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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2,6-Dichloro-3-fluoroacetophenone

Cas:290835-85-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,6-Dichloro-3-Fluoroacetophenone supplier in China

Cas:290835-85-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

2,6-Dichloro-3-fluoroacetophenone

Cas:290835-85-7

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2',6'-Dichloro-3'-fluoroacetophenone

Cas:290835-85-7

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 1-(2,6-dichloro-3-fluorophenyl)ethanone

Cas:290835-85-7

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price OLED 99% 290835-85-7 2,6-Dichloro-3-fluoroacetophenone Manufacturer

Cas:290835-85-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2',6'-Dichloro-3'-fluoroacetophenone

Cas:290835-85-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

2,6-Dichloro-3-fluoroacetophenone CAS 290835-85-7

Cas:290835-85-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

CAS No.290835-85-7 Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher S

CAS No.290835-85-7 2,6-Dichloro-3-fluoroacetophenone

Cas:290835-85-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 290835-85-7 with best quality

Cas:290835-85-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: 2,6-Dichloro-3-Fluoro Acetophenone Synonyms: 2',6'-Dichloro-3'-fluoroacetophenone; 2,6-Dichloro-3-Fluoroacetophenone CAS: 290835-85-7 MF: C8H5Cl2FO Appearance: White powder Storage:Store in cool and dry place, away from sun

2,6-Dichloro-3-Fluoro Acetophenone

Cas:290835-85-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethanone,1-(2,6-dichloro-3-fluorophenyl)- 290835-85-7

Cas:290835-85-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

2,6-Dichloro-3-fluoroacetophenone

Cas:290835-85-7

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

2,6-Dichloro-3-fluoroacetophenone CAS: 290835-85-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali

2,6-Dichloro-3-fluoroacetophenone CAS: 290835-85-7

Cas:290835-85-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:290835-85-7

Cas:290835-85-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe,

2,6-Dichloro-3-fluoroacetophenone cas 290835-85-7

Cas:290835-85-7

Min.Order:1 Kilogram

FOB Price: $80.0 / 100.0

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2,6'-Dichloro-3'-Fluoroacetophenone

Cas:290835-85-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

2,6-Dichloro-3-Fluoro Acetophenone

Cas:290835-85-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2,6-Dichloro-3-fluoroacetophenone

Cas:290835-85-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2',6'-Dichloro-3'-fluoroacetophenone

Cas:290835-85-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2,6-Dichloro-3-fluoroacetophenone

Cas:290835-85-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

advantage: 1. The best price, satisfactory quality; 2. customers have the right to choose the delivery of parcels (EMS, DHL, FedEx, UPS); 3. customers have the right to choose from the recent effective packaging methods of their products packaging

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2,6-Dichloro-3-fluoroacetophenone/High quality/Best price

Cas:290835-85-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2,6-Dichloro-3-Fluoroacetophenone

Cas:290835-85-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 2,6-Dichloro-3-Fluoroacetophenone CAS No.:290835-85-7 Molecule Formula:C8H5Cl2FO Molecule Weight:207.03 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard

High Quality 2,6-Dichloro-3-Fluoroacetophenone on stock

Cas:290835-85-7

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2',6'-Dichloro-3'-fluoroacetophenone ,99%

Cas:290835-85-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 2,6-Dichloro-3-fluoroacetophenone Synonyms: 2,6-DICHLORO-5-FLUORO ACETOPHENONE;2',6'-DICHLORO-3'-FLUOROACETOPHENONE;2,6-DICHLORO-3-FLUOROACETOPHENONE;2',6'-Dichloro-3'-Fluoroacetophenone 3-Fluoro-2,6-Dichlo

2,6-Dichloro-3-fluoroacetophenone

Cas:290835-85-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2,6-Dichloro-3-fluoroacetophenone

Cas:290835-85-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Fred Technology Co.,Ltd.

2,6-Dichloro-3-fluoroacetophenone is one of the most competitive products in our company. We can supply it with good quality and best price. Appearance:liquid Storage:Sealed in dry,Room Temperature Package:According to the demand of customer Applica

2,6-Dichloro-3-fluoroacetophenone

Cas:290835-85-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2',6'-Dichloro-3'-fluro acetophenone

Cas:290835-85-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

1-(2,6-dichloro-3-fluorophenyl)ethanol
756520-66-8

1-(2,6-dichloro-3-fluorophenyl)ethanol

2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

Conditions
ConditionsYield
With chloroamine-T; zinc dibromide In acetonitrile for 5h; Reflux;93%
1,3-dichloro-4-fluorobenzene
1435-48-9

1,3-dichloro-4-fluorobenzene

acetyl chloride
75-36-5

acetyl chloride

2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane; nitrobenzene at 20℃; for 3h;50.7%
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

