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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

2-Pyridinemethanol,alpha-ethynyl-(9CI) CAS:276884-47-0

Cas:276884-47-0

Min.Order:1 Kilogram

FOB Price: $30.0 / 40.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Pyridinemethanol, a-ethynyl- 276884-47-0

Cas:276884-47-0

Min.Order:1 Kilogram

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Qingdao Beluga Import and Export Co., LTD

2-Pyridinemethanol,alpha-ethynyl-(9CI) CAS:276884-47-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high q

2-Pyridinemethanol,alpha-ethynyl-(9CI) CAS:276884-47-0

Cas:276884-47-0

Min.Order:1 Gram

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Pyridinemethanol, a-ethynyl-

Cas:276884-47-0

Min.Order:1 Kilogram

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Pyridinemethanol, a-ethynyl-

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-Pyridinemethanol, a-ethynyl-

Cas:276884-47-0

Min.Order:10 Gram

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

2-Pyridinemethanol, a-ethynyl-

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Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

2-Pyridinemethanol, a-ethynyl-

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2-Pyridinemethanol, a-ethynyl-

Cas:276884-47-0

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Hangzhou Fandachem Co.,Ltd

2-PYRIDINEMETHANOL,A-ETHYNYL-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

2-PYRIDINEMETHANOL,A-ETHYNYL-

Cas:276884-47-0

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-Pyridinemethanol,alpha-ethynyl-(9CI)

Cas:276884-47-0

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-Pyridinemethanol,alpha-ethynyl-(9CI)

Cas:276884-47-0

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Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

1-(2-Pyridyl)-2-propyn-1-ol

Cas:276884-47-0

Min.Order:10 Milligram

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Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

2-Pyridinemethanol, a-ethynyl-

Cas:276884-47-0

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Chungking Joyinchem Co., Ltd.

Joyinchem have been committed to chemical supply for several years and have built good cooperation records with multinational chemical corporations and importers from all over the world. Our services include:-Spot goods-Contract manufacturing-Custom

2-Pyridinemethanol, a-ethynyl-

Cas:276884-47-0

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Nanjing Raymon Biotech Co., Ltd.

2-Pyridinemethanol, a-ethynyl-Appearance:Off white to slight yellow solid Storage:Store in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/Pharmaceutical intermediates Transportation:By Sea,by Air,By

2-Pyridinemethanol, a-ethynyl-

Cas:276884-47-0

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Hebei Ruishun Trade Co.,Ltd

Supply top quality products with a reasonable price Application:api

276884-47-0

Cas:276884-47-0

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Chemical Co.Ltd

Manufacturer,strong R&D,professional team Storage:Store in a cool, dry place. Store in a tightly closed container. Package:according to your requirement Application:ZhiShang Chemical is owned by ZhiShang Group, is a professional new-type chemicals en

2-Pyridinemethanol, a-ethynyl-

Cas:276884-47-0

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Synthetic route

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

acetylenemagnesium bromide
4301-14-8

acetylenemagnesium bromide

3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 20℃; Schlenk technique; Inert atmosphere;92%
In tetrahydrofuran at -78 - 20℃;86%
In tetrahydrofuran at 0℃; for 1h;86%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

acetylene
74-86-2

acetylene

3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

Conditions
ConditionsYield
Stage #1: acetylene With ethylmagnesium bromide In tetrahydrofuran at 20℃; for 0.5h;
Stage #2: pyridine-2-carbaldehyde In tetrahydrofuran at 0℃; for 1h; Further stages.;
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

(2-(1-(tert-butyldimethyl)silanyloxy)prop-2-ynyl)pyridine
912964-92-2

(2-(1-(tert-butyldimethyl)silanyloxy)prop-2-ynyl)pyridine

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane at 20℃; for 1h;97%
With 1H-imidazole In dichloromethane at 20℃; for 1h;97%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 12h;
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 12h;
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

pivaloyl chloride
3282-30-2

pivaloyl chloride

1-(pyridin-2-yl)prop-2-ynyl pivalate
934399-66-3

1-(pyridin-2-yl)prop-2-ynyl pivalate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 3h;84%
With dmap; triethylamine In dichloromethane for 3h;1.46 g
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

tris(triphenylphosphine)ruthenium(II) chloride
15529-49-4, 41756-81-4

tris(triphenylphosphine)ruthenium(II) chloride

[Ru(CHC(PPh3))C(OH)(2-Py)Cl(PPh3)2]Cl
1443430-76-9

[Ru(CHC(PPh3))C(OH)(2-Py)Cl(PPh3)2]Cl

Conditions
ConditionsYield
With triphenylphosphine In dichloromethane at 20℃; for 7h; Inert atmosphere; Schlenk technique;75%
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

1-(pyridin-2-yl)prop-2-yn-1-one
72839-09-9

1-(pyridin-2-yl)prop-2-yn-1-one

Conditions
ConditionsYield
With manganese(IV) oxide In dichloromethane at 20℃; for 16h; Inert atmosphere; Schlenk technique;48%
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

tris(triphenylphosphine)ruthenium(II) chloride
15529-49-4, 41756-81-4

tris(triphenylphosphine)ruthenium(II) chloride

4-phenyl-3-butyne-2-one
1817-57-8

4-phenyl-3-butyne-2-one

C36H29NOP(1+)*BF4(1-)
1443430-74-7

C36H29NOP(1+)*BF4(1-)

Conditions
ConditionsYield
With tetrafluoroboric acid; triphenylphosphine In dichloromethane; chloroform at 20℃; for 24h; Inert atmosphere; Schlenk technique;10%
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

