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Senova Pharma

Multi-target purpose intermediate with wide usage Commercial production from grams to tons, with technical documents package support, and audit and inspection support. With high purity and optimized and stable process. Self Innovation Appeara

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde

Cas:170985-85-0

Min.Order:10 Gram

Negotiable

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde Manufacturer/High quality/Best price/In stock

Cas:170985-85-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)-propyl]-hydrazinecarboxaldehyde

Cas:170985-85-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde CAS 170985-85-0

Cas:170985-85-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxal 170985-85-0

Cas:170985-85-0

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 170985-85-0 with best quality

Cas:170985-85-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

We are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of 2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldeh

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde

Cas:170985-85-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde/ LIDE PHARMA- Factory supply / Best price

Cas:170985-85-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde

Cas:170985-85-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:170985-85-0

Cas:170985-85-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2-[(1S,2S)-1-ETHYL-2-(PHENYLMETHOXY)PROPYL]HYDRAZINECARBOXALDEHYDE

Cas:170985-85-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde

Cas:170985-85-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 2-[(1S,2S)-1-Ethyl-2-(Phenylmethoxy)Propyl]hydrazinecarboxaldehyde CAS No.:170985-85-0 Molecule Formula:C13H20N2O2 Molecule Weight:236.31 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:En

High Quality 2-[(1S,2S)-1-Ethyl-2-(Phenylmethoxy)Propyl]hydrazinecarboxaldehyde

Cas:170985-85-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde

Cas:170985-85-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou Keying Chem Co., Ltd. Is a comprehensive enterprise, dedicated to the development, production and marketing of chemicals. As a technology innovative and service professional enterprise, Our company mainly engages in global pharmaceutical,

N'-[ (2S,3S)-2-(Benzyloxy)pentan-3-yl]formohydrazide

Cas:170985-85-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

170985-85-0 CAS NO.170985-85-0

Cas:170985-85-0

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

N'-[ (2S,3S)-2-(Benzyloxy)pentan-3-yl]formohydrazide

Cas:170985-85-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde

Cas:170985-85-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazine carboxaldehyde

Cas:170985-85-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde

Cas:170985-85-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde

Cas:170985-85-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehydeAppearance:detailed see specifications Storage:Keep away of light, cool place Package:25kg/drum;200kg/drum Application:It is an important raw material and intermediate used in Organic

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde

Cas:170985-85-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

N-[[(2S,3S)-2-phenylmethoxypentan-3-yl]amino]formamide

Cas:170985-85-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde CAS No.170985-85-0

Cas:170985-85-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde

Cas:170985-85-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde cas 170985-85-0Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by expres

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

170985-85-0

Cas:170985-85-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde

Cas:170985-85-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde

Cas:170985-85-0

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

ethyl bromide
74-96-4

ethyl bromide

(S)-N'-(2-(benzyloxy)propylidene) formohydrazide
170985-84-9

(S)-N'-(2-(benzyloxy)propylidene) formohydrazide

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Stage #1: ethyl bromide With iodine; magnesium In tert-butyl methyl ether at 40 - 55℃; for 2h; Inert atmosphere;
Stage #2: (S)-N'-(2-(benzyloxy)propylidene)formylhydrazide With N,O-bis-(trimethylsilyl)-acetamide In tert-butyl methyl ether at 5 - 30℃; for 9h; Temperature; Inert atmosphere;
66%
Stage #1: ethyl bromide With iodine; magnesium In tert-butyl methyl ether at 40 - 53℃; for 2h; Inert atmosphere;
Stage #2: (S)-N'-(2-(benzyloxy)propylidene)formylhydrazide With N,O-bis-(trimethylsilyl)-acetamide In tert-butyl methyl ether at 5 - 30℃; for 9h; Temperature; Inert atmosphere;
60%
Stage #1: ethyl bromide With iodine; magnesium In tert-butyl methyl ether at 40 - 55℃; for 2h; Inert atmosphere;
Stage #2: (S)-N'-(2-(benzyloxy)propylidene)formylhydrazide With N,O-bis-(trimethylsilyl)-acetamide In tert-butyl methyl ether at 0 - 30℃; Inert atmosphere;
48 g
Stage #1: ethyl bromide With iodine; magnesium In tert-butyl methyl ether at 40 - 55℃; Inert atmosphere;
Stage #2: (S)-N'-(2-(benzyloxy)propylidene)formylhydrazide With N,O-bis-(trimethylsilyl)-acetamide In tert-butyl methyl ether at 25 - 30℃; for 1.75h; Inert atmosphere;
ethylmagnesium bromide
925-90-6

