Product Name:3,6-dichloropyrazine-2-carbonitrile Synonym:2-Pyrazinecarbonitrile,3,6-dichloro;3,6-dichloro-2-pyrazinecarbonitrile Cas No:356783-16-9 Molecular Formula:C5HCl2N3 Molecular Weight:173.98754 Appearance:Little yellow powder HP
Cas:356783-16-9
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inquiryProduct Description Product Name 3,6-Dichloro-2-pyrazinecarbonitrile CAS No. 356783-16-9 Appearance
Cas:356783-16-9
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inquiryDayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry3,6-dichloropyrazine-2-carbonitrile CAS:356783-16-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qua
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquirylow price high quality high purity good sevice stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermediat
Cas:356783-16-9
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:356783-16-9
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:356783-16-9
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inquiry3,6-dichloropyrazine-2-carbonitrile/ 356783-16-9/ 98% IN STOCKAppearance:White powder Storage:keep away from heat,sparks and flames Package:according to customers' requirements Application:Pharmaceutical intermediate Transportation:By air(EMS or EUB
Cas:356783-16-9
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inquiry1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m
Cas:356783-16-9
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Cas:356783-16-9
Min.Order:10 Gram
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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inquiryWe product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Product Name:3,6-dichloropyrazine-2-carbonitrile CA
Cas:356783-16-9
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inquiryProduct name: 3,6-Dichloro-2-Pyrazinecarbonitrile CAS No.:356783-16-9 Molecule Formula:C5HCl2N3 Molecule Weight:173.99 Purity: 99.0% Package: 25kg/drum Description: Light yellow powder Manufacture Standards:Enterprise Standard
Cas:356783-16-9
Min.Order:1 Kilogram
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:356783-16-9
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:356783-16-9
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
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inquiry3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
With pyridine; trichlorophosphate at 20 - 80℃; for 8h; Reagent/catalyst; | 90% |
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 6-bromo-3-hydroxypyrazine-2-carboxamide With trichlorophosphate In chlorobenzene at 60℃; for 0.5h; Stage #2: With N-ethyl-N,N-diisopropylamine In chlorobenzene at 90 - 100℃; for 2.66667h; Stage #3: With sodium hydrogencarbonate In water; toluene | 83% |
With N-ethyl-N,N-diisopropylamine; trichlorophosphate In water at 60 - 100℃; for 8h; Solvent; | 70% |
Stage #1: 6-bromo-3-hydroxypyrazine-2-carboxamide With trichlorophosphate at 70℃; for 0.25h; Stage #2: With N-ethyl-N,N-diisopropylamine at 20 - 100℃; for 6h; Stage #3: With water for 1h; | 70% |
Stage #1: 6-bromo-3-hydroxypyrazine-2-carboxamide With trichlorophosphate at 55℃; for 0.5h; Stage #2: With N-ethyl-N,N-diisopropylamine at 110℃; for 5h; | 43.7% |
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; trichlorophosphate at 75℃; for 1h; | 82% |
6-chloro-3-aminopyrazine-2-carbonitrile
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
With tert.-butylnitrite; titanium tetrachloride In dichloromethane at 0 - 20℃; for 3h; Sandmeyer Reaction; | 81% |
1,4-dioxopyrazinamide
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 1,4-dioxopyrazinamide With trichlorophosphate In chlorobenzene at 50 - 70℃; for 1.83333h; Stage #2: With pyridine In chlorobenzene at 110℃; for 8h; Temperature; Reagent/catalyst; | 52.55% |
Stage #1: 1,4-dioxopyrazinamide With trichlorophosphate at 50 - 70℃; for 1.83333h; Stage #2: With triethylamine at 96℃; for 6h; | 45.15% |
2-hydroxypyrazine-3-carboxamide
