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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-[(7aS)-7a-methyl-1,5-dioxooctahydro-1H-inden-4-yl]propanoic acid

Cas:1944-63-4

Min.Order:1

Negotiable

Type:Other

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 1944-63-4 with competitive price

Cas:1944-63-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

3-[(3AS,4S,7AS)-7A-METHYL-1,5-DIOXOOCTAHYDRO-1H-INDEN-4-YL]PROPIONIC ACID CAS:1944-63-4

Cas:1944-63-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Indene-4-propanoicacid, octahydro-7a-methyl-1,5-dioxo-, (3aS,4S,7aS)- 1944-63-4

Cas:1944-63-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid

Cas:1944-63-4

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

1H-Indene-4-propanoicacid, octahydro-7a-methyl-1,5-dioxo-, (3aS,4S,7aS)-

Cas:1944-63-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3-[(3AS,4S,7AS)-7A-METHYL-1,5-DIOXOOCTAHYDRO-1H-INDEN-4-YL]PROPIONIC ACID

Cas:1944-63-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

3-[(3AS,4S,7AS)-7A-METHYL-1,5-DIOXOOCTAHYDRO-1H-INDEN-4-YL]PROPIONIC ACID

Cas:1944-63-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

3-[(3AS,4S,7AS)-7A-METHYL-1,5-DIOXOOCTAHYDRO-1H-INDEN-4-YL]PROPIONIC ACID

Cas:1944-63-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

factory?direct?sale Application:healing drugs

1H-Indene-4-propanoicacid, octahydro-7a-methyl-1,5-dioxo-, (3aS,4S,7aS)-

Cas:1944-63-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

3-[(3AS,4S,7AS)-7A-METHYL-1,5-DIOXOOCTAHYDRO-1H-INDEN-4-YL]PROPANOIC ACIDAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

3-[(3AS,4S,7AS)-7A-METHYL-1,5-DIOXOOCTAHYDRO-1H-INDEN-4-YL]PROPANOIC ACID

Cas:1944-63-4

Min.Order:0

Negotiable

Type:Other

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-[(3AS,4S,7AS)-7A-METHYL-1,5-DIOXOOCTAHYDRO-1H-INDEN-4-YL]PROPIONIC ACID

Cas:1944-63-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Zhengzhou Kingorgchem Chemical Technology Co., Ltd.

Zhengzhou Kingorgchem Chemical Technology Co., Ltd. was founded on the basis of Organophosphorus Chemistry Lab of Institute of Chemistry Henan Academy of Sciences in 2015. The laboratory covers 600 m2 and the pilot plant covers 2000 m2. Kingorgchem i

National Research Platform ISO 9001 1944-63-4

Cas:1944-63-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

suzhou BetterBioChem Co., Ltd.

Betterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in

1H-INDENE-4-PROPANOICACID, OCTAHYDRO-7A-METHYL-1,5-DIOXO-, (3AS,4S,7AS)-

Cas:1944-63-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Run-Biotech Co., Ltd.

Shanghai, Run-Biotech Co., Ltd is a leading domestic pharmaceutical, biopharmaceutical, and health care products R & D outsourcing services company. As an innovation-driven and customer-focused company, Run Biotech provides a broad and integrated por

3-[(3AS,4S,7AS)-7A-METHYL-1,5-DIOXOOCTAHYDRO-1H-INDEN-4-YL]PROPIONIC ACID

Cas:1944-63-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry
View More

Synthetic route

C13H18O3

C13H18O3

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

Conditions
ConditionsYield
With sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene In water; tert-butyl alcohol at 20℃; for 18h;40%
[3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-magnesium chloride
62026-31-7

[3-(2-methyl-[1,3]dioxolan-2-yl)-propyl]-magnesium chloride

C18H26O5
74712-32-6, 88293-64-5

C18H26O5

A

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

B

2,2-dimethyl-6-(2-methyl-[1,3]dioxolan-2-yl)-hexan-3-one
71594-11-1

2,2-dimethyl-6-(2-methyl-[1,3]dioxolan-2-yl)-hexan-3-one

C

(+)-3,3-ethylenedioxy-4,5-seco-19-norandrost-9-en-5,17-dione
24894-29-9

(+)-3,3-ethylenedioxy-4,5-seco-19-norandrost-9-en-5,17-dione

Conditions
ConditionsYield
In tetrahydrofuran at -70℃; for 1h; Yield given;
...Expand
(1R,3aS,4S,7aS)-4-(2-Carboxy-ethyl)-1-hydroxy-7a-methyl-5-oxo-octahydro-indene-1-carboxylic acid
37134-59-1

