Products

Refine

Country

Business Type

Certificate

Display

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Henan Tianfu Chemical Co., Ltd.

Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)- Basic information Product Name: Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)

TIANFU-CHEM Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)- 324763-39-5

Cas:324763-39-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)-

Cas:324763-39-5

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 324763-39-5 with competitive price

Cas:324763-39-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-[(2R)-2-(Chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene 324763-39-5

Cas:324763-39-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)- CAS:324763-39-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of che

Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)- CAS:324763-39-5

Cas:324763-39-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

4-[(2R)-2-(Chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene

Cas:324763-39-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-[(2R)-2-(Chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-[(2R)-2-(Chloromethyl)-3-Methylbutyl]-1-Methoxy-2-(3-Methoxypropoxy)-Benzene

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name 4-[(2R)-2-(Chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene Synonyms Aliskiren inter-1 Molecular Structure

4-[(2R)-2-(Chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene

Cas:324763-39-5

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(R)-4-(2-(Chloromethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene

Cas:324763-39-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-[(2R)-2-(Chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)-

Cas:324763-39-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

(R)-4-(2-(Chloromethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Product Name: Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)- Synonyms: Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbu…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-[(2R)-2-(Chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

4-[(2R)-2-(Chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Enterprise standard Application:Pharma Intermediate

4-[(2R)-2-(Chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high qualityAppearance:white crystalline powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

2-Oxo-1-piperazineacetic acid

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

4-[(2R)-2-(Chloromethyl)-3-Methylbutyl]-1-Methoxy-2-(3-Methoxypropoxy)Benzene

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

4-[(2R)-2-(Chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

4-[(2R)-2-(Chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

4-[(2R)-2-(Chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene cas 324763-39-5Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)-

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers. Prompt reaction, good quality and best service make us reliable and outstanding in this industry.Appearance:White to slightly yellow cr

(R)-4-(2-(Chloromethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene manufacture

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

324763-39-5 Application:intermediate

4-[(2R)-2-(Chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

Benzene, 4-[(2R)-2-(chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)-

Cas:324763-39-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanol
172900-70-8

(R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanol

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
With tetrachloromethane; TOP at 20℃; for 16h; trioctylphosphine was added at 10 °ree;C;82%
With pyridine; thionyl chloride70%
With N,N-dimethyl-formamide; trichlorophosphate In toluene at 80℃;
2-(3-(3-methoxypropoxy)-4-methoxybenzyl)-3-methylbutanol
943349-14-2

2-(3-(3-methoxypropoxy)-4-methoxybenzyl)-3-methylbutanol

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
With thionyl chloride; N,N-dimethyl-formamide In toluene at 90℃; for 2h; Product distribution / selectivity;64%
4-methoxy-3-(3-methoxypropoxy)benzaldehyde
172900-75-3

4-methoxy-3-(3-methoxypropoxy)benzaldehyde

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 82 percent
2.1: H2 / Pd/C / ethyl acetate / 20 °C
3.1: (COCl)2 / dimethylformamide / 20 °C
4.1: NaOH / toluene / 20 °C
5.1: LDA; LiCl / tetrahydrofuran / 0 °C
5.2: tetrahydrofuran / 20 °C / Heating
6.1: 66 percent / BH3*NH3; n-BuLi / tetrahydrofuran / 20 °C
7.1: POCl3; DMF / toluene / 80 °C
View Scheme
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 30 °C
1.2: pH 2
2.1: phosphorus tribromide / dichloromethane / 2.17 h / 0 - 5 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere
3.2: -70 - 5 °C
4.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 30 °C
5.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
5.2: 5.75 h / 0 - 30 °C
6.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: titanium(IV) isopropylate; N-ethyl-N,N-diisopropylamine; titanium tetrachloride / dichloromethane / 1 h / 0 - 5 °C / Inert atmosphere
1.2: -30 - -25 °C
1.3: -30 - 5 °C
2.1: hydrogen; acetic acid / palladium on activated charcoal / 60 - 70 °C / 2942.29 Torr
3.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 15 °C
3.2: 11 h / 60 - 65 °C
4.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
3-[4-methoxy-3-(3-methoxy-propoxy)-phenyl]-propionic acid

3-[4-methoxy-3-(3-methoxy-propoxy)-phenyl]-propionic acid

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: (COCl)2 / dimethylformamide / 20 °C
2.1: NaOH / toluene / 20 °C
3.1: LDA; LiCl / tetrahydrofuran / 0 °C
3.2: tetrahydrofuran / 20 °C / Heating
4.1: 66 percent / BH3*NH3; n-BuLi / tetrahydrofuran / 20 °C
5.1: POCl3; DMF / toluene / 80 °C
View Scheme
3-[4-methoxy-3-(3-methoxy-propoxy)-phenyl]-propionyl chloride

