DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiry2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE CAS:33252-64-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
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inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiry2-hydroxy-3-nitro-5-(trifluoromethyl)pyridineAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
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inquiry1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re
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inquiryhigh purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier
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inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
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inquiry1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiryC6H3F3N2O3 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 33252-64-1 Application:C6H3F3N2O3 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 33252-64-1
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inquiryWe product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Pharm intermediate
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inquirygood quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran
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inquiry3-Nitro-5-(trifluoromethyl)pyridin-2-ol cas 33252-64-1Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
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inquiry5-(Trifluoromethyl)-3-nitro-2-aminopyridine
3-nitro-5-trifluoromethylpyridin-2-ol
Conditions | Yield |
---|---|
With sulfuric acid; sodium nitrite In water at 0 - 20℃; Inert atmosphere; | 73% |
2-hydroxy-5-(trifluoromethyl)pyridine
3-nitro-5-trifluoromethylpyridin-2-ol
Conditions | Yield |
---|---|
Stage #1: 2-hydroxy-5-(trifluoromethyl)pyridine With sulfuric acid; nitric acid at 0 - 65℃; for 25h; Stage #2: With sodium hydroxide In water at 20℃; | 58% |
With sulfuric acid; nitric acid at 80 - 85℃; | 28% |
With sulfuric acid; potassium nitrate at 0 - 65℃; for 4h; | |
With sulfuric acid; nitric acid In water at 80℃; for 1h; | |
With sulfuric acid; nitric acid In water at 60℃; for 18h; |
2-amino-5-trifluoromethylpyridine
3-nitro-5-trifluoromethylpyridin-2-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: nitric acid; sulfuric acid / 0 - 20 °C / Inert atmosphere 2: sulfuric acid; sodium nitrite / water / 0 - 20 °C / Inert atmosphere View Scheme |
benzyltrimethylammonium chloride
3-nitro-5-trifluoromethylpyridin-2-ol
2-chloro-3-nitro-5-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With trichlorophosphate In acetonitrile for 3h; Heating; | 92% |
3-nitro-5-trifluoromethylpyridin-2-ol
2-chloro-3-nitro-5-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With quinoline; trichlorophosphate at 50 - 120℃; for 1.5h; Inert atmosphere; | 88% |
With quinoline; trichlorophosphate for 18h; Heating / reflux; | 87% |
With trichlorophosphate In DMF (N,N-dimethyl-formamide) at 110℃; for 0.5h; | 86% |
3-nitro-5-trifluoromethylpyridin-2-ol
methyl iodide
1-methyl-3-nitro-5-(trifluoromethyl)pyridin-2(1H)-one
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 25℃; for 3h; | 70% |
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 16h; | |
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 1.5h; |
phosphorus pentachloride
3-nitro-5-trifluoromethylpyridin-2-ol
2-chloro-3-nitro-5-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With trichlorophosphate | 52% |
With trichlorophosphate | 52% |
3-nitro-5-trifluoromethylpyridin-2-ol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 66 percent / PCl5, POCl3 / 80 °C 2: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, RT, 18 h 3: 73 percent / Fe, glacial AcOH / 2 h / Heating 4: 43 percent / H2 / 10percent Pd/C / acetic acid / 3 h / 2280 Torr View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
3-benzyloxycarbonyl-6-trifluoromethyl-4-azaoxindole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 66 percent / PCl5, POCl3 / 80 °C 2: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, RT, 18 h 3: 73 percent / Fe, glacial AcOH / 2 h / Heating View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
2-bis(benzyloxycarbonyl)methyl-3-nitro-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 66 percent / PCl5, POCl3 / 80 °C 2: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, RT, 18 h View Scheme |
p-methyloxycarbonylbenzyl chloride
3-nitro-5-trifluoromethylpyridin-2-ol
methyl 4-(3-nitro-5-trifluoromethylpyridine-2-yloxymethyl)benzoate
Conditions | Yield |
---|---|
In argon; toluene |
3-nitro-5-trifluoromethylpyridin-2-ol
2-hydroxy-3-amino-5-trifluoromethylpyridine
Conditions | Yield |
---|---|
With hydrogen; 5% Pd(II)/C(eggshell) In methanol at 20℃; under 760.051 Torr; for 2h; | |
With hydrogen; 5% Pd(II)/C(eggshell) In methanol at 20℃; under 760.051 Torr; for 2h; | |
With hydrogen; 5%-palladium/activated carbon In methanol at 20℃; under 760.051 Torr; for 2h; |
3-nitro-5-trifluoromethylpyridin-2-ol
N-[2-hydroxy-5-(trifluoromethyl)pyridin-3-yl]isonicotinamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 2 h / 20 °C / 760.05 Torr 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 2 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / pyridine / 2 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 2 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 2 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / 2 h / 80 °C View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
