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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

(S)-4,5-dihydro-2-(6-hydroxybenzothiazol-2-yl)thiazole-4-carboxylic acid

Cas:2591-17-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

High quality D-luciferin Cas 2591-17-5 with bulk stock and favorable price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food

High quality D-luciferin Cas 2591-17-5 with bulk stock and favorable price

Cas:2591-17-5

Min.Order:10 Gram

FOB Price: $10.0

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality se T rvice Appearance:Whit

D-(-)-Luciferin [CheMiluMinescence Reagent]

Cas:2591-17-5

Min.Order:100 Gram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

D-Luciferin

Cas:2591-17-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name D-Luciferin CAS No. 2591-17-5 As

D-Luciferin

Cas:2591-17-5

Min.Order:1 Gram

FOB Price: $12.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

D-LUCIFERIN CAS 2591-17-5

Cas:2591-17-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 2591-17-5 with best quality

Cas:2591-17-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 2591-17-5 ,D-LUCIFERIN

Cas:2591-17-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

D-LUCIFERIN

Cas:2591-17-5

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name: D-Luciferin CAS No.: 2591-17-5 Molecular Formula: C11H8N2O3S2 Molecular Weight: 280.32 Appearance: Light yellow to yellow (Solid) Appearance: Yellow Powder Storage:Store in cool and dry place, away from sun light. Package: 25kg

D-Luciferin

Cas:2591-17-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: D-LUCIFERIN CAS: 2591-17-5 MF: C11H8N2O3S2 MW: 280.32 EINECS: 219-981-3 Mol File: 2591-17-5.mol D-LUCIFERIN Structure D-LUCIFERIN Chemical Properties Melting point 200-204 °C alpha D22 -36° (c = 1.2 i

D-LUCIFERIN

Cas:2591-17-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

4-Thiazolecarboxylicacid, 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-, (4S)-

Cas:2591-17-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

D-LUCIFERIN CAS:2591-17-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

D-LUCIFERIN CAS:2591-17-5

Cas:2591-17-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-Thiazolecarboxylicacid, 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-, (4S)-

Cas:2591-17-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-Thiazolecarboxylicacid, 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-, (4S)-

Cas:2591-17-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio

D-Luciferin

Cas:2591-17-5

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

D-Luciferin

Cas:2591-17-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

D-Luciferin

Cas:2591-17-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

D-Luciferin

Cas:2591-17-5

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

D-LUCIFERIN

Cas:2591-17-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

D-(-)-Luciferin [CheMiluMinescence Reagent]

Cas:2591-17-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

D-LUCIFERINAppearance:off-white to light yellow powder Storage:-20°C temperature Package:according to customers' requirements Application:2591-17-5 Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or accordi

D-LUCIFERIN

Cas:2591-17-5

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

D-LUCIFERIN

Cas:2591-17-5

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality moderate price & quick delivery Appearance:off-white to light yellow powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application

4-Thiazolecarboxylicacid, 4,5-dihydro-2-(6-hydroxy-2-benzothiazolyl)-, (4S)-

Cas:2591-17-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

D-LUCIFERIN

Cas:2591-17-5

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

D-Luciferin

Cas:2591-17-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

D-Luciferin

Cas:2591-17-5

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

High quality, competitive price, fast delivery and first-class service we possesses have won the trust and praise of customers. Standard: BP/USP/EP The purity is equal or greater than 99%. As a supplier, we can provide high-quality products. Cle

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

D-LUCIFERIN

Cas:2591-17-5

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

D-LUCIFERIN

Cas:2591-17-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

D-cysteine
921-01-7

D-cysteine

2-cyano-6-hydroxybenzothiazole
939-69-5

2-cyano-6-hydroxybenzothiazole

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
In water at 20℃;95%
With ammonia; sodium In methanol; water94%
Stage #1: D-cysteine; 2-cyano-6-hydroxybenzothiazole In aq. buffer for 1h;
Stage #2: With ATP; magnesium chloride; zinc(II) chloride; luciferase In aq. buffer
27%
D-cysteine hydrochloride
32443-99-5