3-[4-methoxy-3-(3-methoxy-propoxy)-phenyl]-propionyl chloride

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: NaOH / toluene / 20 °C
2.1: LDA; LiCl / tetrahydrofuran / 0 °C
2.2: tetrahydrofuran / 20 °C / Heating
3.1: 66 percent / BH3*NH3; n-BuLi / tetrahydrofuran / 20 °C
4.1: POCl3; DMF / toluene / 80 °C
View Scheme
(E)-3-[4-Methoxy-3-(3-methoxy-propoxy)-phenyl]-acrylic acid
324763-36-2

(E)-3-[4-Methoxy-3-(3-methoxy-propoxy)-phenyl]-acrylic acid

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: H2 / Pd/C / ethyl acetate / 20 °C
2.1: (COCl)2 / dimethylformamide / 20 °C
3.1: NaOH / toluene / 20 °C
4.1: LDA; LiCl / tetrahydrofuran / 0 °C
4.2: tetrahydrofuran / 20 °C / Heating
5.1: 66 percent / BH3*NH3; n-BuLi / tetrahydrofuran / 20 °C
6.1: POCl3; DMF / toluene / 80 °C
View Scheme
(R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid
172900-71-9

(R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / NaBH4; I2 / 96 h / 20 °C
2: 70 percent / SOCl2; pyridine
View Scheme
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
1.2: 5.75 h / 0 - 30 °C
2.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid; sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C
2: thionyl chloride / toluene; N,N-dimethyl acetamide / 2.5 h / 89 - 95 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere; Large scale
1.2: 0 °C / Large scale
2.1: thionyl chloride; sodium hydroxide / toluene; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere; Large scale
View Scheme
N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-3-[4-methoxy-3-(3-methoxy-propoxy)-phenyl]-N-methyl-propionamide
324763-37-3

N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-3-[4-methoxy-3-(3-methoxy-propoxy)-phenyl]-N-methyl-propionamide

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: LDA; LiCl / tetrahydrofuran / 0 °C
1.2: tetrahydrofuran / 20 °C / Heating
2.1: 66 percent / BH3*NH3; n-BuLi / tetrahydrofuran / 20 °C
3.1: POCl3; DMF / toluene / 80 °C
View Scheme
N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-2-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-3,N-dimethyl-butyramide
324763-38-4

N-(2-hydroxy-1-methyl-2-phenyl-ethyl)-2-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-3,N-dimethyl-butyramide

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 66 percent / BH3*NH3; n-BuLi / tetrahydrofuran / 20 °C
2: POCl3; DMF / toluene / 80 °C
View Scheme
3-methylbutyric acid
503-74-2

3-methylbutyric acid

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: dmap / 1,1-dichloroethane / 0.5 h / 20 °C
1.2: 14.5 h / 10 - 30 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere
2.2: -70 - 5 °C
3.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 30 °C
4.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
4.2: 5.75 h / 0 - 30 °C
5.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: dmap / 1,1-dichloroethane / 0.5 h / 20 °C
1.2: 14.5 h / 10 - 30 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere
2.2: -70 - 5 °C
3.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 15 °C
3.2: 11 h / 60 - 65 °C
4.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1.1: dmap / 1,1-dichloroethane / 0.5 h / 20 °C
1.2: 14.5 h / 10 - 30 °C
2.1: titanium(IV) isopropylate; N-ethyl-N,N-diisopropylamine; titanium tetrachloride / dichloromethane / 1 h / 0 - 5 °C / Inert atmosphere
2.2: -30 - -25 °C
2.3: -30 - 5 °C
3.1: hydrogen; acetic acid / palladium on activated charcoal / 60 - 70 °C / 2942.29 Torr
4.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 15 °C
4.2: 11 h / 60 - 65 °C
5.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 6 steps
1.1: dmap / 1,1-dichloroethane / 0.5 h / 20 °C
1.2: 14.5 h / 10 - 30 °C
2.1: titanium(IV) isopropylate; N-ethyl-N,N-diisopropylamine; titanium tetrachloride / dichloromethane / 1 h / 0 - 5 °C / Inert atmosphere
2.2: -30 - -25 °C
2.3: -30 - 5 °C
3.1: hydrogen; acetic acid / palladium on activated charcoal / 60 - 70 °C / 2942.29 Torr
4.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 30 °C
5.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
5.2: 5.75 h / 0 - 30 °C
6.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
4-(bromomethyl)-1-methoxy-2-(3-methoxypropoxy)-benzene
172900-73-1

