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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

5.beta.-Chol-9 (11)-en-24-oic acid, 3.alpha.-hydroxy-12-oxo-, methyl ester, acetate

Cas:4472-02-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

5.beta.-Chol-9 (11)-en-24-oic acid, 3.alpha.-hydroxy-12-oxo-, methyl ester, acetate 4472-02-0

Cas:4472-02-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

3α-Acetyloxy-12-oxo-5β-chol-9(11)-en-24-oic acid methyl ester CAS:4472-02-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical inter

3α-Acetyloxy-12-oxo-5β-chol-9(11)-en-24-oic acid methyl ester CAS:4472-02-0

Cas:4472-02-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

5.beta.-Chol-9 (11)-en-24-oic acid, 3.alpha.-hydroxy-12-oxo-, methyl ester, acetate

Cas:4472-02-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

5.beta.-Chol-9 (11)-en-24-oic acid, 3.alpha.-hydroxy-12-oxo-, methyl ester, acetate

Cas:4472-02-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3|A,7|A-Dihydroxy-5|A-cholanic Acid Methyl Ester

Cas:4472-02-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

3|A,7|A-Dihydroxy-5|A-cholanic Acid Methyl Ester

Cas:4472-02-0

Min.Order:0

Negotiable

Type:Manufacturers

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

5.beta.-Chol-9 (11)-en-24-oic acid, 3.alpha.-hydroxy-12-oxo-, methyl ester, acetate

Cas:4472-02-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

3α-Acetyloxy-12-oxo-5β-chol-9(11)-en-24-oic acid methyl ester CAS No.4472-02-0

Cas:4472-02-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

5.beta.-Chol-9 (11)-en-24-oic acid, 3.alpha.-hydroxy-12-oxo-, methyl ester, acetate cas 4472-02-0Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3α-Acetyloxy-12-oxo-5β-chol-9(11)-en-24-oic acid methyl ester

Cas:4472-02-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

4472-02-0

Cas:4472-02-0

Min.Order:0

Negotiable

Type:Trading Company

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3α-Acetyloxy-12-oxo-5β-chol-9(11)-en-24-oic acid methyl ester

Cas:4472-02-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Changzhou Extraordinary Pharmatech co.,LTD

Changzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa

3|A,7|A-Dihydroxy-5|A-cholanic Acid Methyl Ester

Cas:4472-02-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

HuBei Ipure Biotech CO.,ltd

HuBei ipure is a diversified product production and operation enterprise, with API, pharma intermediates, and other fine chemicals as well as R&D and pigments development and sales as one of the large enterprises, with more than 130 acres of plant

5.beta.-Chol-9 (11)-en-24-oic acid, 3.alpha.-hydroxy-12-oxo-, methyl ester, acetate

Cas:4472-02-0

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Nanjing Raymon Biotech Co., Ltd.

5.beta.-Chol-9 (11)-en-24-oic acid, 3.alpha.-hydroxy-12-oxo-, methyl ester, acetateAppearance:Pls see the Details Storage:keep in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/pharma intermediate T

Hebei Ruishun Trade Co.,Ltd

Supply top quality products with a reasonable price Application:api

4472-02-0

Cas:4472-02-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

methyl 3α-acetoxy-12-oxo-5β-cholan-24-oate
5143-55-5

methyl 3α-acetoxy-12-oxo-5β-cholan-24-oate

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
With 3-iodosylbenzoic acid; diphenyl diselenide In toluene for 96h; Heating;89%
With selenium(IV) oxide; acetic acid for 18h; Reflux;78%
With selenium(IV) oxide; acetic acid
With selenium(IV) oxide; acetic acid at 180℃; for 0.5h; Temperature; Microwave irradiation;
methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate
30365-63-0

methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate

A

C31H50O6
1311972-67-4

C31H50O6

B

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Stage #1: methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate With tert.-butylhydroperoxide; sodium hypochlorite In water; ethyl acetate at 0 - 5℃; for 7h;
Stage #2: With sodium sulfite In ethyl acetate
Stage #3: With pyridinium chlorochromate In ethyl acetate Product distribution / selectivity;
A n/a
B 63%
methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate
30365-63-0

methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Stage #1: methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate With tert.-butylhydroperoxide; sodium hypochlorite In water; ethyl acetate at 0℃; for 8 - 10h;
Stage #2: With sodium sulfite In water; ethyl acetate at 50 - 55℃; for 2h;
Stage #3: With pyridinium chlorochromate In ethyl acetate at 25 - 30℃; for 6 - 8h; Product distribution / selectivity;
62%
Stage #1: methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate With tert.-butylhydroperoxide; sodium hypochlorite In water; ethyl acetate at 0 - 5℃;
Stage #2: With pyridinium chlorochromate In ethyl acetate Solvent; Reagent/catalyst; Temperature;
60.6%
Multi-step reaction with 2 steps
1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 7 h / 0 - 5 °C
2: potassium carbonate; hydrogen / palladium on activated charcoal / dichloromethane / 24 h / 20 °C
View Scheme
Stage #1: methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate With tert.-butylhydroperoxide; sodium hypochlorite In water; ethyl acetate at 0 - 5℃;
Stage #2: With pyridinium chlorochromate In ethyl acetate at 25 - 30℃; Reagent/catalyst; Solvent; Time; Temperature;
13 g
With chromium(VI) oxide In acetic acid at 50℃;
C31H50O6
1311972-67-4

C31H50O6

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
With tert.-butylhydroperoxide; palladium on activated charcoal; potassium carbonate In dichloromethane at 20℃; for 24h;11%
With hydrogen; potassium carbonate; palladium on activated charcoal In dichloromethane at 20℃; for 24h;11 %Chromat.
pyridine
110-86-1

pyridine

3α-acetoxy-11β-bromo-12-oxo-5β-cholan-24-oic acid methyl ester
88128-14-7

3α-acetoxy-11β-bromo-12-oxo-5β-cholan-24-oic acid methyl ester

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

2,4,6-trimethyl-pyridine
108-75-8

2,4,6-trimethyl-pyridine

3α-acetoxy-11α-bromo-12-oxo-5β-cholan-24-oic acid methyl ester
17550-22-0

3α-acetoxy-11α-bromo-12-oxo-5β-cholan-24-oic acid methyl ester

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate
30365-63-0

methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate

A

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

B

3α-acetoxy-9,11β-epoxy-5β,9β-cholan-24-oic acid methyl ester
107329-63-5

3α-acetoxy-9,11β-epoxy-5β,9β-cholan-24-oic acid methyl ester

Conditions
ConditionsYield
With potassium permanganate; acetic acid
12α-hydroxy-3α-acetoxy-5β-cholen-(9(11))-oic acid-(24)-methyl ester
24637-48-7

12α-hydroxy-3α-acetoxy-5β-cholen-(9(11))-oic acid-(24)-methyl ester

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
With chromium(VI) oxide; acetic acid
3α-acetoxy-11β-bromo-12-oxo-5β-cholan-24-oic acid methyl ester
88128-14-7

3α-acetoxy-11β-bromo-12-oxo-5β-cholan-24-oic acid methyl ester

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
With pyridine
methyl 3α-hydroxy-12-oxo-5β-chol-9(11)-en-24-oate
65065-56-7

methyl 3α-hydroxy-12-oxo-5β-chol-9(11)-en-24-oate

acetic anhydride
108-24-7

acetic anhydride

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
With pyridine
methyl 3α-acetoxy-5β-chol-11-ene-24-oate
2242-12-8

