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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

Cas:205444-22-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-chloro-4-iodo-6-(trifluoromethyl)pyridine with high purity

Cas:205444-22-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 205444-22-0 with competitive price

Cas:205444-22-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE CAS:205444-22-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in h

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE CAS:205444-22-0

Cas:205444-22-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Chloro-4-iodo-6-(trifluoromethyl)pyridine

Cas:205444-22-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Chloro-4-iodo-6-(trifluoromethyl)pyridine

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

Cas:205444-22-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

Cas:205444-22-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Chloro-4-iodo-6-(trifluoromethyl)pyridine

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2-chloro-4-iodo-6-(trifluoromethyl)pyridine

Cas:205444-22-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

89466-42-2 4-Chloro-6-methoxy-2-(methylthio)pyrimidine ,98%

Cas:205444-22-0

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

Cas:205444-22-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-Chloro-4-iodo-6-(trifluoromethyl)pyridine

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

Cas:205444-22-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

Cas:205444-22-0

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE/SAGECHEM/Manufacturer in China

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2-Chloro-4-iodo-6-(trifluoromethyl)pyridine

Cas:205444-22-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

Cas:205444-22-0

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-chloro-4-iodo-6-(trifluoromethyl)pyridine cas no. 205444-22-0 98%

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd a comprehensive enterprise, Located in High-Tech Science Park,Changsha,China. Specializing in R&D, manufacture and marketing, Owns one GMP factory and one ISO facotry,cooperated with sever

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

Cas:205444-22-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

2-Chloro-4-iodo-6-(trifluoromethyl)pyridine

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2-Chloro-4-iodo-6-(trifluoromethyl)pyridine

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen AmoyChem Co.,Ltd

Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE Application:2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Other

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE CAS No.205444-22-0

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

205444-22-0

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINEAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan Longxianng Runhui Trading Co.,Ltd

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE Application:205444-22-0 Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport to airport) or by sea LCL/FCL for large amount.

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

2-CHLORO-4-IODO-6-(TRIFLUOROMETHYL)PYRIDINE

Cas:205444-22-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

2-chloro-6-trifluoromethylpyridine
39890-95-4

2-chloro-6-trifluoromethylpyridine

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With n-butyllithium; iodine; diisopropylamine In tetrahydrofuran; hexane 1.) -100 deg C, 2 h; 2.) -100 -> -80 deg C, 30 min;92%
Stage #1: 2-chloro-6-trifluoromethylpyridine With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -100℃; for 2h; Inert atmosphere;
Stage #2: With iodine In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #3: With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 3h; Inert atmosphere;
42%
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
View Scheme
2-chloro-3-iodo-6-(trifluoromethyl)pyridine
205240-59-1

2-chloro-3-iodo-6-(trifluoromethyl)pyridine

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Stage #1: 2-chloro-3-iodo-6-(trifluoromethyl)pyridine With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -75℃; for 0.75h;
Stage #2: With hydrogenchloride In tetrahydrofuran; hexane at 25℃; Further stages.;
83%
With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h; Inert atmosphere;81%
6-chloro-3-iodo-2-(trifluoromethyl)pyridine
945717-57-7

6-chloro-3-iodo-2-(trifluoromethyl)pyridine

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -75 - -72℃; for 1.83333h;69%
4-chloro-2-butanone
6322-49-2

4-chloro-2-butanone

2-(3-methyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)-N-(6'-methyl-5'-(trifluoromethyl)-[2,3-bipyridin]-6-yl)acetamide

2-(3-methyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)-N-(6'-methyl-5'-(trifluoromethyl)-[2,3-bipyridin]-6-yl)acetamide

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 18h; Inert atmosphere;11 mg
2-chloro-6-trifluoromethylpyridine
39890-95-4

2-chloro-6-trifluoromethylpyridine

A

6-chloro-3-iodo-2-(trifluoromethyl)pyridine
945717-57-7

6-chloro-3-iodo-2-(trifluoromethyl)pyridine

B

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Stage #1: 2-chloro-6-trifluoromethylpyridine With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -100℃; for 2h; Inert atmosphere;
Stage #2: With iodine In tetrahydrofuran; hexane at -78℃; for 1h;
5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
885693-20-9

5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

C16H18ClF3N2O2

C16H18ClF3N2O2

Conditions
ConditionsYield
With potassium phosphate; trans-diacetylpalladium(II) bis(dicyclohexylamine) In ethanol at 20℃; for 18h; Inert atmosphere;93%
With potassium phosphate; trans-diacetylpalladium(II) bis(dicyclohexylamine) In ethanol at 20℃; for 18h; Suzuki Coupling; Inert atmosphere;93%
4-fluoroboronic acid
1765-93-1