4-(bromomethyl)-1-methoxy-2-(3-methoxypropoxy)-benzene

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere
1.2: -70 - 5 °C
2.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 30 °C
3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
3.2: 5.75 h / 0 - 30 °C
4.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere
1.2: -70 - 5 °C
2.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 15 °C
2.2: 11 h / 60 - 65 °C
3.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -10 °C / Inert atmosphere; Large scale
1.2: 20 h / 0 °C / Large scale
2.1: dihydrogen peroxide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Large scale
2.2: Large scale
3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere; Large scale
3.2: 0 °C / Large scale
4.1: thionyl chloride; sodium hydroxide / toluene; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere; Large scale
View Scheme
[4-methoxy-3-(3-methoxypropoxy)-phenyl]methanol
172900-74-2

[4-methoxy-3-(3-methoxypropoxy)-phenyl]methanol

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: phosphorus tribromide / dichloromethane / 2.17 h / 0 - 5 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere
2.2: -70 - 5 °C
3.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 30 °C
4.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
4.2: 5.75 h / 0 - 30 °C
5.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: phosphorus tribromide / dichloromethane / 2.17 h / 0 - 5 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere
2.2: -70 - 5 °C
3.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 15 °C
3.2: 11 h / 60 - 65 °C
4.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1.1: thionyl chloride / dichloromethane / 2 h / 0 °C
2.1: sodium iodide / tetrahydrofuran / 16 h / 25 - 30 °C
3.1: 1,1,1,3,3,3-hexamethyl-disilazane; n-butyllithium / tetrahydrofuran; hexane / 1 h / Cooling with ice; Inert atmosphere
3.2: 16 h / -30 - -5 °C
4.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C
5.1: thionyl chloride / toluene; N,N-dimethyl acetamide / 1.5 h / 89 - 95 °C
View Scheme
Multi-step reaction with 6 steps
1.1: thionyl chloride / dichloromethane / 3 h / 0 - 5 °C
2.1: sodium iodide / tetrahydrofuran / 16 h / 25 - 30 °C
3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / -78 - -45 °C / Inert atmosphere
3.2: 1 h / -45 - -20 °C
4.1: dihydrogen peroxide; lithium hydrochloride monohydrate; water / tetrahydrofuran / 0 - 25 °C
5.1: sulfuric acid; sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C
6.1: thionyl chloride / toluene; N,N-dimethyl acetamide / 2.5 h / 89 - 95 °C
View Scheme
Multi-step reaction with 5 steps
1.1: phosphorus tribromide / dichloromethane / 0 - 5 °C / Inert atmosphere; Large scale
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -10 °C / Inert atmosphere; Large scale
2.2: 20 h / 0 °C / Large scale
3.1: dihydrogen peroxide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Large scale
3.2: Large scale
4.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere; Large scale
4.2: 0 °C / Large scale
5.1: thionyl chloride; sodium hydroxide / toluene; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere; Large scale
View Scheme
(4'R)-3-methyl-1-(2'-oxo-4'-phenyloxazolidin-3'-yl)butan-1-one

(4'R)-3-methyl-1-(2'-oxo-4'-phenyloxazolidin-3'-yl)butan-1-one

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere
1.2: -70 - 5 °C
2.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 30 °C
3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
3.2: 5.75 h / 0 - 30 °C
4.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere
1.2: -70 - 5 °C
2.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 15 °C
2.2: 11 h / 60 - 65 °C
3.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: titanium(IV) isopropylate; N-ethyl-N,N-diisopropylamine; titanium tetrachloride / dichloromethane / 1 h / 0 - 5 °C / Inert atmosphere
1.2: -30 - -25 °C
1.3: -30 - 5 °C
2.1: hydrogen; acetic acid / palladium on activated charcoal / 60 - 70 °C / 2942.29 Torr
3.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 15 °C
3.2: 11 h / 60 - 65 °C
4.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 5 steps
1.1: titanium(IV) isopropylate; N-ethyl-N,N-diisopropylamine; titanium tetrachloride / dichloromethane / 1 h / 0 - 5 °C / Inert atmosphere
1.2: -30 - -25 °C
1.3: -30 - 5 °C
2.1: hydrogen; acetic acid / palladium on activated charcoal / 60 - 70 °C / 2942.29 Torr
3.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 30 °C
4.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
4.2: 5.75 h / 0 - 30 °C
5.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
(R)-3-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoyl)-4-phenyloxazolidin-2-one
1350705-31-5

(R)-3-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoyl)-4-phenyloxazolidin-2-one

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 30 °C
2.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
2.2: 5.75 h / 0 - 30 °C
3.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 15 °C
1.2: 11 h / 60 - 65 °C
2.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: dihydrogen peroxide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Large scale
1.2: Large scale
2.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere; Large scale
2.2: 0 °C / Large scale
3.1: thionyl chloride; sodium hydroxide / toluene; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere; Large scale
View Scheme
(4R)-3-(2S)-(2-(hydroxy(4-methoxy-3-(3-methoxypropoxy)phenyl)methyl)-3-methylbutanoyl)-4-phenyloxazolidin-2-one
1350705-32-6