ethylmagnesium bromide

(S)-2-(Benzyloxy)-N-(Formylamino)-Propanimine

(S)-2-(Benzyloxy)-N-(Formylamino)-Propanimine

A

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

B

N'-((2S,3R)-2-(benzyloxy)pent-3-yl)formylhydrazine

N'-((2S,3R)-2-(benzyloxy)pent-3-yl)formylhydrazine

Conditions
ConditionsYield
Stage #1: (S)-2-(Benzyloxy)-N-(Formylamino)-Propanimine With N,N-bis(trimethylsilyl)acetamide In diethyl ether at 20℃; for 0.75h;
Stage #2: ethylmagnesium bromide In diethyl ether at 20℃; Grignard addition;
A 62.3%
B n/a
(S)-2-(benzyloxy)propanal
81445-44-5

(S)-2-(benzyloxy)propanal

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 80 percent / methanol
2.1: bis(trimethylsilyl) acetamide / diethyl ether / 0.75 h / 20 °C
2.2: 62.3 percent / diethyl ether / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: toluene; methanol / 4 h / 0 - 30 °C
2.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere
2.2: 0 - 30 °C / Inert atmosphere
View Scheme
(S)-2-(benzyloxy)-1-(pyrrolidin-1-yl)propan-1-one
122151-32-0

(S)-2-(benzyloxy)-1-(pyrrolidin-1-yl)propan-1-one

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 94 percent / Red-Al / toluene / 5 h
2.1: 80 percent / methanol
3.1: bis(trimethylsilyl) acetamide / diethyl ether / 0.75 h / 20 °C
3.2: 62.3 percent / diethyl ether / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C / Inert atmosphere; Large scale
1.2: 1 h / 0 - 5 °C / Inert atmosphere; Large scale
2.1: sodium tetrahydroborate; lithium bromide; zinc dibromide / tetrahydrofuran / 0 - 5 °C / Inert atmosphere; Large scale
3.1: dmap / dichloromethane / 0.17 h / 0 - 20 °C / Large scale
3.2: 13 h / 30 - 35 °C / Large scale
4.1: hydrazine hydrate / ethanol / 13 h / 25 - 70 °C / Large scale
4.2: 1 h / 20 °C / Large scale
5.1: methanol / 4 h / 50 - 55 °C / Large scale
View Scheme
methyl (S)-2-(benzyloxy)propanoate
77287-11-7

methyl (S)-2-(benzyloxy)propanoate

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: diisobutylaluminium hydride / toluene / 3 h / -75 - -70 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: toluene; methanol / 4 h / 0 - 30 °C
3.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere
3.2: 0 - 30 °C / Inert atmosphere
View Scheme
(S)-1-phenylethanamine (S)-2-(benzyloxy)propanoic acid

(S)-1-phenylethanamine (S)-2-(benzyloxy)propanoic acid

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 0 - 10 °C
2.1: diisobutylaluminium hydride / toluene / 3 h / -75 - -70 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: toluene; methanol / 4 h / 0 - 30 °C
4.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere
4.2: 0 - 30 °C / Inert atmosphere
View Scheme
2-benzyloxypropionic acid methyl ester
53346-03-5