4-fluoroboronic acid

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

2-chloro-4-(4-fluorophenyl)-6-(trifluoromethyl)pyridine

2-chloro-4-(4-fluorophenyl)-6-(trifluoromethyl)pyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane; water for 1.5h; Reflux;90%
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

2-Chloro-4-iodo-6-trifluoromethyl-3-trimethylsilanyl-pyridine

2-Chloro-4-iodo-6-trifluoromethyl-3-trimethylsilanyl-pyridine

Conditions
ConditionsYield
With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -75℃;86%
4-methoxy-benzylamine
2393-23-9

4-methoxy-benzylamine

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

2-chloro-N-[(4-methoxyphenyl)methyl]-6-(trifluoromethyl)pyridin-4-amine

2-chloro-N-[(4-methoxyphenyl)methyl]-6-(trifluoromethyl)pyridin-4-amine

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate In toluene at 100℃; for 3h; Inert atmosphere;82.51%
carbon dioxide
124-38-9

carbon dioxide

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

2-chloro-6-(trifluoromethyl)pyridine-4-carboxylic acid

2-chloro-6-(trifluoromethyl)pyridine-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 2-chloro-4-iodo-6-(trifluoromethyl)pyridine With n-butyllithium; butyl magnesium bromide In tetrahydrofuran; hexane at 0℃; for 0.0833333h;
Stage #2: carbon dioxide In tetrahydrofuran; hexane
Stage #3: With hydrogenchloride In tetrahydrofuran; hexane Further stages.;
74%
Stage #1: 2-chloro-4-iodo-6-(trifluoromethyl)pyridine With n-butyllithium In tetrahydrofuran; hexane at -75 - -72℃; for 0.333333h;
Stage #2: carbon dioxide In tetrahydrofuran; hexane at 20℃;
56%
C10H18INO2Zn

C10H18INO2Zn

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

C16H20ClF3N2O2

C16H20ClF3N2O2

Conditions
ConditionsYield
With bis(tri-t-butylphosphine)palladium(0) In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;70%
C11H20NO2Zn(1+)*I(1-)

C11H20NO2Zn(1+)*I(1-)

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

C17H22ClF3N2O2

C17H22ClF3N2O2

Conditions
ConditionsYield
With bis(tri-t-butylphosphine)palladium(0) at 20℃; for 1h; Inert atmosphere; Reflux;69%
acetone
67-64-1

acetone

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

2-[2-chloro-6-(trifluoromethyl)pyridin-4-yl]propan-2-ol
1379375-72-0

2-[2-chloro-6-(trifluoromethyl)pyridin-4-yl]propan-2-ol

Conditions
ConditionsYield
Stage #1: 2-chloro-4-iodo-6-(trifluoromethyl)pyridine With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.666667h; Inert atmosphere;
Stage #2: acetone In tetrahydrofuran at 20℃; for 2h;
65%
C14H23N3O

C14H23N3O

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

C20H24ClF3N4O

C20H24ClF3N4O

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; DavePhos In 1,4-dioxane at 100℃; Inert atmosphere; Sealed tube;65%
2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

2-chloro-6-(trifluoromethyl)isonicotinonitrile

2-chloro-6-(trifluoromethyl)isonicotinonitrile

Conditions
ConditionsYield
With copper(l) cyanide In 1-methyl-pyrrolidin-2-one at 120℃; for 0.166667h; sealed vessel;64%
3,5-Bis-trimethylsilyl-bromobenzene
81500-92-7

3,5-Bis-trimethylsilyl-bromobenzene

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

4-(3,5-bis(trimethylsilyl)phenyl)-2-chloro-6-(trifluoromethyl)pyridine

4-(3,5-bis(trimethylsilyl)phenyl)-2-chloro-6-(trifluoromethyl)pyridine

Conditions
ConditionsYield
Stage #1: 3,5-Bis-trimethylsilyl-bromobenzene; bis(pinacol)diborane With tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; tricyclohexylphosphine In 1,4-dioxane at 100 - 110℃; for 2h; Inert atmosphere;
Stage #2: 2-chloro-4-iodo-6-(trifluoromethyl)pyridine With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane; water for 0.5h; Reflux;
60%
2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