(4R)-3-(2S)-(2-(hydroxy(4-methoxy-3-(3-methoxypropoxy)phenyl)methyl)-3-methylbutanoyl)-4-phenyloxazolidin-2-one

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogen; acetic acid / palladium on activated charcoal / 60 - 70 °C / 2942.29 Torr
2.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 0 - 30 °C
3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere
3.2: 5.75 h / 0 - 30 °C
4.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogen; acetic acid / palladium on activated charcoal / 60 - 70 °C / 2942.29 Torr
2.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 15 °C
2.2: 11 h / 60 - 65 °C
3.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C
View Scheme
C12H17IO3
1381757-32-9

C12H17IO3

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1,1,1,3,3,3-hexamethyl-disilazane; n-butyllithium / tetrahydrofuran; hexane / 1 h / Cooling with ice; Inert atmosphere
1.2: 16 h / -30 - -5 °C
2.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C
3.1: thionyl chloride / toluene; N,N-dimethyl acetamide / 1.5 h / 89 - 95 °C
View Scheme
Multi-step reaction with 4 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / -78 - -45 °C / Inert atmosphere
1.2: 1 h / -45 - -20 °C
2.1: dihydrogen peroxide; lithium hydrochloride monohydrate; water / tetrahydrofuran / 0 - 25 °C
3.1: sulfuric acid; sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C
4.1: thionyl chloride / toluene; N,N-dimethyl acetamide / 2.5 h / 89 - 95 °C
View Scheme
(2S)-N-<3'-methylbutanoyl>bornane-10,2-sultam

(2S)-N-<3'-methylbutanoyl>bornane-10,2-sultam

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 1,1,1,3,3,3-hexamethyl-disilazane; n-butyllithium / tetrahydrofuran; hexane / 1 h / Cooling with ice; Inert atmosphere
1.2: 16 h / -30 - -5 °C
2.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C
3.1: thionyl chloride / toluene; N,N-dimethyl acetamide / 1.5 h / 89 - 95 °C
View Scheme
isopentanoyl chloride
108-12-3

isopentanoyl chloride

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dmap; triethylamine / toluene / 0 - 25 °C
2.1: 1,1,1,3,3,3-hexamethyl-disilazane; n-butyllithium / tetrahydrofuran; hexane / 1 h / Cooling with ice; Inert atmosphere
2.2: 16 h / -30 - -5 °C
3.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C
4.1: thionyl chloride / toluene; N,N-dimethyl acetamide / 1.5 h / 89 - 95 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydride / toluene / 4 h / 20 - 25 °C
1.2: 1.5 h / 15 - 30 °C
2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / -78 - -45 °C / Inert atmosphere
2.2: 1 h / -45 - -20 °C
3.1: dihydrogen peroxide; lithium hydrochloride monohydrate; water / tetrahydrofuran / 0 - 25 °C
4.1: sulfuric acid; sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C
5.1: thionyl chloride / toluene; N,N-dimethyl acetamide / 2.5 h / 89 - 95 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 15 - 30 °C / Inert atmosphere; Large scale
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -10 °C / Inert atmosphere; Large scale
2.2: 20 h / 0 °C / Large scale
3.1: dihydrogen peroxide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Large scale
3.2: Large scale
4.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere; Large scale
4.2: 0 °C / Large scale
5.1: thionyl chloride; sodium hydroxide / toluene; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere; Large scale
View Scheme
4-chloromethyl-1-methoxy-2-(3-methoxypropoxy)-benzene
1179062-77-1

4-chloromethyl-1-methoxy-2-(3-methoxypropoxy)-benzene

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium iodide / tetrahydrofuran / 16 h / 25 - 30 °C
2.1: 1,1,1,3,3,3-hexamethyl-disilazane; n-butyllithium / tetrahydrofuran; hexane / 1 h / Cooling with ice; Inert atmosphere
2.2: 16 h / -30 - -5 °C
3.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C
4.1: thionyl chloride / toluene; N,N-dimethyl acetamide / 1.5 h / 89 - 95 °C
View Scheme
Multi-step reaction with 5 steps
1.1: sodium iodide / tetrahydrofuran / 16 h / 25 - 30 °C
2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / -78 - -45 °C / Inert atmosphere
2.2: 1 h / -45 - -20 °C
3.1: dihydrogen peroxide; lithium hydrochloride monohydrate; water / tetrahydrofuran / 0 - 25 °C
4.1: sulfuric acid; sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C
5.1: thionyl chloride / toluene; N,N-dimethyl acetamide / 2.5 h / 89 - 95 °C
View Scheme
(R)-4-benzyl-3-(3-methylbutyryl)oxazolidin-2-one
145589-03-3