3-chloro-N-[2-hydroxy-5-(trifluoromethyl)pyridin-3-yl]isonicotinamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 2 h / 20 °C / 760.05 Torr 2: triethylamine / N,N-dimethyl-formamide / 1.5 h / 50 °C / Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C 2: triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 - 50 °C / Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr 2: triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 - 50 °C / Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr 2: triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 - 50 °C / Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr 2: triethylamine / N,N-dimethyl-formamide / 50 °C / Cooling with ice View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
N-[2-hydroxy-5-(trifluoromethyl)pyridin-3-yl]-3-(methoxymethyl)isonicotinamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen / 5% Pd(II)/C(eggshell) / methanol / 2 h / 20 °C / 760.05 Torr 2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 50 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C 2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 50 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr 2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 50 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr 2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 50 °C View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
3-amino-5-trifluoromethyl-2-mercaptopyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: trichlorophosphate; quinoline / 5.5 h / Reflux 1.2: Cooling with ice 2.1: thiourea / ethanol / 5.5 h / 50 °C 2.2: 1.5 h / 20 °C 2.3: Cooling with ice 3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
2-(3-fluoropyridin-4-yl)-6-(trifluoromethyl)thiazolo[5,4-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: trichlorophosphate; quinoline / 5.5 h / Reflux 1.2: Cooling with ice 2.1: thiourea / ethanol / 5.5 h / 50 °C 2.2: 1.5 h / 20 °C 2.3: Cooling with ice 3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C 4.1: dimethyl sulfoxide / 2 h / 170 °C View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
2-(3-ethoxypyridin-4-yl)-6-(trifluoromethyl)thiazolo[5,4-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: trichlorophosphate; quinoline / 5.5 h / Reflux 1.2: Cooling with ice 2.1: thiourea / ethanol / 5.5 h / 50 °C 2.2: 1.5 h / 20 °C 2.3: Cooling with ice 3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C 4.1: dimethyl sulfoxide / 2 h / 170 °C 5.1: potassium carbonate / 8 h / Reflux View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
2-[3-(2,2-difluoroethoxy)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: trichlorophosphate; quinoline / 5.5 h / Reflux 1.2: Cooling with ice 2.1: thiourea / ethanol / 5.5 h / 50 °C 2.2: 1.5 h / 20 °C 2.3: Cooling with ice 3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C 4.1: dimethyl sulfoxide / 2 h / 170 °C 5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C 5.2: 1 h / 20 °C / Cooling with ice View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
2-[3-(methylthio)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: trichlorophosphate; quinoline / 5.5 h / Reflux 1.2: Cooling with ice 2.1: thiourea / ethanol / 5.5 h / 50 °C 2.2: 1.5 h / 20 °C 2.3: Cooling with ice 3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C 4.1: dimethyl sulfoxide / 2 h / 170 °C 5.1: N,N-dimethyl-formamide / 2 h / Cooling with ice View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
2-[3-(ethylthio)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: trichlorophosphate; quinoline / 5.5 h / Reflux 1.2: Cooling with ice 2.1: thiourea / ethanol / 5.5 h / 50 °C 2.2: 1.5 h / 20 °C 2.3: Cooling with ice 3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C 4.1: dimethyl sulfoxide / 2 h / 170 °C 5.1: N,N-dimethyl-formamide / 1 h / Cooling with ice View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
A
2-[3-(ethanesulfinyl)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine
B
2-[3-(ethanesulfonyl)pyridin-4-yl]-6-(trifluoromethyl)thiazolo[5,4-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: trichlorophosphate; quinoline / 5.5 h / Reflux 1.2: Cooling with ice 2.1: thiourea / ethanol / 5.5 h / 50 °C 2.2: 1.5 h / 20 °C 2.3: Cooling with ice 3.1: acetic acid; iron / ethyl acetate; water / 0.17 h / 70 °C 4.1: dimethyl sulfoxide / 2 h / 170 °C 5.1: N,N-dimethyl-formamide / 1 h / Cooling with ice 6.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 1 h / 0 °C View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
5-trifluoromethyl-2-mercapto-3-nitropyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: trichlorophosphate; quinoline / 5.5 h / Reflux 1.2: Cooling with ice 2.1: thiourea / ethanol / 5.5 h / 50 °C 2.2: 1.5 h / 20 °C 2.3: Cooling with ice View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
