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Hunan Wistar Imp. & Exp. Co., Ltd.

The company serves as a key global supplier of statins intermediates, which has a solid industrial foundation in the field of statins for lipid-lowering drugs, and holds a leading position in the market. Leveraging extensive experience in research an

Chinese Factory Supply High Purity 99% 189028-93-1 Safe Transportation

Cas:189028-93-1

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

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ACHIEVER SYSTEAM BIOCHEM CO., LTD.

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of scientists co

2-Oxazolidinone, 3-[5-(4-fluorophenyl)-1,5-dioxopentyl]-4-phenyl-, (4S)-

Cas:189028-93-1

Min.Order:100 Metric Ton

FOB Price: $1.0

Type:Lab/Research institutions

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Shanghai Hohance Chemical Co., ltd

1)Entity factory, can batch production 2)Sample service 3)the most competitive price with good quality: we do this products so many years with Skilled craft can control the cost. so we can provide the most competitive price for our cust

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone

Cas:189028-93-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone Manufacturer/High quality/Best price/In stock

Cas:189028-93-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Jinan Finer Chemical Co., Ltd

Product informations Product Name (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione CAS No.

(S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

Cas:189028-93-1

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:pharmaceutical intermediate Transpo

Hangzhou Think Chemical Co. Ltd

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone CAS No.:189028-93-1 Name: (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone Molecular Structure

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Application:intermediate Port:shanghai

189028-93-1 (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone

Cas:189028-93-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 189028-93-1 Ezetimibe Intermediate Manufacturer

Cas:189028-93-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone

Cas:189028-93-1

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-[5-(Fluorophenyl)-1,5-dioxopentyl]-4(S)-phenyl-2-oxazolidinone

Cas:189028-93-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

CHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis

Highest quality Ezetimibe Intermediate NO.189028-93-1

Cas:189028-93-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Tianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationships with ma

TIANFU 189028-93-1 (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone

Cas:189028-93-1

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone Manufacturer

Cas:189028-93-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 189028-93-1 with best quality

Cas:189028-93-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone Appearance white powder CAS NO. 189028-93-1 Molecular Formula C20H18FNO4

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone CAS:189028-93-1

Cas:189028-93-1

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 189028-93-1 Ezetimibe Impurity 8 with best price

Cas:189028-93-1

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

high quality with lower quotation. and enough stock (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone 189028-93-1 Appearance:white crystalline powder Storage:dry and cool place Package:1kg/pack Application:Ezetimibe intermediate T

High quality (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone

Cas:189028-93-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone

Cas:189028-93-1

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Ezetimibe intermediate, (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone CAS:189028-93-1

Cas:189028-93-1

Min.Order:1 Kilogram

FOB Price: $42.0 / 48.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone CAS: 189028-93-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical interm

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone CAS: 189028-93-1

Cas:189028-93-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone

Cas:189028-93-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Superiority We can customize and synthesize products that other suppliers may not be able to provide. Advantage cof, mof ligand manufacturer Product Detail Quick Details

factory supply 99% Ezetimibe impuriry 26 CAS NO.189028-93-1

Cas:189028-93-1

Min.Order:100 Kilogram

Negotiable

Type:Trading Company

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Lonwin Chemical Group Limited

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone CAS: 189028-93-1 Specification Product Name (S)-1-(4-Fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione CAS No.

Factory supply (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone

Cas:189028-93-1

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone

Cas:189028-93-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

(4S)-3-[5-(4-Fluorophenyl)-1,5-Dioxopenyl]-4-Phenyl-2-Oxazolidinone

Cas:189028-93-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Courier Dang

Ezetimibe Intermediate

Cas:189028-93-1

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane
58518-77-7

((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane

(4S)-3-(1-oxo-2-propen-1-yl)-4-phenyl-1,3-oxazolidin-2-one
259529-54-9

(4S)-3-(1-oxo-2-propen-1-yl)-4-phenyl-1,3-oxazolidin-2-one

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

Conditions
ConditionsYield
With iodine In toluene at 40℃;94%
(4S)-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one

(4S)-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

Conditions
ConditionsYield
With pyridinium chlorochromate In dichloromethane at 40℃; for 2h;91%
(S)-4-phenyl-2-oxazolidinone
99395-88-7