C12H16NO4P

C12H16NO4P

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃;
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

acetyl chloride
75-36-5

acetyl chloride

acetic acid 1-(pyridin-2-yl)prop-2-ynyl ester
949101-30-8

acetic acid 1-(pyridin-2-yl)prop-2-ynyl ester

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃;
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

acetic anhydride
108-24-7

acetic anhydride

acetic acid 1-(pyridin-2-yl)prop-2-ynyl ester
949101-30-8

acetic acid 1-(pyridin-2-yl)prop-2-ynyl ester

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0℃; for 0.5h;
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

1-(diethylphosphatoxy)indolizine

1-(diethylphosphatoxy)indolizine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; DMAP / CH2Cl2 / 20 °C
2: 64 percent / AgBF4 / toluene / 20 °C
View Scheme
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

acetic acid indolizin-1-yl ester
949101-41-1

acetic acid indolizin-1-yl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine; DMAP / CH2Cl2 / 20 °C
2: 87 percent / AgBF4 / toluene / 20 °C
View Scheme
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

1-((tert-butyldimethyl)silanyloxy)indolizine
912964-79-5

1-((tert-butyldimethyl)silanyloxy)indolizine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: imidazole / dimethylformamide / 12 h / 20 °C
2: 57 percent / 2-(dicyclohexylphosphino)biphenyl / platinum(II) chloride / benzene / 16 h / 70 °C
View Scheme
Multi-step reaction with 2 steps
1: 97 percent / imidazole / CH2Cl2 / 1 h / 20 °C
2: 62 percent / AuBr3 / toluene
View Scheme
Multi-step reaction with 2 steps
1: 1H-imidazole / dichloromethane / 1 h / 20 °C
2: gold(I) chloride / toluene / 65 °C / Inert atmosphere
View Scheme
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

indolizin-1-yl pivalate

indolizin-1-yl pivalate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 3 h / 20 °C
2: 79 percent / 2-(dicyclohexylphosphino)biphenyl / platinum(II) chloride / benzene / 8 h / 70 °C
View Scheme
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

2-[1-(tert-butyldimethyl-silanyloxy)prop-2-ynyl]pyridine-d1
912964-94-4

2-[1-(tert-butyldimethyl-silanyloxy)prop-2-ynyl]pyridine-d1

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 97 percent / imidazole / CH2Cl2 / 1 h / 20 °C
2.1: n-BuLi / hexane / 0.17 h
2.2: 89 percent / methanol-d4 / hexane / 0.33 h / -78 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 1H-imidazole / dichloromethane / 1 h / 20 °C
2.1: n-butyllithium / hexane / -78 - 20 °C / Inert atmosphere
2.2: Inert atmosphere
View Scheme
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

C14H19(2)H2NOSi

C14H19(2)H2NOSi

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 97 percent / imidazole / CH2Cl2 / 1 h / 20 °C
2.1: n-BuLi / hexane / 0.17 h
2.2: 89 percent / methanol-d4 / hexane / 0.33 h / -78 °C
3.1: 73 percent / AuBr3 / toluene / 2.5 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 1H-imidazole / dichloromethane / 1 h / 20 °C
2.1: n-butyllithium / hexane / -78 - 20 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: gold(I) chloride / toluene / 65 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: 1H-imidazole / dichloromethane / 1 h / 20 °C
2: gold(I) chloride / toluene / 65 °C / Inert atmosphere
View Scheme
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

(Z)-1,3-dihydro-4-iodo-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2H-indol-2-one
275386-73-7

(Z)-1,3-dihydro-4-iodo-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2H-indol-2-one

rac-(Z)-1,3-dihydro-4-[3-hydroxy-3-(2-pyridinyl)-1-propynyl]-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2H-indol-2-one

rac-(Z)-1,3-dihydro-4-[3-hydroxy-3-(2-pyridinyl)-1-propynyl]-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2H-indol-2-one

Conditions
ConditionsYield
CuI; (Ph3P)2PdCl2 In triethylamine; N,N-dimethyl-formamide
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

methyl 4-(azidomethyl)benzoate
94341-53-4

methyl 4-(azidomethyl)benzoate

C17H16N4O3
1422453-85-7

C17H16N4O3

Conditions
ConditionsYield
With copper(II) sulfate; sodium L-ascorbate In water; tert-butyl alcohol 1,3-dipolar cycloaddition;
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

C20H28N2ORuS4(2+)*2ClO4(1-)

C20H28N2ORuS4(2+)*2ClO4(1-)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: manganese(IV) oxide / dichloromethane / 16 h / 20 °C / Inert atmosphere; Schlenk technique
2.1: methanol / 16 h / Inert atmosphere; Schlenk technique; Reflux
2.2: Inert atmosphere; Schlenk technique
3.1: 16 h / 20 °C / Inert atmosphere; Schlenk technique
View Scheme
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

C24H25N3ORuS3(2+)*2ClO4(1-)

C24H25N3ORuS3(2+)*2ClO4(1-)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: manganese(IV) oxide / dichloromethane / 16 h / 20 °C / Inert atmosphere; Schlenk technique
2: tetrahydrofuran / 16 h / 120 °C / Inert atmosphere; Schlenk technique; Sealed tube
View Scheme
3-hydroxy-3-(2-pyridinyl)-1-propyne
276884-47-0

3-hydroxy-3-(2-pyridinyl)-1-propyne

C18H25ClNORuS4(1+)*ClO4(1-)

C18H25ClNORuS4(1+)*ClO4(1-)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: manganese(IV) oxide / dichloromethane / 16 h / 20 °C / Inert atmosphere; Schlenk technique
2.1: methanol / 16 h / Inert atmosphere; Schlenk technique; Reflux
2.2: Inert atmosphere; Schlenk technique
View Scheme

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