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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Berberine Manufacturer/High quality/Best price/In stock

Cas:2086-83-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High quality Berberine powder with factory price

Cas:2086-83-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Berberine (base and/or unspecified salts)

Cas:2086-83-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Berberine

Cas:2086-83-1

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New productCAS 2086-83-1 with best quality

Cas:2086-83-1

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

BerberineCAS2086-83-1

Cas:2086-83-1

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy- 2086-83-1

Cas:2086-83-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Berberine

Cas:2086-83-1

Min.Order:1 Kilogram

FOB Price: $150.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Berberine CAS:2086-83-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

Berberine CAS:2086-83-1

Cas:2086-83-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Berberine

Cas:2086-83-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

BERBERINE

Cas:2086-83-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

API name: Berberine Certificates: GMP, DMF CAS No.:2086-83-1 Chemical name: EINECS 211-195-9 Formula: C20H18NO4+ Structure: Appearance:White or off white powder Storage:Store sealed at room temperature Package:25Kg/drum Applic

Berberine

Cas:2086-83-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-

Cas:2086-83-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer?Answer: Yes, we are factory founded on 2002. Q2: How to contact with us?Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours. Q3:Which kind of payment terms do yo

High quality Berberine powder with factory price

Cas:2086-83-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hefei Zhaobo Technology Co., Ltd.

Berberine CAS 2086-83-1 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control system,

Berberine CAS 2086-83-1

Cas:2086-83-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

BERBERINE

Cas:2086-83-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Miheng Trading Co., Ltd.

Berberine CAS 2086-83-1 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2 Prof

Berberine CAS 2086-83-1

Cas:2086-83-1

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Berberine

Cas:2086-83-1

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-

Cas:2086-83-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Berberine

Cas:2086-83-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Wuhan Xinhao Biotechnology Co., Ltd.

Our Strengths 1.Place of Origin China with Super quality by reasonable price. 2.Fast delivery by safe express way to all the country. 3.Has a number of highly qualified engineers and experts to provide guidance for reagents. 4.When you meet problems

Factory supply Berberine with Good Price CAS NO.2086-83-1

Cas:2086-83-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery

Top supplier Berberine 2086-83-1 in China

Cas:2086-83-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Berberine Chloride

Cas:2086-83-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Berberine

Cas:2086-83-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

2086-83-1 Berberine

Cas:2086-83-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Berberine

Cas:2086-83-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle

Berberine.99%

Cas:2086-83-1

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Berberine Tannate CAS No.:2086-83-1 Molecule Formula:C20H18NO4 Molecule Weight:336.36 Purity: 99.0% Package: 25kg/drum Description:Yellow powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Best Quality Berberine Tannate

Cas:2086-83-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Top sell products 98% Berberine by HPLC,CAS:2086-83-1

Cas:2086-83-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Synthetic route

C21H19NO6
94272-86-3

C21H19NO6

berberine
2086-83-1

berberine

Conditions
ConditionsYield
With sodium cyanoborohydride In methanol96%
canadine
29074-38-2

canadine

berberine
2086-83-1

berberine

Conditions
ConditionsYield
With iodine In ethanol at 20℃;90%
Multi-step reaction with 2 steps
1.1: 81 percent / mCPBA / CHCl3 / 20 °C
2.1: TFAA / CH2Cl2 / -30 - 20 °C
2.2: NaOAc / CH2Cl2; H2O / 0.5 h / 20 °C
View Scheme
With (S)-tetrahydroprotoberberine oxidase; tris hydrochloride at 37℃; for 2h; pH=8.8; Enzymatic reaction;
2-{6-[(7,8-dimethoxyisoquinolin-3-yl)]benzo[d][1,3]-dioxol-5-yl}ethanol

