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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2-(4-Bromophenyl)-2-methylpropionic acid Manufacturer/High quality/Best price/In stock

Cas:32454-35-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Jinan Finer Chemical Co., Ltd

Product description: Product name 2-(4-Bromophenyl)-2-methylpropionic acid CAS number 32454-35-6 Assay ≥99% Appearance White crystalline solid Capacity 200mt/year Application

2-(4-Bromophenyl)-2-methylpropionic acid

Cas:32454-35-6

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-(4-bromophenyl)-2-methylpropanoic acid

Cas:32454-35-6

Min.Order:1

Negotiable

Type:Other

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Anhui Dexinjia Biopharm Co., Ltd

As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences

2-(4-Bromophenyl)-2-methylpropionic acid

Cas:32454-35-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% 2-Methyl-2-(P-Bromophenyl)Propionic Acid 32454-35-6 Producer

Cas:32454-35-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-(4-Bromophenyl)-2-methylpropionic acid

Cas:32454-35-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

32454-35-6 2-(4-Bromo-phenyl)-2-methyl-propionic acid

Cas:32454-35-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 32454-35-6 with best quality

Cas:32454-35-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM--High purity 2-(4-Bromophenyl)-2-methylpropionic acid factory price

Cas:32454-35-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2-(4-Bromophenyl)-2-methylpropionic acid CAS:32454-35-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high

2-(4-Bromophenyl)-2-methylpropionic acid CAS:32454-35-6

Cas:32454-35-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-(4-Bromophenyl)-2-methylpropionic acid

Cas:32454-35-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:32454-35-6

Cas:32454-35-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

2-(4-bromophenyl)-2-methylpropanoic acid CAS 32454-35-6

Cas:32454-35-6

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-(4-Bromophenyl)-2-Methylpropionic Acid

Cas:32454-35-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-(4-Bromophenyl)-2-methylpropionic acid

Cas:32454-35-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

2-(4-Bromophenyl)-2-methylpropionic acid

Cas:32454-35-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-(4-Bromo-phenyl)-2-methyl-propionic acid

Cas:32454-35-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Organic Intermediate 2-(4-Bromophenyl)-2-methylpropionic acid Powder CAS 32454-35-6

Cas:32454-35-6

Min.Order:1 Kilogram

FOB Price: $8.2 / 8.8

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2-(4-Bromophenyl)-2-methylpropionicacid

Cas:32454-35-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 2-(4-Bromophenyl)-2-methylpropionic acid Synonyms: 2-(4-Bromophenyl)(dimethyl)acetic acid, 2-(4-Bromophenyl)-2-methylpropionic acid;2-(4-Bromophenyl)-2-methylpropionic acid-3;2-METHYL-2-(4-BROMOPHENYL) PROPIONIC ACID;2-(4-BROMOPHE

2-(4-Bromophenyl)-2-methylpropionic acid

Cas:32454-35-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFUCHEM--High purity 2-(4-Bromophenyl)-2-methylpropionic acid factory price

Cas:32454-35-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Senova Technology Company Limited

We have most reliable quality, competitive prices and full documents for this APIs 1. GMP WORKSHOP 2. DMF Appearance:Off-white to white solid powder Application:Bilasten intermediate

2-(4-Bromophenyl)-2-methylpropionic acid

Cas:32454-35-6

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFUCHEM--High purity 2-(4-Bromophenyl)-2-methylpropionic acid factory price

Cas:32454-35-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFUCHEM--High purity 2-(4-Bromophenyl)-2-methylpropionic acid factory price

Cas:32454-35-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical Intermediate

2-(4-Bromophenyl)-2-methylpropionic acid

Cas:32454-35-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

TIANFUCHEM--High purity 2-(4-Bromophenyl)-2-methylpropionic acid factory price

Cas:32454-35-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Greenutra Resource Inc

2-Methyl-2-(P-Bromophenyl)Propionic AcidAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

2-Methyl-2-(P-Bromophenyl)Propionic Acid

Cas:32454-35-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2-Methyl-2-(P-Bromophenyl)Propionic Acid

Cas:32454-35-6

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

2-(4-Bromophenyl)-2-methylpropionic acid

Cas:32454-35-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

2-(4-Bromophenyl)-2-methylpropionic acid

Cas:32454-35-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

2-(4-bromophenyl)-2-methylpropanenitrile
101184-73-0

2-(4-bromophenyl)-2-methylpropanenitrile

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 80 - 85℃; for 18h; Hydrolysis;99%
With water; potassium hydroxide In ethanol for 20h; Reflux;5.3 g
With potassium hydroxide In ethylene glycol for 4h; Reflux;
1-bromo-4-(2-isocyanopropan-2-yl)benzene