D-cysteine hydrochloride

2-cyano-6-hydroxybenzothiazole
939-69-5

2-cyano-6-hydroxybenzothiazole

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
With potassium carbonate In methanol; water for 0.333333h; Inert atmosphere;86%
With potassium carbonate In water; acetonitrile at 20℃; for 0.333333h;86%
With potassium carbonate In methanol; water for 0.0833333h; Yield given;
With potassium carbonate In methanol for 8h; Concentration; Reagent/catalyst; Inert atmosphere;22.76g
l-cysteine hydrochloride
52-89-1

l-cysteine hydrochloride

2-cyano-6-hydroxybenzothiazole
939-69-5

2-cyano-6-hydroxybenzothiazole

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Stage #1: l-cysteine hydrochloride; 2-cyano-6-hydroxybenzothiazole In methanol; water at 20℃; for 0.0833333h; Inert atmosphere;
Stage #2: With potassium carbonate In methanol; water at 20℃; for 0.333333h; Inert atmosphere;
86%
With potassium carbonate In methanol; dichloromethane; water for 0.166667h; Cooling with ice;80%
S,S-cystine
349-46-2

S,S-cystine

2-cyano-6-hydroxybenzothiazole
939-69-5

2-cyano-6-hydroxybenzothiazole

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
(i) Na, liq. NH3, (ii) /BRN= 744134/, aq. MeOH; Multistep reaction;
luciferin 2-nitro-5-methylbenzenesulfonate
918400-82-5

luciferin 2-nitro-5-methylbenzenesulfonate

GLUTATHIONE
70-18-8

GLUTATHIONE

A

2-amino-4-[1-(carboxymethyl-carbamoyl)-2-(5-methyl-2-nitro-phenylsulfanyl)-ethylcarbamoyl]-butyric acid

2-amino-4-[1-(carboxymethyl-carbamoyl)-2-(5-methyl-2-nitro-phenylsulfanyl)-ethylcarbamoyl]-butyric acid

B

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
With human glutathione S-transferase P1-1 In various solvent(s) at 20℃; for 0.5h; Enzyme kinetics; Further Variations:; Reagents;
luciferin 2-nitro-4-methylbenzenesulfonate
918400-81-4

luciferin 2-nitro-4-methylbenzenesulfonate

GLUTATHIONE
70-18-8

GLUTATHIONE

A

2-amino-4-[1-(carboxymethyl-carbamoyl)-2-(4-methyl-2-nitro-phenylsulfanyl)-ethylcarbamoyl]-butyric acid

2-amino-4-[1-(carboxymethyl-carbamoyl)-2-(4-methyl-2-nitro-phenylsulfanyl)-ethylcarbamoyl]-butyric acid

B

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
With human glutathione S-transferase A1-1 In various solvent(s) at 20℃; for 0.5h; Enzyme kinetics;
6-methoxybenzothiazol-2-ylamine
1747-60-0

6-methoxybenzothiazol-2-ylamine

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) AcOH, aq. H2SO4, aq. NaNO2, 2.) NaHCO3 / 1.) 1 h, 2.) water, 30 min
2: 81 percent / pyridinium chloride / 0.75 h / 200 °C
3: K2CO3 / methanol; H2O / 0.08 h
View Scheme
2-cyano-6-methoxybenzothiazole
943-03-3

2-cyano-6-methoxybenzothiazole

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 81 percent / pyridinium chloride / 0.75 h / 200 °C
2: K2CO3 / methanol; H2O / 0.08 h
View Scheme
Multi-step reaction with 2 steps
1: Py*HCl / 200 °C
2: (i) Na, liq. NH3, (ii) /BRN= 744134/, aq. MeOH
View Scheme
Multi-step reaction with 2 steps
1: pyridine hydrochloride / 1 h / 180 °C / Neat (no solvent); Inert atmosphere
2: potassium carbonate / methanol; water / 0.33 h / Inert atmosphere
View Scheme
6-ethoxybenzothiazole-2-sulfonamide
452-35-7