2-{6-[(7,8-dimethoxyisoquinolin-3-yl)]benzo[d][1,3]-dioxol-5-yl}ethanol

berberine
2086-83-1

berberine

Conditions
ConditionsYield
With methanesulfonyl chloride; triethylamine In dichloromethane at 20℃; for 6h;88%
potassium cyanide
151-50-8

potassium cyanide

(+/-)-trans-canadine N-oxide
75821-49-7

(+/-)-trans-canadine N-oxide

A

berberine
2086-83-1

berberine

(8S,14S)-(+/-)-8-cyanocanadine

(8S,14S)-(+/-)-8-cyanocanadine

Conditions
ConditionsYield
Stage #1: (+/-)-trans-canadine N-oxide With trifluoroacetic anhydride In dichloromethane at -30 - 20℃; Elimination; Polonovski-Potier reaction;
Stage #2: potassium cyanide With sodium acetate In dichloromethane; water at 20℃; for 0.5h; Addition; tautomerization; aromatization;
A n/a
B 29%
canadine
29074-38-2

canadine

A

oxyberberine
549-21-3

oxyberberine

B

berberine
2086-83-1

berberine

C

3-<3,4-dihydro-1-oxo-6,7-(methylenedioxy)-2H-isoquinolin-2-yl>-4,5-dimethoxy-1(3H)-isobenzofuranone
64939-64-6, 66408-44-4

3-<3,4-dihydro-1-oxo-6,7-(methylenedioxy)-2H-isoquinolin-2-yl>-4,5-dimethoxy-1(3H)-isobenzofuranone

Conditions
ConditionsYield
With iodosylbenzene; tetra-(n-butyl)ammonium iodide In water; acetonitrile at 50℃; for 18h;A 6%
B 15%
C 25%
canadine
29074-38-2

canadine

A

berberine
2086-83-1

berberine

B

H2O2, H2O

H2O2, H2O

Conditions
ConditionsYield
With (S)-protoberberine oxidase; oxygen Equilibrium constant; enzyme activity for the substrate;
9,10-dimethoxy-5,6,7,8-tetrahydro-2H-1,3-dioxolano[4,5-g]isoquinolino[3,2-a]isoquinoline-8-carbonitrile
113975-46-5

9,10-dimethoxy-5,6,7,8-tetrahydro-2H-1,3-dioxolano[4,5-g]isoquinolino[3,2-a]isoquinoline-8-carbonitrile

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: NaBH4
2.1: 81 percent / mCPBA / CHCl3 / 20 °C
3.1: TFAA / CH2Cl2 / -30 - 20 °C
3.2: NaOAc / CH2Cl2; H2O / 0.5 h / 20 °C
View Scheme
berberine chloride
633-65-8

berberine chloride

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: NaBH4 / methanol
2.1: 81 percent / mCPBA / CHCl3 / 20 °C
3.1: TFAA / CH2Cl2 / -30 - 20 °C
3.2: NaOAc / CH2Cl2; H2O / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 95 percent / methanol; H2O
2.1: NaBH4
3.1: 81 percent / mCPBA / CHCl3 / 20 °C
4.1: TFAA / CH2Cl2 / -30 - 20 °C
4.2: NaOAc / CH2Cl2; H2O / 0.5 h / 20 °C
View Scheme
With sodium tetrahydroborate In pyridine at 20℃;
C21H21NO6
94272-85-2

C21H21NO6

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / silver carbonate / benzene / Heating
2: 96 percent / sodium cyanoborohydride / methanol
View Scheme
spirobenzylisoquinoline
84229-90-3

spirobenzylisoquinoline

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / methanol / Ambient temperature
2: 93 percent / silver carbonate / benzene / Heating
3: 96 percent / sodium cyanoborohydride / methanol
View Scheme
allocryptopine
485-91-6

allocryptopine

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: oxalyl dichloride / chloroform / 1 h / Reflux
2: dimethyl sulfoxide / 25.5 h / 115 - 120 °C
View Scheme
N-methyl-7,8-dihydroberberine
47474-50-0

N-methyl-7,8-dihydroberberine

berberine
2086-83-1

berberine

Conditions
ConditionsYield
In dimethyl sulfoxide at 115 - 120℃; for 25.5h;
7,8-dihydroberberine
483-15-8