(R)-4-benzyl-3-(3-methylbutyryl)oxazolidin-2-one

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / -78 - -45 °C / Inert atmosphere
1.2: 1 h / -45 - -20 °C
2.1: dihydrogen peroxide; lithium hydrochloride monohydrate; water / tetrahydrofuran / 0 - 25 °C
3.1: sulfuric acid; sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C
4.1: thionyl chloride / toluene; N,N-dimethyl acetamide / 2.5 h / 89 - 95 °C
View Scheme
(4R)-3-{(2R)-2-{[4-methoxy-3-(methoxypropoxy)phenyl]methyl-3-methyl}-1-oxobutyl}-4-(phenylmethyl)oxazolidin-2-one
172900-72-0

(4R)-3-{(2R)-2-{[4-methoxy-3-(methoxypropoxy)phenyl]methyl-3-methyl}-1-oxobutyl}-4-(phenylmethyl)oxazolidin-2-one

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dihydrogen peroxide; lithium hydrochloride monohydrate; water / tetrahydrofuran / 0 - 25 °C
2: sulfuric acid; sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C
3: thionyl chloride / toluene; N,N-dimethyl acetamide / 2.5 h / 89 - 95 °C
View Scheme
isovanillin
621-59-0

isovanillin

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: potassium carbonate / toluene; dimethyl sulfoxide / 16 h / 25 - 90 °C
2.1: sodium tetrahydroborate / toluene; methanol / 3 h / 0 - 5 °C
3.1: thionyl chloride / dichloromethane / 3 h / 0 - 5 °C
4.1: sodium iodide / tetrahydrofuran / 16 h / 25 - 30 °C
5.1: lithium diisopropyl amide / tetrahydrofuran; hexane / -78 - -45 °C / Inert atmosphere
5.2: 1 h / -45 - -20 °C
6.1: dihydrogen peroxide; lithium hydrochloride monohydrate; water / tetrahydrofuran / 0 - 25 °C
7.1: sulfuric acid; sodium tetrahydroborate / tetrahydrofuran / 0 - 20 °C
8.1: thionyl chloride / toluene; N,N-dimethyl acetamide / 2.5 h / 89 - 95 °C
View Scheme
C14H17NO3

C14H17NO3

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -10 °C / Inert atmosphere; Large scale
1.2: 20 h / 0 °C / Large scale
2.1: dihydrogen peroxide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Large scale
2.2: Large scale
3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere; Large scale
3.2: 0 °C / Large scale
4.1: thionyl chloride; sodium hydroxide / toluene; N,N-dimethyl-formamide / 0.5 h / 90 °C / Inert atmosphere; Large scale
View Scheme
C10H18ClNO

C10H18ClNO

ethylene dibromide
106-93-4

ethylene dibromide

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

C27H45NO4

C27H45NO4

Conditions
ConditionsYield
Stage #1: ethylene dibromide With magnesium In tetrahydrofuran at 60℃; Mg was added over a period of 2 min;
Stage #2: ethylene dibromide; (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane In tetrahydrofuran for 0.5h; Adding at 62-64 °ree;C; Heating / reflux;
Stage #3: C10H18ClNO; 1-methyl-pyrrolidin-2-one; iron-(III)-acetylacetonate In tetrahydrofuran at 0 - 10℃; for 0.25h; Adding at -5-0 °ree;C;
81%
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(R)-­4-(2-(iodomethyl)­-3-­methylbutyl)-­1-­methoxy-2­-(3-­methoxypropoxy)benzene
900811-38-3

(R)-­4-(2-(iodomethyl)­-3-­methylbutyl)-­1-­methoxy-2­-(3-­methoxypropoxy)benzene

Conditions
ConditionsYield
With sodium iodide In acetone at 20 - 56℃; for 240h;80.5%
(2S,4E)-5-chloro-2-isopropyl-N,N-dimethylpent-4-enamide
324519-68-8

(2S,4E)-5-chloro-2-isopropyl-N,N-dimethylpent-4-enamide

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(2S,7R,E)-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-N,N,8-trimethylnon-4-enamide
325154-26-5

(2S,7R,E)-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-N,N,8-trimethylnon-4-enamide

