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Hubei DiBo chemical co., LTD

Name:L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester CAS NO:261909-49-3 Grade:Medical scientific research and export Molecular formula:C12H17ClNO4P Molecular weight:305.69804 Product Quality 12 years of chemical raw materials M

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester CAS:261909-49-3

Cas:261909-49-3

Min.Order:1 Kilogram

FOB Price: $50.0 / 80.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 261909-49-3 with best quality

Cas:261909-49-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester

Cas:261909-49-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine chemicals, ph

N-(Chlorophenoxyphosphinyl)-L-alanine 1-methylethyl ester

Cas:261909-49-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-methylethyl ester

Cas:261909-49-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-methylethyl ester

Cas:261909-49-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-methylethyl ester

Cas:261909-49-3

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester

Cas:261909-49-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester

Cas:261909-49-3

Min.Order:100 Gram

Negotiable

Type:Other

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester

Cas:261909-49-3

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-methylethyl ester

Cas:261909-49-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

261909-49-3 L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester

Cas:261909-49-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester

Cas:261909-49-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester

Cas:261909-49-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester

Cas:261909-49-3

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester

Cas:261909-49-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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SICHUAN TONGSHENG AMINOACID CO.LTD

Sichuan Tongsheng is the most strongest manufacturer and exporter of amino acids and their derivatives in China, we have the best quality and price. Guarantee high quality, competive price and reliable service. We fully compliance with ISO9001:20

N-(Chlorophenoxyphosphinyl)-L-alanine 1-methylethyl ester

Cas:261909-49-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-methylethyl ester

Cas:261909-49-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-methylethyl ester

Cas:261909-49-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

We are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester

Cas:261909-49-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

261909-49-3

Cas:261909-49-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. is focused on customization, research and development and production of APIs and advanced intermediates, which can effectively compensate for the deficiencies of traditional CRO and CMO. Priority of high-tech barri

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester

Cas:261909-49-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

The factory supplies Application:manufacturing supplies

L-Alanine,N-(chlorophenoxyphosphinyl)-,1-methylethylester

Cas:261909-49-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

261909-49-3

Cas:261909-49-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

Stable supply of goods and provision of high-quality services Application:As raw materials in the field of medicine and biology

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester

Cas:261909-49-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester 261909-49-3

Cas:261909-49-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shenzhen Foris Technology Co. LTD

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester 261909-49-3

Cas:261909-49-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-methylethyl ester

Cas:261909-49-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

HENAN SUNLAKE ENTERPRISE CORPORATION

HENAN SUNLAKE ENTERPRISE CORPORATION Our company advantages: 1、The highest quality with the competitive price. 2、Professional human services. 3、The fastest and safest delivery service. 4、The faster and safest delivery service. 5、The hig

L-Alanine, N-(chlorophenoxyphosphinyl)-, 1-Methylethyl ester

Cas:261909-49-3

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Synthetic route

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

alanine isopropyl ester hydrochloride
39613-92-8, 62062-56-0, 62062-65-1

alanine isopropyl ester hydrochloride

phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

Conditions
ConditionsYield
With triethylamine In tert-butyl methyl ether at -65 - -50℃; for 2h; Inert atmosphere; Cooling with acetone-dry ice;100%
With triethylamine In tert-butyl methyl ether at -55℃; for 2h;100%
With triethylamine In dichloromethane at -78 - 20℃; for 2.5h; Inert atmosphere;93%
isopropyl L-alanine
39825-33-7

isopropyl L-alanine

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

Conditions
ConditionsYield
With triethylamine In dichloromethane at -78 - 20℃; for 1.25h; Inert atmosphere;99%
With triethylamine In dichloromethane78%
With N-ethyl-N,N-diisopropylamine In dichloromethane at -80℃; for 2h;
O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

(isopropoxy-2-oxo-ethyl-L-alaninyl)ammonium salt

(isopropoxy-2-oxo-ethyl-L-alaninyl)ammonium salt

phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

Conditions
ConditionsYield
With triethylamine In dichloromethane at -78 - 20℃; Inert atmosphere;80%
toluene-4-sulfonic acid; compound with 2-amino-propionic acid isopropyl ester

toluene-4-sulfonic acid; compound with 2-amino-propionic acid isopropyl ester

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

Conditions
ConditionsYield
With triethylamine In dichloromethane at -78 - 20℃;55%
With triethylamine In dichloromethane at -78 - 20℃;
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: toluene / Heating
2: triethylamine / CH2Cl2 / -78 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: toluene / 24 h / 120 °C
2: triethylamine / dichloromethane / -78 - 20 °C
View Scheme
phenol
108-95-2

phenol

phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trichlorophosphate; triethylamine / dichloromethane / 2 h / -78 - 20 °C
2: triethylamine / dichloromethane / 2 h / -78 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: trichlorophosphate; triethylamine / dichloromethane / -78 - 20 °C
2: triethylamine / dichloromethane / 2 h / -78 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine; trichlorophosphate / dichloromethane / 2 h / -78 - 20 °C
2: triethylamine / dichloromethane / 2 h / -78 - 20 °C
View Scheme
C6H12ClNO2

