Multi-target purpose intermediate with wide usage Commercial production from grams to tons, with technical documents package support, and audit and inspection support. With high purity and optimized and stable process. Self Innovation Appeara
Cas:170985-85-0
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:170985-85-0
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryWe are concentrating on APIs and pharmaceutical intermediates. With in depth knowledge and understanding in this industry, we are indulged in supplying a wide assortments of 2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldeh
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
Cas:170985-85-0
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:170985-85-0
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryProduct name: 2-[(1S,2S)-1-Ethyl-2-(Phenylmethoxy)Propyl]hydrazinecarboxaldehyde CAS No.:170985-85-0 Molecule Formula:C13H20N2O2 Molecule Weight:236.31 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:En
Cas:170985-85-0
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryHangzhou Keying Chem Co., Ltd. Is a comprehensive enterprise, dedicated to the development, production and marketing of chemicals. As a technology innovative and service professional enterprise, Our company mainly engages in global pharmaceutical,
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryhigh purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
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inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
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Type:Manufacturers
inquiry2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehydeAppearance:detailed see specifications Storage:Keep away of light, cool place Package:25kg/drum;200kg/drum Application:It is an important raw material and intermediate used in Organic
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inquiryWe product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate
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inquiryFactory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
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inquirygood quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran
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inquiry2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde cas 170985-85-0Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by expres
Cas:170985-85-0
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inquirySupply top quality products with a reasonable price Application:api
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiryethyl bromide
(S)-N'-(2-(benzyloxy)propylidene) formohydrazide
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Stage #1: ethyl bromide With iodine; magnesium In tert-butyl methyl ether at 40 - 55℃; for 2h; Inert atmosphere; Stage #2: (S)-N'-(2-(benzyloxy)propylidene)formylhydrazide With N,O-bis-(trimethylsilyl)-acetamide In tert-butyl methyl ether at 5 - 30℃; for 9h; Temperature; Inert atmosphere; | 66% |
Stage #1: ethyl bromide With iodine; magnesium In tert-butyl methyl ether at 40 - 53℃; for 2h; Inert atmosphere; Stage #2: (S)-N'-(2-(benzyloxy)propylidene)formylhydrazide With N,O-bis-(trimethylsilyl)-acetamide In tert-butyl methyl ether at 5 - 30℃; for 9h; Temperature; Inert atmosphere; | 60% |
Stage #1: ethyl bromide With iodine; magnesium In tert-butyl methyl ether at 40 - 55℃; for 2h; Inert atmosphere; Stage #2: (S)-N'-(2-(benzyloxy)propylidene)formylhydrazide With N,O-bis-(trimethylsilyl)-acetamide In tert-butyl methyl ether at 0 - 30℃; Inert atmosphere; | 48 g |
Stage #1: ethyl bromide With iodine; magnesium In tert-butyl methyl ether at 40 - 55℃; Inert atmosphere; Stage #2: (S)-N'-(2-(benzyloxy)propylidene)formylhydrazide With N,O-bis-(trimethylsilyl)-acetamide In tert-butyl methyl ether at 25 - 30℃; for 1.75h; Inert atmosphere; |
ethylmagnesium bromide
A
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Stage #1: (S)-2-(Benzyloxy)-N-(Formylamino)-Propanimine With N,N-bis(trimethylsilyl)acetamide In diethyl ether at 20℃; for 0.75h; Stage #2: ethylmagnesium bromide In diethyl ether at 20℃; Grignard addition; | A 62.3% B n/a |
(S)-2-(benzyloxy)propanal
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 80 percent / methanol 2.1: bis(trimethylsilyl) acetamide / diethyl ether / 0.75 h / 20 °C 2.2: 62.3 percent / diethyl ether / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene; methanol / 4 h / 0 - 30 °C 2.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere 2.2: 0 - 30 °C / Inert atmosphere View Scheme |
(S)-2-(benzyloxy)-1-(pyrrolidin-1-yl)propan-1-one