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: bromine / acetonitrile / 6 h / 0 - 40 °C 2.1: trichlorophosphate / chlorobenzene / 0.5 h / 60 °C 2.2: 2.67 h / 90 - 100 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: bromine; pyridine / N,N-dimethyl-formamide / 2 h / 80 - 85 °C / Inert atmosphere 2.1: trichlorophosphate / 0.5 h / 55 °C 2.2: 5 h / 110 °C View Scheme |
2-pyrazine carbonitrile
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: acetic acid; dihydrogen peroxide / 22 h / -5 - 95 °C 2.1: trichlorophosphate / 1.83 h / 50 - 70 °C 2.2: 6 h / 96 °C View Scheme |
3-aminopyrazinoic acid
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sulfuric acid / 20 °C / Cooling with ice 2: N-Bromosuccinimide / acetonitrile / 20 °C 3: sulfuric acid; sodium nitrite / 2 h / -5 - 20 °C 4: ammonium hydroxide / 3 h / 20 °C 5: trichlorophosphate; N-ethyl-N,N-diisopropylamine / water / 8 h / 60 - 100 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: sulfuric acid / 48 h / Cooling with ice 2.1: N-Bromosuccinimide / acetonitrile / 24 h / 20 °C / Inert atmosphere 3.1: sulfuric acid; sodium nitrite / 2 h / -5 - 25 °C 3.2: 1.5 h 4.1: ammonium hydroxide / 3 h / 20 °C 5.1: trichlorophosphate / 0.25 h / 70 °C 5.2: 6 h / 20 - 100 °C 5.3: 1 h View Scheme |
Methyl 3-amino-2-pyrazinecarboxylate
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: N-Bromosuccinimide / acetonitrile / 20 °C 2: sulfuric acid; sodium nitrite / 2 h / -5 - 20 °C 3: ammonium hydroxide / 3 h / 20 °C 4: trichlorophosphate; N-ethyl-N,N-diisopropylamine / water / 8 h / 60 - 100 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: N-Bromosuccinimide / acetonitrile / 24 h / 20 °C / Inert atmosphere 2.1: sulfuric acid; sodium nitrite / 2 h / -5 - 25 °C 2.2: 1.5 h 3.1: ammonium hydroxide / 3 h / 20 °C 4.1: trichlorophosphate / 0.25 h / 70 °C 4.2: 6 h / 20 - 100 °C 4.3: 1 h View Scheme |
methyl 3-amino-6-bromopyrazine-2-carboxylate
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sulfuric acid; sodium nitrite / 2 h / -5 - 20 °C 2: ammonium hydroxide / 3 h / 20 °C 3: trichlorophosphate; N-ethyl-N,N-diisopropylamine / water / 8 h / 60 - 100 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sulfuric acid; sodium nitrite / 2 h / -5 - 25 °C 1.2: 1.5 h 2.1: ammonium hydroxide / 3 h / 20 °C 3.1: trichlorophosphate / 0.25 h / 70 °C 3.2: 6 h / 20 - 100 °C 3.3: 1 h View Scheme |
3-hydroxy-6-bromopyrazine-2-carboxylic acid methyl ester
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ammonium hydroxide / 3 h / 20 °C 2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / water / 8 h / 60 - 100 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: ammonium hydroxide / 3 h / 20 °C 2.1: trichlorophosphate / 0.25 h / 70 °C 2.2: 6 h / 20 - 100 °C 2.3: 1 h View Scheme |
pyrazinamide
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: acetic acid; 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 24 h / 0 - 20 °C 2.1: trichlorophosphate / chlorobenzene / 1.83 h / 50 - 70 °C 2.2: 8 h / 110 °C View Scheme |
2-hydroxy-5-bromopyrazine
formamide
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Stage #1: 2-hydroxy-5-bromopyrazine With trichlorophosphate at 60℃; for 2h; Stage #2: formamide With dipotassium peroxodisulfate; iron In water at 80 - 85℃; Further stages; | 320 g |
3,6-dichloropyrazine-2-carbonitrile
3,6-dichloropyrazine-2-carbonitrile
3,6-difluoropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
With potassium fluoride; tetrabutylammomium bromide In dimethyl sulfoxide; toluene at 60℃; for 2.5h; | 92.3% |
With potassium fluoride In dimethyl sulfoxide at 60 - 90℃; Large scale; | 85% |
With tetrabutyl ammonium fluoride; tetrabutylammomium bromide at 60℃; for 3h; Reagent/catalyst; Temperature; Solvent; Sealed tube; | 62.37% |
3,6-dichloropyrazine-2-carbonitrile
6-chloro-3-hydroxylpyrazine-2-carbonitrile
Conditions | Yield |
---|---|
With tetrabutylammomium bromide; sodium hydroxide In dichloromethane at 20℃; for 3h; | 85% |