(1R,3aS,4S,7aS)-4-(2-Carboxy-ethyl)-1-hydroxy-7a-methyl-5-oxo-octahydro-indene-1-carboxylic acid

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

Conditions
ConditionsYield
With sodium bismuthate In acetic acid
(S)-Halos-Parish ketone
17553-86-5

(S)-Halos-Parish ketone

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate / ethanol / 0 °C / Inert atmosphere
2.1: 1-methyl-1H-imidazole; iodine / tetrahydrofuran / 42 h / 20 °C / Inert atmosphere
3.1: dimethyl sulfoxide; sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere
3.2: 18 h / 20 °C / Inert atmosphere
4.1: palladium on activated charcoal; hydrogen
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C
7.1: periodic acid / ethyl acetate / 20 °C
8.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate / ethanol / 0 °C / Inert atmosphere
2.1: 1-methyl-1H-imidazole; iodine / tetrahydrofuran / 42 h / 20 °C / Inert atmosphere
3.1: dimethyl sulfoxide; sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere
3.2: 18 h / 20 °C / Inert atmosphere
4.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 1 h / -35 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C
7.1: periodic acid / ethyl acetate / 20 °C
8.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate / ethanol / 0 °C / Inert atmosphere
2.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
3.1: dimethyl sulfoxide; sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere
3.2: 18 h / 20 °C / Inert atmosphere
4.1: palladium on activated charcoal; hydrogen
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C
7.1: periodic acid / ethyl acetate / 20 °C
8.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate / ethanol / 0 °C / Inert atmosphere
2.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
3.1: dimethyl sulfoxide; sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere
3.2: 18 h / 20 °C / Inert atmosphere
4.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 1 h / -35 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C
7.1: periodic acid / ethyl acetate / 20 °C
8.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
C23H40O4Si

C23H40O4Si

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 1 h / -35 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C
4: periodic acid / ethyl acetate / 20 °C
5: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: palladium on activated charcoal; hydrogen
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
3: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C
4: periodic acid / ethyl acetate / 20 °C
5: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
C23H42O4Si

C23H42O4Si

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C
3: periodic acid / ethyl acetate / 20 °C
4: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
C17H28O4

C17H28O4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C
2: periodic acid / ethyl acetate / 20 °C
3: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
(1S,7aS)-1-hydroxy-7a-methyl-2,3,7,7a-tetrahydro-1H-inden-5(6H)-one
16271-49-1

(1S,7aS)-1-hydroxy-7a-methyl-2,3,7,7a-tetrahydro-1H-inden-5(6H)-one

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2.1: dimethyl sulfoxide; sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere
2.2: 18 h / 20 °C / Inert atmosphere
3.1: palladium on activated charcoal; hydrogen
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C
6.1: periodic acid / ethyl acetate / 20 °C
7.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2.1: dimethyl sulfoxide; sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere
2.2: 18 h / 20 °C / Inert atmosphere
3.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 1 h / -35 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C
6.1: periodic acid / ethyl acetate / 20 °C
7.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: 1-methyl-1H-imidazole; iodine / tetrahydrofuran / 42 h / 20 °C / Inert atmosphere
2.1: dimethyl sulfoxide; sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere
2.2: 18 h / 20 °C / Inert atmosphere
3.1: palladium on activated charcoal; hydrogen
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C
6.1: periodic acid / ethyl acetate / 20 °C
7.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: 1-methyl-1H-imidazole; iodine / tetrahydrofuran / 42 h / 20 °C / Inert atmosphere
2.1: dimethyl sulfoxide; sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere
2.2: 18 h / 20 °C / Inert atmosphere
3.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 1 h / -35 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C
6.1: periodic acid / ethyl acetate / 20 °C
7.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
C17H26O4

C17H26O4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: periodic acid / ethyl acetate / 20 °C
2: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
(1S,7aS)-1-((tert-butyldimethylsilyl)oxy)-7a-methyl-1,2,3,6,7,7a-hexahydro-5H-inden-5-one
149789-99-1, 126541-53-5

(1S,7aS)-1-((tert-butyldimethylsilyl)oxy)-7a-methyl-1,2,3,6,7,7a-hexahydro-5H-inden-5-one

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: dimethyl sulfoxide; sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere
1.2: 18 h / 20 °C / Inert atmosphere
2.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol / 1 h / -35 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C
5.1: periodic acid / ethyl acetate / 20 °C
6.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: dimethyl sulfoxide; sodium hydride / tetrahydrofuran; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere
1.2: 18 h / 20 °C / Inert atmosphere
2.1: palladium on activated charcoal; hydrogen
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C
4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 18 h / 20 °C
5.1: periodic acid / ethyl acetate / 20 °C
6.1: sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 18 h / 20 °C
View Scheme
methanol
67-56-1

methanol

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(3aS,7aS)-1,5-dioxo-4α-methylpropionic-3aα,4,5,6,7,7a-hexahydro-7a-methylindan
59005-87-7