2-benzyloxypropionic acid methyl ester

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: water; sodium hydroxide / 5 h / 0 - 30 °C
2.1: toluene / 6 h / 25 - 30 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 0 - 10 °C
4.1: diisobutylaluminium hydride / toluene / 3 h / -75 - -70 °C / Inert atmosphere
4.2: Inert atmosphere
5.1: toluene; methanol / 4 h / 0 - 30 °C
6.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere
6.2: 0 - 30 °C / Inert atmosphere
View Scheme
benzyl chloride
100-44-7

benzyl chloride

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 5 h / -20 - -10 °C
2.1: water; sodium hydroxide / 5 h / 0 - 30 °C
3.1: toluene / 6 h / 25 - 30 °C
4.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 0 - 10 °C
5.1: diisobutylaluminium hydride / toluene / 3 h / -75 - -70 °C / Inert atmosphere
5.2: Inert atmosphere
6.1: toluene; methanol / 4 h / 0 - 30 °C
7.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere
7.2: 0 - 30 °C / Inert atmosphere
View Scheme
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: toluene / 6 h / 25 - 30 °C
2.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 0 - 10 °C
3.1: diisobutylaluminium hydride / toluene / 3 h / -75 - -70 °C / Inert atmosphere
3.2: Inert atmosphere
4.1: toluene; methanol / 4 h / 0 - 30 °C
5.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere
5.2: 0 - 30 °C / Inert atmosphere
View Scheme
2-[2S-1-ethyl-2-benzyloxypropylidene]hydrazinecarbaldehyde

2-[2S-1-ethyl-2-benzyloxypropylidene]hydrazinecarbaldehyde

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
With sodium tetrahydroborate In isopropyl alcohol at 0 - 15℃; for 3h;9.1 g
(S)-2-(benzyloxy)propanoic acid
33106-32-0

(S)-2-(benzyloxy)propanoic acid

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene / 2 h / 150 °C
2.1: sodium / ethanol / 0.5 h / 0 °C / Inert atmosphere
2.2: 1 h / Inert atmosphere; Reflux
3.1: toluene; methanol / 3 h / 0 - 30 °C
4.1: iodine; magnesium / tert-butyl methyl ether / 2 h / 40 - 53 °C / Inert atmosphere
4.2: 9 h / 5 - 30 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: phosphorus trichloride / toluene / 7 h / Reflux
2.1: hydrogen; 10 percent palladium on barium sulphate / toluene / 750.08 Torr / Reflux
3.1: methanol / 3 h / 0 - 30 °C
4.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere
4.2: 9 h / 5 - 30 °C / Inert atmosphere
View Scheme
(S)-2-(1-benzyloxyethyl)-4,5-dihydro-1H-imidazole

(S)-2-(1-benzyloxyethyl)-4,5-dihydro-1H-imidazole

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium / ethanol / 0.5 h / 0 °C / Inert atmosphere
1.2: 1 h / Inert atmosphere; Reflux
2.1: toluene; methanol / 3 h / 0 - 30 °C
3.1: iodine; magnesium / tert-butyl methyl ether / 2 h / 40 - 53 °C / Inert atmosphere
3.2: 9 h / 5 - 30 °C / Inert atmosphere
View Scheme
(S)-2-benzyloxy-3-pentanone
132489-33-9

(S)-2-benzyloxy-3-pentanone

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate; lithium bromide; zinc dibromide / tetrahydrofuran / 0 - 5 °C / Inert atmosphere; Large scale
2.1: dmap / dichloromethane / 0.17 h / 0 - 20 °C / Large scale
2.2: 13 h / 30 - 35 °C / Large scale
3.1: hydrazine hydrate / ethanol / 13 h / 25 - 70 °C / Large scale
3.2: 1 h / 20 °C / Large scale
4.1: methanol / 4 h / 50 - 55 °C / Large scale
View Scheme
(2S)-2-(benzyloxy)pentan-3-ol

(2S)-2-(benzyloxy)pentan-3-ol

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dmap / dichloromethane / 0.17 h / 0 - 20 °C / Large scale
1.2: 13 h / 30 - 35 °C / Large scale
2.1: hydrazine hydrate / ethanol / 13 h / 25 - 70 °C / Large scale
2.2: 1 h / 20 °C / Large scale
3.1: methanol / 4 h / 50 - 55 °C / Large scale
View Scheme
(2S)-2-(benzyloxy)-1-ethylpropyl-4-chlorobenzene sulfonate