(S)-4-phenyl-2-oxazolidinone

5-(4-fluorophenyl)-5-oxopentanoic acid
149437-76-3

5-(4-fluorophenyl)-5-oxopentanoic acid

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane86%
Stage #1: 5-(4-fluorophenyl)-5-oxopentanoic acid With dmap; pivaloyl chloride In N,N-dimethyl-formamide at 2 - 20℃; for 1.5h;
Stage #2: (S)-4-phenyl-2-oxazolidinone In N,N-dimethyl-formamide at 30 - 35℃; for 2h;
85.7%
Stage #1: 5-(4-fluorophenyl)-5-oxopentanoic acid With pivaloyl chloride; triethylamine In tetrahydrofuran at -10℃; for 4h; Evans Aldol Reaction; Inert atmosphere;
Stage #2: (S)-4-phenyl-2-oxazolidinone With lithium chloride In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;
85%
pivaloyl chloride
3282-30-2

pivaloyl chloride

5-(4-fluorophenyl)-5-oxopentanoic acid
149437-76-3

5-(4-fluorophenyl)-5-oxopentanoic acid

(S)-5-phenyl-1,3-oxazolidine-2-one
186343-35-1

(S)-5-phenyl-1,3-oxazolidine-2-one

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

Conditions
ConditionsYield
Stage #1: pivaloyl chloride; 5-(4-fluorophenyl)-5-oxopentanoic acid With dmap In N,N-dimethyl-formamide at 2 - 20℃; for 1.5h;
Stage #2: (S)-5-phenyl-1,3-oxazolidine-2-one With dmap In N,N-dimethyl-formamide at 30 - 35℃; for 2h;
85.7%
C16H19FO4
1056188-47-6

C16H19FO4

(S)-4-phenyl-2-oxazolidinone
99395-88-7

(S)-4-phenyl-2-oxazolidinone

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

Conditions
ConditionsYield
Stage #1: C16H19FO4; (S)-4-phenyl-2-oxazolidinone With dmap In N,N-dimethyl-formamide for 7h; Heating / reflux;
Stage #2: With sulfuric acid In water; N,N-dimethyl-formamide for 0.5h;
Stage #3: With sodium hydrogencarbonate In water; N,N-dimethyl-formamide
With dmap In DMF (N,N-dimethyl-formamide) for 7h; Heating / reflux;
(S)-4-phenyl-2-oxazolidinone
99395-88-7

(S)-4-phenyl-2-oxazolidinone

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: chloro-trimethyl-silane / dichloromethane / 0.5 h / 0 - 10 °C
1.2: 2 h / 0 - 10 °C
1.3: 2 h / 0 - 20 °C
2.1: iodine / toluene / 40 °C
View Scheme
C24H26FNO5

C24H26FNO5

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Candida rugosa lipase / di-isopropyl ether; aq. phosphate buffer / 120 h / 40 °C / Enzymatic reaction
2: Candida antarctica B lipase / toluene / 120 h / 35 °C / Enzymatic reaction
3: pyridinium chlorochromate / dichloromethane / 2 h / 40 °C
View Scheme
Multi-step reaction with 3 steps
1: Candida rugosa lipase / di-isopropyl ether; aq. phosphate buffer / 120 h / 40 °C / Enzymatic reaction
2: Candida antarctica B lipase / toluene / 120 h / 35 °C / Enzymatic reaction
3: pyridinium chlorochromate / dichloromethane / 2 h / 40 °C
View Scheme
C24H26FNO5

C24H26FNO5

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Candida rugosa lipase / di-isopropyl ether; aq. phosphate buffer / 120 h / 40 °C / Enzymatic reaction
2: Candida antarctica B lipase / toluene / 120 h / 35 °C / Enzymatic reaction
3: pyridinium chlorochromate / dichloromethane / 2 h / 40 °C
View Scheme
Multi-step reaction with 3 steps
1: Candida rugosa lipase / di-isopropyl ether; aq. phosphate buffer / 120 h / 40 °C / Enzymatic reaction
2: Candida antarctica B lipase / toluene / 120 h / 35 °C / Enzymatic reaction
3: pyridinium chlorochromate / dichloromethane / 2 h / 40 °C
View Scheme
(R,S)-3-[5-(4-fluorophenyl)-5-hydroxy-pentanoyl]-4-phenyl-oxazolidin-2-one
1246853-48-4