2-[2-(2,2,2-trifluoroethoxy)-phenyl]-6-trifluoromethyl-oxazolo[5,4-b]pyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr 2.1: tetrahydrofuran / 22.5 h / 20 °C / Cooling with ice 2.2: 4.5 h 3.1: trichlorophosphate / 4 h / 120 °C 3.2: pH 7 / Cooling with ice View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C 2.1: tetrahydrofuran / 22.5 h / 20 °C / Cooling with ice 2.2: 4.5 h / 20 °C 3.1: trichlorophosphate / 4 h / 120 °C 3.2: pH 7 / Cooling with ice View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr 2.1: tetrahydrofuran / 22.5 h / 20 °C / Cooling with ice 2.2: 4.5 h 3.1: trichlorophosphate / 4 h / 120 °C 3.2: pH ~ 7 / Cooling with ice View Scheme | |
Multi-step reaction with 3 steps 1.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr 2.1: tetrahydrofuran / 22.5 h / 20 °C / Cooling with ice 2.2: 4.5 h 3.1: trichlorophosphate / 4 h / 120 °C 3.2: pH ~ 7 / Cooling with ice View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
N-(2-hydroxy-5-trifluoromethylpyridin-3-yl)-3-(2,2,2-trifluoroethoxy)-isonicotinamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C 2.1: tetrahydrofuran / 22.5 h / 20 °C / Cooling with ice 2.2: 4.5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr 2.1: tetrahydrofuran / 22.5 h / 20 °C / Cooling with ice 2.2: 4.5 h View Scheme | |
Multi-step reaction with 2 steps 1.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr 2.1: tetrahydrofuran / 22.5 h / 20 °C / Cooling with ice 2.2: 4.5 h View Scheme | |
Multi-step reaction with 2 steps 1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr 2: tetrahydrofuran / 20 °C / Cooling with ice View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
N-[2-hydroxy-6-(trifluoromethyl)pyridin-3-yl]-isonicotinamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr 2: triethylamine / N,N-dimethyl-formamide / 3.5 h / 20 - 50 °C View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 20 °C / 760.05 Torr 2: tetrahydrofuran / 20 °C / Cooling with ice 3: trichlorophosphate / 4 h / 120 °C View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
3-nitro-5-trifluoromethyl-pyridine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux 2: tetrabutylammomium bromide / toluene / 10 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux 2: tetrabutylammomium bromide / toluene / 9 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: phosphorus(V) oxybromide / 20 °C / Reflux 2: tetrabutylammomium bromide / toluene / 9 h / Reflux View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
3-amino-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux 2.1: tetrabutylammomium bromide / toluene / 10 h / Reflux 3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / Inert atmosphere 4.1: hydrogenchloride; water / 24 h / Reflux 5.1: sulfuric acid / 48 h / Reflux 5.2: 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux 2.1: tetrabutylammomium bromide / toluene / 9 h / Reflux 3.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 18 h 3.2: 24 h / Reflux 3.3: 84 h / Reflux View Scheme | |
Multi-step reaction with 3 steps 1.1: phosphorus(V) oxybromide / 20 °C / Reflux 2.1: tetrabutylammomium bromide / toluene / 9 h / Reflux 3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h 3.2: 24 h / Reflux 3.3: 84 h / Reflux View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux 2.1: tetrabutylammomium bromide / toluene / 10 h / Reflux 3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / Inert atmosphere 4.1: hydrogenchloride; water / 24 h / Reflux 5.1: sulfuric acid / 48 h / Reflux 5.2: 20 °C 6.1: bromine; sulfuric acid; acetic acid / water / 20 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux 2.1: tetrabutylammomium bromide / toluene / 9 h / Reflux 3.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 18 h 3.2: 24 h / Reflux 3.3: 84 h / Reflux 4.1: bromine; acetic acid; sulfuric acid / water / 19.5 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: phosphorus(V) oxybromide / 20 °C / Reflux 2.1: tetrabutylammomium bromide / toluene / 9 h / Reflux 3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h 3.2: 24 h / Reflux 3.3: 84 h / Reflux 4.1: bromine; acetic acid; sulfuric acid / water / 19.5 h / 20 °C View Scheme |
3-nitro-5-trifluoromethylpyridin-2-ol
3-amino-6-methoxy-5-trifluoromethylpyridine-2-carboxylic acid (3,3,3-trifluoro-2-hydroxy-2-methylpropyl)amide
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C / Reflux 2.1: tetrabutylammomium bromide / toluene / 10 h / Reflux 3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 18 h / Inert atmosphere 4.1: hydrogenchloride; water / 24 h / Reflux 5.1: sulfuric acid / 48 h / Reflux 5.2: 20 °C 6.1: bromine; sulfuric acid; acetic acid / water / 20 h / 20 °C 7.1: toluene-4-sulfonic acid / toluene / 2 h / Reflux 8.1: sodium hydroxide; water / 1 h / 20 °C 8.2: pH 1 9.1: hydroxylamine hydrochloride; triethylamine; ethanol / 5 h / Reflux 10.1: N-ethyl-N,N-diisopropylamine; HATU / 1-methyl-pyrrolidin-2-one / 2 h View Scheme | |
Multi-step reaction with 8 steps 1.1: phosphorus(V) oxybromide / acetonitrile / 20 °C 2.1: tetrabutylammomium bromide; copper(l) cyanide / toluene / 10 h / Reflux 3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h 3.2: 24 h / Reflux 3.3: 48 h / Reflux 4.1: sulfuric acid / water / 0.5 h 4.2: 18 h / 20 °C 5.1: toluene-4-sulfonic acid / toluene / 20 °C / Reflux; Dean-Stark 6.1: sodium hydroxide; methanol / 1 h / 20 °C 7.1: triethylamine; hydroxylamine hydrochloride / water; ethanol / 5 h / Reflux 8.1: HATU; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h View Scheme |
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