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Suzhou SuKaiLu Chemical Technology Co., Ltd.

Our Company main product 一:suzuki reaction customization 二:Boronic acid derivative ①:phenylboronic acid derivative ②:Phenylboronic acid pinacol ester derivative ③:Potassium phenyltrifluoroborate derivative ④:Phenylboronic acid MIDA ester derivative

2-FLUORO-3-METHOXYPHENYLBORONIC ACID

Cas:352303-67-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2-Fluoro-3-methoxybenzeneboronic acid Manufacturer/High quality/Best price/In stock

Cas:352303-67-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Fluoro-3-Methoxyphenylboronic Acid supplier in China

Cas:352303-67-4

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

The company has a professional R & D team, mature technology, very competitive prices and stable high quality products for customers to order high quality and low price product efforts! Appearance:white crystalline powder Storage:Sealed

352303-67-4 2-FLUORO-3-METHOXYPHENYLBORONIC ACID

Cas:352303-67-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name 2-Fluoro-3-methoxybenzeneboronic acid CAS number 352303-67-4 Assay ≥99% Appearance White powder Capacity 200mt/year Application OLED/pharmac

2-Fluoro-3-methoxybenzeneboronic acid

Cas:352303-67-4

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (2-fluoro-3-methoxyphenyl)boronic acid

Cas:352303-67-4

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price OLED 99% 352303-67-4 2-fluoro-3-methoxyphenylboronic acid Manufacturer

Cas:352303-67-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Fluoro-3-methoxybenzeneboronic acid

Cas:352303-67-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

High purity CAS 352303-67-4 2-FLUORO-3-METHOXYPHENYLBORONIC ACID in stock Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLE

High purity CAS 352303-67-4 2-FLUORO-3-METHOXYPHENYLBORONIC ACID in stock

Cas:352303-67-4

Min.Order:1 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2-FLUORO-3-METHOXYPHENYLBORONIC ACID

Cas:352303-67-4

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Benzenemethanol, -alpha-,2,3-trimethyl- (9CI) Basic information Product Name: Benzenemethanol, -alpha-,2,3-trimethyl- (9CI) Synonyms: Benzenemethanol, -alpha

2-Fluoro-3-methoxybenzeneboronic acid

Cas:352303-67-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Competitve Price in stock CAS 352303-67-4 with high-quality service

Cas:352303-67-4

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:powder Storage:Store in sealed containers at cool & dry pla

High quality 2-Fluoro-3-methoxybenzeneboronic acid cas no352303-67-4

Cas:352303-67-4

Min.Order:100 Gram

Negotiable

Type:Other

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Chemical Intermediate, 2-FLUORO-3-METHOXYPHENYLBORONIC ACID CAS:352303-67-4

Cas:352303-67-4

Min.Order:1 Kilogram

FOB Price: $184.0 / 198.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2-FLUORO-3-METHOXYPHENYLBORONIC ACID CAS:352303-67-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qu

2-FLUORO-3-METHOXYPHENYLBORONIC ACID CAS:352303-67-4

Cas:352303-67-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:352303-67-4

Cas:352303-67-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Fluoro-3-Methoxyphenylboronic Acid

Cas:352303-67-4

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and quality c

2-Fluoro-3-methoxybenzeneboronic acid

Cas:352303-67-4

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

(2-fluoro-3-methoxyphenyl)boronic acid 352303-67-4

Cas:352303-67-4

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2-Fluoro-3-Methoxyphenylboronic acid

Cas:352303-67-4

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Fluoro-3-Methoxyphenylboronic Acid

Cas:352303-67-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 2-Fluoro-3-Methoxyphenylboronic acid

Cas:352303-67-4

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-Fluoro-3-methoxybenzeneboronic acid CAS NO.352303-67-4

Cas:352303-67-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

2-FLUORO-3-METHOXYPHENYLBORONIC ACID

Cas:352303-67-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

2-FLUORO-3-METHOXYPHENYLBORONIC ACID

Cas:352303-67-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Elagolix 2-Fluoro-3-Methoxyphenylboronic acid

Cas:352303-67-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less 8 years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediates, herbal

Topsale 2-Fluoro-3-Methoxyphenylboronic Acid

Cas:352303-67-4

Min.Order:25 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 2-FLUORO-3-METHOXYPHENYLBORONIC ACID Synonyms: Fluoro-3-Methoxyphenylboronic;2-F,3-MeOC6H3B(OH)2;3-Borono-2-fluoroanisole;2-FLUORO-3-METHOXYPHENYLBORONIC ACID;2-FLUORO-3-METHOXYBENZENEBORONIC ACID;2-Fluoro-3-Methoxyphenylboroni;2-