7,8-dihydroberberine

berberine
2086-83-1

berberine

Conditions
ConditionsYield
With iodine; potassium acetate In ethanol at 20℃; Inert atmosphere;6.7 mg
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere
2: iodine / ethanol / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: diborane
2: iodine / ethanol / 20 °C
View Scheme
C21H21NO5

C21H21NO5

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Wilkinson's catalyst
2: iodine / ethanol / 20 °C
View Scheme
C21H20BrNO4

C21H20BrNO4

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
2: 9-borabicyclo[3.3.1]nonane dimer; sodium hydroperoxide
3: Wilkinson's catalyst
4: iodine / ethanol / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
2: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
3: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
4: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
5: potassium acetate; iodine / ethanol / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 6 steps
1: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
2: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
3: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
4: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
5: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere
6: iodine / ethanol / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
2: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
3: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
4: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
5: diborane
6: iodine / ethanol / 20 °C
View Scheme
5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline
94143-83-6

5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: copper(l) iodide; benzoic acid / toluene / 12 h / 80 °C / Inert atmosphere; Molecular sieve
2: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
3: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
4: 9-borabicyclo[3.3.1]nonane dimer; sodium hydroperoxide
5: Wilkinson's catalyst
6: iodine / ethanol / 20 °C
View Scheme
Multi-step reaction with 7 steps
1: copper(l) iodide; benzoic acid / toluene / 12 h / 80 °C / Inert atmosphere; Molecular sieve
2: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
3: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
5: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
6: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
7: potassium acetate; iodine / ethanol / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 8 steps
1: copper(l) iodide; benzoic acid / toluene / 12 h / 80 °C / Inert atmosphere; Molecular sieve
2: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
3: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
5: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
6: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
7: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere
8: iodine / ethanol / 20 °C
View Scheme
Multi-step reaction with 8 steps
1: copper(l) iodide; benzoic acid / toluene / 12 h / 80 °C / Inert atmosphere; Molecular sieve
2: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
3: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
5: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
6: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
7: diborane
8: iodine / ethanol / 20 °C
View Scheme
6-bromo-2,3-dimethoxybenzaldehyde
53811-50-0

6-bromo-2,3-dimethoxybenzaldehyde

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: copper(l) iodide; benzoic acid / toluene / 12 h / 80 °C / Inert atmosphere; Molecular sieve
2: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
3: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
4: 9-borabicyclo[3.3.1]nonane dimer; sodium hydroperoxide
5: Wilkinson's catalyst
6: iodine / ethanol / 20 °C
View Scheme
Multi-step reaction with 7 steps
1: copper(l) iodide; benzoic acid / toluene / 12 h / 80 °C / Inert atmosphere; Molecular sieve
2: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
3: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
5: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
6: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
7: potassium acetate; iodine / ethanol / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 8 steps
1: copper(l) iodide; benzoic acid / toluene / 12 h / 80 °C / Inert atmosphere; Molecular sieve
2: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
3: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
5: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
6: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
7: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere
8: iodine / ethanol / 20 °C
View Scheme
Multi-step reaction with 8 steps
1: copper(l) iodide; benzoic acid / toluene / 12 h / 80 °C / Inert atmosphere; Molecular sieve
2: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
3: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
5: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
6: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
7: diborane
8: iodine / ethanol / 20 °C
View Scheme
C21H21NO4

C21H21NO4

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 9-borabicyclo[3.3.1]nonane dimer; sodium hydroperoxide
2: Wilkinson's catalyst
3: iodine / ethanol / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
2: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
3: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
4: potassium acetate; iodine / ethanol / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
2: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
3: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
4: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere
5: iodine / ethanol / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
2: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
3: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
4: diborane
5: iodine / ethanol / 20 °C
View Scheme
C24H28BrNO4Si