1-bromo-4-(2-isocyanopropan-2-yl)benzene

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
With water; sodium hydroxide In ethanol at 100℃; for 16h;99%
methyl 2-(4-bromophenyl)-2,2-dimethylacetate
154825-97-5

methyl 2-(4-bromophenyl)-2,2-dimethylacetate

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
Stage #1: methyl 2-(4-bromophenyl)-2,2-dimethylacetate With water; lithium hydroxide In 1,4-dioxane at 50℃; for 5.5h;
Stage #2: With hydrogenchloride In 1,4-dioxane; water
94%
Stage #1: methyl 2-(4-bromophenyl)-2,2-dimethylacetate With methanol; lithium hydroxide; water In tetrahydrofuran at 0 - 20℃; for 3h;
Stage #2: With hydrogenchloride In water at 0℃;
Stage #1: methyl 2-(4-bromophenyl)-2,2-dimethylacetate With potassium hydroxide; ethanol; water at 90℃; for 15h;
Stage #2: With hydrogenchloride; water pH=2.0;
C15H20BrClO2

C15H20BrClO2

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
With water; sodium hydroxide In methanol for 2h; Reflux;86%
2-methyl-2-phenylpropionic acid
826-55-1

2-methyl-2-phenylpropionic acid

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
Stage #1: 2-methyl-2-phenylpropionic acid With bromine; sodium carbonate In water at 25 - 30℃; pH=7;
Stage #2: With hydrogenchloride In water pH=1 - 2; Product distribution / selectivity;
81%
Stage #1: 2-methyl-2-phenylpropionic acid With bromine; sodium hydrogencarbonate In water at 25 - 35℃; for 13h; Industry scale;
Stage #2: With hydrogenchloride In water at 0 - 10℃; pH=5; Product distribution / selectivity;
46.6%
With tetrachloromethane; bromine; iron
Ethyl 4-bromophenylacetate
14062-25-0

Ethyl 4-bromophenylacetate

methyl iodide
74-88-4

methyl iodide

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
With sodium hydride
2-(4-bromophenyl)-2-methyl-propionic acid ethyl ester
32454-36-7

2-(4-bromophenyl)-2-methyl-propionic acid ethyl ester

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
With methanol; sodium hydroxide; water In tetrahydrofuran at 20℃; for 16h;
Stage #1: 2-(4-bromophenyl)-2-methyl-propionic acid ethyl ester With methanol; potassium hydroxide; water at 0℃; for 2h; Heating / reflux;
Stage #2: With hydrogenchloride; methanol In water
potassium trimethylsilonate
10519-96-7

potassium trimethylsilonate

methyl 2-(4-bromophenyl)-2,2-dimethylacetate
154825-97-5

methyl 2-(4-bromophenyl)-2,2-dimethylacetate

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran
benzene
71-43-2

benzene

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / Industry scale
2.1: sodium hydrogencarbonate; bromine / water / 13 h / 25 - 35 °C / Industry scale
2.2: 0 - 10 °C / pH 5
View Scheme
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / Industry scale
2.1: bromine; sodium carbonate / water / 25 - 30 °C / pH 7
2.2: pH 1 - 2
View Scheme
2-(4-bromophenyl)propionic acid
53086-53-6

2-(4-bromophenyl)propionic acid

methyl iodide
74-88-4

methyl iodide

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)propionic acid With lithium diisopropyl amide In tetrahydrofuran at 45℃; for 1h; Inert atmosphere; Cooling with ice;
Stage #2: methyl iodide In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
(4-bromo-phenyl)-acetic acid methyl ester
41841-16-1

(4-bromo-phenyl)-acetic acid methyl ester

methyl iodide
74-88-4

methyl iodide

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

Conditions
ConditionsYield
Stage #1: (4-bromo-phenyl)-acetic acid methyl ester; methyl iodide With sodium hydride
Stage #2: With potassium hydroxide
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

2,2-dimethyl-2-(4-bromophenyl)ethanol
32454-37-8

2,2-dimethyl-2-(4-bromophenyl)ethanol

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)-2-methylpropionic acid With borane-THF In tetrahydrofuran at 0 - 20℃;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
100%
With lithium aluminium tetrahydride; diethyl ether
With lithium aluminium tetrahydride In diethyl ether at -78 - 23℃;
With lithium aluminium tetrahydride In diethyl ether at 20℃; Inert atmosphere;
methanol
67-56-1

methanol

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

methyl 2-(4-bromophenyl)-2,2-dimethylacetate
154825-97-5

methyl 2-(4-bromophenyl)-2,2-dimethylacetate

Conditions
ConditionsYield
With sulfuric acid; acetonitrile at 80 - 85℃; for 16 - 18h;98%
With sulfuric acid In toluene at 63 - 67℃; for 16h; Industry scale;79%
With sulfuric acid In toluene at 63 - 67℃; for 16h; Industry scale;79%
tert-butyl methyl ether
1634-04-4