2-Fluoro-3-methoxyphenylboronic acid 352303-67-4 C7H8BFO3

Cas:352303-67-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 2-Fluoro-3-Methoxyphenylboronic Acid CAS No.:352303-67-4 Molecule Formula:C7H8BFO3 Molecule Weight:169.94 Purity: 99% Package: 20kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard

Best Quality 2-Fluoro-3-Methoxyphenylboronic Acid

Cas:352303-67-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-FLUORO-3-METHOXYPHENYLBORONIC ACID

Cas:352303-67-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

tetramethylpiperidine

tetramethylpiperidine

Trimethyl borate
121-43-7

Trimethyl borate

1-fluoro-2-methoxybenzene
321-28-8

1-fluoro-2-methoxybenzene

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

Conditions
ConditionsYield
In tetrahydrofuran26%
C9H12BFO3

C9H12BFO3

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

Conditions
ConditionsYield
With hydrogenchloride
1-bromo-2-fluoro-3-methoxybenzene
295376-21-5

1-bromo-2-fluoro-3-methoxybenzene

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

Conditions
ConditionsYield
Stage #1: 2-fluoro-3-methoxy-1-bromobenzene With n-butyllithium In tetrahydrofuran at -78℃; for 0.166667h; Inert atmosphere;
Stage #2: With Triisopropyl borate In tetrahydrofuran at -78 - 20℃; for 1h; Inert atmosphere;
Stage #3: With water; ammonium chloride In tetrahydrofuran for 0.5h;
tert-butyl {[5-bromo-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate
881678-18-8

tert-butyl {[5-bromo-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

tert-butyl {[5-(2-fluoro-3-methoxyphenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate
928325-18-2

tert-butyl {[5-(2-fluoro-3-methoxyphenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]methyl}methylcarbamate

Conditions
ConditionsYield
With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium(0) In 1,2-dimethoxyethane; water at 100℃; for 2h;100%
(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

(2-fluoro-3-hydroxyphenyl)boronic acid
855230-60-3

(2-fluoro-3-hydroxyphenyl)boronic acid

Conditions
ConditionsYield
Stage #1: (2-fluoro-3-methoxyphenyl)boronic acid With boron tribromide In dichloromethane at 5 - 20℃; Inert atmosphere;
Stage #2: With sodium hydrogencarbonate In ethanol; dichloromethane Cooling;
96%
With boron tribromide In dichloromethane at 5 - 20℃; for 1h; Inert atmosphere;96%
Stage #1: (2-fluoro-3-methoxyphenyl)boronic acid With boron tribromide In dichloromethane at 0℃; for 1h;
Stage #2: With methanol In dichloromethane at 0℃; for 1h;
(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

2-fluoro-3-methoxyphenol
447462-87-5

2-fluoro-3-methoxyphenol

Conditions
ConditionsYield
With dihydrogen peroxide In 1,4-dioxane at 20℃; Cooling with ice;96%
With dihydrogen peroxide; acetic acid In tetrahydrofuran; water at 0 - 20℃;81%
With water; triethylamine In acetonitrile at 20℃; for 36h; Irradiation;72%
2-bromothiophene
1003-09-4

2-bromothiophene

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

2-(2-fluoro-3-methoxyphenyl)thiophene

2-(2-fluoro-3-methoxyphenyl)thiophene

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,2-dimethoxyethane; water for 4h; Suzuki Coupling; Inert atmosphere; Reflux;96%
(6-bromopyridin-2-yl)-(4-fluoro-3-methoxyphenyl)-methanone
1357564-27-2

(6-bromopyridin-2-yl)-(4-fluoro-3-methoxyphenyl)-methanone

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

(4-fluoro-3-methoxyphenyl)[6-(2-fluoro-3-methoxyphenyl)-pyridin-2-yl]methanone

(4-fluoro-3-methoxyphenyl)[6-(2-fluoro-3-methoxyphenyl)-pyridin-2-yl]methanone

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,2-dimethoxyethane; water at 80℃; Suzuki Coupling; Inert atmosphere;95%
(6-bromopyridin-2-yl)(2,3,4-trimethoxyphenyl)methanone