(R)-1-(2,6-dichloro-3-fluorophenyl)-1-ethanol
330156-50-8

(R)-1-(2,6-dichloro-3-fluorophenyl)-1-ethanol

Conditions
ConditionsYield
With RuBr2[(R,R)-2,4-bis-(di-3,5-xylylphosphino)pentane]-(6-(p-tolyl)-2-pyridyl)methanamine; potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; under 7600.51 Torr; for 21h; Reagent/catalyst; Autoclave; Inert atmosphere;100%
With methanol; sodium tetrahydroborate; (S)-diphenylprolinol at 5 - 20℃; for 5h; stereoselective reaction;98.3%
With sodium tetrahydroborate; chloro-trimethyl-silane; (S)-diphenylprolinol In tetrahydrofuran at 25 - 70℃; for 1h;95%
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

1-(2,6-dichloro-3-fluorophenyl)ethanol
756520-66-8

1-(2,6-dichloro-3-fluorophenyl)ethanol

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 0 - 20℃; for 0.666667h;100%
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With sodium tetrahydroborate In methanol at 0 - 20℃; for 1h;
Stage #2: With hydrogenchloride In methanol; water at 0℃; pH=6;
98%
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With sodium tetrahydroborate In methanol at 0 - 20℃; for 1h;
Stage #2: With hydrogenchloride In methanol; water at 0℃; pH=6;
98%
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol
877397-65-4

(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol

Conditions
ConditionsYield
With RuBr2[(S,S)-2,4-bis(diphenylphosphino)pentane](2-aminomethyl-3,5-dimethylpyridine); potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; for 21h; Reagent/catalyst; Concentration; Autoclave; Inert atmosphere;100%
With RuBr2[(S,S)-2,4-bis-(di-3,5-xylylphosphino)pentane]-2-picolylamine; potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; under 7600.51 Torr; for 21h; Catalytic behavior; Reagent/catalyst; Pressure; Concentration; Time; Autoclave; Inert atmosphere;100%
With potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; under 7600.51 Torr; for 21h; Reagent/catalyst; Autoclave; Inert atmosphere;100%
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

A

(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol
877397-65-4

(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol

B

(R)-1-(2,6-dichloro-3-fluorophenyl)-1-ethanol
330156-50-8

(R)-1-(2,6-dichloro-3-fluorophenyl)-1-ethanol

Conditions
ConditionsYield
With RuBr2[(S,S)-2,4-bis(diphenylphosphino)pentane](2-picolylamine); potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; for 21h; Autoclave; Inert atmosphere;A 100%
B n/a
With C33H29FeMnN2O3P(1+)*Br(1-); potassium tert-butylate; hydrogen In ethanol at 50℃; under 37503.8 Torr; for 16h; Autoclave; Overall yield = 92 %; enantioselective reaction;A n/a
B n/a
With C41H46FeMnN3O5P(1+)*Br(1-); hydrogen; potassium carbonate In ethanol at 50℃; under 37503.8 Torr; for 16h; Overall yield = 90 percent; enantioselective reaction;A n/a
B n/a
With hydrogen; C42H36FeMnN3O3P(1+)*Br(1-); potassium hydroxide In methanol at 20℃; under 22502.3 Torr; for 10h; Inert atmosphere; Glovebox; Autoclave; Overall yield = 88 percent; Overall yield = 182.2 mg; enantioselective reaction;A n/a
B n/a
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

α,α,α,2,6-pentachloro-3-fluoroacetophenone
1341170-75-9

α,α,α,2,6-pentachloro-3-fluoroacetophenone

Conditions
ConditionsYield
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With chlorine In acetic acid at 60℃; for 5h;
Stage #2: With sodium acetate In acetic acid at 60 - 100℃;
98%
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

2,6‑dichloro‑3‑fluorobenzoic acid

2,6‑dichloro‑3‑fluorobenzoic acid

Conditions
ConditionsYield
With sodium hypochlorite at 50℃; Temperature;84%
With water; bromine; sodium hydroxide In 1,4-dioxane at -5 - 20℃; for 3h;
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With sodium hypobromide In 1,4-dioxane; water at 0 - 20℃; for 3h;
Stage #2: With hydrogenchloride In 1,4-dioxane; water
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With bromine; sodium hydroxide In 1,4-dioxane; water at -5 - 20℃;
Stage #2: With hydrogenchloride In 1,4-dioxane; water
With water; bromine; sodium hydroxide In 1,4-dioxane at 0 - 20℃;
amidinothiocarbamide
2114-02-5

amidinothiocarbamide

2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

N-(4-(2,6-dichloro-3-fluorophenyl)-1,3-thiazol-2-yl)guanidine

N-(4-(2,6-dichloro-3-fluorophenyl)-1,3-thiazol-2-yl)guanidine

Conditions
ConditionsYield
With Oxone; sodium bromide In methanol at 60℃; for 2h;71%
2-amino-5-chlorobenzyl alcohol
37585-25-4