(R,S)-3-[5-(4-fluorophenyl)-5-hydroxy-pentanoyl]-4-phenyl-oxazolidin-2-one

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Candida antarctica B lipase / toluene / 120 h / 35 °C / Enzymatic reaction
2: pyridinium chlorochromate / dichloromethane / 2 h / 40 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine; dmap / dichloromethane / 4 h / 0 °C
2: Candida rugosa lipase / di-isopropyl ether; aq. phosphate buffer / 120 h / 40 °C / Enzymatic reaction
3: Candida antarctica B lipase / toluene / 120 h / 35 °C / Enzymatic reaction
4: pyridinium chlorochromate / dichloromethane / 2 h / 40 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine; dmap / dichloromethane / 4 h / 0 °C
2: Candida rugosa lipase / di-isopropyl ether; aq. phosphate buffer / 120 h / 40 °C / Enzymatic reaction
3: Candida antarctica B lipase / toluene / 120 h / 35 °C / Enzymatic reaction
4: pyridinium chlorochromate / dichloromethane / 2 h / 40 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine; dmap / dichloromethane / 4 h / 0 °C
2: Candida rugosa lipase / di-isopropyl ether; aq. phosphate buffer / 120 h / 40 °C / Enzymatic reaction
3: Candida antarctica B lipase / toluene / 120 h / 35 °C / Enzymatic reaction
4: pyridinium chlorochromate / dichloromethane / 2 h / 40 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine; dmap / dichloromethane / 4 h / 0 °C
2: Candida rugosa lipase / di-isopropyl ether; aq. phosphate buffer / 120 h / 40 °C / Enzymatic reaction
3: Candida antarctica B lipase / toluene / 120 h / 35 °C / Enzymatic reaction
4: pyridinium chlorochromate / dichloromethane / 2 h / 40 °C
View Scheme
1-(4-fluorophenyl)ethanone
403-42-9

1-(4-fluorophenyl)ethanone

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere
2: iodine / toluene / 40 °C
View Scheme
fluorobenzene
462-06-6

fluorobenzene

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / 5 h / 15 - 30 °C
1.2: 0 - 20 °C
2.1: triethylamine; pivaloyl chloride / dichloromethane
2.2: 13 h / Reflux
View Scheme
glutaric anhydride,
108-55-4

glutaric anhydride,

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / 5 h / 15 - 30 °C
1.2: 0 - 20 °C
2.1: triethylamine; pivaloyl chloride / dichloromethane
2.2: 13 h / Reflux
View Scheme
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

2-(4-fluorophenyl)-6-oxo-6-(2-oxo-4(S)-phenyloxazolidin-3-yl)-2-trimethylsilyloxyhexanenitrile
1232148-22-9

2-(4-fluorophenyl)-6-oxo-6-(2-oxo-4(S)-phenyloxazolidin-3-yl)-2-trimethylsilyloxyhexanenitrile

Conditions
ConditionsYield
With iodine In dichloromethane at 0℃; for 2.33333h;100%
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

trimethyl orthoformate
149-73-5

trimethyl orthoformate

(S)-3-(5-(4-fluorophenyl)-5,5-dimethoxypentanoyl)-4-phenyloxazolidin-2-one
1185883-41-3

(S)-3-(5-(4-fluorophenyl)-5,5-dimethoxypentanoyl)-4-phenyloxazolidin-2-one

Conditions
ConditionsYield
toluene-4-sulfonic acid In methanol Reflux;99.02%
With sulfuric acid In methanol for 1.5h; Reflux;80%
toluene-4-sulfonic acid In methanol at 20℃; Reflux;
With toluene-4-sulfonic acid at 20℃; for 23h; Reflux;
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
189028-95-3

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one

Conditions
ConditionsYield
Stage #1: (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione With TarB-N02 In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: With lithium borohydride In tetrahydrofuran for 0.666667h; Reagent/catalyst; enantioselective reaction;
96%
Stage #1: (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In dichloromethane; toluene at -5 - 0℃; for 4 - 6h;
Stage #2: With sulfuric acid; dihydrogen peroxide In methanol; dichloromethane; water; toluene for 0.25h;
95%
Stage #1: With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In dichloromethane; toluene at -5 - 0℃; for 0.25h;
Stage #2: (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione In dichloromethane; toluene at -5 - 0℃; for 4 - 6h;
95%
ethylene glycol
107-21-1

