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Afine Chemicals Limited

NITROCEFIN, 3-(2,4-DINITROSTYRYL)-(6R, 7R)-7-(2-THIENYLACETAMIDO)-CEPH-3-EM-4 CARBOXYLIC ACID, E-ISOMER;(6R)-3-[(E)-2-(2,4-Dinitrophenyl)ethenyl]-8-oxo-7α-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid CAS No.:4

NITROCEFIN CAS No 41906-86-9

Cas:41906-86-9

Min.Order:1 Kilogram

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Nitrocefin

Cas:41906-86-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

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Cas:41906-86-9

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

41906-86-9 Nitrocefin / high quality /Best price/In stock

Cas:41906-86-9

Min.Order:10 Kilogram

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Lyander (Xiamen) Medical Technology Co., LTD

Lyander’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Lyander can provide different quantities of cu

Nitrocefin

Cas:41906-86-9

Min.Order:1 Gram

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Nitrocefin

Cas:41906-86-9

Min.Order:1 Milligram

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

41906-86-9 Nitrocefin / high quality /Best price/In stock

Cas:41906-86-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

41906-86-9 Nitrocefin / high quality /Best price/In stock

Cas:41906-86-9

Min.Order:1 Metric Ton

FOB Price: $1.5

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

41906-86-9 Nitrocefin / high quality /Best price/In stock

Cas:41906-86-9

Min.Order:1 Metric Ton

FOB Price: $1.0

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

Nitrocefin

Cas:41906-86-9

Min.Order:0

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Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec NITROCEFIN 25mg

Cas:41906-86-9

Min.Order:1 bottle

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

NITROCEFIN

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Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

NITROCEFIN

Cas:41906-86-9

Min.Order:0

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Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

Appearance: Off-White crystalline powder Water: ≤1.0% Melting point :129.0 ~ 134.0℃ Specific rotation (C=0.5,Acetone) -6.5…Appearance:Off-White crystalline powder Storage:cool and dry Package:25kg/drum Application:Preservative

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

NITROCEFIN

Cas:41906-86-9

Min.Order:0

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Antimex Chemical Limied

hight degree of purity Application:Fine chemical intermediates, used as the main raw material for he synthesis of various pesticides, medicines, surfactants, polymer monomers, Ond Ontifungal agents

Hubei Langyou International Trading Co., Ltd

41906-86-9 Nitrocefin / high quality /Best price/In stock Application:41906-86-9 Nitrocefin / high quality /Best price/In stock

41906-86-9 Nitrocefin / high quality /Best price/In stock

Cas:41906-86-9

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Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Nitrocefin CAS No.41906-86-9

Cas:41906-86-9

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DB BIOTECH CO., LTD

best seller Application:API

NITROCEFIN

Cas:41906-86-9

Min.Order:0

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Hangzhou Fandachem Co.,Ltd

NITROCEFINAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

NITROCEFIN

Cas:41906-86-9

Min.Order:0

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Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

Nitrocefin

Cas:41906-86-9

Min.Order:0

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

NITROCEFIN

Cas:41906-86-9

Min.Order:0

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SAGECHEM LIMITED

41906-86-9 Application:intermediate

Nitrocefin

Cas:41906-86-9

Min.Order:0

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Hunan Longxianng Runhui Trading Co.,Ltd

41906-86-9 Nitrocefin / high quality /Best price/In stockAppearance:solid Storage:Keep in a cool & dry place Package:Neutral Application:raw material Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport

41906-86-9 Nitrocefin / high quality /Best price/In stock

Cas:41906-86-9

Min.Order:0

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Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:5mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any port

Nitrocefin

Cas:41906-86-9

Min.Order:0

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

41906-86-9

Cas:41906-86-9

Min.Order:0

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Hebei Muhuang Technology Co., Ltd

best seller Application:API

NITROCEFIN

Cas:41906-86-9

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Synthetic route

C34H26N4O8S2

C34H26N4O8S2

Nitrocefin
41906-86-9

Nitrocefin

Conditions
ConditionsYield
With methoxybenzene; trifluoroacetic acid In dichloromethane at 0℃; for 0.5h;87%
2-thienylacetic acid chloride
39098-97-0

2-thienylacetic acid chloride

(6R,7R)-7-Amino-3-[(E)-2-(2,4-dinitro-phenyl)-vinyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-7-Amino-3-[(E)-2-(2,4-dinitro-phenyl)-vinyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Nitrocefin
41906-86-9

Nitrocefin

Conditions
ConditionsYield
With N,N'-bis(trimethylsilyl)urea; ammonium bromide 1.) CH2Cl2, reflux, 1.5 h, 2.) CH2Cl2, -10 deg C, 1.5 h; Yield given. Multistep reaction;
(6R,7R)-3-[(Z)-2,4-dinitrostyryl]-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid

(6R,7R)-3-[(Z)-2,4-dinitrostyryl]-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid

Nitrocefin
41906-86-9

Nitrocefin

Conditions
ConditionsYield
In chloroform; dimethyl sulfoxide at 20℃; for 24h;120 mg
p-methoxybenzyl (6R,7R)-3-(2,4-dinitrostyryl)-7-(2-thienylacetamido)-3-cephem-4-carboxylate

p-methoxybenzyl (6R,7R)-3-(2,4-dinitrostyryl)-7-(2-thienylacetamido)-3-cephem-4-carboxylate

A

Nitrocefin
41906-86-9

Nitrocefin

B

(6R,7R)-3-[(Z)-2,4-dinitrostyryl]-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid

(6R,7R)-3-[(Z)-2,4-dinitrostyryl]-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid

Conditions
ConditionsYield
With methoxybenzene; trifluoroacetic acid In dichloromethane for 0.25h; cooling; Title compound not separated from byproducts;
2-thienylacetic acid chloride
39098-97-0

2-thienylacetic acid chloride

Nitrocefin
41906-86-9

Nitrocefin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 78 percent / potassium trimethylsilanolate / CH2Cl2; acetonitrile / 1 h / 20 °C
2.1: sodium iodide / butan-2-one / 20 °C
3.1: potassium trimethylsilanolate / CH2Cl2; acetonitrile / 1 h / -10 °C
3.2: 0.90 g / CH2Cl2; acetonitrile / 5 h / -10 - 20 °C
4.1: trifluoroacetic acid; anisole / CH2Cl2 / 0.25 h / cooling
View Scheme
Multi-step reaction with 5 steps
1.1: 78 percent / potassium trimethylsilanolate / CH2Cl2; acetonitrile / 1 h / 20 °C
2.1: sodium iodide / butan-2-one / 20 °C
3.1: potassium trimethylsilanolate / CH2Cl2; acetonitrile / 1 h / -10 °C
3.2: 0.90 g / CH2Cl2; acetonitrile / 5 h / -10 - 20 °C
4.1: trifluoroacetic acid; anisole / CH2Cl2 / 0.25 h / cooling
5.1: 120 mg / CHCl3; dimethylsulfoxide / 24 h / 20 °C
View Scheme
(6R,7R)-4-methoxybenzyl-3-(chloromethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
101182-25-6

(6R,7R)-4-methoxybenzyl-3-(chloromethyl)-8-oxo-7-(2-(thiophen-2-yl)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Nitrocefin
41906-86-9

Nitrocefin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium iodide / butan-2-one / 20 °C
2.1: potassium trimethylsilanolate / CH2Cl2; acetonitrile / 1 h / -10 °C
2.2: 0.90 g / CH2Cl2; acetonitrile / 5 h / -10 - 20 °C
3.1: trifluoroacetic acid; anisole / CH2Cl2 / 0.25 h / cooling
View Scheme
Multi-step reaction with 4 steps
1.1: sodium iodide / butan-2-one / 20 °C
2.1: potassium trimethylsilanolate / CH2Cl2; acetonitrile / 1 h / -10 °C
2.2: 0.90 g / CH2Cl2; acetonitrile / 5 h / -10 - 20 °C
3.1: trifluoroacetic acid; anisole / CH2Cl2 / 0.25 h / cooling
4.1: 120 mg / CHCl3; dimethylsulfoxide / 24 h / 20 °C
View Scheme
para-methoxybenzyl (6R,7R)-7-amino-3-chloromethyl-3-cephem-4-carboxylate hydrochloride

para-methoxybenzyl (6R,7R)-7-amino-3-chloromethyl-3-cephem-4-carboxylate hydrochloride

Nitrocefin
41906-86-9

Nitrocefin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 78 percent / potassium trimethylsilanolate / CH2Cl2; acetonitrile / 1 h / 20 °C
2.1: sodium iodide / butan-2-one / 20 °C
3.1: potassium trimethylsilanolate / CH2Cl2; acetonitrile / 1 h / -10 °C
3.2: 0.90 g / CH2Cl2; acetonitrile / 5 h / -10 - 20 °C
4.1: trifluoroacetic acid; anisole / CH2Cl2 / 0.25 h / cooling
View Scheme
Multi-step reaction with 5 steps
1.1: 78 percent / potassium trimethylsilanolate / CH2Cl2; acetonitrile / 1 h / 20 °C
2.1: sodium iodide / butan-2-one / 20 °C
3.1: potassium trimethylsilanolate / CH2Cl2; acetonitrile / 1 h / -10 °C
3.2: 0.90 g / CH2Cl2; acetonitrile / 5 h / -10 - 20 °C
4.1: trifluoroacetic acid; anisole / CH2Cl2 / 0.25 h / cooling
5.1: 120 mg / CHCl3; dimethylsulfoxide / 24 h / 20 °C
View Scheme
p-methoxybenzyl (6R,7R)-3-(2,4-dinitrostyryl)-7-(2-thienylacetamido)-3-cephem-4-carboxylate

p-methoxybenzyl (6R,7R)-3-(2,4-dinitrostyryl)-7-(2-thienylacetamido)-3-cephem-4-carboxylate