C6H12ClNO2

O-phenyl phosphorodichloridate
770-12-7

O-phenyl phosphorodichloridate

phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

Conditions
ConditionsYield
With triethylamine In dichloromethane at -78 - 20℃;760 g
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

2,3,4,5,6-pentafluorophenol
771-61-9

2,3,4,5,6-pentafluorophenol

(S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester
1256490-52-4

(S)-2-[(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino]propionic acid isopropyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 25℃; for 1h; Inert atmosphere;100%
With triethylamine In dichloromethane at -5 - 20℃; for 20.33h; Inert atmosphere;41%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

1-[(2R,3R,4R,5R)-4-(benzyloxy)-3-fluoro-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione

1-[(2R,3R,4R,5R)-4-(benzyloxy)-3-fluoro-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione

(2S)-isopropyl 2-{[({(2R,3R,4R,5R)-3-(benzyloxy)-5-[2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-4-fluoro-4-methyltetrahydrofuran-2-yl}methoxy)(phenoxy)phosphoryl]amino}propanoate

(2S)-isopropyl 2-{[({(2R,3R,4R,5R)-3-(benzyloxy)-5-[2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-4-fluoro-4-methyltetrahydrofuran-2-yl}methoxy)(phenoxy)phosphoryl]amino}propanoate

Conditions
ConditionsYield
Stage #1: 1-[(2R,3R,4R,5R)-4-(benzyloxy)-3-fluoro-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione With isopropylmagnesium chloride, lithium chloride complex In tetrahydrofuran at -20℃; for 2h;
Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at -20℃; for 4h;
99%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

C22H41FN2O6Si2

C22H41FN2O6Si2

C34H57FN3O10PSi2

C34H57FN3O10PSi2

Conditions
ConditionsYield
Stage #1: C22H41FN2O6Si2 With isopropylmagnesium chloride In tetrahydrofuran at -25℃; for 2h;
Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at -25 - -5℃; for 15h; Temperature;
99%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione
1613589-05-1

1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione

C24H31FN3O11P

C24H31FN3O11P

Conditions
ConditionsYield
Stage #1: 1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.333333h;
Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 20℃;
93%
Stage #1: 1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.333333h;
Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 0 - 20℃;
93%
Stage #1: 1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.333333h;
Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 20℃;
93%
Stage #1: 1-((3aR,4R,6S,6aS)-6-fluoro-6-(hydroxymethyl)-2-methoxy-3a-methyltetrahydrofuro [3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4-(1H,3H)-dione With isopropylmagnesium chloride In tetrahydrofuran at 0℃; for 0.333333h;
Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 20℃;
93%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

O2',O3'-isopropylidene-1-methyl-guanosine
23392-07-6

O2',O3'-isopropylidene-1-methyl-guanosine

C26H35N6O9P

C26H35N6O9P

Conditions
ConditionsYield
With 1-methyl-1H-imidazole In tetrahydrofuran; acetonitrile at 20℃; for 3h;91%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-chloro-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl tert-butyl carbonate

(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-chloro-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl tert-butyl carbonate

isopropyl ((((2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-((tert-butoxycarbonyl)oxy)-4-chloro-4-fluorotetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

isopropyl ((((2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-((tert-butoxycarbonyl)oxy)-4-chloro-4-fluorotetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions
ConditionsYield
With tert-butylmagnesium chloride In tetrahydrofuran at 20℃; for 1h;89%
Stage #1: (2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-chloro-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl tert-butyl carbonate With tert-butylmagnesium chloride In tetrahydrofuran at 0℃; for 0.333333h;
Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 20℃; for 1h;
89%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

5(R)-<5-methyl-2,4(1H,3H)-pyrimidinedione>tetrahydro-3(S)-furanmethanol
146558-01-2