(6-bromopyridin-2-yl)(2,3,4-trimethoxyphenyl)methanone

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

[6-(2-fluoro-3-methoxyphenyl)pyridin-2-yl](2,3,4-trimethoxyphenyl)methanone

[6-(2-fluoro-3-methoxyphenyl)pyridin-2-yl](2,3,4-trimethoxyphenyl)methanone

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,2-dimethoxyethane; water at 80℃; Suzuki Coupling; Inert atmosphere;94%
potassium hydrogen difluoride

potassium hydrogen difluoride

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

potassium 2-fluoro-3-methoxy-phenyl-1-trifluoroborate

potassium 2-fluoro-3-methoxy-phenyl-1-trifluoroborate

Conditions
ConditionsYield
In methanol; water at 70℃; for 24h;94%
(6-bromopyridin-2-yl)(2,3-dimethoxyphenyl)methanone

(6-bromopyridin-2-yl)(2,3-dimethoxyphenyl)methanone

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

(2,3-dimethoxyphenyl)[6-(2-fluoro-3-methoxyphenyl)pyridin-2-yl]methanone

(2,3-dimethoxyphenyl)[6-(2-fluoro-3-methoxyphenyl)pyridin-2-yl]methanone

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,2-dimethoxyethane; water at 80℃; Suzuki Coupling; Inert atmosphere;93%
3-bromo-2-chlorobenzenamine
56131-46-5

3-bromo-2-chlorobenzenamine

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

2-chloro-2'-fluoro-3'-methoxybiphenyl-3-amine

2-chloro-2'-fluoro-3'-methoxybiphenyl-3-amine

Conditions
ConditionsYield
With [1,1′-bis(di-cyclohexylphosphino)ferrocene]dichloropalladium (II); sodium carbonate In 1,4-dioxane; water at 90℃; for 2h; Inert atmosphere;93%
(6-bromopyridin-2-yl)(2,3-dimethoxyphenyl)methanol

(6-bromopyridin-2-yl)(2,3-dimethoxyphenyl)methanol

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

(2,3-dimethoxyphenyl)[6-(2-fluoro-3-methoxyphenyl)pyridin-2-yl]methanol

(2,3-dimethoxyphenyl)[6-(2-fluoro-3-methoxyphenyl)pyridin-2-yl]methanol

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,2-dimethoxyethane; water at 80℃; Suzuki Coupling; Inert atmosphere;92%
(6-bromopyridin-2-yl)(2-methoxyphenyl)methanone
80100-50-1

(6-bromopyridin-2-yl)(2-methoxyphenyl)methanone

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

[6-(2-fluoro-3-methoxyphenyl)pyridin-2-yl](2-methoxyphenyl)methanone

[6-(2-fluoro-3-methoxyphenyl)pyridin-2-yl](2-methoxyphenyl)methanone

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,2-dimethoxyethane; water at 80℃; Suzuki Coupling; Inert atmosphere;92%
6-bromo-N-(4-fluoro-3-methoxyphenyl)pyridine-2-carboxamide

6-bromo-N-(4-fluoro-3-methoxyphenyl)pyridine-2-carboxamide

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

6-(2-fluoro-3-methoxyphenyl)-N-(4-fluoro-3-methoxyphenyl)pyridine-2-carboxamide

6-(2-fluoro-3-methoxyphenyl)-N-(4-fluoro-3-methoxyphenyl)pyridine-2-carboxamide

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,2-dimethoxyethane; water at 80℃; Suzuki Coupling; Inert atmosphere;92%
[14C]1-(2-fluoro-6-(trifluoromethyl)benzyl)-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione

[14C]1-(2-fluoro-6-(trifluoromethyl)benzyl)-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

[14C]5-(2-fluoro-3-methoxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

[14C]5-(2-fluoro-3-methoxyphenyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methylpyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
Stage #1: [14C]1-(2-fluoro-6-(trifluoromethyl)benzyl)-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione; (2-fluoro-3-methoxyphenyl)boronic acid With potassium hydroxide; tri tert-butylphosphoniumtetrafluoroborate In acetone at 45℃; for 0.5h; Inert atmosphere;
Stage #2: With palladium diacetate In acetone at 55℃; for 1.5h; Inert atmosphere;
92%
3-bromo-2-fluorobenzaldehyde
149947-15-9