ethylene glycol

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one
942485-56-5

(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one

Conditions
ConditionsYield
Stage #1: ethylene glycol; (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione; chloro-trimethyl-silane at 20 - 25℃; for 20h;
Stage #2: With water; sodium hydrogencarbonate In toluene at 50℃; for 0.5h; Product distribution / selectivity;
95%
With N-Bromosuccinimide; trimethyl orthoformate at 70℃; for 8h; Inert atmosphere;95%
Stage #1: ethylene glycol; (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione With toluene-4-sulfonic acid In toluene for 20 - 24h; Heating / reflux;
Stage #2: With water; sodium carbonate In toluene at 50℃; Product distribution / selectivity;
94.9%
methanol
67-56-1

methanol

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

(S)-3-(5-(4-fluorophenyl)-5,5-dimethoxypentanoyl)-4-phenyloxazolidin-2-one
1185883-41-3

(S)-3-(5-(4-fluorophenyl)-5,5-dimethoxypentanoyl)-4-phenyloxazolidin-2-one

Conditions
ConditionsYield
With N-Bromosuccinimide; trimethyl orthoformate at 50℃; for 9h; Inert atmosphere;91%
2,2-Dimethyl-1,3-propanediol
126-30-7

2,2-Dimethyl-1,3-propanediol

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

3-{4-[2-(4-fluorophenyl)-5,5-dimethyl-[1,3]dioxin-2-yl]butyryl}(4S)-phenyl-1,3-oxazolidin-2-one
953805-20-4

3-{4-[2-(4-fluorophenyl)-5,5-dimethyl-[1,3]dioxin-2-yl]butyryl}(4S)-phenyl-1,3-oxazolidin-2-one

Conditions
ConditionsYield
With phosphorus pentoxide; sulfuric acid In dichloromethane for 5h; Reflux;89%
With Pyridine hydrobromide In toluene at 20 - 115℃; for 5h; Product distribution / selectivity;
With chloro-trimethyl-silane In dichloromethane at 20 - 115℃; for 5h; Product distribution / selectivity;
2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane
7381-30-8

2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one
942485-56-5

(S)-3-{4-[2-(4-fluorophenyl)dioxolan-2-yl]butanoyl}-4-phenyl-oxazolidin-2-one

Conditions
ConditionsYield
Stage #1: 2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane; (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione With trimethylsilyl trifluoromethanesulfonate In toluene at 20 - 50℃; for 3 - 4h;
Stage #2: With water; sodium hydrogencarbonate In toluene Product distribution / selectivity;
89%
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

trimethyleneglycol
504-63-2

trimethyleneglycol

(S)-3-[4-[2-(4-fluorophenyl)-[1,3]dioxan-2-yl]-1-oxobutyl]-4-phenyloxazolidin-2-one
1056460-25-3

(S)-3-[4-[2-(4-fluorophenyl)-[1,3]dioxan-2-yl]-1-oxobutyl]-4-phenyloxazolidin-2-one

Conditions
ConditionsYield
With N-Bromosuccinimide; trimethyl orthoformate at 100℃; for 12h; Inert atmosphere;86.8%
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

(R,S)-3-[5-(4-fluorophenyl)-5-hydroxy-pentanoyl]-4-phenyl-oxazolidin-2-one
1246853-48-4

(R,S)-3-[5-(4-fluorophenyl)-5-hydroxy-pentanoyl]-4-phenyl-oxazolidin-2-one

Conditions
ConditionsYield
With borane-THF In dichloromethane at 0 - 20℃; for 6h; Inert atmosphere;70%
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

A

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
189028-95-3

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one

B

(4S)-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one

(4S)-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one

C

(S)-3-[(S)-5-(4-Fluoro-phenyl)-1,5-dihydroxy-pentyl]-4-phenyl-oxazolidin-2-one

(S)-3-[(S)-5-(4-Fluoro-phenyl)-1,5-dihydroxy-pentyl]-4-phenyl-oxazolidin-2-one

Conditions
ConditionsYield
With borane-THF; boron trifluoride diethyl etherate; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In tetrahydrofuran at 25℃; Product distribution; Further Variations:; Catalysts; Temperatures; acid additives, water content;
With BH3-DEA; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In tetrahydrofuran; 1,2-dimethoxyethane; toluene at 40℃;
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