3,6-dichloropyrazine-2-carbonitrile
4-methoxy-phenol
6-chloro-3-(4-methoxyphenoxy)-2-pyrazinecarbonitrile
Conditions | Yield |
---|---|
With potassium carbonate In N-methyl-acetamide; water; ethyl acetate |
3,6-dichloropyrazine-2-carbonitrile
thiophenol
6-chloro-3-(phenylsulfanyl)-2-pyrazinecarbonitrile
Conditions | Yield |
---|---|
With sodium chloride; potassium carbonate In water; ethyl acetate; N,N-dimethyl-formamide |
3,6-dichloropyrazine-2-carbonitrile
4-Benzyloxyphenol
3-[(4-(benzyloxy)phenoxy)]-6-chloro-2-pyrazinecarbonitrile
Conditions | Yield |
---|---|
With potassium carbonate In N-methyl-acetamide; di-isopropyl ether; water; ethyl acetate |
2-Methylcyclopentane-1,3-dione
3,6-dichloropyrazine-2-carbonitrile
6-fluoro-3-[(2-methyl-3-oxo-1-cyclopenten-1-yl)oxy]-2pyrazinecarbonitrile
Conditions | Yield |
---|---|
With potassium fluoride; triethylamine In water; dimethyl sulfoxide; ethyl acetate |
3,6-dichloropyrazine-2-carbonitrile
favipiravir
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium fluoride; tetrabutylammomium bromide / toluene; dimethyl sulfoxide / 2.5 h / 60 °C 2.1: sodium acetate; water / toluene; dimethyl sulfoxide / 7 h / 50 °C 3.1: sulfuric acid / 4 h / 50 °C 3.2: 0.67 h / 3 - 10 °C 3.3: 0.75 h / 10 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium fluoride; tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 55 °C / Sealed tube 2: dihydrogen peroxide / 2 h / 27 °C 3: sodium hydrogencarbonate; water / 8.5 h / 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium fluoride; tetrabutylammomium bromide / toluene; dimethyl sulfoxide / 3 h / 55 °C 2: dihydrogen peroxide / toluene; dimethyl sulfoxide / 2 h / 27 °C / Cooling with ice 3: sodium hydrogencarbonate; water / 8.5 h / 50 °C View Scheme |
3,6-dichloropyrazine-2-carbonitrile
3,6-difluoro-2-pyrazinecarboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium fluoride; tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 55 °C / Sealed tube 2: dihydrogen peroxide / 2 h / 27 °C View Scheme | |
Multi-step reaction with 2 steps 1: potassium fluoride; tetrabutylammomium bromide / toluene; dimethyl sulfoxide / 3 h / 55 °C 2: dihydrogen peroxide / toluene; dimethyl sulfoxide / 2 h / 27 °C / Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1: potassium fluoride dihydrate; tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 50 °C 2: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide; water / 1.5 h / 25 °C View Scheme |
3,6-dichloropyrazine-2-carbonitrile
6-fluoro-3-hydroxy-2-cyanopyrazine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tetrabutyl ammonium fluoride; tetrabutylammomium bromide / 3 h / 60 °C / Sealed tube 2: sodium acetate; water / 1,4-dioxane / 7 h / 55 °C View Scheme | |
Multi-step reaction with 2 steps 1: potassium fluoride / dimethyl sulfoxide / 60 - 90 °C / Large scale 2: sodium acetate; water / dimethyl sulfoxide / 4 h / 5 - 45 °C / Large scale View Scheme | |
Stage #1: 3,6-dichloropyrazine-2-carbonitrile With potassium fluoride In N,N-dimethyl-formamide at 105 - 112℃; Stage #2: With acetic acid; triethylamine In N,N-dimethyl-formamide at 0 - 15℃; for 1h; |
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: toluene / 3 h / 0 °C 2: bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); potassium propionate / 1,4-dioxane / 3 h / 85 °C / Inert atmosphere 3: potassium carbonate / 2 h / 70 °C View Scheme |
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: toluene / 3 h / 0 °C 2: bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); potassium propionate / 1,4-dioxane / 3 h / 85 °C / Inert atmosphere 3: potassium carbonate / 2 h / 70 °C 4: copper(I) bromide; tert.-butylnitrite / acetonitrile / 3 h / 0 - 20 °C View Scheme |
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: toluene / 3 h / 0 °C 2: bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); potassium propionate / 1,4-dioxane / 3 h / 85 °C / Inert atmosphere 3: potassium carbonate / 2 h / 70 °C 4: copper(I) bromide; tert.-butylnitrite / acetonitrile / 3 h / 0 - 20 °C 5: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 5 h / 80 - 100 °C / Inert atmosphere View Scheme |