6-ethoxybenzothiazole-2-sulfonamide

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dimethylsulfoxide / 2.5 h / 125 °C
2: Py*HCl / 2 h / 185 - 195 °C
3: (i) Na, liq. NH3, (ii) /BRN= 744134/, aq. MeOH
View Scheme
ethyl 4'-methoxyoxanilate
18522-99-1

ethyl 4'-methoxyoxanilate

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: (i) P2S5, xylene, (ii) K3, aq. NaOH
2: HCl
3: NH3 / methanol
4: POCl3
5: Py*HCl / 200 °C
6: (i) Na, liq. NH3, (ii) /BRN= 744134/, aq. MeOH
View Scheme
Multi-step reaction with 6 steps
1: (i) P2S5, xylene, (ii) K3, aq. NaOH
2: methanol; diethyl ether
3: NH3 / methanol
4: POCl3
5: Py*HCl / 200 °C
6: (i) Na, liq. NH3, (ii) /BRN= 744134/, aq. MeOH
View Scheme
6-ethoxy-benzothiazole-2-carbonitrile
91634-13-8

6-ethoxy-benzothiazole-2-carbonitrile

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Py*HCl / 2 h / 185 - 195 °C
2: (i) Na, liq. NH3, (ii) /BRN= 744134/, aq. MeOH
View Scheme
6-methoxybenzothiazole-2-carboxamide
946-12-3

6-methoxybenzothiazole-2-carboxamide

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: POCl3
2: Py*HCl / 200 °C
3: (i) Na, liq. NH3, (ii) /BRN= 744134/, aq. MeOH
View Scheme
6-methoxybenzo[d]thiazol-2-carboxylic acid
946-13-4

6-methoxybenzo[d]thiazol-2-carboxylic acid

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: HCl
2: NH3 / methanol
3: POCl3
4: Py*HCl / 200 °C
5: (i) Na, liq. NH3, (ii) /BRN= 744134/, aq. MeOH
View Scheme
Multi-step reaction with 5 steps
1: methanol; diethyl ether
2: NH3 / methanol
3: POCl3
4: Py*HCl / 200 °C
5: (i) Na, liq. NH3, (ii) /BRN= 744134/, aq. MeOH
View Scheme
6-methoxy-benzothiazole-2-carboxylic acid methyl ester
884-22-0

6-methoxy-benzothiazole-2-carboxylic acid methyl ester

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NH3 / methanol
2: POCl3
3: Py*HCl / 200 °C
4: (i) Na, liq. NH3, (ii) /BRN= 744134/, aq. MeOH
View Scheme
C27H22N4O8S3

C27H22N4O8S3

A

C16H16N2O6S

C16H16N2O6S

B

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
With sodium chloride; TEM-1 β-lactamase In phosphate buffer at 25℃; pH=7.4; Enzyme kinetics;
(S)-2-(6'-(2-nitrobenzyloxy)-2'-benzothiazolyl)-Δ2-thiazoline-4-carboxylic acid
1186015-41-7

(S)-2-(6'-(2-nitrobenzyloxy)-2'-benzothiazolyl)-Δ2-thiazoline-4-carboxylic acid

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
In lead(II) sulfide Quantum yield; UV-irradiation;
(S)-2-(6'-(4,5-dimethoxy-2-nitrobenzyloxy)-2'-benzothiazolyl)-Δ2-thiazoline-4-carboxylic acid
1186015-42-8

(S)-2-(6'-(4,5-dimethoxy-2-nitrobenzyloxy)-2'-benzothiazolyl)-Δ2-thiazoline-4-carboxylic acid

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
In lead(II) sulfide Quantum yield; UV-irradiation;
(S)-2-(6'-(1-(2-nitrophenyl)ethoxy)-2'-benzothiazolyl)-Δ2-thiazoline-4-carboxylic acid
1186015-43-9

(S)-2-(6'-(1-(2-nitrophenyl)ethoxy)-2'-benzothiazolyl)-Δ2-thiazoline-4-carboxylic acid

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
In lead(II) sulfide Quantum yield; UV-irradiation;
(4-methoxyphenyl)carbamothioyl cyanide
4968-41-6

(4-methoxyphenyl)carbamothioyl cyanide

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: copper(l) iodide; tetrabutylammomium bromide; palladium dichloride / dimethyl sulfoxide; N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere
2: pyridine hydrochloride / 1 h / 180 °C / Neat (no solvent); Inert atmosphere
3: potassium carbonate / methanol; water / 0.33 h / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: palladium dichloride; copper(l) iodide; tetrabutylammomium bromide / N,N-dimethyl-formamide; dimethyl sulfoxide / 2 h / 120 °C
2: pyridine hydrochloride / sulfolane / 180 °C / Sealed tube; Inert atmosphere
3: potassium carbonate / acetonitrile; water / 0.33 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: palladium dichloride; copper(l) iodide; tetrabutylammomium bromide / Inert atmosphere
2: pyridine hydrochloride / Inert atmosphere
3: Inert atmosphere
View Scheme
4-methoxy-aniline
104-94-9

