloride
75-57-0

tetramethlyammonium chloride

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With caesium carbonate In 1,2-dimethoxyethane at 145℃; for 2h; Microwave irradiation; Inert atmosphere; Sealed vessel;90%
{5-Methoxy-2-[3-((1S,5S)-1-methyl-2-oxo-5-vinyl-cyclopentyl)-1-trimethylsilanyl-propyl]-benzyl}-trimethyl-ammonium; iodide
76463-52-0

{5-Methoxy-2-[3-((1S,5S)-1-methyl-2-oxo-5-vinyl-cyclopentyl)-1-trimethylsilanyl-propyl]-benzyl}-trimethyl-ammonium; iodide

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With cesium fluoride In acetonitrile for 1.5h; Heating;86%
3-methoxy-estra-1,3,5(10),8(9),14(15)-pentaene-17-one
966-47-2

3-methoxy-estra-1,3,5(10),8(9),14(15)-pentaene-17-one

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
Stage #1: 3-methoxy-estra-1,3,5(10),8(9),14(15)-pentaene-17-one With palladium 10% on activated carbon; hydrogen In benzene at 0℃; for 12h;
Stage #2: With triethylsilane; trifluoroacetic acid In benzene at 20℃; for 13h; stereoselective reaction;
82%
Stage #1: 3-methoxy-estra-1,3,5(10),8(9),14(15)-pentaene-17-one With triethylsilane; palladium 10% on activated carbon; hydrogen In benzene at 0℃; for 20h;
Stage #2: With tetra-(n-butyl)ammonium iodide; trifluoroacetic acid In dichloromethane at 0℃; for 5h;
71%
19-acetoxyandrosta-1,4-diene-3,17-dione
95282-98-7

19-acetoxyandrosta-1,4-diene-3,17-dione

trimethyl orthoformate
149-73-5

trimethyl orthoformate

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With toluene-4-sulfonic acid In methanol at 60℃; for 1h;82%
17β-hydroxy-3-methoxy-1,3,5(10),14-estratetraene
35644-58-7

17β-hydroxy-3-methoxy-1,3,5(10),14-estratetraene

A

3-O-methyl-17β-oestradiol
1035-77-4

3-O-methyl-17β-oestradiol

B

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

C

3-methoxy-14β-1,3,5(10)-estratriene-17β-ol
90025-05-1

3-methoxy-14β-1,3,5(10)-estratriene-17β-ol

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol for 10h; Ambient temperature;A 5%
B 3%
C 81%
methylene chloride
74-87-3

methylene chloride

Estrone
53-16-7

Estrone

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With potassium carbonate; phosphonium resin In dichloromethane; water; N,N-dimethyl-formamide for 120h; Ambient temperature;73%
(+)-3-methoxy-1,3,5(10),8-estratetraen-17-one
6885-44-5

(+)-3-methoxy-1,3,5(10),8-estratetraen-17-one

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With triethylsilane; trifluoroacetic acid In benzene for 12h; Ambient temperature;73%
With triethylsilane; trifluoroacetic acid In dichloromethane; benzene65%
With chromium(VI) oxide; aniline 1) liq. NH3, 2) acetone, H2O 1 h, r. t.; Yield given. Multistep reaction;
C23H35N2O3P

C23H35N2O3P

A

3-methoxyestra-1,3,5(10),16-tetraene
28336-31-4

3-methoxyestra-1,3,5(10),16-tetraene

B

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With lithiumnaphthalide (0.66 M in THF) In tetrahydrofuran at 25℃; for 0.5h;A 73%
B 13%
(+)-3-methoxy-17β-2-(quinolinylmethoxy)-estra-1,3,5(10)-triene
142820-33-5

(+)-3-methoxy-17β-2-(quinolinylmethoxy)-estra-1,3,5(10)-triene

A

3-methoxy-13α-estra-1,3,5(10)-trien-17-one
17554-55-1

3-methoxy-13α-estra-1,3,5(10)-trien-17-one

B

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
In acetonitrile for 4h; Irradiation;A 12%
B 72%
(2S,3S)-2-[2-(3-Methoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-ethyl]-2-methyl-3-vinyl-cyclopentanone
106212-95-7

(2S,3S)-2-[2-(3-Methoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-ethyl]-2-methyl-3-vinyl-cyclopentanone

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
In 1,2-dichloro-benzene at 180℃;70%
methanol
67-56-1

methanol

estra-4-ene-3,17-dione
734-32-7

estra-4-ene-3,17-dione

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With copper(ll) bromide; trimethyl orthoformate for 0.666667h; Heating;70%
3-methoxy-1,3,5(10)-estratrien-17α-ol
3434-76-2