Nitrocefin
41906-86-9

Nitrocefin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trifluoroacetic acid; anisole / CH2Cl2 / 0.25 h / cooling
2: 120 mg / CHCl3; dimethylsulfoxide / 24 h / 20 °C
View Scheme
[(6R,7R)-2-(4-Methoxy-benzyloxycarbonyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl]-triphenyl-phosphonium; iodide

[(6R,7R)-2-(4-Methoxy-benzyloxycarbonyl)-8-oxo-7-(2-thiophen-2-yl-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl]-triphenyl-phosphonium; iodide

Nitrocefin
41906-86-9

Nitrocefin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium trimethylsilanolate / CH2Cl2; acetonitrile / 1 h / -10 °C
1.2: 0.90 g / CH2Cl2; acetonitrile / 5 h / -10 - 20 °C
2.1: trifluoroacetic acid; anisole / CH2Cl2 / 0.25 h / cooling
View Scheme
Multi-step reaction with 3 steps
1.1: potassium trimethylsilanolate / CH2Cl2; acetonitrile / 1 h / -10 °C
1.2: 0.90 g / CH2Cl2; acetonitrile / 5 h / -10 - 20 °C
2.1: trifluoroacetic acid; anisole / CH2Cl2 / 0.25 h / cooling
3.1: 120 mg / CHCl3; dimethylsulfoxide / 24 h / 20 °C
View Scheme
7-Aminocephalosporanic acid
957-68-6

7-Aminocephalosporanic acid

Nitrocefin
41906-86-9

Nitrocefin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: water; sodium hydroxide / methanol / -20 - -10 °C
2.1: sodium hydroxide / acetone; water / 0 °C / pH 8
2.2: 0.5 h
3.1: phosphorus tribromide / tetrahydrofuran / -5 °C / Inert atmosphere
4.1: ethyl acetate / 15 h / 20 °C
5.1: sodium carbonate / dichloromethane / 2.5 h / 0 - 20 °C
6.1: methoxybenzene; trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C
View Scheme
(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
15690-38-7

(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Nitrocefin
41906-86-9

Nitrocefin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide / acetone; water / 0 °C / pH 8
1.2: 0.5 h
2.1: phosphorus tribromide / tetrahydrofuran / -5 °C / Inert atmosphere
3.1: ethyl acetate / 15 h / 20 °C
4.1: sodium carbonate / dichloromethane / 2.5 h / 0 - 20 °C
5.1: methoxybenzene; trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C
View Scheme
3-hydroxymethyl-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester
29126-13-4

3-hydroxymethyl-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester

Nitrocefin
41906-86-9

Nitrocefin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: phosphorus tribromide / tetrahydrofuran / -5 °C / Inert atmosphere
2: ethyl acetate / 15 h / 20 °C
3: sodium carbonate / dichloromethane / 2.5 h / 0 - 20 °C
4: methoxybenzene; trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C
View Scheme
(6R)-3-bromomethyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
30361-56-9

(6R)-3-bromomethyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Nitrocefin
41906-86-9

Nitrocefin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethyl acetate / 15 h / 20 °C
2: sodium carbonate / dichloromethane / 2.5 h / 0 - 20 °C
3: methoxybenzene; trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C
View Scheme
oxacillin bound N146K/E150K double mutant variant of penicillin binding protein 2a (residues 23-668) from staphylococcus aureus ATCC 700699

oxacillin bound N146K/E150K double mutant variant of penicillin binding protein 2a (residues 23-668) from staphylococcus aureus ATCC 700699

Nitrocefin
41906-86-9

Nitrocefin

nitrocefin complexed with oxacillin bound N146K/E150K double mutant variant of penicillin binding protein 2a (residues 23-668) from staphylococcus aureus ATCC 700699

nitrocefin complexed with oxacillin bound N146K/E150K double mutant variant of penicillin binding protein 2a (residues 23-668) from staphylococcus aureus ATCC 700699

Conditions
ConditionsYield
In aq. buffer at 20℃; for 0.166667h; pH=7; Kinetics;
oxacillin bound N146K/E150K/H351N triple mutant variant of penicillin binding protein 2a (residues 23-668) from staphylococcus aureus ATCC 700699

oxacillin bound N146K/E150K/H351N triple mutant variant of penicillin binding protein 2a (residues 23-668) from staphylococcus aureus ATCC 700699

Nitrocefin
41906-86-9

Nitrocefin

nitrocefin complexed with oxacillin bound N146K/E150K/H351N triple mutant variant of penicillin binding protein 2a (residues 23-668) from staphylococcus aureus ATCC 700699

nitrocefin complexed with oxacillin bound N146K/E150K/H351N triple mutant variant of penicillin binding protein 2a (residues 23-668) from staphylococcus aureus ATCC 700699

Conditions
ConditionsYield
In aq. buffer at 20℃; for 0.166667h; pH=7; Kinetics;
Nitrocefin
41906-86-9

Nitrocefin

C21H18N4O9S2

C21H18N4O9S2

Conditions
ConditionsYield
With β-lactamase Enzymatic reaction;

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