4-methoxy-aniline

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: dichloromethane / 1 h / 20 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / -5 °C
3.1: copper(l) iodide; tetrabutylammomium bromide; palladium dichloride / dimethyl sulfoxide; N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere
4.1: pyridine hydrochloride / 1 h / 180 °C / Neat (no solvent); Inert atmosphere
5.1: potassium carbonate / methanol; water / 0.33 h / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: sulfolane / 3.33 h / 40 - 180 °C / Sealed tube; Inert atmosphere
1.2: 1 h / 180 °C / Sealed tube; Inert atmosphere
2.1: potassium carbonate / acetonitrile; water / 0.33 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sulfolane / 3.33 h / 40 - 180 °C / Sealed tube; Inert atmosphere
1.2: 1 h / 180 °C / Sealed tube; Inert atmosphere
2.1: pyridine hydrochloride / sulfolane / 180 °C / Sealed tube; Inert atmosphere
3.1: potassium carbonate / acetonitrile; water / 0.33 h / 20 °C
View Scheme
N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4-methoxyaniline
75318-49-9

N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4-methoxyaniline

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / -5 °C
2: copper(l) iodide; tetrabutylammomium bromide; palladium dichloride / dimethyl sulfoxide; N,N-dimethyl-formamide / 3 h / 120 °C / Inert atmosphere
3: pyridine hydrochloride / 1 h / 180 °C / Neat (no solvent); Inert atmosphere
4: potassium carbonate / methanol; water / 0.33 h / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: pyridine hydrochloride / sulfolane / 1 h / 180 °C
2: potassium carbonate / acetonitrile; water / 0.33 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: pyridine hydrochloride / sulfolane / 1 h / 180 °C
2: pyridine hydrochloride / sulfolane / 180 °C / Sealed tube; Inert atmosphere
3: potassium carbonate / acetonitrile; water / 0.33 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / Inert atmosphere
2: palladium dichloride; copper(l) iodide; tetrabutylammomium bromide / Inert atmosphere
3: pyridine hydrochloride / Inert atmosphere
4: Inert atmosphere
View Scheme
(S)-2-( 6-(4-borono-3-fluorobenzyloxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid
1622311-98-1

(S)-2-( 6-(4-borono-3-fluorobenzyloxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
With water; 3-morpholinosydnonymine; 2-amino-2-hydroxymethyl-1,3-propanediol In aq. buffer at 37℃; for 1h; pH=8.5; Kinetics; Reagent/catalyst;
(S)-2-(6-(4-boronobenzyloxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

(S)-2-(6-(4-boronobenzyloxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
With water; 3-morpholinosydnonymine; 2-amino-2-hydroxymethyl-1,3-propanediol In aq. buffer at 37℃; for 1.5h; pH=8.5; Kinetics; Reagent/catalyst; Time;
2-cyano-6-hydroxybenzothiazole
939-69-5

2-cyano-6-hydroxybenzothiazole

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: cesium chloride / N,N-dimethyl-formamide / 60 °C
2.1: potassium carbonate / water; dichloromethane; methanol / Inert atmosphere
2.2: Inert atmosphere
3.1: water; 3-morpholinosydnonymine; 2-amino-2-hydroxymethyl-1,3-propanediol / aq. buffer / 1 h / 37 °C / pH 8.5
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 70 °C
2: potassium carbonate / water; methanol / 1 h / 20 °C / pH 8 / Inert atmosphere; Darkness
3: ozone; pyrrolidine / aq. phosphate buffer; dimethyl sulfoxide / 1 h / 37 °C / pH 7
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / acetonitrile / 90 °C
2: potassium carbonate / methanol; water / 20 °C
3: oxygen; cobalt(II) chloride
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetonitrile / Inert atmosphere
1.2: Inert atmosphere
2.1: oxygen; tyrosinase / aq. acetate buffer / 3 h / 37 °C / pH 7.4 / Enzymatic reaction
View Scheme
C13H12N2O3S2