5(R)-<5-methyl-2,4(1H,3H)-pyrimidinedione>tetrahydro-3(S)-furanmethanol

1'-(thymin-1-yl)-2',3'-dideoxy-β-D-apio-D-furanose [phenyl-(isopropoxy-L-alaninyl)]phosphate
1610460-03-1

1'-(thymin-1-yl)-2',3'-dideoxy-β-D-apio-D-furanose [phenyl-(isopropoxy-L-alaninyl)]phosphate

Conditions
ConditionsYield
With 1-methyl-1H-imidazole In tetrahydrofuran at 25℃; for 48h; Inert atmosphere;88%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

2',3'-O-cyclopentylidene-4'-azidoinosine
926309-62-8

2',3'-O-cyclopentylidene-4'-azidoinosine

C27H33N8O9P
1170666-22-4

C27H33N8O9P

Conditions
ConditionsYield
With tert-butylmagnesium bromide In tetrahydrofuran at 20℃; for 17h;87%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

1-((1R,3S,5S)-3-(hydroxymethyl)-2-oxabicyclo[3.1.0]hexan-1-yl)pyrimidine-2,4(1H,3H)-dione

1-((1R,3S,5S)-3-(hydroxymethyl)-2-oxabicyclo[3.1.0]hexan-1-yl)pyrimidine-2,4(1H,3H)-dione

isopropyl((((1R,3S,5S)-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-oxabicyclo[3.1.0]hexan-3-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

isopropyl((((1R,3S,5S)-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-oxabicyclo[3.1.0]hexan-3-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions
ConditionsYield
Stage #1: 1-((1R,3S,5S)-3-(hydroxymethyl)-2-oxabicyclo[3.1.0]hexan-1-yl)pyrimidine-2,4(1H,3H)-dione With tert-butylmagnesium chloride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere;
Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran for 2h; Inert atmosphere;
85%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl tert-butyl carbonate
250698-51-2

(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl tert-butyl carbonate

2′-deoxy-2′,2′-difluoro-3′-O-(tert-butoxycarbonyloxy)-D-cytidine-5′-O-[phenyl(isopropoxy-L-alaninyl)]phosphate

2′-deoxy-2′,2′-difluoro-3′-O-(tert-butoxycarbonyloxy)-D-cytidine-5′-O-[phenyl(isopropoxy-L-alaninyl)]phosphate

Conditions
ConditionsYield
With tert-butylmagnesium chloride In tetrahydrofuran at 20℃; for 16h; Inert atmosphere;84%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

diethyl (2-amino-9-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-9H-purin-6-yl)phosphonate
1345969-94-9

diethyl (2-amino-9-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-9H-purin-6-yl)phosphonate

isopropyl ((((2R,3R,4R,5R)-5-(2-amino-6-(diethoxyphosphoryl)-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

isopropyl ((((2R,3R,4R,5R)-5-(2-amino-6-(diethoxyphosphoryl)-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions
ConditionsYield
With 1-methyl-1H-imidazole In tetrahydrofuran; acetonitrile at 20℃; for 3h;77%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

4-amino-1-((1R,3S,5S)-3-(hydroxymethyl)-2-oxabicyclo[3.1.0]hexan-1-yl)pyrimidin-2(1H)-one

4-amino-1-((1R,3S,5S)-3-(hydroxymethyl)-2-oxabicyclo[3.1.0]hexan-1-yl)pyrimidin-2(1H)-one

C22H29N4O7P

C22H29N4O7P

Conditions
ConditionsYield
Stage #1: 4-amino-1-((1R,3S,5S)-3-(hydroxymethyl)-2-oxabicyclo[3.1.0]hexan-1-yl)pyrimidin-2(1H)-one With tert-butylmagnesium chloride In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere;
Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran Inert atmosphere;
72%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

(3S,4R,5S,6R)-3-acetamido-6-(hydroxymethyl)-tetrahydro-2H-pyran-2,4,5-triyl triacetate
63597-75-1

(3S,4R,5S,6R)-3-acetamido-6-(hydroxymethyl)-tetrahydro-2H-pyran-2,4,5-triyl triacetate

(3S,4R,5S,6R)-3-acetamido-6-((((((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate

(3S,4R,5S,6R)-3-acetamido-6-((((((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)tetrahydro-2H-pyran-2,4,5-triyl triacetate

Conditions
ConditionsYield
Stage #1: (3S,4R,5S,6R)-3-acetamido-6-(hydroxymethyl)-tetrahydro-2H-pyran-2,4,5-triyl triacetate With tert-butylmagnesium chloride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere;
68%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