(3aS,7aS)-1,5-dioxo-4α-methylpropionic-3aα,4,5,6,7,7a-hexahydro-7a-methylindan

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 23h;96%
With toluene-4-sulfonic acid for 2h; Esterification; Heating;90%
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

1,6,6a,7,8,9,9a,9b-octahydro-6a-methyl-<6aS-(6aα,9aβ,9bα)>cyclopenta<1>benzopyran-3(2H)-7-dione
39783-27-2

1,6,6a,7,8,9,9a,9b-octahydro-6a-methyl-<6aS-(6aα,9aβ,9bα)>cyclopenta<1>benzopyran-3(2H)-7-dione

Conditions
ConditionsYield
With sodium acetate; acetic anhydride for 4h; Heating;93%
With perchloric acid; acetic anhydride In ethyl acetate81%
With perchloric acid; acetic anhydride In ethyl acetate80%
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

A

(3aS,9aS,9bS)-3a-Methyl-1,2,4,6,8,9,9a,9b-octahydro-3aH-6-aza-cyclopenta[a]naphthalene-3,7-dione
24967-14-4

(3aS,9aS,9bS)-3a-Methyl-1,2,4,6,8,9,9a,9b-octahydro-3aH-6-aza-cyclopenta[a]naphthalene-3,7-dione

B

(3aS,9bS)-3a-Methyl-1,2,4,5,6,8,9,9b-octahydro-3aH-6-aza-cyclopenta[a]naphthalene-3,7-dione

(3aS,9bS)-3a-Methyl-1,2,4,5,6,8,9,9b-octahydro-3aH-6-aza-cyclopenta[a]naphthalene-3,7-dione

Conditions
ConditionsYield
With formic acid; ammonium bicarbonate at 120℃; for 1h; Yields of byproduct given;A 59%
B n/a
With formic acid; ammonium bicarbonate at 120℃; for 1h; Yield given. Yields of byproduct given;
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(3aS,7aS)-4-ethylidene-5,6,7,7a-tetrahydro-7a-methylindan-1,5-dione

(3aS,7aS)-4-ethylidene-5,6,7,7a-tetrahydro-7a-methylindan-1,5-dione

Conditions
ConditionsYield
With pyridine; copper diacetate; [bis(acetoxy)iodo]benzene In benzene for 8h; Decarboxylation; Heating;40%
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

pivaloyl chloride
3282-30-2

pivaloyl chloride

C18H26O5
74712-32-6, 88293-64-5

C18H26O5

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at -20℃; Yield given;
With triethylamine In tetrahydrofuran at -30℃; for 3.5h; Temperature; Inert atmosphere;
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

17β-Hydroxy-5-oxo-des-A-10-aza-oestran
17261-92-6

17β-Hydroxy-5-oxo-des-A-10-aza-oestran

Conditions
ConditionsYield
With hydrogenchloride; formic acid; sodium cyanoborohydride; ammonium bicarbonate 1.) 120 deg C, 1 h, 2.) MeOH, pH 1.5-2, room temperature, 48 h; Yield given. Multistep reaction;
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