A

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
189028-95-3

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one

B

(S)-3-[(S)-5-(4-Fluoro-phenyl)-1,5-dihydroxy-pentyl]-4-phenyl-oxazolidin-2-one

(S)-3-[(S)-5-(4-Fluoro-phenyl)-1,5-dihydroxy-pentyl]-4-phenyl-oxazolidin-2-one

Conditions
ConditionsYield
With sodium tetrahydroborate; dimethyl sulfate; N,N-diethylaniline; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In tetrahydrofuran; toluene at 20℃; Product distribution; Further Variations:; Reagents; Temperatures;A 13 g
B n/a
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-([12C6]-4-hydroxyphenyl)-2-azetidinone

1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]-4-([12C6]-4-hydroxyphenyl)-2-azetidinone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: (R)-(CH2)3CHCPh2O(B-Me)N; BH3*SMe2 / CH2Cl2 / 2 h / 0 °C
2.1: TiCl4 / CH2Cl2 / 3 h / -35 - -30 °C
3.1: 995 mg / CH2Cl2 / 0.5 h / Heating
4.1: BSA / CH2Cl2 / 0.25 h / 20 °C
4.2: TBAF*3H2O / CH2Cl2 / 90 h / 0 °C
4.3: 90 percent / aq. H2SO4 / propan-2-ol / 1 h
View Scheme
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

C30(13)C6H38F2N2O5Si

C30(13)C6H38F2N2O5Si

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (R)-(CH2)3CHCPh2O(B-Me)N; BH3*SMe2 / CH2Cl2 / 2 h / 0 °C
2: TiCl4 / CH2Cl2 / 3 h / -35 - -30 °C
View Scheme
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

C33(13)C6H46F2N2O5Si2
438624-70-5

C33(13)C6H46F2N2O5Si2

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (R)-(CH2)3CHCPh2O(B-Me)N; BH3*SMe2 / CH2Cl2 / 2 h / 0 °C
2: TiCl4 / CH2Cl2 / 3 h / -35 - -30 °C
3: 995 mg / CH2Cl2 / 0.5 h / Heating
View Scheme
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

A

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
189028-95-3

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one

B

(4S)-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one

(4S)-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one

Conditions
ConditionsYield
Stage #1: (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione With borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole In tetrahydrofuran; toluene at 18 - 20℃; for 1h;
Stage #2: With water; potassium carbonate In tetrahydrofuran; toluene at 20 - 30℃; for 0.5h;
Stage #1: (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione With sodium tetrahydroborate; chloro-trimethyl-silane; (R)-α,α-diphenylprolinol In tetrahydrofuran at 24℃; for 3h; Heating / reflux;
Stage #2: With hydrogenchloride; water In tetrahydrofuran; toluene at 4℃; for 0.5h; Product distribution / selectivity;
A n/a
B n/a
Stage #1: (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione With sodium tetrahydroborate; chloro-trimethyl-silane; (R)-2-[bis(4-trifluorophenyl)hydroxymethyl]pyrrolidine In tetrahydrofuran at 24℃; for 3h; Heating / reflux;
Stage #2: With hydrogenchloride; water In tetrahydrofuran; toluene at 4℃; for 0.5h; Product distribution / selectivity;
A n/a
B n/a
With chloro[(1S,2S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine]-(mesitylene) ruthenium (II); formic acid/triethylamine complex 5:2 In tert-butyl methyl ether at 42℃; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; stereoselective reaction;A n/a
B n/a
isopropyl alcohol
67-63-0

isopropyl alcohol

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one
189028-95-3

(4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one

Conditions
ConditionsYield
With magnesium sulfate In triethanolamine(chloride)
hydroxylamine hydrochloride
5470-11-1

hydroxylamine hydrochloride

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

(S)-3-(5-(4-fluorophenyl)-5-(hydroxyimino)pentanoyl)-4-phenyloxazolidin-2-one

(S)-3-(5-(4-fluorophenyl)-5-(hydroxyimino)pentanoyl)-4-phenyloxazolidin-2-one

Conditions
ConditionsYield
With potassium carbonate In isopropyl alcohol for 2 - 4h; Reflux;
N-methoxylamine hydrochloride
593-56-6

N-methoxylamine hydrochloride

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

C21H21FN2O4
1246611-03-9

C21H21FN2O4

Conditions
ConditionsYield
With triethylamine In ethanol at 80 - 85℃; for 10h;
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