C24H28BrNO4Si

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
2: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
3: 9-borabicyclo[3.3.1]nonane dimer; sodium hydroperoxide
4: Wilkinson's catalyst
5: iodine / ethanol / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
2: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
3: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
4: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
5: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
6: potassium acetate; iodine / ethanol / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 7 steps
1: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
2: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
3: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
4: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
5: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
6: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere
7: iodine / ethanol / 20 °C
View Scheme
Multi-step reaction with 7 steps
1: potassium carbonate / methanol / 0.5 h / 20 °C / Inert atmosphere
2: sodium formate; tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere
3: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / acetonitrile / 2 h / 50 °C / Inert atmosphere; Molecular sieve
4: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
5: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
6: diborane
7: iodine / ethanol / 20 °C
View Scheme
Oxyberberine-13-carboxaldehyde
75767-29-2

Oxyberberine-13-carboxaldehyde

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
2: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
3: potassium acetate; iodine / ethanol / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
2: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
3: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere
4: iodine / ethanol / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: Wilkinson's catalyst; diphenyl phosphoryl azide / diethylene glycol dimethyl ether / 12 h / 160 °C / Inert atmosphere
2: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
3: diborane
4: iodine / ethanol / 20 °C
View Scheme
oxyberberine
549-21-3

oxyberberine

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
2: potassium acetate; iodine / ethanol / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
2: sodium tetrahydroborate / methanol / 2 h / 20 °C / Inert atmosphere
3: iodine / ethanol / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 2 h / Reflux; Inert atmosphere
2: diborane
3: iodine / ethanol / 20 °C
View Scheme
C10H8ClNO2

C10H8ClNO2

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / tetrahydrofuran / 65 °C
2: sodium carbonate; tris-(dibenzylideneacetone)dipalladium(0); XPhos / toluene; ethanol / 12 h / 110 °C / Inert atmosphere
3: triethylamine; methanesulfonyl chloride / dichloromethane / 6 h / 20 °C
View Scheme
3-chloro-7,8-dimethoxyisoquinoline

3-chloro-7,8-dimethoxyisoquinoline

berberine
2086-83-1

berberine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate; tris-(dibenzylideneacetone)dipalladium(0); XPhos / toluene; ethanol / 12 h / 110 °C / Inert atmosphere
2: triethylamine; methanesulfonyl chloride / dichloromethane / 6 h / 20 °C
View Scheme
berberine
2086-83-1

berberine

Conditions
ConditionsYield
In chloroform for 0.0833333h; microwave irradiation;98%
In neat (no solvent) at 190℃; for 0.75h;79%
at 180℃; for 1h;
glycyrrhizic acid

glycyrrhizic acid

berberine
2086-83-1

berberine

C20H18NO4(1+)*C42H61O16(1-)

C20H18NO4(1+)*C42H61O16(1-)

Conditions
ConditionsYield
With sodium hydroxide In ethanol at 60 - 70℃; pH=7 - 8;92%
enoxolone
471-53-4

enoxolone

berberine
2086-83-1

berberine

C30H45O4(1-)*C20H18NO4(1+)

C30H45O4(1-)*C20H18NO4(1+)

Conditions
ConditionsYield
In ethanol at 60 - 70℃; pH=7 - 8;86%
berberine
2086-83-1

berberine

canadine
29074-38-2

canadine

Conditions
ConditionsYield
With indium; ammonium chloride In ethanol for 10h; Heating;83%
With hydrogenchloride; zinc for 3h; Heating;65%
With sodium tetrahydroborate
With sodium tetrahydroborate In water for 1h; Cooling with ice;
With sodium tetrahydroborate In methanol for 24.25h;
berberine
2086-83-1

berberine

7,8-dihydroberberine
483-15-8

7,8-dihydroberberine

Conditions
ConditionsYield
With sodium tetrahydroborate; potassium carbonate; sodium hydroxide In methanol at 20℃; for 3h;81%
With pyridine; sodium tetrahydroborate at 20℃; for 1h;
With sodium tetrahydroborate
With pyridine; sodium tetrahydroborate at 25℃;
berberine
2086-83-1

berberine

berberrubine
17388-19-1

berberrubine

Conditions
ConditionsYield
With C60H54N2O10(2+) In N,N-dimethyl-formamide at 50 - 400℃; Solvent;75%
at 190 - 200℃; under 20 - 30 Torr; for 0.5h;75%
at 190 - 200℃; under 20 - 30 Torr; for 0.5h;75%
berberine
2086-83-1

berberine

Dehydro-berberubinium
54313-01-8

Dehydro-berberubinium

Conditions
ConditionsYield
at 190 - 200℃; under 20 - 30 Torr; for 0.5h;75%
Mangiferin

