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inquiryName: 2,6-Dichloro-3-Fluoro Acetophenone Synonyms: 2',6'-Dichloro-3'-fluoroacetophenone; 2,6-Dichloro-3-Fluoroacetophenone CAS: 290835-85-7 MF: C8H5Cl2FO Appearance: White powder Storage:Store in cool and dry place, away from sun
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inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
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inquiryProduct name: 2,6-Dichloro-3-Fluoroacetophenone CAS No.:290835-85-7 Molecule Formula:C8H5Cl2FO Molecule Weight:207.03 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard
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inquiryProduct Name: 2,6-Dichloro-3-fluoroacetophenone Synonyms: 2,6-DICHLORO-5-FLUORO ACETOPHENONE;2',6'-DICHLORO-3'-FLUOROACETOPHENONE;2,6-DICHLORO-3-FLUOROACETOPHENONE;2',6'-Dichloro-3'-Fluoroacetophenone 3-Fluoro-2,6-Dichlo
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inquiry1-(2,6-dichloro-3-fluorophenyl)ethanol
2',6'-dichloro-3'-fluoroacetophenone
Conditions | Yield |
---|---|
With chloroamine-T; zinc dibromide In acetonitrile for 5h; Reflux; | 93% |
1,3-dichloro-4-fluorobenzene
acetyl chloride
2',6'-dichloro-3'-fluoroacetophenone
Conditions | Yield |
---|---|
With aluminum (III) chloride In dichloromethane; nitrobenzene at 20℃; for 3h; | 50.7% |
2',6'-dichloro-3'-fluoroacetophenone
(R)-1-(2,6-dichloro-3-fluorophenyl)-1-ethanol
Conditions | Yield |
---|---|
With RuBr2[(R,R)-2,4-bis-(di-3,5-xylylphosphino)pentane]-(6-(p-tolyl)-2-pyridyl)methanamine; potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; under 7600.51 Torr; for 21h; Reagent/catalyst; Autoclave; Inert atmosphere; | 100% |
With methanol; sodium tetrahydroborate; (S)-diphenylprolinol at 5 - 20℃; for 5h; stereoselective reaction; | 98.3% |
With sodium tetrahydroborate; chloro-trimethyl-silane; (S)-diphenylprolinol In tetrahydrofuran at 25 - 70℃; for 1h; | 95% |
2',6'-dichloro-3'-fluoroacetophenone
1-(2,6-dichloro-3-fluorophenyl)ethanol
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol at 0 - 20℃; for 0.666667h; | 100% |
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With sodium tetrahydroborate In methanol at 0 - 20℃; for 1h; Stage #2: With hydrogenchloride In methanol; water at 0℃; pH=6; | 98% |
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With sodium tetrahydroborate In methanol at 0 - 20℃; for 1h; Stage #2: With hydrogenchloride In methanol; water at 0℃; pH=6; | 98% |
2',6'-dichloro-3'-fluoroacetophenone
(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol
Conditions | Yield |
---|---|
With RuBr2[(S,S)-2,4-bis(diphenylphosphino)pentane](2-aminomethyl-3,5-dimethylpyridine); potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; for 21h; Reagent/catalyst; Concentration; Autoclave; Inert atmosphere; | 100% |
With RuBr2[(S,S)-2,4-bis-(di-3,5-xylylphosphino)pentane]-2-picolylamine; potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; under 7600.51 Torr; for 21h; Catalytic behavior; Reagent/catalyst; Pressure; Concentration; Time; Autoclave; Inert atmosphere; | 100% |
With potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; under 7600.51 Torr; for 21h; Reagent/catalyst; Autoclave; Inert atmosphere; | 100% |
2',6'-dichloro-3'-fluoroacetophenone
A
(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol
B
(R)-1-(2,6-dichloro-3-fluorophenyl)-1-ethanol
Conditions | Yield |
---|---|
With RuBr2[(S,S)-2,4-bis(diphenylphosphino)pentane](2-picolylamine); potassium tert-butylate; hydrogen In isopropyl alcohol at 40℃; for 21h; Autoclave; Inert atmosphere; | A 100% B n/a |
With C33H29FeMnN2O3P(1+)*Br(1-); potassium tert-butylate; hydrogen In ethanol at 50℃; under 37503.8 Torr; for 16h; Autoclave; Overall yield = 92 %; enantioselective reaction; | A n/a B n/a |
With C41H46FeMnN3O5P(1+)*Br(1-); hydrogen; potassium carbonate In ethanol at 50℃; under 37503.8 Torr; for 16h; Overall yield = 90 percent; enantioselective reaction; | A n/a B n/a |
With hydrogen; C42H36FeMnN3O3P(1+)*Br(1-); potassium hydroxide In methanol at 20℃; under 22502.3 Torr; for 10h; Inert atmosphere; Glovebox; Autoclave; Overall yield = 88 percent; Overall yield = 182.2 mg; enantioselective reaction; | A n/a B n/a |
2',6'-dichloro-3'-fluoroacetophenone
α,α,α,2,6-pentachloro-3-fluoroacetophenone
Conditions | Yield |
---|---|
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With chlorine In acetic acid at 60℃; for 5h; Stage #2: With sodium acetate In acetic acid at 60 - 100℃; | 98% |
2',6'-dichloro-3'-fluoroacetophenone
Conditions | Yield |
---|---|
With sodium hypochlorite at 50℃; Temperature; | 84% |
With water; bromine; sodium hydroxide In 1,4-dioxane at -5 - 20℃; for 3h; | |
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With sodium hypobromide In 1,4-dioxane; water at 0 - 20℃; for 3h; Stage #2: With hydrogenchloride In 1,4-dioxane; water | |
Stage #1: 2',6'-dichloro-3'-fluoroacetophenone With bromine; sodium hydroxide In 1,4-dioxane; water at -5 - 20℃; Stage #2: With hydrogenchloride In 1,4-dioxane; water | |
With water; bromine; sodium hydroxide In 1,4-dioxane at 0 - 20℃; |
amidinothiocarbamide
2',6'-dichloro-3'-fluoroacetophenone
Conditions | Yield |
---|---|
With Oxone; sodium bromide In methanol at 60℃; for 2h; | 71% |
2-amino-5-chlorobenzyl alcohol
2',6'-dichloro-3'-fluoroacetophenone