2-amino-5-chlorobenzyl alcohol

2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

2-(2,6-dichloro-3-fluorophenyl)quinoline

2-(2,6-dichloro-3-fluorophenyl)quinoline

Conditions
ConditionsYield
With sodium hydroxide In toluene at 135℃; for 24h; Green chemistry;61%
4-[2-(5-ethylpyridyl)ethoxy]benzaldehyde
114393-97-4

4-[2-(5-ethylpyridyl)ethoxy]benzaldehyde

2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

C24H20Cl2FNO2
1207094-14-1

C24H20Cl2FNO2

Conditions
ConditionsYield
With sodium hydroxide In methanol at 20℃;
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

C25H21Cl2FN4O
1207094-29-8

C25H21Cl2FN4O

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / methanol / 20 °C
2: sodium hydroxide / methanol
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

1-(4-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-6-(2,6-dichloro-5-fluorophenyl)pyrimidin-2-yl)-2-phenyl-4-(3,4,5-trimethoxybenzylidene)-1H-imidazol-5(4H)-one
1304143-30-3

1-(4-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-6-(2,6-dichloro-5-fluorophenyl)pyrimidin-2-yl)-2-phenyl-4-(3,4,5-trimethoxybenzylidene)-1H-imidazol-5(4H)-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / methanol / 20 °C
2: sodium hydroxide / methanol
3: acetic acid / Reflux
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

methyl 2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoate

methyl 2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid
877399-13-8

2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation
6.1: lithium hydroxide / methanol; water / 0.75 h / 60 °C / Inert atmosphere
6.2: pH 5 / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

C19H17Cl2FN4O3

C19H17Cl2FN4O3

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

C18H15Cl2FN4O3

C18H15Cl2FN4O3

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation
6.1: lithium hydroxide / methanol; water / 60 °C / Inert atmosphere
6.2: pH 5 / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

tert-butyl 4-((4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)methyl)-4-hydroxypiperidine-1-carboxylate

tert-butyl 4-((4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)methyl)-4-hydroxypiperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 85 °C / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

tert-butyl 3-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate
877399-36-5

tert-butyl 3-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
5.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 85 °C / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

C25H28Cl2FN5O3

C25H28Cl2FN5O3

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
5.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 85 °C / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

C25H28Cl2FN5O3

C25H28Cl2FN5O3

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
5.1: dmap / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
6.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere
7.1: hydrogenchloride / 1,4-dioxane; dichloromethane; water / 12 h / 40 °C / Inert atmosphere
8.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 16 h / 87 °C / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

C26H30Cl2FN5O3

C26H30Cl2FN5O3

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
5.1: dmap / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
6.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere
7.1: hydrogenchloride / 1,4-dioxane; dichloromethane; water / 12 h / 40 °C / Inert atmosphere
8.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 16 h / 87 °C / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine
756521-08-1

(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol / 0.67 h / 0 - 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C
2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
756520-67-9

(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 3 steps
1: sodium tetrahydroborate / methanol / 0.67 h / 0 - 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
3: acetic acid; iron / ethanol / 1.25 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C
2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
3: iron; acetic acid / ethanol / 1 h / Reflux
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

(±)-5-bromo-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)pyridin-2-amine
756503-69-2

(±)-5-bromo-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)pyridin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / methanol / 0.67 h / 0 - 20 °C
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
3: acetic acid; iron / ethanol / 1.25 h / Reflux
4: N-Bromosuccinimide / acetonitrile; dichloromethane / 0.17 h / 0 °C
View Scheme
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C
2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
3: iron; acetic acid / ethanol / 1 h / Reflux
4: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

5-iodo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
756520-48-6

5-iodo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1H-pyrazol-1-yl)pyridin-2-amine

3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1H-pyrazol-1-yl)pyridin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: copper(l) iodide; potassium phosphate; dodecane / dimethyl sulfoxide / 2 h / 150 °C / Inert atmosphere; Microwave irradiation
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

N-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-pyridin-3-yl)benzamide
877620-62-7

N-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-pyridin-3-yl)benzamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: copper(l) iodide; potassium phosphate; dodecane / dimethyl sulfoxide / 2 h / 150 °C / Inert atmosphere; Microwave irradiation
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-nicotinonitrile
756508-98-2

6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-nicotinonitrile

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere
5.1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene / water; N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere
View Scheme
2',6'-dichloro-3'-fluoroacetophenone
290835-85-7

2',6'-dichloro-3'-fluoroacetophenone

3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-phenylpyridin-2-amine

3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-phenylpyridin-2-amine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere
3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux
4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere
5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,2-dimethoxyethane; water / 12 h / 80 °C / Inert atmosphere
View Scheme

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