Conditions
ConditionsYield
Stage #1: (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane With magnesium; ethylene dibromide In 2-methyltetrahydrofuran at 60 - 65℃;
Stage #2: (2S,4E)-5-chloro-2-isopropyl-N,N-dimethylpent-4-enamide; iron(III)-acetylacetonate In 2-methyltetrahydrofuran; 1-methyl-pyrrolidin-2-one at 10℃; for 0.25h; Product distribution / selectivity;
80%
Stage #1: (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane With magnesium; ethylene dibromide In tetrahydrofuran at 63 - 68℃; for 4.16667h; Inert atmosphere;
Stage #2: (2S,4E)-5-chloro-2-isopropyl-N,N-dimethylpent-4-enamide; iron(III)-acetylacetonate In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 0 - 5℃; for 1h;
Stage #1: (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane With iodine; methylmagnesium chloride; magnesium; 1-Bromo-2-chloroethane In tetrahydrofuran at 60℃; Reflux;
Stage #2: (2S,4E)-5-chloro-2-isopropyl-N,N-dimethylpent-4-enamide With 1-methyl-pyrrolidin-2-one; iron(III)-acetylacetonate In tetrahydrofuran at 0 - 30℃; for 2h;
120 g
Stage #1: (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane With methylmagnesium chloride; magnesium; ethylene dibromide In tetrahydrofuran at 60 - 65℃; Inert atmosphere; Industrial scale;
Stage #2: (2S,4E)-5-chloro-2-isopropyl-N,N-dimethylpent-4-enamide With iron(III)-acetylacetonate In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 0 - 5℃; Concentration; Reagent/catalyst; Temperature; Time; Kumada Cross-Coupling; Inert atmosphere; Industrial scale;
Stage #1: (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane With magnesium; ethylene dibromide In tetrahydrofuran at 65℃; Inert atmosphere;
Stage #2: (2S,4E)-5-chloro-2-isopropyl-N,N-dimethylpent-4-enamide With 1-Methylpyrrolidine; iron(III)-acetylacetonate In tetrahydrofuran at -5 - 20℃;
6.5 g
(2S,3S,5R,7S,9S)-9-Isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]nonane-7-carbaldehyde
324763-44-2

(2S,3S,5R,7S,9S)-9-Isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]nonane-7-carbaldehyde

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

A

(3S,5S)-5-{(1R,3S)-1-Hydroxy-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one
324763-45-3

(3S,5S)-5-{(1R,3S)-1-Hydroxy-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one

B

(3S,5S)-dihydro-5-{(1S,3S)-1-hydroxy-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-3-(1-methylethyl)furan-2(3H)-one
325740-67-8

(3S,5S)-dihydro-5-{(1S,3S)-1-hydroxy-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-3-(1-methylethyl)furan-2(3H)-one

Conditions
ConditionsYield
Multistep reaction;A 51%
B n/a
diethyl malonate
105-53-3

diethyl malonate

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

C24H38O7
1322077-28-0

C24H38O7

Conditions
ConditionsYield
With sodium ethanolate; sodium iodide In ethanol37%
(S)-tetrahydro-5-oxo-2-furancarbonyl chloride
54848-33-8

(S)-tetrahydro-5-oxo-2-furancarbonyl chloride

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(S)-5-{(S)-3-[4-Methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentanoyl}-dihydro-furan-2-one
325740-63-4

(S)-5-{(S)-3-[4-Methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentanoyl}-dihydro-furan-2-one

Conditions
ConditionsYield
With magnesium; ethylene dibromide In tetrahydrofuran at 20℃;
tetrahydro-4-isopropyl-5-oxofuran-2-carbonyl chloride
325740-60-1

tetrahydro-4-isopropyl-5-oxofuran-2-carbonyl chloride

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(3S,5S)-3-Isopropyl-5-{(S)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentanoyl}-dihydro-furan-2-one
325740-64-5

(3S,5S)-3-Isopropyl-5-{(S)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentanoyl}-dihydro-furan-2-one

Conditions
ConditionsYield
With magnesium; ethylene dibromide In tetrahydrofuran at 20℃;
Stage #1: (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane With magnesium; iodine In tetrahydrofuran; 1,2-dibromomethane for 5h; Inert atmosphere; Heating; Reflux;
Stage #2: tetrahydro-4-isopropyl-5-oxofuran-2-carbonyl chloride In tetrahydrofuran at 22℃; for 0.5h; Cooling with ice/water bath;
Stage #3: With water In tetrahydrofuran Cooling with ice;
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

A

N-Benzyl-N-{(1S,3S)-1-((2S,3S,5S,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-hydroxylamine
361460-39-1

N-Benzyl-N-{(1S,3S)-1-((2S,3S,5S,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-hydroxylamine

B

N-Benzyl-N-{(1R,3S)-1-((2S,3S,5S,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-hydroxylamine
361460-38-0

N-Benzyl-N-{(1R,3S)-1-((2S,3S,5S,7S,9S)-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-hydroxylamine

Conditions
ConditionsYield
Stage #1: (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane With magnesium; ethylene dibromide In tetrahydrofuran at 45℃; for 1h;
Stage #2: C25H32N2O3 In tetrahydrofuran at -40℃; for 15h;
Stage #1: (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane With magnesium; ethylene dibromide In tetrahydrofuran at 45℃; for 1h;
Stage #2: C25H32N2O3 With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone In tetrahydrofuran at -10℃; for 15h;
Stage #1: (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane With magnesium; iodine; ethylene dibromide In tetrahydrofuran at 75℃; for 2.25h;
Stage #2: C25H32N2O3 In tetrahydrofuran at -10℃; for 15h;
A n/a
B n/a
Stage #1: (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane With cerium(III) chloride
Stage #2: C25H32N2O3
A n/a
B n/a
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(S)-5-{(1S,3S)-1-Hydroxy-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-dihydro-furan-2-one
325740-66-7