2-Chloro-3,4-diiodo-6-trifluoromethyl-pyridine

2-Chloro-3,4-diiodo-6-trifluoromethyl-pyridine

Conditions
ConditionsYield
With n-butyllithium; iodine; diisopropylamine In tetrahydrofuran; hexane at -75℃;59%
N-tert-butoxycarbonyl-3-piperidinol
85275-45-2

N-tert-butoxycarbonyl-3-piperidinol

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

C16H20ClF3N2O3

C16H20ClF3N2O3

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 16h;59%
Stage #1: N-tert-butoxycarbonyl-3-piperidinol With sodium hydride In N,N-dimethyl-formamide; mineral oil at -40℃; for 0.5h;
Stage #2: 2-chloro-4-iodo-6-(trifluoromethyl)pyridine In N,N-dimethyl-formamide; mineral oil at -40 - 20℃; for 16h;
59%
(±)-tert-butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate

(±)-tert-butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

tert-Butyl 7-(2-Chloro-6-(trifluoromethyl)pyridin-4-yl)-2,7-diazaspiro[4.4]nonane-2-carboxylate

tert-Butyl 7-(2-Chloro-6-(trifluoromethyl)pyridin-4-yl)-2,7-diazaspiro[4.4]nonane-2-carboxylate

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate In toluene at 100℃; for 16h; Sealed tube; Inert atmosphere;53%
1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane
423-39-2

1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane

allyl 1-methyl-1H-indole-3-carboxylate

allyl 1-methyl-1H-indole-3-carboxylate

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

(S)-2-(2-chloro-6-(trifluoromethyl)pyridin-4-yl)-4,4,5,5,6,6,7,7,7-nonafluoroheptyl 1-methyl-1H-indole-3-carboxylate

(S)-2-(2-chloro-6-(trifluoromethyl)pyridin-4-yl)-4,4,5,5,6,6,7,7,7-nonafluoroheptyl 1-methyl-1H-indole-3-carboxylate

Conditions
ConditionsYield
Stage #1: allyl 1-methyl-1H-indole-3-carboxylate; 2-chloro-4-iodo-6-(trifluoromethyl)pyridine With manganese; (1,2-dimethoxyethane)dichloronickel(II); (4R,4'R)-4,4'-di(heptan-4-yl)-4,4',5,5'-tetrahydro-2,2'-bioxazole In 1,2-dimethoxyethane for 0.5h; Inert atmosphere;
Stage #2: 1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane With chloro-trimethyl-silane In 1,2-dimethoxyethane at -10℃; for 24h; Inert atmosphere; enantioselective reaction;
50%
C10H18INO2Zn

C10H18INO2Zn

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

C16H20ClF3N2O2

C16H20ClF3N2O2

Conditions
ConditionsYield
With bis(tri-t-butylphosphine)palladium(0) In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;39%
oxetan-3-one
6704-31-0

oxetan-3-one

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

3-[2-chloro-6-(trifluoromethyl)pyridin-4-yl]oxetan-3-ol

3-[2-chloro-6-(trifluoromethyl)pyridin-4-yl]oxetan-3-ol

Conditions
ConditionsYield
Stage #1: 2-chloro-4-iodo-6-(trifluoromethyl)pyridine With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: oxetan-3-one In tetrahydrofuran for 1h;
38%
(S)-N-(4-cyanophenethyl)pyrrolidine-2-carboxamide hydrochloride

(S)-N-(4-cyanophenethyl)pyrrolidine-2-carboxamide hydrochloride

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

(S)-N-(4-cyanophenethyl)-1-(4-iodo-6-(trifluoromethyl)pyridin-2-yl)pyrrolidine-2-carboxamide

(S)-N-(4-cyanophenethyl)-1-(4-iodo-6-(trifluoromethyl)pyridin-2-yl)pyrrolidine-2-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 95℃; for 96h;30%
3,4-dimethoxybenzylamine
5763-61-1

3,4-dimethoxybenzylamine

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

N-(3,4-dimethoxybenzyl)-4-iodo-6-(trifluoromethyl)pyridin-2-amine

N-(3,4-dimethoxybenzyl)-4-iodo-6-(trifluoromethyl)pyridin-2-amine

Conditions
ConditionsYield
With triethylamine In 1-methyl-pyrrolidin-2-one at 100℃; for 0.333333h; Inert atmosphere; Microwave irradiation;28%
copper(l) cyanide

copper(l) cyanide

2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

2-chloro-6-(trifluoromethyl)isonicotinamide

2-chloro-6-(trifluoromethyl)isonicotinamide

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one at 120℃; for 3h; Inert atmosphere;7%
2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

tert-butyl 4-{[4-(aminocarbonyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidine-1-carboxylate
1379376-03-0

tert-butyl 4-{[4-(aminocarbonyl)-6-(trifluoromethyl)pyridin-2-yl]oxy}piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper(l) cyanide / 1-methyl-pyrrolidin-2-one / 0.17 h / 120 °C / sealed vessel
2: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h
View Scheme
2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