Conditions | Yield |
---|---|
With sodium hydroxide In toluene at 135℃; for 24h; Green chemistry; | 61% |
4-[2-(5-ethylpyridyl)ethoxy]benzaldehyde
2',6'-dichloro-3'-fluoroacetophenone
C24H20Cl2FNO2
Conditions | Yield |
---|---|
With sodium hydroxide In methanol at 20℃; |
2',6'-dichloro-3'-fluoroacetophenone
C25H21Cl2FN4O
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / methanol / 20 °C 2: sodium hydroxide / methanol View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
1-(4-{4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}-6-(2,6-dichloro-5-fluorophenyl)pyrimidin-2-yl)-2-phenyl-4-(3,4,5-trimethoxybenzylidene)-1H-imidazol-5(4H)-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / methanol / 20 °C 2: sodium hydroxide / methanol 3: acetic acid / Reflux View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere 5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
2-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere 5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation 6.1: lithium hydroxide / methanol; water / 0.75 h / 60 °C / Inert atmosphere 6.2: pH 5 / Inert atmosphere View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere 5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere 5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / 1,2-dimethoxyethane; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation 6.1: lithium hydroxide / methanol; water / 60 °C / Inert atmosphere 6.2: pH 5 / Inert atmosphere View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere 5.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 85 °C / Inert atmosphere View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
tert-butyl 3-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere 5.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 85 °C / Inert atmosphere View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere 5.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 85 °C / Inert atmosphere View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere 5.1: dmap / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere 6.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere 7.1: hydrogenchloride / 1,4-dioxane; dichloromethane; water / 12 h / 40 °C / Inert atmosphere 8.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 16 h / 87 °C / Inert atmosphere View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere 5.1: dmap / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere 6.1: 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium acetate / dimethyl sulfoxide / 12 h / 80 °C / Inert atmosphere 7.1: hydrogenchloride / 1,4-dioxane; dichloromethane; water / 12 h / 40 °C / Inert atmosphere 8.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; water / 16 h / 87 °C / Inert atmosphere View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: sodium tetrahydroborate / methanol / 0.67 h / 0 - 20 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C 2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux View Scheme | |
Multi-step reaction with 3 steps 1: sodium tetrahydroborate / methanol / 0.67 h / 0 - 20 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere 3: acetic acid; iron / ethanol / 1.25 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C 2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere 3: iron; acetic acid / ethanol / 1 h / Reflux View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
(±)-5-bromo-3-(1-(2,6-dichloro-3-fluoropheny)ethoxy)pyridin-2-amine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: sodium tetrahydroborate / methanol / 0.67 h / 0 - 20 °C 2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere 3: acetic acid; iron / ethanol / 1.25 h / Reflux 4: N-Bromosuccinimide / acetonitrile; dichloromethane / 0.17 h / 0 °C View Scheme | |
Multi-step reaction with 4 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C 2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere 3: iron; acetic acid / ethanol / 1 h / Reflux 4: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
5-iodo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere 5.1: copper(l) iodide; potassium phosphate; dodecane / dimethyl sulfoxide / 2 h / 150 °C / Inert atmosphere; Microwave irradiation View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
N-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-pyridin-3-yl)benzamide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere 5.1: copper(l) iodide; potassium phosphate; dodecane / dimethyl sulfoxide / 2 h / 150 °C / Inert atmosphere; Microwave irradiation View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-nicotinonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-Bromosuccinimide / acetonitrile / 0.25 h / 0 °C / Inert atmosphere 5.1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene / water; N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere View Scheme |
2',6'-dichloro-3'-fluoroacetophenone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere 1.2: 0.5 h / 20 °C / Inert atmosphere 2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux 4.1: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere 5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,2-dimethoxyethane; water / 12 h / 80 °C / Inert atmosphere View Scheme |
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