3-methoxy-1,3,5(10)-estratrien-17α-ol

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With potassium dichromate; supported on AlPO-BPO In diethyl ether for 0.75h; Ambient temperature;54%
methanol
67-56-1

methanol

estra-4-ene-3,17-dione
734-32-7

estra-4-ene-3,17-dione

A

3-O-methylestra-1,3,5(10)-trien-3-ol-6,17-dione
19115-79-8

3-O-methylestra-1,3,5(10)-trien-3-ol-6,17-dione

B

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With ammonium cerium(IV) nitrate; iodine for 2h; Heating;A 27%
B 48%
With iodine; ammonium cerium (IV) nitrate for 2h; Heating / reflux;A 40%
B 47%
With copper(ll) bromide for 1h; Heating;A n/a
B 39%
17α-trimethylsilylacetylenyl-3-methoxy-1,3,5(10)-estratrien-17β-ol
50866-94-9

17α-trimethylsilylacetylenyl-3-methoxy-1,3,5(10)-estratrien-17β-ol

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With dicarbonylcyclopentadienylcobalt In xylene for 12h; Heating;48%
3-methoxyestra-1,3,5(10)-trien-17β-yl p-toluenesulfonate
54064-42-5

3-methoxyestra-1,3,5(10)-trien-17β-yl p-toluenesulfonate

potassium acetate
127-08-2

potassium acetate

A

3-methoxy-1,3,5(10)-estratrien-17α-ol
3434-76-2

3-methoxy-1,3,5(10)-estratrien-17α-ol

B

3-methoxy-17ξ-methylestra-1,3,5(10),13-tetraene
114297-13-1

3-methoxy-17ξ-methylestra-1,3,5(10),13-tetraene

C

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
In dimethyl sulfoxide at 100℃; for 6h; Mechanism; Product distribution; also in the presence of acetic acid and without DMSO.;A 45%
B 26%
C 28%
3-methoxyestra-1,3,5(10)-trien-17β-yl p-toluenesulfonate
54064-42-5

3-methoxyestra-1,3,5(10)-trien-17β-yl p-toluenesulfonate

A

3-methoxy-1,3,5(10)-estratrien-17α-ol
3434-76-2

3-methoxy-1,3,5(10)-estratrien-17α-ol

B

3-methoxy-17ξ-methylestra-1,3,5(10),13-tetraene
114297-13-1

3-methoxy-17ξ-methylestra-1,3,5(10),13-tetraene

C

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With potassium acetate In dimethyl sulfoxide at 100℃; for 6h;A 45%
B 26%
C 28%
mestranol
72-33-3

mestranol

A

C63H78O6

C63H78O6

B

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With dicarbonylcyclopentadienylcobalt In xylene at 140℃; for 2.5h;A 44%
B 12%
(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro(cyclopenta[a]phenanthrene-17,2'-oxirane)
16669-02-6

(8R,9S,13S,14S,17S)-3-methoxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydrospiro(cyclopenta[a]phenanthrene-17,2'-oxirane)

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With pyridinium chlorochromate In dichloromethane for 5h; Ambient temperature;40%
Estrone
53-16-7

Estrone

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In methanol; hexane; acetonitrile for 18h; Ambient temperature;38%
4-(Dimethylamino)azoestrone 3-Methyl Ether
74356-39-1

4-(Dimethylamino)azoestrone 3-Methyl Ether

A

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

B

4,6-Diazaethenoestrone 3-Methyl Ether
13945-93-2

4,6-Diazaethenoestrone 3-Methyl Ether

Conditions
ConditionsYield
With pyridine hydrogenfluoride In benzene 1.) room temperature, 30 min, 2.) 50 deg C, 10 min;A 15%
B 36%
estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

2-(aminooxy)-2-methylpropanoic acid hydrochloride

2-(aminooxy)-2-methylpropanoic acid hydrochloride

2-((((8R,9S,13S,14S,E)-3-methoxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-17H-cyclopenta[a]phenanthren-17-ylidene)amino)oxy)-2-methylpropanoic acid

2-((((8R,9S,13S,14S,E)-3-methoxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-17H-cyclopenta[a]phenanthren-17-ylidene)amino)oxy)-2-methylpropanoic acid

Conditions
ConditionsYield
With sodium acetate In methanol Reflux;100%
estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

ethylene glycol
107-21-1

ethylene glycol

17,17-ethylenedioxy-3-methoxyoestra-1,3,5(10)-triene
28336-29-0

17,17-ethylenedioxy-3-methoxyoestra-1,3,5(10)-triene

Conditions
ConditionsYield
Stage #1: ethylene glycol With boron trifluoride diethyl etherate; orthoformic acid triethyl ester at 25℃; for 0.25h;
Stage #2: estrone 3-methyl ether In dichloromethane at 25℃; for 5h;
99%
With toluene-4-sulfonic acid; orthoformic acid triethyl ester at 70℃; for 1h;99%
With toluene-4-sulfonic acid In benzene for 12h;
With toluene-4-sulfonic acid
1,3-diethynylbenzene
1785-61-1