(2S)-2-(benzyloxy)-1-ethylpropyl-4-chlorobenzene sulfonate

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrazine hydrate / ethanol / 13 h / 25 - 70 °C / Large scale
1.2: 1 h / 20 °C / Large scale
2.1: methanol / 4 h / 50 - 55 °C / Large scale
View Scheme
C12H20N2O*C18H14O8

C12H20N2O*C18H14O8

formic acid ethyl ester
109-94-4

formic acid ethyl ester

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
In methanol at 50 - 55℃; for 4h; Large scale;
(S)-2-(benzyloxy)-1-morpholinopropan-1-one

(S)-2-(benzyloxy)-1-morpholinopropan-1-one

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C / Inert atmosphere; Large scale
1.2: 1 h / 0 - 5 °C / Large scale
2.1: sodium tetrahydroborate; lithium bromide; zinc dibromide / tetrahydrofuran / 0 - 5 °C / Inert atmosphere; Large scale
3.1: dmap / dichloromethane / 0.17 h / 0 - 20 °C / Large scale
3.2: 13 h / 30 - 35 °C / Large scale
4.1: hydrazine hydrate / ethanol / 13 h / 25 - 70 °C / Large scale
4.2: 1 h / 20 °C / Large scale
5.1: methanol / 4 h / 50 - 55 °C / Large scale
View Scheme
(2S)-2-Benzyloxypropanoic acid chloride
90192-47-5

(2S)-2-Benzyloxypropanoic acid chloride

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogen; 10 percent palladium on barium sulphate / toluene / 750.08 Torr / Reflux
2.1: methanol / 3 h / 0 - 30 °C
3.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere
3.2: 9 h / 5 - 30 °C / Inert atmosphere
View Scheme
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

[4-(4-{4-[(3R,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-carbamic acid phenyl ester

[4-(4-{4-[(3R,5R)-5-(2,4-Difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-carbamic acid phenyl ester

4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one
170985-86-1

4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene85%
4-(4-(4-(4-aminophenyl)piperazin-1-yl)phenyl)carbamic acid phenyl ester

4-(4-(4-(4-aminophenyl)piperazin-1-yl)phenyl)carbamic acid phenyl ester

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

2-((2S,3S)-2-(benzyloxy)-3-pentyl)-4-(4-(4-(4-aminophenyl)piperazin-1-yl)phenyl)-2,4-dihydro-1,2,4-triazole-3(4H)-one

2-((2S,3S)-2-(benzyloxy)-3-pentyl)-4-(4-(4-(4-aminophenyl)piperazin-1-yl)phenyl)-2,4-dihydro-1,2,4-triazole-3(4H)-one

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane at 80 - 120℃; for 24h; Inert atmosphere;82%
C23H23N3O2

C23H23N3O2

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one
184177-83-1

2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 30 - 110℃; Temperature; Reagent/catalyst; Solvent; Inert atmosphere;75.2%
phenyl N-(4-(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl)carbamate
184177-81-9

phenyl N-(4-(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl)carbamate

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one
184177-83-1

2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane at 90 - 100℃; for 24h;70%
With triethylamine In 1,4-dioxane at 90 - 95℃; Large scale;0.89 kg
With triethylamine In 1,4-dioxane at 90 - 100℃; for 24h;
With triethylamine In acetonitrile at 65℃; for 30h;
C21H27N3O3

C21H27N3O3

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one
184177-83-1

2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane at 85℃; for 35h; Inert atmosphere;61%
C35H40F2N6O4

C35H40F2N6O4

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one
170985-86-1

4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane at 90℃; for 30h; Inert atmosphere;55%
phenyl (5-iodopyridin-2-yl)carbamate

phenyl (5-iodopyridin-2-yl)carbamate

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

2-((2S,3S)-2-(benzyloxy)pentan-3-yl)-4-(5-iodopyridin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one

2-((2S,3S)-2-(benzyloxy)pentan-3-yl)-4-(5-iodopyridin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
With potassium carbonate In 1,4-dioxane at 0 - 90℃; for 16h; Inert atmosphere;45%
C24H25N3O3