tert-butyl methyl ether

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

methyl 2-(4-bromophenyl)-2,2-dimethylacetate
154825-97-5

methyl 2-(4-bromophenyl)-2,2-dimethylacetate

Conditions
ConditionsYield
With sulfuric acid Reflux; regioselective reaction;93%
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

benzyl alcohol
100-51-6

benzyl alcohol

benzyl N-[1-(4-bromophenyl)-1-methylethyl]carbamate
578729-08-5

benzyl N-[1-(4-bromophenyl)-1-methylethyl]carbamate

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)-2-methylpropionic acid With diphenyl phosphoryl azide; triethylamine In toluene for 4h; Reflux;
Stage #2: benzyl alcohol In toluene Reflux;
69%
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

2-(4-bromophenyl)propan-2-ol
2077-19-2

2-(4-bromophenyl)propan-2-ol

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine; water; tert-butylammonium hexafluorophosphate(V) In acetone at 20℃; for 3h; Electrolysis;67%
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

3-[3-(4-fluoro-phenyl)-1-isopropyl-2,3-dihydro-1H-indol-2-yl]-propenal

3-[3-(4-fluoro-phenyl)-1-isopropyl-2,3-dihydro-1H-indol-2-yl]-propenal

2-(4-{3-[3-(4-fluoro-phenyl)-1-isopropyl-2,3-dihydro-1H-indol-2-yl]-1-hydroxy-allyl}-phenyl)-2-methyl-propionic acid

2-(4-{3-[3-(4-fluoro-phenyl)-1-isopropyl-2,3-dihydro-1H-indol-2-yl]-1-hydroxy-allyl}-phenyl)-2-methyl-propionic acid

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)-2-methylpropionic acid With sodium hydride In tetrahydrofuran deprotonation;
Stage #2: With tert.-butyl lithium In tetrahydrofuran at -72℃; Metallation;
Stage #3: 3-[3-(4-fluoro-phenyl)-1-isopropyl-2,3-dihydro-1H-indol-2-yl]-propenal In tetrahydrofuran at -72℃; Condensation;
65%
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid
909187-36-6

2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoic acid

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In dimethyl sulfoxide at 80℃; Inert atmosphere;63%
With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane; water at 80℃; for 18h;
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

6-bromo-3,3-dimethylbenzofuran-2(3H)-one
1418028-03-1

6-bromo-3,3-dimethylbenzofuran-2(3H)-one

Conditions
ConditionsYield
With [bis(acetoxy)iodo]benzene; potassium acetate; palladium diacetate; N-acetylglycine In tert-butyl alcohol at 100℃; for 12h; Sealed tube;63%
With isopropylmagnesium bromide; triphenylphosphine; cobalt(II) chloride In tetrahydrofuran at 20℃; for 18h; Green chemistry;41%
With [bis(acetoxy)iodo]benzene; palladium diacetate; potassium carbonate; N-acetylglycine In tert-butyl alcohol at 100℃; for 20h; Inert atmosphere;26%
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyraldehyde
105955-84-8

4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyraldehyde

fexofenadine
83799-24-0

fexofenadine

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)-2-methylpropionic acid With sodium hydride In tetrahydrofuran at 25℃; for 0.5h; deprotonation;
Stage #2: With tert.-butyl lithium In tetrahydrofuran at -72℃; for 0.916667h; Metallation;
Stage #3: 4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyraldehyde In tetrahydrofuran at -72℃; for 2.5h; Condensation;
60%
1,2,3-triazole
288-36-8

1,2,3-triazole

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

2-(2-(4-bromophenyl)propan-2-yl)oxazole
1236409-17-8

2-(2-(4-bromophenyl)propan-2-yl)oxazole

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)-2-methylpropionic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h;
Stage #2: 1,2,3-triazole With potassium carbonate In sulfolane at 120℃; for 1h;
43%
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

trans-β-chloroacrylonitrile
871-29-4, 3721-37-7, 3721-38-8

trans-β-chloroacrylonitrile

2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-2-methylpropionic acid
1356089-38-7

2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-2-methylpropionic acid

Conditions
ConditionsYield
Stage #1: 2-(4-bromophenyl)-2-methylpropionic acid With phenyllithium In tetrahydrofuran; toluene at -80℃; for 0.0833333h; Inert atmosphere;
Stage #2: With n-butyllithium In tetrahydrofuran; hexane; toluene for 0.333333h; Inert atmosphere;
Stage #3: trans-β-chloroacrylonitrile Further stages;
43%
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