methyl 3α-acetoxy-5β-chol-11-ene-24-oate

N-bromoacetamide
79-15-2

N-bromoacetamide

A

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

B

methyl 3α-acetoxy-11-oxo-5β-cholan-24-oate
4651-66-5

methyl 3α-acetoxy-11-oxo-5β-cholan-24-oate

Conditions
ConditionsYield
With water; acetone Behandeln einer Loesung des Reaktionsprodukts in Chloroform und Essigsaeure mit Chrom(VI)-oxid und Erwaermen des danach isolierten Reaktionsprodukts mit Zink, Natriumacetat und Essigsaeure;
With water; tert-butyl alcohol Behandeln einer Loesung des Reaktionsprodukts in Chloroform und Essigsaeure mit Chrom(VI)-oxid und Erwaermen des danach isolierten Reaktionsprodukts mit Zink, Natriumacetat und Essigsaeure;
methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate
30365-63-0

methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate

acetic acid
64-19-7

acetic acid

chromium (VI)-oxide

chromium (VI)-oxide

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate
30365-63-0

methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate

water containing acetic acid

water containing acetic acid

aqueous potassium permanganate solution

aqueous potassium permanganate solution

A

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

B

3α-acetoxy-9.11β-epoxy-5β.9β-cholanoic acid (24)-methyl ester

3α-acetoxy-9.11β-epoxy-5β.9β-cholanoic acid (24)-methyl ester

methyl 3α-acetoxy-5β-chol-11-ene-24-oate
2242-12-8

methyl 3α-acetoxy-5β-chol-11-ene-24-oate

water
7732-18-5

water

sodium acetate
127-09-3

sodium acetate

acetone
67-64-1

acetone

N-bromoacetamide
79-15-2

N-bromoacetamide

A

11β.12α-dibromo-3α-acetoxy-5β-cholanoic acid-(24)-methyl ester

11β.12α-dibromo-3α-acetoxy-5β-cholanoic acid-(24)-methyl ester

B

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

C

3α-acetoxy-11β.12β-epoxy-5β-cholanoic acid (24)-methyl ester

3α-acetoxy-11β.12β-epoxy-5β-cholanoic acid (24)-methyl ester

Conditions
ConditionsYield
Chromatographieren des Reaktionsprodukts an alkalihaltigem Aluminiumoxid;
methyl 3α-acetoxy-5β-chol-11-ene-24-oate
2242-12-8

methyl 3α-acetoxy-5β-chol-11-ene-24-oate

water
7732-18-5

water

acetone
67-64-1

acetone

N-bromoacetamide
79-15-2

N-bromoacetamide

A

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

B

methyl 3α-acetoxy-11-oxo-5β-cholan-24-oate
4651-66-5

methyl 3α-acetoxy-11-oxo-5β-cholan-24-oate

Conditions
ConditionsYield
Reaktion ueber mehrere Stufen;
methyl 3α-acetoxy-5β-chol-11-ene-24-oate
2242-12-8

methyl 3α-acetoxy-5β-chol-11-ene-24-oate

water
7732-18-5

water

tert-butyl alcohol
75-65-0

tert-butyl alcohol

N-bromoacetamide
79-15-2

N-bromoacetamide

A

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

B

methyl 3α-acetoxy-11-oxo-5β-cholan-24-oate
4651-66-5

methyl 3α-acetoxy-11-oxo-5β-cholan-24-oate

Conditions
ConditionsYield
Reaktion ueber mehrere Stufen;
9(11),(5β)-cholenic acid-3α-ol-12-one
6874-18-6

9(11),(5β)-cholenic acid-3α-ol-12-one

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diazomethane; diethyl ether
2: pyridine
View Scheme
12-oxolithocholic acid
5130-29-0

12-oxolithocholic acid

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetic acid
2: hydrogen bromide; acetic acid; bromine
3: diazomethane; diethyl ether
4: pyridine
View Scheme
3α-hydroxy-12-oxo-5β-cholan-24-oic acid methyl ester
28050-47-7

3α-hydroxy-12-oxo-5β-cholan-24-oic acid methyl ester

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: benzene; pyridine
2: bromine; acetic acid / Erwaermen des Reaktionsprodukts mit aethanol. Natriumaethylat
3: diazomethane; diethyl ether
4: pyridine
View Scheme
3α-acetoxy-12-oxo-5β-cholanoic acid-(24)
66874-05-3