C24H25N3O3

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one
184177-83-1

2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
With triethylamine In 1,2-dimethoxyethane Solvent; Inert atmosphere; Reflux;22.5%
acetic acid 4-[4-(4-phenoxycarbonylamino-phenyl)-piperazin-1-yl]-phenyl ester
1197458-94-8

acetic acid 4-[4-(4-phenoxycarbonylamino-phenyl)-piperazin-1-yl]-phenyl ester

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

C32H37N5O4

C32H37N5O4

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide; toluene at 80 - 100℃; for 24 - 30h; Product distribution / selectivity;
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one
170985-86-1

4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / 1,4-dioxane / 24 h / 90 - 100 °C
2.1: sodium hydroxide / water; dimethyl sulfoxide / 0.75 h / 25 - 30 °C
2.2: 5 h / 25 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1.1: triethylamine / 1,4-dioxane / 90 - 95 °C / Large scale
2.1: sodium hydroxide / water; dimethyl sulfoxide / 1 h / 20 °C / Large scale
2.2: Large scale
View Scheme
Multi-step reaction with 2 steps
1.1: triethylamine / 1,4-dioxane / 90 - 95 °C / Large scale
2.1: sodium hydroxide / water; dimethyl sulfoxide / 1 h / 20 °C / Large scale
2.2: Large scale
View Scheme
Multi-step reaction with 2 steps
1.1: triethylamine / 1,4-dioxane / 90 - 95 °C / Large scale
2.1: sodium hydroxide / water; dimethyl sulfoxide / 1 h / 20 °C / Large scale
2.2: Large scale
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / acetonitrile / 30 h / 65 °C
2: sodium hydroxide / dimethyl sulfoxide; water / 20 - 50 °C
View Scheme
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

posaconazote
171228-49-2

posaconazote

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / 1,4-dioxane / 24 h / 90 - 100 °C
2.1: sodium hydroxide / water; dimethyl sulfoxide / 0.75 h / 25 - 30 °C
2.2: 5 h / 25 - 30 °C
3.1: palladium 10% on activated carbon; hydrogen; hydrogenchloride / water; methanol / 5 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / 1,4-dioxane / 90 - 95 °C / Large scale
2.1: sodium hydroxide / water; dimethyl sulfoxide / 1 h / 20 °C / Large scale
2.2: Large scale
3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / water; methanol / 50 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / 1,4-dioxane / 90 - 95 °C / Large scale
2.1: sodium hydroxide / water; dimethyl sulfoxide / 1 h / 20 °C / Large scale
2.2: Large scale
3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / water; methanol / 50 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / 1,4-dioxane / 90 - 95 °C / Large scale
2.1: sodium hydroxide / water; dimethyl sulfoxide / 1 h / 20 °C / Large scale
2.2: Large scale
3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / water; methanol / 50 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / acetonitrile / 30 h / 65 °C
2: sodium hydroxide / dimethyl sulfoxide; water / 20 - 50 °C
3: hydrogenchloride / water / 40 - 50 °C
View Scheme
phenyl chloroformate
1885-14-9

phenyl chloroformate

1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine
74853-08-0

1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one
184177-83-1

2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
Stage #1: phenyl chloroformate; 1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine In N,N-dimethyl-formamide; toluene at -10 - 20℃; for 4h;
Stage #2: N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide With triethylamine In N,N-dimethyl-formamide; toluene at 100 - 110℃; Temperature; Solvent;
phenyl (5-bromo-3-fluoropyridin-2-yl)carbamate

phenyl (5-bromo-3-fluoropyridin-2-yl)carbamate

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
170985-85-0

N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide

2-((2S,3S)-2-(benzyloxy)pentan-3-yl)-4-(5-bromo-3-fluoropyridin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one

2-((2S,3S)-2-(benzyloxy)pentan-3-yl)-4-(5-bromo-3-fluoropyridin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
In 1,4-dioxane at 80℃; for 16h; Inert atmosphere; Sealed tube;600 mg

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