4-(1-hydroxy-2-methylpropan-2-yl)benzoic acid
75492-21-6

4-(1-hydroxy-2-methylpropan-2-yl)benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: LiAlH4; diethyl ether
2: butyl lithium; diethyl ether / anschliessend Behandeln mit CO2
View Scheme
(S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-(((S)-2,2,2-trifluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)amino)pentanamide
847358-99-0

(S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-(((S)-2,2,2-trifluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)amino)pentanamide

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

4'-[(1S)-1-[[(1S)-1-[[(1-cyanocyclopropyl)amino]carbonyl]-3-fluoro-3-methylbutyl]amino]-2,2,2-trifluoroethyl]-α,α-dimethyl-[1,1'-biphenyl]-4-acetic acid

4'-[(1S)-1-[[(1S)-1-[[(1-cyanocyclopropyl)amino]carbonyl]-3-fluoro-3-methylbutyl]amino]-2,2,2-trifluoroethyl]-α,α-dimethyl-[1,1'-biphenyl]-4-acetic acid

Conditions
ConditionsYield
With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In DMF (N,N-dimethyl-formamide); water at 80℃; for 3h;
trans-4-aminoadamantan-1-carboxylic acid methyl ester hydrochloride

trans-4-aminoadamantan-1-carboxylic acid methyl ester hydrochloride

2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

E-4-[2-(4-bromo-phenyl)-2-methyl-propionylamino]-adamantane-1-carboxylic acid methyl ester

E-4-[2-(4-bromo-phenyl)-2-methyl-propionylamino]-adamantane-1-carboxylic acid methyl ester

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

2-(4-bromophenyl)-2-methylpropanoic acid chloride
1040860-77-2

2-(4-bromophenyl)-2-methylpropanoic acid chloride

Conditions
ConditionsYield
With thionyl chloride for 2h; Heating / reflux;
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

C24H34O3Si

C24H34O3Si

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium aluminium tetrahydride / diethyl ether / -78 - 23 °C
2.1: 1H-imidazole / dichloromethane / 23 °C
3.1: n-butyllithium / tetrahydrofuran / -78 °C
3.2: 23 °C
4.1: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / 1,2-dimethoxyethane / 100 °C
View Scheme
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

C22H39BO3Si
1322094-75-6

C22H39BO3Si

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / diethyl ether / -78 - 23 °C
2.1: 1H-imidazole / dichloromethane / 23 °C
3.1: n-butyllithium / tetrahydrofuran / -78 °C
3.2: 23 °C
View Scheme
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

C23H32O3Si
1322094-76-7

C23H32O3Si

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / diethyl ether / -78 - 23 °C
2.1: 1H-imidazole / dichloromethane / 23 °C
3.1: n-butyllithium / tetrahydrofuran / -78 °C
3.2: 23 °C
4.1: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / 1,2-dimethoxyethane / 100 °C
5.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 23 °C
View Scheme
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-prop-2-ynylisobutyramide
1365091-34-4

2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-prop-2-ynylisobutyramide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: phenyllithium / tetrahydrofuran; toluene / 0.08 h / -80 °C / Inert atmosphere
1.2: 0.33 h / Inert atmosphere
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: phenyllithium / toluene; tetrahydrofuran / 0.08 h / -80 °C / Inert atmosphere
1.2: 0.33 h
1.3: 0.25 h
2.1: acetic acid / water; methanol / 20 °C
2.2: 1 h
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h
View Scheme
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

(E)-3-{4-[1,1-dimethyl-2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-benzenesulfonyl}acrylonitrile
1365091-28-6

(E)-3-{4-[1,1-dimethyl-2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-benzenesulfonyl}acrylonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: phenyllithium / tetrahydrofuran; toluene / 0.08 h / -80 °C / Inert atmosphere
1.2: 0.33 h / Inert atmosphere
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: phenyllithium / toluene; tetrahydrofuran / 0.08 h / -80 °C / Inert atmosphere
1.2: 0.33 h
1.3: 0.25 h
2.1: acetic acid / water; methanol / 20 °C
2.2: 1 h
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 20 °C
View Scheme
2-(4-bromophenyl)-2-methylpropionic acid
32454-35-6

2-(4-bromophenyl)-2-methylpropionic acid

2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-pyridin-2-ylmethylisobutyramide
1365091-35-5

2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-pyridin-2-ylmethylisobutyramide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: phenyllithium / tetrahydrofuran; toluene / 0.08 h / -80 °C / Inert atmosphere
1.2: 0.33 h / Inert atmosphere
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: phenyllithium / toluene; tetrahydrofuran / 0.08 h / -80 °C / Inert atmosphere
1.2: 0.33 h
1.3: 0.25 h
2.1: acetic acid / water; methanol / 20 °C
2.2: 1 h
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 20 °C
View Scheme

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