3α-acetoxy-12-oxo-5β-cholanoic acid-(24)

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogen bromide; acetic acid; bromine
2: diazomethane; diethyl ether
3: pyridine
View Scheme
Multi-step reaction with 3 steps
1: bromine; acetic acid / Erwaermen des Reaktionsprodukts mit aethanol. Natriumaethylat
2: diazomethane; diethyl ether
3: pyridine
View Scheme
3α-acetoxy-11β-bromo-12α-hydroxy-5β-cholan-24-oic acid methyl ester
117863-38-4

3α-acetoxy-11β-bromo-12α-hydroxy-5β-cholan-24-oic acid methyl ester

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: silver acetate; acetic acid
2: chromium (VI)-oxide; acetic acid
View Scheme
Multi-step reaction with 2 steps
1: chromium (VI)-oxide; acetic acid
2: pyridine
View Scheme
11β-bromo-3α-acetoxy-12-oxo-5β-cholanoic acid-(24)

11β-bromo-3α-acetoxy-12-oxo-5β-cholanoic acid-(24)

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diazomethane; diethyl ether
2: pyridine
View Scheme
3α-benzoyloxy-12-oxo-5β-cholanoic acid-(24)-methyl ester
17225-41-1, 89887-44-5

3α-benzoyloxy-12-oxo-5β-cholanoic acid-(24)-methyl ester

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: bromine; acetic acid / Erwaermen des Reaktionsprodukts mit aethanol. Natriumaethylat
2: diazomethane; diethyl ether
3: pyridine
View Scheme
12α-chloro-3α-acetoxy-5β-cholen-(9(11))-oic acid-(24)-methyl ester
107159-90-0

12α-chloro-3α-acetoxy-5β-cholen-(9(11))-oic acid-(24)-methyl ester

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: silver carbonate; aqueous acetone
2: chromium (VI)-oxide; acetic acid
View Scheme
12α-methoxy-3α-acetoxy-5β-cholen-(9(11))-oic acid-(24)-methyl ester
107177-54-8

12α-methoxy-3α-acetoxy-5β-cholen-(9(11))-oic acid-(24)-methyl ester

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: chloroform; hydrogen chloride
2: silver carbonate; aqueous acetone
3: chromium (VI)-oxide; acetic acid
View Scheme
9-alpha-hydroxyandrost-4-ene-3,17-dione
560-62-3, 23015-99-8

9-alpha-hydroxyandrost-4-ene-3,17-dione

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 3 h / 25 - 35 °C / 3102.97 Torr
2.1: sulfuric acid / dichloromethane / 2.15 h / 10 - 35 °C
3.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -45 - -40 °C / Inert atmosphere
4.1: potassium tert-butylate / tetrahydrofuran / 1.33 h / 25 - 35 °C / Inert atmosphere
4.2: 3 - 5 h / 25 - 35 °C / Inert atmosphere
4.3: Cooling
5.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
6.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
6.2: Cooling
7.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
8.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 7 h / 0 - 5 °C
9.1: potassium carbonate; hydrogen / palladium on activated charcoal / dichloromethane / 24 h / 20 °C
View Scheme
Multi-step reaction with 8 steps
1.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 3 h / 25 - 35 °C / 3102.97 Torr
2.1: sulfuric acid / dichloromethane / 2.15 h / 10 - 35 °C
3.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -45 - -40 °C / Inert atmosphere
4.1: potassium tert-butylate / tetrahydrofuran / 1.33 h / 25 - 35 °C / Inert atmosphere
4.2: 3 - 5 h / 25 - 35 °C / Inert atmosphere
4.3: Cooling
5.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
6.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
6.2: Cooling
7.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
8.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 7 h / 0 - 5 °C
View Scheme
Multi-step reaction with 8 steps
1.1: hydrogen / palladium 10% on activated carbon / N,N-dimethyl-formamide / 3 h / 25 - 35 °C / 3102.97 Torr
2.1: sulfuric acid / dichloromethane / 2.15 h / 10 - 35 °C
3.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -45 - -40 °C / Inert atmosphere
4.1: potassium tert-butylate / tetrahydrofuran / 1.33 h / 25 - 35 °C / Inert atmosphere
4.2: 3 - 5 h / 25 - 35 °C / Inert atmosphere
4.3: Cooling
5.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
6.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
6.2: Cooling
7.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
8.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 8 - 10 h / 0 °C
8.2: 2 h / 50 - 55 °C
8.3: 6 - 8 h / 25 - 30 °C
View Scheme
9α-hydroxy-5β-androstan-3,17-dione
1093397-61-5