Mangiferin

berberine
2086-83-1

berberine

mangiferin-berberine salt

mangiferin-berberine salt

Conditions
ConditionsYield
Stage #1: Mangiferin With sodium hydrogencarbonate In ethanol; water
Stage #2: berberine In ethanol; water for 12h;
70.5%
5-(4-(2-bromoethoxy)benzyl)thiazolidine-2,4-dione

5-(4-(2-bromoethoxy)benzyl)thiazolidine-2,4-dione

berberine
2086-83-1

berberine

9-(2-(4-((2,4-thiazolidinedione-5-yl)methyl)phenoxy)ethoxy)-O-berberine hydrobromide

9-(2-(4-((2,4-thiazolidinedione-5-yl)methyl)phenoxy)ethoxy)-O-berberine hydrobromide

Conditions
ConditionsYield
With sodium hydride In dimethyl sulfoxide; mineral oil at 50℃; for 5h;70%
5-(4-((2-bromoethyl)thio)benzyl)thiazolidine-2,4-dione

5-(4-((2-bromoethyl)thio)benzyl)thiazolidine-2,4-dione

berberine
2086-83-1

berberine

9-(3-(4-((2,4-thiazolidinedione-5-yl)methyl)phenylthio)propoxy)-O-berberine hydrobromide

9-(3-(4-((2,4-thiazolidinedione-5-yl)methyl)phenylthio)propoxy)-O-berberine hydrobromide

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 50℃; for 8h;69%
5-(4-(4-bromobutoxy)benzyl)thiazolidine-2,4-dione

5-(4-(4-bromobutoxy)benzyl)thiazolidine-2,4-dione

berberine
2086-83-1

berberine

9-(4-(4-((2,4-thiazolidinedione-5-yl)methyl)phenoxy)butoxy)-O-berberine hydrobromide

9-(4-(4-((2,4-thiazolidinedione-5-yl)methyl)phenoxy)butoxy)-O-berberine hydrobromide

Conditions
ConditionsYield
With sodium hydride In dimethyl sulfoxide; mineral oil at 60℃; for 6h;66%
5-(4-((4-bromobutyl)thio)benzyl)thiazolidine-2,4-dione

5-(4-((4-bromobutyl)thio)benzyl)thiazolidine-2,4-dione

berberine
2086-83-1

berberine

9-(4-(4-((2,4-thiazolidinedione-5-yl)methyl)phenylthio)butoxy)-O-berberine hydrobromide

9-(4-(4-((2,4-thiazolidinedione-5-yl)methyl)phenylthio)butoxy)-O-berberine hydrobromide

Conditions
ConditionsYield
With sodium hydride In dimethyl sulfoxide; mineral oil at 55℃; for 7h;65%
5-(4-((3-bromopropyl)thio)benzyl)thiazolidine-2,4-dione

5-(4-((3-bromopropyl)thio)benzyl)thiazolidine-2,4-dione

berberine
2086-83-1

berberine

9-(3-(4-((2,4-thiazolidinedione-5-yl)methyl)phenylthio)butoxy)-O-berberine hydrobromide

9-(3-(4-((2,4-thiazolidinedione-5-yl)methyl)phenylthio)butoxy)-O-berberine hydrobromide

Conditions
ConditionsYield
With sodium hydride In dimethyl sulfoxide; mineral oil at 60℃; for 5h;61.7%
Octanal
124-13-0

Octanal

berberine
2086-83-1

berberine

9,10-dimethoxy-13-octyl-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride
947599-36-2

9,10-dimethoxy-13-octyl-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride

Conditions
ConditionsYield
Stage #1: berberine With sodium tetrahydroborate; potassium carbonate; sodium hydroxide In methanol at 20℃; for 2h;
Stage #2: Octanal With acetic acid In ethanol at 90℃; for 6h;
51%
berberine
2086-83-1

berberine

A

oxyberberine
549-21-3

oxyberberine

B

3-<3,4-dihydro-1-oxo-6,7-(methylenedioxy)-2H-isoquinolin-2-yl>-4,5-dimethoxy-1(3H)-isobenzofuranone
64939-64-6, 66408-44-4

3-<3,4-dihydro-1-oxo-6,7-(methylenedioxy)-2H-isoquinolin-2-yl>-4,5-dimethoxy-1(3H)-isobenzofuranone

C

13-hydroxy-8-oxo-berberine
66408-27-3

13-hydroxy-8-oxo-berberine

Conditions
ConditionsYield
With iodosylbenzene; tetra-(n-butyl)ammonium iodide In water; acetonitrile at 50℃; for 18h;A 5%
B 37%
C 14%
methanol
67-56-1

methanol

berberine
2086-83-1

berberine

8-methoxyberberine phenolbetaine
61138-60-1

8-methoxyberberine phenolbetaine

Conditions
ConditionsYield
(i) K3Fe(CN)6, (ii) /BRN= 1098229/, HCl; Multistep reaction;
methanol
67-56-1

methanol

berberine
2086-83-1

berberine

1-[(3',4'-dimethoxy-2'-methylcarboxy)benzoyl]-6,7-methylenedioxyisoquinoline
71733-98-7

1-[(3',4'-dimethoxy-2'-methylcarboxy)benzoyl]-6,7-methylenedioxyisoquinoline

Conditions
ConditionsYield
(i) K3Fe(CN)6, (ii) Py*HCl, (iii) HCl, /BRN= 1098229/; Multistep reaction;
methanol
67-56-1

methanol

berberine
2086-83-1

berberine

9,10,13a-trimethoxy-2,3-(methylenedioxy)-8,13-dioxo-5,6,13,13a-tetrahydro-8H-dibenzoquinolizine
71733-96-5, 95585-80-1

9,10,13a-trimethoxy-2,3-(methylenedioxy)-8,13-dioxo-5,6,13,13a-tetrahydro-8H-dibenzoquinolizine

Conditions
ConditionsYield
(i) K3Fe(CN)6, (ii) Py*HCl, (iii) /BRN= 1098229/; Multistep reaction;
berberine
2086-83-1

berberine

13a-hydroxy-9,10-dimethoxy-2,3-(methylenedioxy)-8,13-dioxo-5,6,13,13a-tetrahydro-8H-dibenzoquinolizine
71766-69-3

13a-hydroxy-9,10-dimethoxy-2,3-(methylenedioxy)-8,13-dioxo-5,6,13,13a-tetrahydro-8H-dibenzoquinolizine

Conditions
ConditionsYield
(i) K3Fe(CN)6, (ii) Py*HCl; Multistep reaction;
berberine
2086-83-1

berberine

sodium methylate
124-41-4

sodium methylate

7,8-dihydro-8-methoxyberberine
60229-96-1

7,8-dihydro-8-methoxyberberine

Conditions
ConditionsYield
In methanol Ambient temperature;
berberine
2086-83-1

berberine

coptisine
3486-66-6

coptisine

Conditions
ConditionsYield
Multistep reaction;
berberine
2086-83-1

berberine

9,10-dimethoxy-2,3-methylenedioxy-8,14-cycloberbin-13-one
80665-65-2

9,10-dimethoxy-2,3-methylenedioxy-8,14-cycloberbin-13-one

berberine
2086-83-1

berberine

acetone
67-64-1

acetone

acetoneberberine
39024-13-0

acetoneberberine

Conditions
ConditionsYield
With alkali
berberine
2086-83-1

berberine

dimethyl sulfate
77-78-1

dimethyl sulfate

9,10-dimethoxy-7-methyl-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; methyl sulfate
32245-50-4

9,10-dimethoxy-7-methyl-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium; methyl sulfate

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