1,3-diethynylbenzene

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

C29H30O2
1227009-27-9

C29H30O2

Conditions
ConditionsYield
Stage #1: 1,3-diethynylbenzene With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere;
Stage #2: estrone 3-methyl ether In tetrahydrofuran at -50℃; for 3h; Inert atmosphere;
99%
methylmagnesium bromide
75-16-1

methylmagnesium bromide

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

(8R,9S,13S,14S,17S)-3-methoxy-13,17-dimethyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol
15236-73-4

(8R,9S,13S,14S,17S)-3-methoxy-13,17-dimethyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol

Conditions
ConditionsYield
In diethyl ether; benzene for 2h; Inert atmosphere; Reflux;99%
In tetrahydrofuran; diethyl ether at 0 - 20℃; Schlenk technique; Inert atmosphere;69%
estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

triphenylmethylhydrazine hydrochloride
104370-29-8

triphenylmethylhydrazine hydrochloride

C38H40N2O

C38H40N2O

Conditions
ConditionsYield
Stage #1: triphenylmethylhydrazine hydrochloride With sodium acetate trihydrate In methanol; water Inert atmosphere;
Stage #2: estrone 3-methyl ether In methanol; dichloromethane; water at 22 - 26℃; for 336h; Inert atmosphere;
99%
estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

cinnamyl tert-butyl carbonate
124517-47-1

cinnamyl tert-butyl carbonate

C28H32O2

C28H32O2

Conditions
ConditionsYield
Stage #1: estrone 3-methyl ether With lithium hexamethyldisilazane In tetrahydrofuran; toluene at 0 - 20℃; for 0.5h; Inert atmosphere;
Stage #2: cinnamyl tert-butyl carbonate With bis(η3-allyl-μ-chloropalladium(II)); potassium tert-butylate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride In tetrahydrofuran; toluene at 20℃; for 24h; Inert atmosphere;
99%
estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

3-methoxy-17-hydroxyestra-2,5(10)-diene
1091-93-6

3-methoxy-17-hydroxyestra-2,5(10)-diene

Conditions
ConditionsYield
With N,N'-Dimethylurea; tris(pyrrolidino)phosphine oxide; lithium bromide In tetrahydrofuran Electrochemical reaction;99%
estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

3-methoxy-16-(4-nitrobenzylidene)-1,3,5(10)-estratrien-17-one

3-methoxy-16-(4-nitrobenzylidene)-1,3,5(10)-estratrien-17-one

Conditions
ConditionsYield
With potassium hydroxide In methanol for 15h; Heating;98.63%
estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

4-cyanobenzaldehyde
105-07-7

4-cyanobenzaldehyde

16-(4-cyanobenzylidene)-3-methoxy-1,3,5(10)-estratrien-17-one

16-(4-cyanobenzylidene)-3-methoxy-1,3,5(10)-estratrien-17-one

Conditions
ConditionsYield
With potassium hydroxide In methanol for 14h; Heating;98.63%
estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

acetylene
74-86-2

acetylene

mestranol
72-33-3

mestranol

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 0 - 20℃;98%
With potassium 2-methylbutan-2-olate
t-butyldimethylsiyl triflate
69739-34-0

t-butyldimethylsiyl triflate

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

tert-Butyl-((8R,9S,13S,14S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthren-17-yloxy)-dimethyl-silane
96157-01-6

tert-Butyl-((8R,9S,13S,14S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthren-17-yloxy)-dimethyl-silane

Conditions
ConditionsYield
With triethylamine In dichloromethane for 0.25h;98%
methyl cyanoformate
17640-15-2

methyl cyanoformate

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

17α-cyano-3-methoxy-17β-(methoxycarbonyloxy)estra-1,3,5(10)-triene

17α-cyano-3-methoxy-17β-(methoxycarbonyloxy)estra-1,3,5(10)-triene

Conditions
ConditionsYield
With N-t-butylethylamine In tetrahydrofuran at 20℃; for 18h; Addition;98%
With diisopropylamine In tetrahydrofuran at 20℃; for 24h; Product distribution; Further Variations:; Reagents; Temperatures; Solvents; reaction time; water presence; concentration of reaction partners; Addition;92%
estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

trimethylsilylacetylene
1066-54-2

trimethylsilylacetylene

17α-trimethylsilylacetylenyl-3-methoxy-1,3,5(10)-estratrien-17β-ol
50866-94-9

17α-trimethylsilylacetylenyl-3-methoxy-1,3,5(10)-estratrien-17β-ol

Conditions
ConditionsYield
Stage #1: trimethylsilylacetylene With n-butyllithium In tetrahydrofuran; hexane at -40 - -20℃; for 1h; Inert atmosphere;
Stage #2: estrone 3-methyl ether In tetrahydrofuran; hexane at -40 - 20℃; for 1.5h; Inert atmosphere;
Stage #3: With hydrogenchloride In tetrahydrofuran; hexane; water
98%
N,N-phenylbistrifluoromethane-sulfonimide
37595-74-7