3-bromo-2-fluorobenzaldehyde

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

2,2’-difluoro-3’-methoxy-[1,1’-biphenyl]-3-carbaldehyde

2,2’-difluoro-3’-methoxy-[1,1’-biphenyl]-3-carbaldehyde

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water Suzuki Coupling; Reflux;90.3%
methyl 2-bromo-5-nitrobenzoate
6942-36-5

methyl 2-bromo-5-nitrobenzoate

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

2'-fluoro-3'-methoxy-4-nitro-biphenyl-2-carboxylic acid methyl ester

2'-fluoro-3'-methoxy-4-nitro-biphenyl-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; toluene for 18h; Suzuki coupling; Heating;90%
3-bromo-4-(2,6-difluoro-4-nitrophenoxy)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine

3-bromo-4-(2,6-difluoro-4-nitrophenoxy)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

4-(2,6-difluoro-4-nitrophenoxy)-3-(2-fluoro-3-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine

4-(2,6-difluoro-4-nitrophenoxy)-3-(2-fluoro-3-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 100℃; for 3h; Suzuki Coupling; Inert atmosphere;90%
{(R)-2-[5-bromo-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester
830346-49-1

{(R)-2-[5-bromo-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

Pamoic acid
130-85-8

Pamoic acid

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

3-[2(R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione pamoic acid salt

3-[2(R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methylpyrimidine-2,4(1H,3H)-dione pamoic acid salt

Conditions
ConditionsYield
Stage #1: {(R)-2-[5-bromo-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester; (2-fluoro-3-methoxyphenyl)boronic acid With sodium carbonate In 1,4-dioxane; water for 0.25h; Inert atmosphere;
Stage #2: With tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 95 - 100℃; Inert atmosphere;
Stage #3: Pamoic acid Further stages;
90%
3-(R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6-trifluoromethylbenzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione hydrochloride

3-(R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6-trifluoromethylbenzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione hydrochloride

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

3-[(2R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione trifluoroacetate
830346-50-4

3-[(2R)-amino-2-phenylethyl]-5-(2-fluoro-3-methoxyphenyl)-1-[2-fluoro-6-(trifluoromethyl)benzyl]-6-methyl-2,4(1H,3H)-pyrimidinedione trifluoroacetate

Conditions
ConditionsYield
With potassium phosphate tribasic trihydrate; palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate In water; acetone at 20 - 60℃; for 20h; Time; Inert atmosphere;89.2%
(6-bromopyridin-2-yl)(2,4-difluoro-3-methoxyphenyl)methanone

(6-bromopyridin-2-yl)(2,4-difluoro-3-methoxyphenyl)methanone

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

(2,4-difluoro-3-methoxyphenyl)[6-(2-fluoro-3-methoxyphenyl)pyridin-2-yl]methanone

(2,4-difluoro-3-methoxyphenyl)[6-(2-fluoro-3-methoxyphenyl)pyridin-2-yl]methanone

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water at 150℃; for 1h; Suzuki Coupling; Inert atmosphere; Microwave irradiation;89%
(3-bromophenyl)(2,3-dimethoxyphenyl)methanone

(3-bromophenyl)(2,3-dimethoxyphenyl)methanone

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

(2,3-dimethoxyphenyl)(2'-fluoro-3'-methoxybiphenyl-3-yl)methanone

(2,3-dimethoxyphenyl)(2'-fluoro-3'-methoxybiphenyl-3-yl)methanone

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,2-dimethoxyethane; water at 80℃; Suzuki Coupling; Inert atmosphere;89%
1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione
1150560-54-5

1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione
1150560-59-0

5-(2-fluoro-3-methoxyphenyl)-1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-6-methylpyrimidine-2,4(1H,3H)-dione

Conditions
ConditionsYield
With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium hydroxide In water; acetone at 40 - 45℃; for 2.5h;88.4%
Stage #1: 1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione; (2-fluoro-3-methoxyphenyl)boronic acid With potassium hydroxide In water; acetone for 0.5 - 1h;
Stage #2: 1,1-(bis-di-t-butylphosphino)ferrocene palladium dichloride In water; acetone at 40 - 45℃; for 2.5h; Product distribution / selectivity;
87%
Stage #1: 1-{[2-fluoro-6-(trifluoromethyl)phenyl]methyl}-5-iodo-6-methylpyrimidine-2,4(1H,3H)-dione; (2-fluoro-3-methoxyphenyl)boronic acid With potassium hydroxide; tri tert-butylphosphoniumtetrafluoroborate In water; acetone at 15 - 45℃; for 0.833333h;
Stage #2: With palladium diacetate In water; acetone
85%
3-bromo-2-fluorobenzoic acid
161957-56-8