C13H12N2O3S2

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
With pig liver esterase In aq. phosphate buffer at 37℃; for 24h; Inert atmosphere; Enzymatic reaction;
2-cyano-6-hydroxybenzothiazole
939-69-5

2-cyano-6-hydroxybenzothiazole

A

C14H12N2O4S2

C14H12N2O4S2

B

C14H14N2O5S2

C14H14N2O5S2

C

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 70 °C
2: potassium carbonate / water; methanol / 1 h / 20 °C / pH 8 / Inert atmosphere; Darkness
3: ozone / aq. phosphate buffer; dimethyl sulfoxide / 1 h / 37 °C / pH 7
View Scheme
2-cyano-6-(3-butenyloxy)benzothiazole

2-cyano-6-(3-butenyloxy)benzothiazole

A

C14H12N2O4S2

C14H12N2O4S2

B

C14H14N2O5S2

C14H14N2O5S2

C

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / water; methanol / 1 h / 20 °C / pH 8 / Inert atmosphere; Darkness
2: ozone / aq. phosphate buffer; dimethyl sulfoxide / 1 h / 37 °C / pH 7
View Scheme
2-cyano-6-(3-butenyloxy)benzothiazole

2-cyano-6-(3-butenyloxy)benzothiazole

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / water; methanol / 1 h / 20 °C / pH 8 / Inert atmosphere; Darkness
2: ozone; pyrrolidine / aq. phosphate buffer; dimethyl sulfoxide / 1 h / 37 °C / pH 7
View Scheme
C15H14N2O3S2

C15H14N2O3S2

A

C14H12N2O4S2

C14H12N2O4S2

B

C14H14N2O5S2

C14H14N2O5S2

C

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
With ozone In aq. phosphate buffer; dimethyl sulfoxide at 37℃; for 1h; pH=7;
C15H14N2O3S2

C15H14N2O3S2

D-luciferin
2591-17-5

D-luciferin

Conditions
ConditionsYield
With pyrrolidine; ozone In aq. phosphate buffer; dimethyl sulfoxide at 37℃; for 1h; pH=7; Reagent/catalyst;
D-luciferin
2591-17-5

D-luciferin

hydrazone of 2-nitroacetophenone
116271-34-2

hydrazone of 2-nitroacetophenone

C19H15N3O5S2

C19H15N3O5S2

Conditions
ConditionsYield
Stage #1: hydrazone of 2-nitroacetophenone With manganese(IV) oxide In dichloromethane at -20℃; for 1h;
Stage #2: D-luciferin In methanol; dichloromethane Cooling with ice;
69.4%
D-luciferin
2591-17-5

D-luciferin

2-(6’-hydroxy-2'-benzothiazolyl)-thiazole-4-carboxylic acid
20115-09-7

2-(6’-hydroxy-2'-benzothiazolyl)-thiazole-4-carboxylic acid

Conditions
ConditionsYield
With oxygen; sodium hydroxide65%
With sodium hydroxide Heating;
D-luciferin
2591-17-5

D-luciferin

N-acetyl-4,7,8,9-tetra-O-acetyl-2-chloro-2-deoxyneuraminic acid methyl ester
67670-69-3

N-acetyl-4,7,8,9-tetra-O-acetyl-2-chloro-2-deoxyneuraminic acid methyl ester

luciferyl N-acetylneuraminic acid

luciferyl N-acetylneuraminic acid

Conditions
ConditionsYield
Stage #1: D-luciferin With sodium hydroxide In water at 0 - 20℃; Inert atmosphere; Darkness;
Stage #2: N-acetyl-4,7,8,9-tetra-O-acetyl-2-chloro-2-deoxyneuraminic acid methyl ester With sodium iodide dihydrate; sodium hydroxide In water; acetone at 20℃; for 2h; pH=9 - 10; Inert atmosphere; Darkness;
Stage #3: With sodium hydroxide In methanol; water for 1h;
43%
methanol
67-56-1

methanol

D-luciferin
2591-17-5

D-luciferin

(S)-methyl 2-(6-hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylate
73918-26-0

(S)-methyl 2-(6-hydroxybenzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylate

Conditions
ConditionsYield
With pyridine; dicyclohexyl-carbodiimide for 3h; Inert atmosphere;42%
With thionyl chloride at 20℃; for 1h;
tert-butylsulfinyl chloride
31562-43-3

tert-butylsulfinyl chloride

D-luciferin
2591-17-5

D-luciferin

C15H16N2O4S3

C15H16N2O4S3

Conditions
ConditionsYield
With sodium hydroxide In water at 0 - 20℃; for 2h; Inert atmosphere;40%
D-luciferin
2591-17-5

D-luciferin

2,4-Dinitrofluorobenzene
70-34-8

2,4-Dinitrofluorobenzene

C17H10N4O7S2

C17H10N4O7S2

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 2h;30%
C18H28ClNO10
1400692-83-2

C18H28ClNO10

D-luciferin
2591-17-5

D-luciferin

luciferyl 4,7-di-O-methyl-N-acetylneuraminic acid

luciferyl 4,7-di-O-methyl-N-acetylneuraminic acid

Conditions
ConditionsYield
Stage #1: D-luciferin With sodium hydroxide In water at 0 - 20℃; Darkness; Inert atmosphere;
Stage #2: C18H28ClNO10 With sodium iodide dihydrate; sodium hydroxide In water; acetone at 20℃; for 2.42h; pH=9 - 10; Inert atmosphere; Darkness;
Stage #3: With sodium hydroxide In methanol; water for 1h;
28%
D-luciferin
2591-17-5

D-luciferin

(S)-2-(6-Hydroxy-7-iodo-benzothiazol-2-yl)-4,5-dihydro-thiazole-4-carboxylic acid

(S)-2-(6-Hydroxy-7-iodo-benzothiazol-2-yl)-4,5-dihydro-thiazole-4-carboxylic acid

Conditions
ConditionsYield
With chloroamine-T; sodium iodide In ethanol at 20℃; for 0.166667h;22%
4-(bromomethyl)phenyl 2-methylpropane-2-sulfinate

4-(bromomethyl)phenyl 2-methylpropane-2-sulfinate

D-luciferin
2591-17-5

D-luciferin

C22H22N2O5S3

C22H22N2O5S3

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water at 0 - 20℃; for 3.5h; Inert atmosphere;12%
D-luciferin
2591-17-5

D-luciferin

D-(-)-2-(6'-hydroxy-7'-[123I]iodobenzothiazolyl)-Δ2-thiazoline-4-carboxylic acid

D-(-)-2-(6'-hydroxy-7'-[123I]iodobenzothiazolyl)-Δ2-thiazoline-4-carboxylic acid

Conditions
ConditionsYield
With [123I] sodium iodide; chloroamine-T In ethanol at 20℃; for 0.0833333h;
D-luciferin
2591-17-5

D-luciferin

[11C]methyl triflate
145577-00-0

[11C]methyl triflate

C11(11)CH10N2O3S2

C11(11)CH10N2O3S2

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydroxide In methanol; acetonitrile at 70 - 80℃; for 0.0333333h;
D-luciferin
2591-17-5

D-luciferin

2-(6-hydroxy-1,3-benzothiazol-2-yl)-1,3-thiazol-4(5H)-one
17002-50-5

2-(6-hydroxy-1,3-benzothiazol-2-yl)-1,3-thiazol-4(5H)-one

Conditions
ConditionsYield
With oxygen; rose bengal; ATP; firefly luciferase In water at 25℃; pH=7.8; Kinetics; Further Variations:; Reagents;
Multi-step reaction with 2 steps
1: triethylamine / N,N-dimethyl-formamide
2: triethylamine; oxygen / N,N-dimethyl-formamide
View Scheme
With firefly luciferase; oxygen; ATP; magnesium chloride In aq. buffer at 20℃; Concentration; Enzymatic reaction;
D-luciferin
2591-17-5

D-luciferin

2-(6-acetoxy-benzothiazol-2-yl)-thiazole-4-carboxylic acid methyl ester

2-(6-acetoxy-benzothiazol-2-yl)-thiazole-4-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. NaOH / Heating
2: (i) MeOH, Et2O, (ii) /BRN= 385737/, Py
View Scheme
D-luciferin
2591-17-5

D-luciferin

2-thiazol-2-yl-benzothiazol-6-ol
63565-77-5

2-thiazol-2-yl-benzothiazol-6-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. NaOH / Heating
2: 150 °C
View Scheme

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