estradiol
50-28-2

estradiol

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4.1: 85 percent / K2CO3 / methanol / 20 °C
5.1: 78 percent / 4-DMAP / 3 h / 20 °C
6.1: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
7.1: KBH4 / methanol / 1 h / 0 °C
8.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
9.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
10.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
10.2: NCS / tetrahydrofuran / -105 - 25 °C
10.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
11.1: KNH(CH2)3NH2 / tetrahydrofuran / 15 h / 20 °C
11.2: 48 percent HF / acetonitrile / 20 °C
11.3: 45 percent / TFA; Et3SiH / benzene / 15 h / 20 °C
12.1: 80 percent / TFA; Pb(OTFA)4 / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 12 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4.1: 85 percent / K2CO3 / methanol / 20 °C
5.1: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
6.1: t-BuOK / tetrahydrofuran / 0 °C
7.1: KBH4 / methanol / 1 h / 0 °C
8.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
9.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
10.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
10.2: NCS / tetrahydrofuran / -105 - 25 °C
10.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
11.1: KNH(CH2)3NH2 / tetrahydrofuran / 15 h / 20 °C
11.2: 48 percent HF / acetonitrile / 20 °C
11.3: 45 percent / TFA; Et3SiH / benzene / 15 h / 20 °C
12.1: 80 percent / TFA; Pb(OTFA)4 / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 13 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4.1: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5.1: 85 percent / K2CO3 / methanol / 20 °C
6.1: 78 percent / 4-DMAP / 3 h / 20 °C
7.1: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
8.1: KBH4 / methanol / 1 h / 0 °C
9.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
10.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
11.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
11.2: NCS / tetrahydrofuran / -105 - 25 °C
11.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
12.1: KNH(CH2)3NH2 / tetrahydrofuran / 15 h / 20 °C
12.2: 48 percent HF / acetonitrile / 20 °C
12.3: 45 percent / TFA; Et3SiH / benzene / 15 h / 20 °C
13.1: 80 percent / TFA; Pb(OTFA)4 / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 13 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4.1: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5.1: 85 percent / K2CO3 / methanol / 20 °C
6.1: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
7.1: t-BuOK / tetrahydrofuran / 0 °C
8.1: KBH4 / methanol / 1 h / 0 °C
9.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
10.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
11.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
11.2: NCS / tetrahydrofuran / -105 - 25 °C
11.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
12.1: KNH(CH2)3NH2 / tetrahydrofuran / 15 h / 20 °C
12.2: 48 percent HF / acetonitrile / 20 °C
12.3: 45 percent / TFA; Et3SiH / benzene / 15 h / 20 °C
13.1: 80 percent / TFA; Pb(OTFA)4 / 0.5 h / 20 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(3aS,4R,7aS)-7a-Methyl-4-vinyl-2,3,3a,4,7,7a-hexahydro-inden-1-one

(3aS,4R,7aS)-7a-Methyl-4-vinyl-2,3,3a,4,7,7a-hexahydro-inden-1-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4: 85 percent / K2CO3 / methanol / 20 °C
5: 78 percent / 4-DMAP / 3 h / 20 °C
6: 65 percent / t-BuOK / tetrahydrofuran / 0 °C
View Scheme
Multi-step reaction with 6 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4: 85 percent / K2CO3 / methanol / 20 °C
5: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
6: t-BuOK / tetrahydrofuran / 0 °C
View Scheme
Multi-step reaction with 7 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5: 85 percent / K2CO3 / methanol / 20 °C
6: 78 percent / 4-DMAP / 3 h / 20 °C
7: 65 percent / t-BuOK / tetrahydrofuran / 0 °C
View Scheme
Multi-step reaction with 7 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5: 85 percent / K2CO3 / methanol / 20 °C
6: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
7: t-BuOK / tetrahydrofuran / 0 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(3aS,7aS)-7a-Methyl-4-vinyl-2,3,3a,6,7,7a-hexahydro-inden-1-one
250331-22-7

(3aS,7aS)-7a-Methyl-4-vinyl-2,3,3a,6,7,7a-hexahydro-inden-1-one

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4: 85 percent / K2CO3 / methanol / 20 °C
5: 78 percent / 4-DMAP / 3 h / 20 °C
6: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
View Scheme
Multi-step reaction with 6 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4: 85 percent / K2CO3 / methanol / 20 °C
5: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
6: t-BuOK / tetrahydrofuran / 0 °C
View Scheme
Multi-step reaction with 7 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5: 85 percent / K2CO3 / methanol / 20 °C
6: 78 percent / 4-DMAP / 3 h / 20 °C
7: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
View Scheme
Multi-step reaction with 7 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5: 85 percent / K2CO3 / methanol / 20 °C
6: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
7: t-BuOK / tetrahydrofuran / 0 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(1S,3aS,7aS)-7a-Methyl-4-vinyl-2,3,3a,6,7,7a-hexahydro-1H-inden-1-ol
332900-29-5

(1S,3aS,7aS)-7a-Methyl-4-vinyl-2,3,3a,6,7,7a-hexahydro-1H-inden-1-ol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4: 85 percent / K2CO3 / methanol / 20 °C
5: 78 percent / 4-DMAP / 3 h / 20 °C
6: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
7: KBH4 / methanol / 1 h / 0 °C
View Scheme
Multi-step reaction with 7 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4: 85 percent / K2CO3 / methanol / 20 °C
5: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
6: t-BuOK / tetrahydrofuran / 0 °C
7: KBH4 / methanol / 1 h / 0 °C
View Scheme
Multi-step reaction with 8 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5: 85 percent / K2CO3 / methanol / 20 °C
6: 78 percent / 4-DMAP / 3 h / 20 °C
7: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
8: KBH4 / methanol / 1 h / 0 °C
View Scheme
Multi-step reaction with 8 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5: 85 percent / K2CO3 / methanol / 20 °C
6: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
7: t-BuOK / tetrahydrofuran / 0 °C
8: KBH4 / methanol / 1 h / 0 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(3aS,7aS)-4α-ethenyl-5α-hydroxy-1-oxo-,4,5,6,7,7a-hexahydro-7a-methylindan
250331-20-5