3-bromo-2-fluorobenzoic acid

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

2,2’-difluoro-3’-methoxy-[1,1‘-biphenyl]-3-carboxylic acid

2,2’-difluoro-3’-methoxy-[1,1‘-biphenyl]-3-carboxylic acid

Conditions
ConditionsYield
With potassium phosphate; potassium dihydrogenphosphate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) In 1,2-dimethoxyethane; ethanol; water at 60℃; for 5h; Suzuki Coupling;88%
2-bromo-6-(4-fluoro-3-methoxyphenoxy)pyridine

2-bromo-6-(4-fluoro-3-methoxyphenoxy)pyridine

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

2-(4-fluoro-3-methoxyphenoxy)-6-(2-fluoro-3-methoxyphenyl)pyridine

2-(4-fluoro-3-methoxyphenoxy)-6-(2-fluoro-3-methoxyphenyl)pyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,2-dimethoxyethane; water at 80℃; Suzuki Coupling; Inert atmosphere;88%
1-(3-bromophenyl)-2-phenylethane-1,2-dione
40396-54-1

1-(3-bromophenyl)-2-phenylethane-1,2-dione

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

1-(2'-fluoro-3'-methoxy-[1,1'-biphenyl]-3-yl)-2-phenylethane-1,2-dione

1-(2'-fluoro-3'-methoxy-[1,1'-biphenyl]-3-yl)-2-phenylethane-1,2-dione

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In 1,4-dioxane; water at 100℃; for 3h; Inert atmosphere;88%
5-bromo-N-methyl-N-(3-methylphenyl)thiophene-2-carboxamide
1252464-84-8

5-bromo-N-methyl-N-(3-methylphenyl)thiophene-2-carboxamide

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

5-(2-fluoro-3-methoxyphenyl)-N-methyl-N-(m-tolylthiophene)-2-carboxamide
1396243-08-5

5-(2-fluoro-3-methoxyphenyl)-N-methyl-N-(m-tolylthiophene)-2-carboxamide

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water at 80℃; for 14h; Inert atmosphere;85%
(2R)-4-(4-iodo-2-oxopyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide
1312478-57-1

(2R)-4-(4-iodo-2-oxopyridin-1(2H)-yl)-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

(2R)-4-[4-(2-fluoro-3-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide
1358778-86-5

(2R)-4-[4-(2-fluoro-3-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Conditions
ConditionsYield
With potassium carbonate In ethanol; water at 70℃; Suzuki-Miyaura coupling;84%
5-bromo-N-(3-methoxyphenyl)thiophene-2-carboxamide
885572-88-3

5-bromo-N-(3-methoxyphenyl)thiophene-2-carboxamide

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

5-(2-fluoro-3-methoxyphenyl)-N-(3-methoxyphenyl)thiophene-2-carboxamide
1396243-33-6

5-(2-fluoro-3-methoxyphenyl)-N-(3-methoxyphenyl)thiophene-2-carboxamide

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water at 80℃; for 14h; Inert atmosphere;84%
2-chloro-3-cyanopyrazine
55557-52-3

2-chloro-3-cyanopyrazine

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

3-(2'-fluoro-3'-methoxyphenyl)pyrazine-2-carbonitrile
1439364-58-5

3-(2'-fluoro-3'-methoxyphenyl)pyrazine-2-carbonitrile

Conditions
ConditionsYield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; sodium carbonate In 1,2-dimethoxyethane; water at 80℃; for 0.25h; Suzuki Coupling; Inert atmosphere;84%
2-bromo-6-(dimethoxymethyl)-3-iodopyridine

2-bromo-6-(dimethoxymethyl)-3-iodopyridine

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

2-bromo-6-(dimethoxymethyl)-3-(2-fluoro-3-methoxyphenyl)pyridine

2-bromo-6-(dimethoxymethyl)-3-(2-fluoro-3-methoxyphenyl)pyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,2-dimethoxyethane; water at 80℃; Suzuki Coupling; Inert atmosphere;84%
{(R)-2-[5-bromo-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester
830346-49-1

{(R)-2-[5-bromo-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

(2-fluoro-3-methoxyphenyl)boronic acid
352303-67-4

(2-fluoro-3-methoxyphenyl)boronic acid

(R)-(2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)carbamic acid tert-butyl ester
830346-51-5

(R)-(2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 90℃; Suzuki Coupling;83%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,4-dioxane; water at 90℃; Suzuki coupling; Inert atmosphere;83%
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 90℃; Suzuki Coupling;83%

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