2-(piperidin-4-yloxy)-6-(trifluoromethyl)isonicotinamide
1379376-04-1

2-(piperidin-4-yloxy)-6-(trifluoromethyl)isonicotinamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: copper(l) cyanide / 1-methyl-pyrrolidin-2-one / 0.17 h / 120 °C / sealed vessel
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h
3.1: hydrogenchloride / 1,4-dioxane / 2.5 h
3.2: pH 11
View Scheme
2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

2-[(1-{cis-3-(cyanomethyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}piperidin-4-yl)oxy]-6-(trifluoromethyl)isonicotinamide

2-[(1-{cis-3-(cyanomethyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}piperidin-4-yl)oxy]-6-(trifluoromethyl)isonicotinamide

2-[(1-{trans-3-(cyanomethyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}piperidin-4-yl)oxy]-6-(trifluoromethyl)isonicotinamide

2-[(1-{trans-3-(cyanomethyl)-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}piperidin-4-yl)oxy]-6-(trifluoromethyl)isonicotinamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: copper(l) cyanide / 1-methyl-pyrrolidin-2-one / 0.17 h / 120 °C / sealed vessel
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h
3.1: hydrogenchloride / 1,4-dioxane / 2.5 h
3.2: pH 11
4.1: sodium cyanoborohydride; zinc(II) chloride / methanol
View Scheme
2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

2-[(1-{cis-3-(cyanomethyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}piperidin-4-yl)oxy]-6-(trifluoromethyl)isonicotinonitrile

2-[(1-{cis-3-(cyanomethyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}piperidin-4-yl)oxy]-6-(trifluoromethyl)isonicotinonitrile

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: copper(l) cyanide / 1-methyl-pyrrolidin-2-one / 0.17 h / 120 °C / sealed vessel
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.75 h
3.1: hydrogenchloride / 1,4-dioxane / 2.5 h
3.2: pH 11
4.1: sodium cyanoborohydride; zinc(II) chloride / methanol
5.1: triethylamine; trichloroacetic acid anhydride / dichloromethane / 0.42 h / 0 °C
5.2: 1 h
View Scheme
2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

{cis-3-(4-{[4-(2-hydroxyethyl)-6-(trifluoromethyl)pyridin-2-yl]amino}piperidin-1-yl)-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile

{cis-3-(4-{[4-(2-hydroxyethyl)-6-(trifluoromethyl)pyridin-2-yl]amino}piperidin-1-yl)-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C
1.2: 1.5 h / -78 - 20 °C
2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 3.33 h / 100 - 140 °C / Microwave irradiation
3.1: sodium cyanoborohydride; zinc(II) chloride / methanol / 1.33 h
4.1: trifluoroacetic acid / dichloromethane / 1 h
View Scheme
2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

{trans-3-(4-{[4-(2-hydroxyethyl)-6-(trifluoromethyl)pyridin-2-yl]amino}piperidin-1-yl)-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile

{trans-3-(4-{[4-(2-hydroxyethyl)-6-(trifluoromethyl)pyridin-2-yl]amino}piperidin-1-yl)-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutyl}acetonitrile

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C
1.2: 1.5 h / -78 - 20 °C
2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 3.33 h / 100 - 140 °C / Microwave irradiation
3.1: sodium cyanoborohydride; zinc(II) chloride / methanol / 1.33 h
4.1: trifluoroacetic acid / dichloromethane / 1 h
View Scheme
2-chloro-4-iodo-6-(trifluoromethyl)pyridine
205444-22-0

2-chloro-4-iodo-6-(trifluoromethyl)pyridine

2-[2-(piperidin-4-ylamino)-6-(trifluoromethyl)pyridin-4-yl]ethanol

2-[2-(piperidin-4-ylamino)-6-(trifluoromethyl)pyridin-4-yl]ethanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -78 °C
1.2: 1.5 h / -78 - 20 °C
2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 3.33 h / 100 - 140 °C / Microwave irradiation
View Scheme

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