(3aS,7aS)-4α-ethenyl-5α-hydroxy-1-oxo-,4,5,6,7,7a-hexahydro-7a-methylindan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4: 85 percent / K2CO3 / methanol / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5: 85 percent / K2CO3 / methanol / 20 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(3aS,7aS)-4α-ethenyl-5α-formyloxy-1-oxo-,4,5,6,7,7a-hexahydro-7a-methylindan
250331-19-2

(3aS,7aS)-4α-ethenyl-5α-formyloxy-1-oxo-,4,5,6,7,7a-hexahydro-7a-methylindan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
View Scheme
Multi-step reaction with 4 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(3aS,5aR,9bS)-7-Hydroxy-3a-methyl-decahydro-6-oxa-cyclopenta[a]naphthalen-3-one

(3aS,5aR,9bS)-7-Hydroxy-3a-methyl-decahydro-6-oxa-cyclopenta[a]naphthalen-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(3aS,7aS)-1,5-dihydroxy-4α-β-propionolactone-3a,4,5,6,7,7a-hexahydro-7a-methylindan

(3aS,7aS)-1,5-dihydroxy-4α-β-propionolactone-3a,4,5,6,7,7a-hexahydro-7a-methylindan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 85 percent / KBH4 / methanol / 0.5 h / 0 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(3aS,7aS)-4α-ethenyl-5α-methanesulfonyl-1-oxo-,4,5,6,7,7a-hexahydro-7a-methylindan
250331-21-6

(3aS,7aS)-4α-ethenyl-5α-methanesulfonyl-1-oxo-,4,5,6,7,7a-hexahydro-7a-methylindan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4: 85 percent / K2CO3 / methanol / 20 °C
5: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
View Scheme
Multi-step reaction with 6 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5: 85 percent / K2CO3 / methanol / 20 °C
6: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(3aS,7aS)-5-formyloxy-4α-(2'-iodoethyl)-1-oxo-3a,4,5,6,7,7a-hexahydro-7a-methylindan
250331-18-1

(3aS,7aS)-5-formyloxy-4α-(2'-iodoethyl)-1-oxo-3a,4,5,6,7,7a-hexahydro-7a-methylindan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

A

(3aS,7aS)-4α-ethenyl-1-[(tert-butyldimethylsilyl)oxy]-3a-methyl-3a,6,7,7a-tetrahydro-4-indene
250331-25-0

(3aS,7aS)-4α-ethenyl-1-[(tert-butyldimethylsilyl)oxy]-3a-methyl-3a,6,7,7a-tetrahydro-4-indene

B

(η6-4-trimethylsilylthiepin-1,1-dioxide)chromium(0)

(η6-4-trimethylsilylthiepin-1,1-dioxide)chromium(0)

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4: 85 percent / K2CO3 / methanol / 20 °C
5: 78 percent / 4-DMAP / 3 h / 20 °C
6: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
7: KBH4 / methanol / 1 h / 0 °C
8: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4: 85 percent / K2CO3 / methanol / 20 °C
5: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
6: t-BuOK / tetrahydrofuran / 0 °C
7: KBH4 / methanol / 1 h / 0 °C
8: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
View Scheme
Multi-step reaction with 9 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5: 85 percent / K2CO3 / methanol / 20 °C
6: 78 percent / 4-DMAP / 3 h / 20 °C
7: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
8: KBH4 / methanol / 1 h / 0 °C
9: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
View Scheme
Multi-step reaction with 9 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5: 85 percent / K2CO3 / methanol / 20 °C
6: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
7: t-BuOK / tetrahydrofuran / 0 °C
8: KBH4 / methanol / 1 h / 0 °C
9: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(3aS,7aS)-5-hydroxy-4α-β-propionolactone-1-[(tert-butyldimethylsilyl)oxy]-3a,4,5,6,7,7a-hexahydro-7a-methylindan

(3aS,7aS)-5-hydroxy-4α-β-propionolactone-1-[(tert-butyldimethylsilyl)oxy]-3a,4,5,6,7,7a-hexahydro-7a-methylindan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 85 percent / KBH4 / methanol / 0.5 h / 0 °C
3: 85 percent / imidazole / dimethylformamide / 18 h / 20 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

3-(tert-butyl-dimethyl-silanyloxy)-3a-methyl-dodecahydro-6-oxa-cyclopenta[a]naphthalen-7-ol