9α-hydroxy-5β-androstan-3,17-dione

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sulfuric acid / dichloromethane / 2.15 h / 10 - 35 °C
2.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -45 - -40 °C / Inert atmosphere
3.1: potassium tert-butylate / tetrahydrofuran / 1.33 h / 25 - 35 °C / Inert atmosphere
3.2: 3 - 5 h / 25 - 35 °C / Inert atmosphere
3.3: Cooling
4.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
5.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
5.2: Cooling
6.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
7.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 7 h / 0 - 5 °C
8.1: potassium carbonate; hydrogen / palladium on activated charcoal / dichloromethane / 24 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: sulfuric acid / dichloromethane / 2.15 h / 10 - 35 °C
2.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -45 - -40 °C / Inert atmosphere
3.1: potassium tert-butylate / tetrahydrofuran / 1.33 h / 25 - 35 °C / Inert atmosphere
3.2: 3 - 5 h / 25 - 35 °C / Inert atmosphere
3.3: Cooling
4.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
5.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
5.2: Cooling
6.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
7.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 7 h / 0 - 5 °C
View Scheme
Multi-step reaction with 7 steps
1.1: sulfuric acid / dichloromethane / 2.15 h / 10 - 35 °C
2.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -45 - -40 °C / Inert atmosphere
3.1: potassium tert-butylate / tetrahydrofuran / 1.33 h / 25 - 35 °C / Inert atmosphere
3.2: 3 - 5 h / 25 - 35 °C / Inert atmosphere
3.3: Cooling
4.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
5.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
5.2: Cooling
6.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
7.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 8 - 10 h / 0 °C
7.2: 2 h / 50 - 55 °C
7.3: 6 - 8 h / 25 - 30 °C
View Scheme
(5β)-androst-9(11)-ene-3,17-dione
1093397-63-7

(5β)-androst-9(11)-ene-3,17-dione

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -45 - -40 °C / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 1.33 h / 25 - 35 °C / Inert atmosphere
2.2: 3 - 5 h / 25 - 35 °C / Inert atmosphere
2.3: Cooling
3.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
4.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
4.2: Cooling
5.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
6.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 7 h / 0 - 5 °C
7.1: potassium carbonate; hydrogen / palladium on activated charcoal / dichloromethane / 24 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -45 - -40 °C / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 1.33 h / 25 - 35 °C / Inert atmosphere
2.2: 3 - 5 h / 25 - 35 °C / Inert atmosphere
2.3: Cooling
3.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
4.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
4.2: Cooling
5.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
6.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 7 h / 0 - 5 °C
View Scheme
Multi-step reaction with 6 steps
1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -45 - -40 °C / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 1.33 h / 25 - 35 °C / Inert atmosphere
2.2: 3 - 5 h / 25 - 35 °C / Inert atmosphere
2.3: Cooling
3.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
4.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
4.2: Cooling
5.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
6.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 8 - 10 h / 0 °C
6.2: 2 h / 50 - 55 °C
6.3: 6 - 8 h / 25 - 30 °C
View Scheme
3α-hydroxy-5β-androst-9(11)-en-17-one
571-49-3