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: toluene / 3 h / 0 °C 2: bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); potassium propionate / 1,4-dioxane / 3 h / 85 °C / Inert atmosphere 3: potassium carbonate / 2 h / 70 °C 4: copper(I) bromide; tert.-butylnitrite / acetonitrile / 3 h / 0 - 20 °C 5: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 5 h / 80 - 100 °C / Inert atmosphere 6: hydrogen; Rh/Al2O3 / ethanol / 8 h View Scheme |
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: toluene / 3 h / 0 °C 2: bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); potassium propionate / 1,4-dioxane / 3 h / 85 °C / Inert atmosphere 3: potassium carbonate / 2 h / 70 °C 4: copper(I) bromide; tert.-butylnitrite / acetonitrile / 3 h / 0 - 20 °C 5: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 5 h / 80 - 100 °C / Inert atmosphere 6: hydrogen; Rh/Al2O3 / ethanol / 8 h 7: hydrogenchloride / isopropyl alcohol / 48 h / 20 °C 8: acetic acid; sodium cyanoborohydride / ethanol / 3 h View Scheme |
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: toluene / 3 h / 0 °C 2: bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); potassium propionate / 1,4-dioxane / 3 h / 85 °C / Inert atmosphere 3: potassium carbonate / 2 h / 70 °C 4: copper(I) bromide; tert.-butylnitrite / acetonitrile / 3 h / 0 - 20 °C 5: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 5 h / 80 - 100 °C / Inert atmosphere 6: hydrogen; Rh/Al2O3 / ethanol / 8 h 7: hydrogenchloride / isopropyl alcohol / 48 h / 20 °C 8: acetic acid; sodium cyanoborohydride / ethanol / 3 h 9: hydrogenchloride / isopropyl alcohol View Scheme |
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: toluene / 3 h / 0 °C 2: bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); potassium propionate / 1,4-dioxane / 3 h / 85 °C / Inert atmosphere 3: potassium carbonate / 2 h / 70 °C 4: copper(I) bromide; tert.-butylnitrite / acetonitrile / 3 h / 0 - 20 °C 5: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 5 h / 80 - 100 °C / Inert atmosphere 6: hydrogen; Rh/Al2O3 / ethanol / 8 h 7: hydrogenchloride / isopropyl alcohol / 48 h / 20 °C 8: acetic acid; sodium cyanoborohydride / ethanol / 3 h 9: hydrogenchloride / isopropyl alcohol 10: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h View Scheme |
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1: toluene / 3 h / 0 °C 2: bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); potassium propionate / 1,4-dioxane / 3 h / 85 °C / Inert atmosphere 3: potassium carbonate / 2 h / 70 °C 4: copper(I) bromide; tert.-butylnitrite / acetonitrile / 3 h / 0 - 20 °C 5: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 5 h / 80 - 100 °C / Inert atmosphere 6: hydrogen; Rh/Al2O3 / ethanol / 8 h 7: hydrogenchloride / isopropyl alcohol / 48 h / 20 °C 8: acetic acid; sodium cyanoborohydride / ethanol / 3 h 9: hydrogenchloride / isopropyl alcohol 10: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h 11: methanol; sodium hydroxide / tetrahydrofuran / 2.5 h / 60 °C View Scheme |
3,6-dichloropyrazine-2-carbonitrile
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: toluene / 3 h / 0 °C 2: bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II); potassium propionate / 1,4-dioxane / 3 h / 85 °C / Inert atmosphere 3: potassium carbonate / 2 h / 70 °C 4: copper(I) bromide; tert.-butylnitrite / acetonitrile / 3 h / 0 - 20 °C 5: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 5 h / 80 - 100 °C / Inert atmosphere 6: hydrogen; Rh/Al2O3 / ethanol / 8 h 7: hydrogenchloride / isopropyl alcohol / 48 h / 20 °C 8: acetic acid; sodium cyanoborohydride / ethanol / 3 h 9: hydrogenchloride / isopropyl alcohol 10: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h View Scheme |
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