3-(tert-butyl-dimethyl-silanyloxy)-3a-methyl-dodecahydro-6-oxa-cyclopenta[a]naphthalen-7-ol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 85 percent / KBH4 / methanol / 0.5 h / 0 °C
3: 85 percent / imidazole / dimethylformamide / 18 h / 20 °C
4: DIBALH / CH2Cl2; hexane / 1 h / -78 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(3aS,7aS)-4α-ethenyl-1-oxo-5-(4'-methylbenzenesulfonyl)-3a,4,5,6,7,7a-hexahydro-7a-methylindan
250331-24-9

(3aS,7aS)-4α-ethenyl-1-oxo-5-(4'-methylbenzenesulfonyl)-3a,4,5,6,7,7a-hexahydro-7a-methylindan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4: 85 percent / K2CO3 / methanol / 20 °C
5: 78 percent / 4-DMAP / 3 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5: 85 percent / K2CO3 / methanol / 20 °C
6: 78 percent / 4-DMAP / 3 h / 20 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(3aS,7aS)-5-formyloxy-4α-(2'-iodoethylene)-1-[tert-(butyldimethyl)silyloxy]-3a,4,5,6,7,7a-hexahydro-7a-methylindan

(3aS,7aS)-5-formyloxy-4α-(2'-iodoethylene)-1-[tert-(butyldimethyl)silyloxy]-3a,4,5,6,7,7a-hexahydro-7a-methylindan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 85 percent / KBH4 / methanol / 0.5 h / 0 °C
3: 85 percent / imidazole / dimethylformamide / 18 h / 20 °C
4: DIBALH / CH2Cl2; hexane / 1 h / -78 °C
5: 75 percent / I2; iodobenzene diacetate / cyclohexane / Photolysis
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

1β-hydroxy-3-trimethylsilylestra-1,3,5(10)-triene
250331-30-7

1β-hydroxy-3-trimethylsilylestra-1,3,5(10)-triene

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4.1: 85 percent / K2CO3 / methanol / 20 °C
5.1: 78 percent / 4-DMAP / 3 h / 20 °C
6.1: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
7.1: KBH4 / methanol / 1 h / 0 °C
8.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
9.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
10.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
10.2: NCS / tetrahydrofuran / -105 - 25 °C
10.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
11.1: KNH(CH2)3NH2 / tetrahydrofuran / 15 h / 20 °C
11.2: 48 percent HF / acetonitrile / 20 °C
11.3: 45 percent / TFA; Et3SiH / benzene / 15 h / 20 °C
View Scheme
Multi-step reaction with 11 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4.1: 85 percent / K2CO3 / methanol / 20 °C
5.1: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
6.1: t-BuOK / tetrahydrofuran / 0 °C
7.1: KBH4 / methanol / 1 h / 0 °C
8.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
9.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
10.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
10.2: NCS / tetrahydrofuran / -105 - 25 °C
10.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
11.1: KNH(CH2)3NH2 / tetrahydrofuran / 15 h / 20 °C
11.2: 48 percent HF / acetonitrile / 20 °C
11.3: 45 percent / TFA; Et3SiH / benzene / 15 h / 20 °C
View Scheme
Multi-step reaction with 12 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4.1: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5.1: 85 percent / K2CO3 / methanol / 20 °C
6.1: 78 percent / 4-DMAP / 3 h / 20 °C
7.1: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
8.1: KBH4 / methanol / 1 h / 0 °C
9.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
10.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
11.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
11.2: NCS / tetrahydrofuran / -105 - 25 °C
11.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
12.1: KNH(CH2)3NH2 / tetrahydrofuran / 15 h / 20 °C
12.2: 48 percent HF / acetonitrile / 20 °C
12.3: 45 percent / TFA; Et3SiH / benzene / 15 h / 20 °C
View Scheme
Multi-step reaction with 12 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4.1: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5.1: 85 percent / K2CO3 / methanol / 20 °C
6.1: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
7.1: t-BuOK / tetrahydrofuran / 0 °C
8.1: KBH4 / methanol / 1 h / 0 °C
9.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
10.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
11.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
11.2: NCS / tetrahydrofuran / -105 - 25 °C
11.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
12.1: KNH(CH2)3NH2 / tetrahydrofuran / 15 h / 20 °C
12.2: 48 percent HF / acetonitrile / 20 °C
12.3: 45 percent / TFA; Et3SiH / benzene / 15 h / 20 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

17-(tert-butyl-dimethyl-silanyloxy)-13-methyl-3-trimethylsilanyl-7,8,12,13,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthrene

17-(tert-butyl-dimethyl-silanyloxy)-13-methyl-3-trimethylsilanyl-7,8,12,13,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthrene

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4.1: 85 percent / K2CO3 / methanol / 20 °C
5.1: 78 percent / 4-DMAP / 3 h / 20 °C
6.1: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
7.1: KBH4 / methanol / 1 h / 0 °C
8.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
9.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
10.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
10.2: NCS / tetrahydrofuran / -105 - 25 °C
10.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
11.1: potassium 3-aminopropylamide / tetrahydrofuran / 15 h / 20 °C
View Scheme
Multi-step reaction with 11 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4.1: 85 percent / K2CO3 / methanol / 20 °C
5.1: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
6.1: t-BuOK / tetrahydrofuran / 0 °C
7.1: KBH4 / methanol / 1 h / 0 °C
8.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
9.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
10.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
10.2: NCS / tetrahydrofuran / -105 - 25 °C
10.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
11.1: potassium 3-aminopropylamide / tetrahydrofuran / 15 h / 20 °C
View Scheme
Multi-step reaction with 12 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4.1: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5.1: 85 percent / K2CO3 / methanol / 20 °C
6.1: 78 percent / 4-DMAP / 3 h / 20 °C
7.1: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
8.1: KBH4 / methanol / 1 h / 0 °C
9.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
10.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
11.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
11.2: NCS / tetrahydrofuran / -105 - 25 °C
11.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
12.1: potassium 3-aminopropylamide / tetrahydrofuran / 15 h / 20 °C
View Scheme
Multi-step reaction with 12 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4.1: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5.1: 85 percent / K2CO3 / methanol / 20 °C
6.1: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
7.1: t-BuOK / tetrahydrofuran / 0 °C
8.1: KBH4 / methanol / 1 h / 0 °C
9.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
10.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
11.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
11.2: NCS / tetrahydrofuran / -105 - 25 °C
11.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
12.1: potassium 3-aminopropylamide / tetrahydrofuran / 15 h / 20 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

1-[(tert-butyldimethylsilyl)oxy]-3-trimethylsilyl-9Hβ-estra-1,3,5(10),7-tetraene
250331-27-2

1-[(tert-butyldimethylsilyl)oxy]-3-trimethylsilyl-9Hβ-estra-1,3,5(10),7-tetraene

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4.1: 85 percent / K2CO3 / methanol / 20 °C
5.1: 78 percent / 4-DMAP / 3 h / 20 °C
6.1: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
7.1: KBH4 / methanol / 1 h / 0 °C
8.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
9.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
10.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
10.2: NCS / tetrahydrofuran / -105 - 25 °C
10.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
View Scheme
Multi-step reaction with 10 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4.1: 85 percent / K2CO3 / methanol / 20 °C
5.1: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
6.1: t-BuOK / tetrahydrofuran / 0 °C
7.1: KBH4 / methanol / 1 h / 0 °C
8.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
9.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
10.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
10.2: NCS / tetrahydrofuran / -105 - 25 °C
10.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
View Scheme
Multi-step reaction with 11 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4.1: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5.1: 85 percent / K2CO3 / methanol / 20 °C
6.1: 78 percent / 4-DMAP / 3 h / 20 °C
7.1: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
8.1: KBH4 / methanol / 1 h / 0 °C
9.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
10.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
11.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
11.2: NCS / tetrahydrofuran / -105 - 25 °C
11.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
View Scheme
Multi-step reaction with 11 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4.1: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5.1: 85 percent / K2CO3 / methanol / 20 °C
6.1: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
7.1: t-BuOK / tetrahydrofuran / 0 °C
8.1: KBH4 / methanol / 1 h / 0 °C
9.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
10.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
11.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
11.2: NCS / tetrahydrofuran / -105 - 25 °C
11.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

17-(tert-butyl-dimethyl-silanyloxy)-13-methyl-3-trimethylsilanyl-7,11,12,13,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthrene

17-(tert-butyl-dimethyl-silanyloxy)-13-methyl-3-trimethylsilanyl-7,11,12,13,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthrene