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 94 percent / Red-Al / toluene / 5 h 2.1: 80 percent / methanol 3.1: bis(trimethylsilyl) acetamide / diethyl ether / 0.75 h / 20 °C 3.2: 62.3 percent / diethyl ether / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C / Inert atmosphere; Large scale 1.2: 1 h / 0 - 5 °C / Inert atmosphere; Large scale 2.1: sodium tetrahydroborate; lithium bromide; zinc dibromide / tetrahydrofuran / 0 - 5 °C / Inert atmosphere; Large scale 3.1: dmap / dichloromethane / 0.17 h / 0 - 20 °C / Large scale 3.2: 13 h / 30 - 35 °C / Large scale 4.1: hydrazine hydrate / ethanol / 13 h / 25 - 70 °C / Large scale 4.2: 1 h / 20 °C / Large scale 5.1: methanol / 4 h / 50 - 55 °C / Large scale View Scheme |
methyl (S)-2-(benzyloxy)propanoate
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: diisobutylaluminium hydride / toluene / 3 h / -75 - -70 °C / Inert atmosphere 1.2: Inert atmosphere 2.1: toluene; methanol / 4 h / 0 - 30 °C 3.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere 3.2: 0 - 30 °C / Inert atmosphere View Scheme |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 0 - 10 °C 2.1: diisobutylaluminium hydride / toluene / 3 h / -75 - -70 °C / Inert atmosphere 2.2: Inert atmosphere 3.1: toluene; methanol / 4 h / 0 - 30 °C 4.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere 4.2: 0 - 30 °C / Inert atmosphere View Scheme |
2-benzyloxypropionic acid methyl ester
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: water; sodium hydroxide / 5 h / 0 - 30 °C 2.1: toluene / 6 h / 25 - 30 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 0 - 10 °C 4.1: diisobutylaluminium hydride / toluene / 3 h / -75 - -70 °C / Inert atmosphere 4.2: Inert atmosphere 5.1: toluene; methanol / 4 h / 0 - 30 °C 6.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere 6.2: 0 - 30 °C / Inert atmosphere View Scheme |
benzyl chloride
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: potassium tert-butylate / N,N-dimethyl-formamide / 5 h / -20 - -10 °C 2.1: water; sodium hydroxide / 5 h / 0 - 30 °C 3.1: toluene / 6 h / 25 - 30 °C 4.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 0 - 10 °C 5.1: diisobutylaluminium hydride / toluene / 3 h / -75 - -70 °C / Inert atmosphere 5.2: Inert atmosphere 6.1: toluene; methanol / 4 h / 0 - 30 °C 7.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere 7.2: 0 - 30 °C / Inert atmosphere View Scheme |
2-(benzyloxy)propanoic acid
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: toluene / 6 h / 25 - 30 °C 2.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 0 - 10 °C 3.1: diisobutylaluminium hydride / toluene / 3 h / -75 - -70 °C / Inert atmosphere 3.2: Inert atmosphere 4.1: toluene; methanol / 4 h / 0 - 30 °C 5.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere 5.2: 0 - 30 °C / Inert atmosphere View Scheme |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
With sodium tetrahydroborate In isopropyl alcohol at 0 - 15℃; for 3h; | 9.1 g |
(S)-2-(benzyloxy)propanoic acid
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: toluene / 2 h / 150 °C 2.1: sodium / ethanol / 0.5 h / 0 °C / Inert atmosphere 2.2: 1 h / Inert atmosphere; Reflux 3.1: toluene; methanol / 3 h / 0 - 30 °C 4.1: iodine; magnesium / tert-butyl methyl ether / 2 h / 40 - 53 °C / Inert atmosphere 4.2: 9 h / 5 - 30 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1.1: phosphorus trichloride / toluene / 7 h / Reflux 2.1: hydrogen; 10 percent palladium on barium sulphate / toluene / 750.08 Torr / Reflux 3.1: methanol / 3 h / 0 - 30 °C 4.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere 4.2: 9 h / 5 - 30 °C / Inert atmosphere View Scheme |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium / ethanol / 0.5 h / 0 °C / Inert atmosphere 1.2: 1 h / Inert atmosphere; Reflux 2.1: toluene; methanol / 3 h / 0 - 30 °C 3.1: iodine; magnesium / tert-butyl methyl ether / 2 h / 40 - 53 °C / Inert atmosphere 3.2: 9 h / 5 - 30 °C / Inert atmosphere View Scheme |
(S)-2-benzyloxy-3-pentanone
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium tetrahydroborate; lithium bromide; zinc dibromide / tetrahydrofuran / 0 - 5 °C / Inert atmosphere; Large scale 2.1: dmap / dichloromethane / 0.17 h / 0 - 20 °C / Large scale 2.2: 13 h / 30 - 35 °C / Large scale 3.1: hydrazine hydrate / ethanol / 13 h / 25 - 70 °C / Large scale 3.2: 1 h / 20 °C / Large scale 4.1: methanol / 4 h / 50 - 55 °C / Large scale View Scheme |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: dmap / dichloromethane / 0.17 h / 0 - 20 °C / Large scale 1.2: 13 h / 30 - 35 °C / Large scale 2.1: hydrazine hydrate / ethanol / 13 h / 25 - 70 °C / Large scale 2.2: 1 h / 20 °C / Large scale 3.1: methanol / 4 h / 50 - 55 °C / Large scale View Scheme |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrazine hydrate / ethanol / 13 h / 25 - 70 °C / Large scale 1.2: 1 h / 20 °C / Large scale 2.1: methanol / 4 h / 50 - 55 °C / Large scale View Scheme |
formic acid ethyl ester
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