C41H34F2N2O7
1185883-42-4

C41H34F2N2O7

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / 23 h / 20 °C / Reflux
2.1: dichloromethane; toluene / 0.83 h / -33 - -30 °C
2.2: 3.5 h / -33 °C
3.1: acetic acid; sodium dihydrogencitrate / dichloromethane; toluene / 0.58 h / -33 °C
View Scheme
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

C41H36F2N2O7
1185883-38-8

C41H36F2N2O7

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / 23 h / 20 °C / Reflux
2.1: dichloromethane; toluene / 0.83 h / -33 - -30 °C
2.2: 3.5 h / -33 °C
3.1: acetic acid; sodium dihydrogencitrate / dichloromethane; toluene / 0.58 h / -33 °C
4.1: (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
4.2: 1.67 h / Inert atmosphere
4.3: 0.17 h
View Scheme
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

C43H40F2N2O8

C43H40F2N2O8

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / 23 h / 20 °C / Reflux
2.1: dichloromethane; toluene / 0.83 h / -33 - -30 °C
2.2: 3.5 h / -33 °C
View Scheme
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

(3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one
190595-65-4

(3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydroxylamine hydrochloride / pyridine / 0 - 20 °C
2.1: titanium(IV) isopropylate; N-ethyl-N,N-diisopropylamine; titanium tetrachloride / dichloromethane / 0 °C
2.2: -15 °C
3.1: N,O-bis-(trimethylsilyl)-acetamide / toluene / 0.5 h / 60 °C
3.2: 8 h / 60 °C
3.3: 20 h / 20 °C
4.1: hydrogenchloride; formaldehyd / water; tetrahydrofuran / 6 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: hydroxylamine hydrochloride / pyridine / 0 - 20 °C
2.1: dmap; 1H-imidazole / dichloromethane / 0.17 h / 20 °C
2.2: 5 h
3.1: titanium(IV) isopropylate; N-ethyl-N,N-diisopropylamine; titanium tetrachloride / dichloromethane / 0 °C
3.2: 3 h / -15 °C
4.1: N,O-bis-(trimethylsilyl)-acetamide / toluene / 0.5 h / 60 °C
4.2: 8 h / 60 °C
5.1: hydrogenchloride; formaldehyd / water; tetrahydrofuran / 4 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: phosphorus pentoxide; sulfuric acid / dichloromethane / 5 h / Reflux
2: N-ethyl-N,N-diisopropylamine; titanium(IV) isopropylate; titanium tetrachloride / dichloromethane / 3 h / -5 °C
3: N,O-Bis(trimethylsilyl)acetamide; tetrabutyl ammonium fluoride / toluene / 48 h / Reflux
4: formic acid / dichloromethane / 12 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / hexane / 6 h / 25 °C
2: N,O-bis-(trimethylsilyl)-acetamide; tetrabutyl ammonium fluoride / toluene / 60 °C
View Scheme
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

(S)-3-(5-(4-fluorophenyl)-5-(hydroxyimino)pentanoyl)-4-phenyloxazolidin-2-one

(S)-3-(5-(4-fluorophenyl)-5-(hydroxyimino)pentanoyl)-4-phenyloxazolidin-2-one

Conditions
ConditionsYield
Stage #1: (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione With hydroxylamine hydrochloride In pyridine at 0 - 20℃;
Stage #2: With hydrogenchloride In water; ethyl acetate Product distribution / selectivity;
(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione
189028-93-1

(S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione

(S)-3-((S)-2-((S)-(4-(benzyloxy)phenyl)(4-fluorophenylamino)methyl)-5-(tert-butyldimethylsilyloxyimino)-5-(4-fluorophenyl)pentanoyl)-4-phenyloxazolidin-2-one

(S)-3-((S)-2-((S)-(4-(benzyloxy)phenyl)(4-fluorophenylamino)methyl)-5-(tert-butyldimethylsilyloxyimino)-5-(4-fluorophenyl)pentanoyl)-4-phenyloxazolidin-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride / pyridine / 0 - 20 °C
2.1: dmap; 1H-imidazole / dichloromethane / 0.17 h / 20 °C
2.2: 5 h
3.1: titanium(IV) isopropylate; N-ethyl-N,N-diisopropylamine; titanium tetrachloride / dichloromethane / 0 °C
3.2: 3 h / -15 °C
View Scheme

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