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4.1: 85 percent / K2CO3 / methanol / 20 °C
5.1: 78 percent / 4-DMAP / 3 h / 20 °C
6.1: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
7.1: KBH4 / methanol / 1 h / 0 °C
8.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
9.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
10.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
10.2: NCS / tetrahydrofuran / -105 - 25 °C
10.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
11.1: potassium 3-aminopropylamide / tetrahydrofuran / 15 h / 20 °C
View Scheme
Multi-step reaction with 11 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4.1: 85 percent / K2CO3 / methanol / 20 °C
5.1: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
6.1: t-BuOK / tetrahydrofuran / 0 °C
7.1: KBH4 / methanol / 1 h / 0 °C
8.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
9.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
10.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
10.2: NCS / tetrahydrofuran / -105 - 25 °C
10.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
11.1: potassium 3-aminopropylamide / tetrahydrofuran / 15 h / 20 °C
View Scheme
Multi-step reaction with 12 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4.1: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5.1: 85 percent / K2CO3 / methanol / 20 °C
6.1: 78 percent / 4-DMAP / 3 h / 20 °C
7.1: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
8.1: KBH4 / methanol / 1 h / 0 °C
9.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
10.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
11.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
11.2: NCS / tetrahydrofuran / -105 - 25 °C
11.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
12.1: potassium 3-aminopropylamide / tetrahydrofuran / 15 h / 20 °C
View Scheme
Multi-step reaction with 12 steps
1.1: 90 percent / p-TsOH / 2 h / Heating
2.1: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3.1: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4.1: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5.1: 85 percent / K2CO3 / methanol / 20 °C
6.1: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
7.1: t-BuOK / tetrahydrofuran / 0 °C
8.1: KBH4 / methanol / 1 h / 0 °C
9.1: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
10.1: 70 percent / 1,2-dichloro-ethane / UV-irradiation
11.1: t-BuOK / tetrahydrofuran / 0.25 h / -105 °C
11.2: NCS / tetrahydrofuran / -105 - 25 °C
11.3: 60 percent / t-BuOK / tetrahydrofuran / 4 h / 20 °C
12.1: potassium 3-aminopropylamide / tetrahydrofuran / 15 h / 20 °C
View Scheme
3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione
1944-63-4

3aα-H-4α-(3’-propionic acid)-7aβ-methylhexahydro-1,5-indanedione

(1S,2S,5S,9S,13S)-6-[(tert-butyldimethylsilyl)oxy]-5-methyl-15-trimethylsilyl-18-thiatetracyclo[11.4.1.02,10.05,9]-10,14,16-triene-18,18-dioxide
250331-26-1

(1S,2S,5S,9S,13S)-6-[(tert-butyldimethylsilyl)oxy]-5-methyl-15-trimethylsilyl-18-thiatetracyclo[11.4.1.02,10.05,9]-10,14,16-triene-18,18-dioxide

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4: 85 percent / K2CO3 / methanol / 20 °C
5: 78 percent / 4-DMAP / 3 h / 20 °C
6: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
7: KBH4 / methanol / 1 h / 0 °C
8: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
9: 70 percent / 1,2-dichloro-ethane / UV-irradiation
View Scheme
Multi-step reaction with 9 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 82 percent / Pb(OAc)4; Cu(OAc)2; pyridine / benzene / Heating
4: 85 percent / K2CO3 / methanol / 20 °C
5: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
6: t-BuOK / tetrahydrofuran / 0 °C
7: KBH4 / methanol / 1 h / 0 °C
8: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
9: 70 percent / 1,2-dichloro-ethane / UV-irradiation
View Scheme
Multi-step reaction with 10 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5: 85 percent / K2CO3 / methanol / 20 °C
6: 78 percent / 4-DMAP / 3 h / 20 °C
7: 78 percent / t-BuOK / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 °C
8: KBH4 / methanol / 1 h / 0 °C
9: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
10: 70 percent / 1,2-dichloro-ethane / UV-irradiation
View Scheme
Multi-step reaction with 10 steps
1: 90 percent / p-TsOH / 2 h / Heating
2: 86 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C
3: 78 percent / iodobenzene diacetate; I2 / cyclohexane / Photolysis
4: 30 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / Heating
5: 85 percent / K2CO3 / methanol / 20 °C
6: 65 percent / Et3N / CH2Cl2 / 2 h / 0 °C
7: t-BuOK / tetrahydrofuran / 0 °C
8: KBH4 / methanol / 1 h / 0 °C
9: 80 percent / imidazole / dimethylformamide / 18 h / 20 °C
10: 70 percent / 1,2-dichloro-ethane / UV-irradiation
View Scheme

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Cyclohexanecarboxylicacid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (1R,2S)-rel-
194471-87-9

Benzenepropanoic acid,4-chloro-b-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-
19448-61-4

Propanoic-d5 acid-d(9CI)
194490-15-8

1H-Indole-3-carbonitrile,5-fluoro-
194490-17-0

1H-Indole-3-carbonitrile,6-chloro-
194491-03-7

Benzoic acid,2-(iodomethyl)-, ethyl ester
194491-31-1

Glycine,N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, tetrasodium salt, hydrate (9CI)

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