(S)-5-{(1S,3S)-1-Hydroxy-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-dihydro-furan-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: K-Selectride / tetrahydrofuran / -78 - 0 °C
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(S)-5-{(1R,3S)-1-Hydroxy-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-dihydro-furan-2-one
325740-65-6

(S)-5-{(1R,3S)-1-Hydroxy-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-dihydro-furan-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: K-Selectride / tetrahydrofuran / -78 - 0 °C
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(3S,5S)-5-{(1R,3S)-1-Hydroxy-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one
324763-45-3

(3S,5S)-5-{(1R,3S)-1-Hydroxy-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: H2 / [Ru2Cl4((S)-BINAP)]NEt3 / methanol / 40 h / 40 °C / 37503 Torr
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(3S,5S)-dihydro-5-{(1S,3S)-1-hydroxy-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-3-(1-methylethyl)furan-2(3H)-one
325740-67-8

(3S,5S)-dihydro-5-{(1S,3S)-1-hydroxy-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-3-(1-methylethyl)furan-2(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: H2 / [Ru2Cl4((S)-BINAP)]NEt3 / methanol / 40 h / 40 °C / 37503 Torr
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(3S,5S)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one
325740-70-3

(3S,5S)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: H2 / [Ru2Cl4((S)-BINAP)]NEt3 / methanol / 40 h / 40 °C / 37503 Torr
3: NEt3 / CH2Cl2
4: 85 percent / NaN3; 15-crown-6; DMPU
View Scheme
Multi-step reaction with 5 steps
1.1: magnesium; ethylene dibromide / tetrahydrofuran / 4.17 h / 63 - 68 °C / Inert atmosphere
1.2: 12.5 h / 0 - 5 °C
2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 26 h / 65 - 70 °C
2.2: 0.5 h / 0 - 5 °C
3.1: hydrogenchloride / 1,1-dichloroethane; water / 0 - 5 °C / pH 2.5
3.2: 14.25 h / 0 - 30 °C
4.1: N-Bromosuccinimide; phosphoric acid / water; tetrahydrofuran / 1.25 h / 0 - 5 °C
5.1: sodium azide / ethylene glycol / 20 h / 80 - 85 °C
View Scheme
Multi-step reaction with 2 steps
1.1: magnesium; ethylene dibromide / tetrahydrofuran / 4.17 h / 63 - 68 °C / Inert atmosphere
1.2: 1 h / 0 - 5 °C
1.3: 0.75 h / 0 - 5 °C
2.1: sodium azide / ethylene glycol / 20 h / 80 - 85 °C
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one
324763-46-4

(3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: H2 / [Ru2Cl4((S)-BINAP)]NEt3 / methanol / 40 h / 40 °C / 37503 Torr
3: NEt3 / CH2Cl2
4: 85 percent / NaN3; 15-crown-6; DMPU
View Scheme
Multi-step reaction with 3 steps
1: 51 percent
2: DMAP / CH2Cl2 / 20 °C
3: NaN3; NMP / 60 °C
View Scheme
Multi-step reaction with 3 steps
1.1: magnesium; ethylene dibromide / 2-methyltetrahydrofuran / 60 - 65 °C
1.2: 0.25 h / 10 °C
2.1: N-Bromosuccinimide; phosphoric acid / water; tetrahydrofuran / 5 °C
3.1: sodium azide; Aliquat 336 / water / 48 h / 75 - 80 °C
View Scheme
Multi-step reaction with 3 steps
1.1: magnesium; ethylene dibromide / tetrahydrofuran / 65 °C / Inert atmosphere
1.2: -5 - 20 °C
2.1: N-Bromosuccinimide; phosphoric acid / tetrahydrofuran; water / 2 h / 0 - 10 °C / Inert atmosphere
3.1: sodium azide / 2,2'-[1,2-ethanediylbis(oxy)]bisethanol / 72 h / 90 °C / Inert atmosphere
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(3S,5S)-5-{(S)-1-[(Z)-Hydroxyimino]-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one

(3S,5S)-5-{(S)-1-[(Z)-Hydroxyimino]-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: 89 percent / NaHCO3
3: 74 percent / H2 / Pd/C / methanol
View Scheme
Multi-step reaction with 2 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: 81 percent / NH2OH*HCl; NaHCO3 / methanol / 20 °C
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Methanesulfonic acid (1R,3S)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-1-((S)-5-oxo-tetrahydro-furan-2-yl)-pentyl ester