3α-hydroxy-5β-androst-9(11)-en-17-one

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium tert-butylate / tetrahydrofuran / 1.33 h / 25 - 35 °C / Inert atmosphere
1.2: 3 - 5 h / 25 - 35 °C / Inert atmosphere
1.3: Cooling
2.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
3.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
3.2: Cooling
4.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
5.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 7 h / 0 - 5 °C
6.1: potassium carbonate; hydrogen / palladium on activated charcoal / dichloromethane / 24 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / tetrahydrofuran / 1.33 h / 25 - 35 °C / Inert atmosphere
1.2: 3 - 5 h / 25 - 35 °C / Inert atmosphere
1.3: Cooling
2.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
3.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
3.2: Cooling
4.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
5.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 7 h / 0 - 5 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / tetrahydrofuran / 1.33 h / 25 - 35 °C / Inert atmosphere
1.2: 3 - 5 h / 25 - 35 °C / Inert atmosphere
1.3: Cooling
2.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
3.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
3.2: Cooling
4.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
5.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 8 - 10 h / 0 °C
5.2: 2 h / 50 - 55 °C
5.3: 6 - 8 h / 25 - 30 °C
View Scheme
(Z)-3α-hydroxy-5β-pregna-9(11),17(20)-diene
1093397-66-0

(Z)-3α-hydroxy-5β-pregna-9(11),17(20)-diene

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
2.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
2.2: Cooling
3.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
4.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 7 h / 0 - 5 °C
5.1: potassium carbonate; hydrogen / palladium on activated charcoal / dichloromethane / 24 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
2.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
2.2: Cooling
3.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
4.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 7 h / 0 - 5 °C
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / dmap / tert-butyl methyl ether / 2 h / 25 - 35 °C / Inert atmosphere
2.1: ethylaluminum dichloride / dichloromethane; toluene / 20 h / 0 - 35 °C / Inert atmosphere
2.2: Cooling
3.1: hydrogen / palladium on activated charcoal / ethyl acetate / 16 h / 25 - 35 °C / 3620.13 Torr
4.1: tert.-butylhydroperoxide; sodium hypochlorite / ethyl acetate; water / 8 - 10 h / 0 °C
4.2: 2 h / 50 - 55 °C
4.3: 6 - 8 h / 25 - 30 °C
View Scheme
methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

methyl 3α-acetoxy-12-oxo-5β-cholan-24-oate
5143-55-5

methyl 3α-acetoxy-12-oxo-5β-cholan-24-oate

Conditions
ConditionsYield
Stage #1: methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate With hydrogen; palladium 10% on activated carbon In ethyl acetate at 45 - 50℃; for 18h;
Stage #2: With pyridinium chlorochromate In ethyl acetate at 20℃; for 2h;
Stage #3: With hydrogen; palladium on activated charcoal In ethyl acetate at 45 - 50℃; under 2585.81 Torr; for 18h;
95%
With hydrogen; palladium 10% on activated carbon In ethyl acetate at 45 - 50℃; under 2585.81 Torr; for 16h; Product distribution / selectivity;83.1%
Stage #1: methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate With hydrogen; palladium-on-charcoal In ethyl acetate at 45 - 50℃; under 2585.81 Torr; for 16h; Autoclave;
Stage #2: With pyridinium chlorochromate In ethyl acetate at 25 - 35℃; for 2h; Product distribution / selectivity;
83.1%
Stage #1: methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate With palladium 10% on activated carbon; hydrogen In ethyl acetate at 45 - 50℃; under 2585.81 Torr; for 16h;
Stage #2: With pyridinium chlorochromate In ethyl acetate at 25 - 35℃; for 2h; Concentration; Reagent/catalyst; Temperature;
83.1%
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 50℃; under 2585.81 Torr; for 16h; Autoclave;80%
methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

5β-chol-9(11)-en-3α,24-diol
13002-74-9

5β-chol-9(11)-en-3α,24-diol

Conditions
ConditionsYield
With aluminum (III) chloride; lithium aluminium tetrahydride In tetrahydrofuran for 4h; Reflux;64%
With lithium aluminium tetrahydride; aluminium trichloride
methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

3α-hydroxy-5β-chol-9(11)-en-24-oic acid
62797-60-8

3α-hydroxy-5β-chol-9(11)-en-24-oic acid

Conditions
ConditionsYield
With sodium ethanolate; hydrazine hydrate at 170℃;
methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