N,N-phenylbistrifluoromethane-sulfonimide

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

(8R,9S,13S,14S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthren-17-yl trifluoromethanesulfonate
95667-45-1

(8R,9S,13S,14S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthren-17-yl trifluoromethanesulfonate

Conditions
ConditionsYield
With potassium hexamethylsilazane In tetrahydrofuran at -78℃; for 2h;98%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

(8R,9S,13S,14S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthren-17-yl trifluoromethanesulfonate
95667-45-1

(8R,9S,13S,14S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthren-17-yl trifluoromethanesulfonate

Conditions
ConditionsYield
With 2,6-di-tert-butyl-4-methylpyridine In dichloromethane at 20℃; for 12h;97%
With 2,6-di-tert-butyl-4-methylpyridine In dichloromethane88%
With 2,6-di-tert-butyl-4-methylpyridine In dichloromethane at 20℃; for 1h; Inert atmosphere;88%
estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

benzaldehyde
100-52-7

benzaldehyde

3-methoxy-16-benzylidene-estra-1,3,5(10)-triene-17-one

3-methoxy-16-benzylidene-estra-1,3,5(10)-triene-17-one

Conditions
ConditionsYield
With ethylene glycol; N1-butyl-N2,N2,N3,N3-tetramethylguanidine at 50℃; for 4h; Claisen-Schmidt Condensation; Inert atmosphere; Schlenk technique;97%
With potassium hydroxide In ethanol at 100℃; for 0.333333h; Claisen-Schmidt Condensation; Microwave irradiation;497 mg
pyridine-4-carbaldehyde
872-85-5

pyridine-4-carbaldehyde

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

3-methoxy-16-(4-pyridylmethylene)-1,3,5(10)-estratrien-17-one

3-methoxy-16-(4-pyridylmethylene)-1,3,5(10)-estratrien-17-one

Conditions
ConditionsYield
With potassium hydroxide In methanol for 23h; Heating;96.77%
estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

3-O-methyl-17β-oestradiol
1035-77-4

3-O-methyl-17β-oestradiol

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol; water at 20℃; for 72h; Inert atmosphere;96%
With methanol; sodium tetrahydroborate In dichloromethane at 50℃; for 1h;94%
With sodium tetrahydroborate In methanol at 50℃; for 2h;92%
estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

formic acid ethyl ester
109-94-4

formic acid ethyl ester

16-(hydroxymethylene)-3-methoxyestra-1,3,5(10)-trien-17-one
59877-96-2

16-(hydroxymethylene)-3-methoxyestra-1,3,5(10)-trien-17-one

Conditions
ConditionsYield
With sodium methylate In benzene for 4h; Heating;96%
With sodium methylate In benzene93%
With sodium hydride In benzene
With sodium methylate In benzene
With sodium methylate In benzene for 4h; Reflux;
tert-butyldimethylsilyl cyanide
56522-24-8

tert-butyldimethylsilyl cyanide

estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

(17S)-17-<oxy>estrone-17-carbonitrile 3-methyl ether

(17S)-17-<oxy>estrone-17-carbonitrile 3-methyl ether

Conditions
ConditionsYield
zinc(II) iodide In dichloromethane at 25℃; for 2.5h;95%
estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

3-Methoxy-estra-1,3,5(10)-trien-17-on-hydrazone
105663-60-3

3-Methoxy-estra-1,3,5(10)-trien-17-on-hydrazone

Conditions
ConditionsYield
With hydrazine hydrate; triethylamine In ethanol95%
With hydrazine hydrate; triethylamine In ethanol for 6h; Inert atmosphere; Reflux;
With hydrazine
estrone 3-methyl ether
1624-62-0

estrone 3-methyl ether

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

(8R,9S,13S,14S)-methyl 7,8,9,11,12,13,14,15,16,17-decahydro-3-methoxy-13-methyl-17-oxo-6H-cyclopenta[a]phenanthrene-16-carboxylate
135682-91-6

(8R,9S,13S,14S)-methyl 7,8,9,11,12,13,14,15,16,17-decahydro-3-methoxy-13-methyl-17-oxo-6H-cyclopenta[a]phenanthrene-16-carboxylate

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran Heating;95%
With methanol; sodium hydride for 3h; Reflux;95%
With potassium hydride In tetrahydrofuran; mineral oil at 75℃; Inert atmosphere;81%
With potassium hydride In tetrahydrofuran for 3h; Heating;78%

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