Methanesulfonic acid (1R,3S)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-1-((S)-5-oxo-tetrahydro-furan-2-yl)-pentyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: K-Selectride / tetrahydrofuran / -78 - 0 °C
3: NEt3 / CH2Cl2
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Methanesulfonic acid (1S,3S)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-1-((S)-5-oxo-tetrahydro-furan-2-yl)-pentyl ester

Methanesulfonic acid (1S,3S)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-1-((S)-5-oxo-tetrahydro-furan-2-yl)-pentyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: K-Selectride / tetrahydrofuran / -78 - 0 °C
3: NEt3 / CH2Cl2
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Methanesulfonic acid (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester
325740-68-9

Methanesulfonic acid (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: H2 / [Ru2Cl4((S)-BINAP)]NEt3 / methanol / 40 h / 40 °C / 37503 Torr
3: NEt3 / CH2Cl2
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

Methanesulfonic acid (1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester
325740-69-0

Methanesulfonic acid (1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: H2 / [Ru2Cl4((S)-BINAP)]NEt3 / methanol / 40 h / 40 °C / 37503 Torr
3: NEt3 / CH2Cl2
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(3S,5S)-5-{(S)-1-[(Z)-Benzyloxyimino]-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one
325740-72-5

(3S,5S)-5-{(S)-1-[(Z)-Benzyloxyimino]-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: 89 percent / NaHCO3
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

4-Bromo-benzenesulfonic acid (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester
387353-75-5

4-Bromo-benzenesulfonic acid (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 51 percent
2: DMAP / CH2Cl2 / 20 °C
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(2S,4S,5R,7S)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methyl-2-isopropylnonanamide
325154-32-3

(2S,4S,5R,7S)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methyl-2-isopropylnonanamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: H2 / [Ru2Cl4((S)-BINAP)]NEt3 / methanol / 40 h / 40 °C / 37503 Torr
3: NEt3 / CH2Cl2
4: 85 percent / NaN3; 15-crown-6; DMPU
5: 59 percent / 2-OH-pyridine; NEt3
6: H2; aq. HCl / Pd/C / methanol
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide
173334-57-1

(2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: H2 / [Ru2Cl4((S)-BINAP)]NEt3 / methanol / 40 h / 40 °C / 37503 Torr
3: NEt3 / CH2Cl2
4: 85 percent / NaN3; 15-crown-6; DMPU
5: 59 percent / 2-OH-pyridine; NEt3
6: H2; aq. HCl / Pd/C / methanol
View Scheme
Multi-step reaction with 13 steps
1.1: sodium ethanolate; sodium iodide / ethanol
2.1: potassium acetate / water; dimethyl sulfoxide
3.1: sodium hydroxide
4.1: thionyl chloride
5.1: pyridine / 12 h / 40 °C
6.1: dicyclohexyl(trifluoromethylsulfonyloxy)borane; triethylamine / -78 - 0 °C
7.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 0.25 h
7.2: Acidic aq. solution
8.1: water; lithium hydroxide / 1,4-dioxane / 120 h / 40 °C
9.1: diphenyl phosphoryl azide; triethylamine / toluene / 0.33 h / 20 °C
10.1: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 65 °C
11.1: 1.5 h / 65 °C
12.1: 2-hydroxypyridin / tert-butyl methyl ether / 65 °C
13.1: 10% palladium on activated charcoal; hydrogen
View Scheme
Multi-step reaction with 7 steps
1.1: magnesium; ethylene dibromide / tetrahydrofuran / 4.17 h / 63 - 68 °C / Inert atmosphere
1.2: 12.5 h / 0 - 5 °C
2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 26 h / 65 - 70 °C
2.2: 0.5 h / 0 - 5 °C
3.1: hydrogenchloride / 1,1-dichloroethane; water / 0 - 5 °C / pH 2.5
3.2: 14.25 h / 0 - 30 °C
4.1: N-Bromosuccinimide; phosphoric acid / water; tetrahydrofuran / 1.25 h / 0 - 5 °C
5.1: sodium azide / ethylene glycol / 20 h / 80 - 85 °C
6.1: triethylamine; 2-hydroxypyridin / 16 h / 85 - 90 °C
7.1: hydrogen; ethanolamine / palladium 10% on activated carbon / isopropyl alcohol / 3 h
View Scheme
(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane
324763-39-5

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(2S,4S,5R,7S)-5-Azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide
325154-31-2

(2S,4S,5R,7S)-5-Azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C
2: H2 / [Ru2Cl4((S)-BINAP)]NEt3 / methanol / 40 h / 40 °C / 37503 Torr
3: NEt3 / CH2Cl2
4: 85 percent / NaN3; 15-crown-6; DMPU
5: 59 percent / 2-OH-pyridine; NEt3
View Scheme

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View