9(11),(5β)-cholenic acid-3α-ol-12-one
6874-18-6

9(11),(5β)-cholenic acid-3α-ol-12-one

Conditions
ConditionsYield
With potassium hydroxide
Multi-step reaction with 2 steps
1: hydrogen chloride; methanol
2: methanol. KOH-solution
View Scheme
methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

methyl 3α-hydroxy-12-oxo-5β-chol-9(11)-en-24-oate
65065-56-7

methyl 3α-hydroxy-12-oxo-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
With hydrogenchloride; methanol
With methanol; potassium hydroxide at 20℃; for 1.5h;
methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

A

12β-hydroxy-3α-acetoxy-5β-cholen-(9(11))-oic acid-(24)-methyl ester
24637-47-6

12β-hydroxy-3α-acetoxy-5β-cholen-(9(11))-oic acid-(24)-methyl ester

B

12α-hydroxy-3α-acetoxy-5β-cholen-(9(11))-oic acid-(24)-methyl ester
24637-48-7

12α-hydroxy-3α-acetoxy-5β-cholen-(9(11))-oic acid-(24)-methyl ester

Conditions
ConditionsYield
With ethanol; acetic acid; platinum Hydrogenation;
methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

methyl 3α-acetoxy-12-hydroxy-9(11)-cholenate
24637-47-6, 24637-48-7

methyl 3α-acetoxy-12-hydroxy-9(11)-cholenate

Conditions
ConditionsYield
With sodium tetrahydroborate; cerium(III) chloride In methanol for 0.5h; Ambient temperature;1.28 g
ethanol
64-17-5

ethanol

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

acetic acid
64-19-7

acetic acid

platinum

platinum

methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate
30365-63-0

methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate

Conditions
ConditionsYield
Hydrogenation;
methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

sodium ethanolate
141-52-6

sodium ethanolate

hydrazine hydrate
7803-57-8

hydrazine hydrate

A

methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate
30365-63-0

methyl 3α-acetoxy-5β-chol-9(11)-en-24-oate

B

methyl 3α-acetoxy-5β-chol-11-ene-24-oate
2242-12-8

methyl 3α-acetoxy-5β-chol-11-ene-24-oate

Conditions
ConditionsYield
at 170℃; Behandeln des Reaktionsprodukts mit Diazomethan in Aether und Behandeln des danach isolierten Reaktionsprodukts mit Acetanhydrid und Pyridin;
ethanol
64-17-5

ethanol

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

acetic acid
64-19-7

acetic acid

platinum

platinum

A

12β-hydroxy-3α-acetoxy-5β-cholen-(9(11))-oic acid-(24)-methyl ester
24637-47-6

12β-hydroxy-3α-acetoxy-5β-cholen-(9(11))-oic acid-(24)-methyl ester

B

12α-hydroxy-3α-acetoxy-5β-cholen-(9(11))-oic acid-(24)-methyl ester
24637-48-7

12α-hydroxy-3α-acetoxy-5β-cholen-(9(11))-oic acid-(24)-methyl ester

Conditions
ConditionsYield
Hydrogenation;
methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

methyl 3α,12β-diacetoxy-9(11)-cholenate
24637-51-2

methyl 3α,12β-diacetoxy-9(11)-cholenate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.28 g / NaBH4, CeCl3*6H2O / methanol / 0.5 h / Ambient temperature
2: toluene; pyridine / 6 h / 100 °C
View Scheme
methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate
4472-02-0

methyl 3α-acetoxy-12-oxo-5β-chol-9(11)-en-24-oate

methyl 3α,12α-diacetoxy-9(11)-cholenate
24637-34-1

methyl 3α,12α-diacetoxy-9(11)-cholenate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.28 g / NaBH4, CeCl3*6H2O / methanol / 0.5 h / Ambient temperature
2: toluene; pyridine / 6 h / 100 °C
View Scheme

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