In methanol at 50 - 55℃; for 4h; Large scale; |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: magnesium / tetrahydrofuran / 1 h / 60 - 65 °C / Inert atmosphere; Large scale 1.2: 1 h / 0 - 5 °C / Large scale 2.1: sodium tetrahydroborate; lithium bromide; zinc dibromide / tetrahydrofuran / 0 - 5 °C / Inert atmosphere; Large scale 3.1: dmap / dichloromethane / 0.17 h / 0 - 20 °C / Large scale 3.2: 13 h / 30 - 35 °C / Large scale 4.1: hydrazine hydrate / ethanol / 13 h / 25 - 70 °C / Large scale 4.2: 1 h / 20 °C / Large scale 5.1: methanol / 4 h / 50 - 55 °C / Large scale View Scheme |
(2S)-2-Benzyloxypropanoic acid chloride
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogen; 10 percent palladium on barium sulphate / toluene / 750.08 Torr / Reflux 2.1: methanol / 3 h / 0 - 30 °C 3.1: magnesium; iodine / tert-butyl methyl ether / 2 h / 40 - 55 °C / Inert atmosphere 3.2: 9 h / 5 - 30 °C / Inert atmosphere View Scheme |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene | 85% |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane at 80 - 120℃; for 24h; Inert atmosphere; | 82% |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide at 30 - 110℃; Temperature; Reagent/catalyst; Solvent; Inert atmosphere; | 75.2% |
phenyl N-(4-(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl)carbamate
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane at 90 - 100℃; for 24h; | 70% |
With triethylamine In 1,4-dioxane at 90 - 95℃; Large scale; | 0.89 kg |
With triethylamine In 1,4-dioxane at 90 - 100℃; for 24h; | |
With triethylamine In acetonitrile at 65℃; for 30h; |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane at 85℃; for 35h; Inert atmosphere; | 61% |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane at 90℃; for 30h; Inert atmosphere; | 55% |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
With potassium carbonate In 1,4-dioxane at 0 - 90℃; for 16h; Inert atmosphere; | 45% |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one
Conditions | Yield |
---|---|
With triethylamine In 1,2-dimethoxyethane Solvent; Inert atmosphere; Reflux; | 22.5% |
acetic acid 4-[4-(4-phenoxycarbonylamino-phenyl)-piperazin-1-yl]-phenyl ester
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl-formamide; toluene at 80 - 100℃; for 24 - 30h; Product distribution / selectivity; |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / 1,4-dioxane / 24 h / 90 - 100 °C 2.1: sodium hydroxide / water; dimethyl sulfoxide / 0.75 h / 25 - 30 °C 2.2: 5 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: triethylamine / 1,4-dioxane / 90 - 95 °C / Large scale 2.1: sodium hydroxide / water; dimethyl sulfoxide / 1 h / 20 °C / Large scale 2.2: Large scale View Scheme | |
Multi-step reaction with 2 steps 1.1: triethylamine / 1,4-dioxane / 90 - 95 °C / Large scale 2.1: sodium hydroxide / water; dimethyl sulfoxide / 1 h / 20 °C / Large scale 2.2: Large scale View Scheme | |
Multi-step reaction with 2 steps 1.1: triethylamine / 1,4-dioxane / 90 - 95 °C / Large scale 2.1: sodium hydroxide / water; dimethyl sulfoxide / 1 h / 20 °C / Large scale 2.2: Large scale View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / acetonitrile / 30 h / 65 °C 2: sodium hydroxide / dimethyl sulfoxide; water / 20 - 50 °C View Scheme |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
posaconazote
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / 1,4-dioxane / 24 h / 90 - 100 °C 2.1: sodium hydroxide / water; dimethyl sulfoxide / 0.75 h / 25 - 30 °C 2.2: 5 h / 25 - 30 °C 3.1: palladium 10% on activated carbon; hydrogen; hydrogenchloride / water; methanol / 5 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / 1,4-dioxane / 90 - 95 °C / Large scale 2.1: sodium hydroxide / water; dimethyl sulfoxide / 1 h / 20 °C / Large scale 2.2: Large scale 3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / water; methanol / 50 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / 1,4-dioxane / 90 - 95 °C / Large scale 2.1: sodium hydroxide / water; dimethyl sulfoxide / 1 h / 20 °C / Large scale 2.2: Large scale 3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / water; methanol / 50 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / 1,4-dioxane / 90 - 95 °C / Large scale 2.1: sodium hydroxide / water; dimethyl sulfoxide / 1 h / 20 °C / Large scale 2.2: Large scale 3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / water; methanol / 50 °C / Large scale View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / acetonitrile / 30 h / 65 °C 2: sodium hydroxide / dimethyl sulfoxide; water / 20 - 50 °C 3: hydrogenchloride / water / 40 - 50 °C View Scheme |
phenyl chloroformate
1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one
Conditions | Yield |
---|---|
Stage #1: phenyl chloroformate; 1-(4-aminophenyl)-4-(4-hydroxyphenyl)piperazine In N,N-dimethyl-formamide; toluene at -10 - 20℃; for 4h; Stage #2: N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide With triethylamine In N,N-dimethyl-formamide; toluene at 100 - 110℃; Temperature; Solvent; |
N’-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]formic hydrazide
Conditions | Yield |
---|---|
In 1,4-dioxane at 80℃; for 16h; Inert atmosphere; Sealed tube; | 600 mg |
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