C21H34N2O5Si

C21H34N2O5Si

isopropyl ((((3aS,4R,6R,6aR)-4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dimethyl-tetrahydrospiro[cyclopenta[d][1,3] dioxole-5,1’-cyclopropan]-6-yl)methoxy)(phenoxy)phos phoryl)-L-alaninate

isopropyl ((((3aS,4R,6R,6aR)-4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dimethyl-tetrahydrospiro[cyclopenta[d][1,3] dioxole-5,1’-cyclopropan]-6-yl)methoxy)(phenoxy)phos phoryl)-L-alaninate

Conditions
ConditionsYield
With 1-methyl-1H-imidazole In tetrahydrofuran at -78 - 20℃; Inert atmosphere;68%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

sodium pentafluorophenolate
2263-53-8

sodium pentafluorophenolate

(S)-2-[((S)-(2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester
1334513-02-8

(S)-2-[((S)-(2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester

Conditions
ConditionsYield
Stage #1: phenyl(isopropoxy-L-alaninyl) phosphorochloridate; sodium pentafluorophenolate In tetrahydrofuran at -10℃;
Stage #2: With triethylamine In n-heptane; tert-butyl methyl ether pH=8;
66.81%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

4-((benzyloxy)amino)-1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one
1609192-93-9

4-((benzyloxy)amino)-1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one

(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(4-((benzyloxy)amino)-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
1609193-17-0

(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(4-((benzyloxy)amino)-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

Conditions
ConditionsYield
With 1-methyl-1H-imidazole In tetrahydrofuran at 20℃; for 3h; Inert atmosphere;66%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

2',3'-O,O-cyclopentylidene-4'-azidouridine
926309-54-8

2',3'-O,O-cyclopentylidene-4'-azidouridine

2-propyl N-[{1-[(3aR,4R,6R,6aS)-4-azido-tetrahydro-4-(hydroxymethyl)-2,2-cyclopentylfuro[3,4-d][1,3]dioxol-6-yl]pyrimidine-2,4(1H,3H)-dione} (phenoxy)-phosphoryl]-L-alaninate

2-propyl N-[{1-[(3aR,4R,6R,6aS)-4-azido-tetrahydro-4-(hydroxymethyl)-2,2-cyclopentylfuro[3,4-d][1,3]dioxol-6-yl]pyrimidine-2,4(1H,3H)-dione} (phenoxy)-phosphoryl]-L-alaninate

Conditions
ConditionsYield
Stage #1: 2',3'-O,O-cyclopentylidene-4'-azidouridine With tert-butylmagnesium chloride In tetrahydrofuran for 0.25h;
Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran for 17h; Further stages.;
64%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

(+)-9-[(1′R,2′R,3′R,4′R)-2′-fluoro-3′-hydroxy-4′-(hydroxymethyl)-5′-methylenecyclopentan-1′-yl]-adenine
1307273-70-6

(+)-9-[(1′R,2′R,3′R,4′R)-2′-fluoro-3′-hydroxy-4′-(hydroxymethyl)-5′-methylenecyclopentan-1′-yl]-adenine

{[(1R,3R,4R)-3-(6-amino-9H-purin-9-yl)-4-fluoro-5-hydroxy-2-methylenecyclopentyl]methoxy}(phenoxyphosphoryl amino) propionic Acid Isopropyl Ester

{[(1R,3R,4R)-3-(6-amino-9H-purin-9-yl)-4-fluoro-5-hydroxy-2-methylenecyclopentyl]methoxy}(phenoxyphosphoryl amino) propionic Acid Isopropyl Ester

Conditions
ConditionsYield
With 1-methyl-1H-imidazole In tetrahydrofuran at 0 - 20℃; Inert atmosphere;61%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

5'-(5-hexadecyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)phospho-AZT

5'-(5-hexadecyl-2-oxido-1,3,2-dioxaphosphinan-2-yl)phospho-AZT

5'-(phosphoamidate-phospho)-AZT

5'-(phosphoamidate-phospho)-AZT

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; acetonitrile for 18h;60%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

5-(6-amino-9H-purin-9-yl)-2,2,3,3,4,4-hexafluoropentan-1-ol

5-(6-amino-9H-purin-9-yl)-2,2,3,3,4,4-hexafluoropentan-1-ol

isopropyl (((5-(6-amino-9H-purin-9-yl)-2,2,3,3,4,4-hexafluoropentyl)oxy)(phenoxy)phosphoryl)-L-alaninate

isopropyl (((5-(6-amino-9H-purin-9-yl)-2,2,3,3,4,4-hexafluoropentyl)oxy)(phenoxy)phosphoryl)-L-alaninate

Conditions
ConditionsYield
Stage #1: 5-(6-amino-9H-purin-9-yl)-2,2,3,3,4,4-hexafluoropentan-1-ol With 1-methyl-1H-imidazole In tetrahydrofuran at 0℃; for 0.25h;
Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 20℃; for 2h;
60%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

N'-(9-((2-hydroxyethoxy)-methyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide
100699-59-0

N'-(9-((2-hydroxyethoxy)-methyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide

C23H32N7O7P
1184942-68-4

C23H32N7O7P

Conditions
ConditionsYield
With tert-butylmagnesium chloride In tetrahydrofuran at 20℃; Inert atmosphere;59%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

1′-cyano-2′-C-methyl-4-aza-7,9-dideazaadenosine
1191237-49-6

1′-cyano-2′-C-methyl-4-aza-7,9-dideazaadenosine

(2S)-isopropyl 2-((((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f]-[1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate
1350735-57-7

(2S)-isopropyl 2-((((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f]-[1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Conditions
ConditionsYield
With 1-methyl-1H-imidazole; trimethyl phosphite In tetrahydrofuran at 0 - 20℃; for 1.5h;59%
With 1-methyl-1H-imidazole; trimethyl phosphite In tetrahydrofuran at 0 - 20℃; for 1.5h;59%
With 1-methyl-1H-imidazole; trimethyl phosphite In tetrahydrofuran at 0 - 25℃; for 1.5h;59%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

C11H13N5O7

C11H13N5O7

C23H29N6O11P

C23H29N6O11P

Conditions
ConditionsYield
Stage #1: C11H13N5O7 With tert-butylmagnesium bromide In tetrahydrofuran at 0 - 20℃; for 0.5h; Inert atmosphere;
Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 0 - 20℃; for 20h; Inert atmosphere;
58%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

(3aR,4R,6S,6aS)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-fluoro-6-(hydroxymethyl)-2-methoxytetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile

(3aR,4R,6S,6aS)-4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-fluoro-6-(hydroxymethyl)-2-methoxytetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile

isopropyl((((3aS,4S,6R,6aR)-6-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-cyano-4-fluoro-2-methoxytetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

isopropyl((((3aS,4S,6R,6aR)-6-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-cyano-4-fluoro-2-methoxytetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions
ConditionsYield
With 1-methyl-1H-imidazole In acetonitrile at 0 - 20℃; for 1h; Inert atmosphere;57%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

C22H26N8O3

C22H26N8O3

propan-2-yl (2S)-2-([phenoxy[(2R)-2-[3-[6-([[4-(piperidine-1-carbonyl)pyridin-2-yl]carbamoyl]amino)pyridin-2-yl]-4H-1,2,4-triazol-4-yl]propoxy]phosphoryl]amino)propanoate

propan-2-yl (2S)-2-([phenoxy[(2R)-2-[3-[6-([[4-(piperidine-1-carbonyl)pyridin-2-yl]carbamoyl]amino)pyridin-2-yl]-4H-1,2,4-triazol-4-yl]propoxy]phosphoryl]amino)propanoate

Conditions
ConditionsYield
With tert-butylmagnesium chloride In N,N-dimethyl-formamide at -40 - 20℃; for 16h; Inert atmosphere;56%
phenyl(isopropoxy-L-alaninyl) phosphorochloridate
261909-49-3

phenyl(isopropoxy-L-alaninyl) phosphorochloridate

4-((2-hydroxyethoxy)methyl)-3-oxo-3,4-dihydropyrazine-2-carboxamide

4-((2-hydroxyethoxy)methyl)-3-oxo-3,4-dihydropyrazine-2-carboxamide

isopropyl ((2-((3-carbamoyl-2-oxopyrazin-1(2H)-yl)methoxy)ethoxy)(phenoxy)phosphoryl)-L-alaninate

isopropyl ((2-((3-carbamoyl-2-oxopyrazin-1(2H)-yl)methoxy)ethoxy)(phenoxy)phosphoryl)-L-alaninate

Conditions
ConditionsYield
Stage #1: 4-((2-hydroxyethoxy)methyl)-3-oxo-3,4-dihydropyrazine-2-carboxamide With pyridine; 1-methyl-1H-imidazole In tetrahydrofuran at 20℃; for 0.333333h; Inert atmosphere;
Stage #2: phenyl(isopropoxy-L-alaninyl) phosphorochloridate In tetrahydrofuran at 20℃; Inert atmosphere;
55%

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