Products

Refine

Country

Business Type

Certificate

Display

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

inquiry

ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

N-Methyl-N-[(3R,4R)-4-methylpiperidin-3-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 477600-74-1

Cas:477600-74-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 477600-74-1 with competitive price

Cas:477600-74-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-methyl-N-[(3R,4R)-4-methyl-3-piperidinyl]- 477600-74-1

Cas:477600-74-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:1 Kilogram

FOB Price: $89.0 / 100.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine CAS:477600-74-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemic

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine CAS:477600-74-1

Cas:477600-74-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-methyl-N-[(3R,4R)-4-methyl-3-piperidinyl]-

Cas:477600-74-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-methyl-N-[(3R,4R)-4-methyl-3-piperidinyl]-

Cas:477600-74-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:As

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (N-1 BASE)

Cas:477600-74-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

cas 477600-74-1 N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

N-METHYL-N-((3R,4R)-4-METHYLPIPERIDIN-3-YL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE (CAS NO.477600-74-1)

Cas:477600-74-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-methyl-N-[(3R,4R)-4-methyl-3-piperidinyl]-

Cas:477600-74-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine CAS NO.477600-74-1

Cas:477600-74-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: N-Methyl-N-[(3R,4R)-4-Methylpiperidin-3-yl]-7H-Pyrrolo[2,3-d]Pyrimidin-4-Amine CAS No.:477600-74-1 Molecule Formula:C13H19N5 Molecule Weight:245.32 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture

Best Quality N-Methyl-N-[(3R,4R)-4-Methylpiperidin-3-yl]-7H-Pyrrolo[2,3-d]Pyrimidin-4-Amine

Cas:477600-74-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFUCHEM--N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Basic information Product Name: N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Synonyms: N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Cas:477600-74-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Synthetic route

(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-2-chloro-N-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amine

(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-2-chloro-N-methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amine

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
With hydrogenchloride; palladium 10% on activated carbon; hydrogen In water at 65 - 75℃; under 1551.49 Torr; for 3h; Inert atmosphere;96%
With triethylsilane; 5%-palladium/activated carbon; acetic acid In methanol at 30℃; for 0.166667h;93.1%
With 10 wt% Pd(OH)2 on carbon; hydrazine hydrate; acetic acid In ethanol at 70 - 75℃; for 2h; Reagent/catalyst;75.8%
(3R,4R)-tert-butyl 4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
1450663-24-7

(3R,4R)-tert-butyl 4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
With zinc dibromide In dichloromethane for 12h;95%
((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amine

((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amine

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
With palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; hydrogen In methanol at 45℃; under 6000.6 Torr;93%
With 20% palladium hydroxide-activated charcoal; ammonium formate In methanol at 60℃; for 6h; Solvent; Reagent/catalyst; Temperature; Inert atmosphere;93.3%
With 20% palladium hydroxide-activated charcoal; hydrogen; acetic acid In methanol; water at 50℃; under 3000.3 - 4500.45 Torr; for 12h;92.38%
C20H25N5*CH2O2

C20H25N5*CH2O2

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; water at 20℃; for 1h;91%
C27H31N5

C27H31N5

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In ethanol at 60 - 70℃;85%
3-(3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-(yl)amino)piperidin-1-yl)-3-oxopropionic acid

3-(3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-(yl)amino)piperidin-1-yl)-3-oxopropionic acid

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
With sulfuric acid at 90℃;28.9%
(S)-5-hydroxypiperidin-2-one
24211-54-9

(S)-5-hydroxypiperidin-2-one

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: 1H-imidazole / 24.5 h / 5 - 20 °C
2.1: 1,4-diaza-bicyclo[2.2.2]octane; n-butyllithium / tetrahydrofuran / 1 h / -78 °C
2.2: 2 h
3.1: n-butyllithium; hexamethyldisilazan / tetrahydrofuran; hexane / 0.5 h / -78 °C
3.2: 2 h / -78 °C
4.1: magnesium / diethyl ether
4.2: 0.25 h / -20 °C
4.3: 2 h / 20 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C
7.1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C
8.1: zinc dibromide / dichloromethane / 12 h
View Scheme
(5S)-5-tert-butyldiphenylsilyloxy-piperidine-2-one
176966-76-0

(5S)-5-tert-butyldiphenylsilyloxy-piperidine-2-one

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: 1,4-diaza-bicyclo[2.2.2]octane; n-butyllithium / tetrahydrofuran / 1 h / -78 °C
1.2: 2 h
2.1: n-butyllithium; hexamethyldisilazan / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 2 h / -78 °C
3.1: magnesium / diethyl ether
3.2: 0.25 h / -20 °C
3.3: 2 h / 20 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C
6.1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C
7.1: zinc dibromide / dichloromethane / 12 h
View Scheme
7-deazaadenine
1500-85-2

7-deazaadenine

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: water; acetonitrile / 0.25 h / 20 °C
1.2: 1 h
2.1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C
3.1: zinc dibromide / dichloromethane / 12 h
View Scheme
tert-butyl (5S)-5-tert-butyldiphenylsilyloxy-piperidine-2-one-1-carboxylate
176966-77-1

tert-butyl (5S)-5-tert-butyldiphenylsilyloxy-piperidine-2-one-1-carboxylate

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: n-butyllithium; hexamethyldisilazan / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 2 h / -78 °C
2.1: magnesium / diethyl ether
2.2: 0.25 h / -20 °C
2.3: 2 h / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C
5.1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C
6.1: zinc dibromide / dichloromethane / 12 h
View Scheme
tert-butyl (5S)-5-(tert-butyldiphenylsilyloxy)-3,4-dehydro-piperidine-2-one-1-carboxylate
176966-78-2

tert-butyl (5S)-5-(tert-butyldiphenylsilyloxy)-3,4-dehydro-piperidine-2-one-1-carboxylate

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: magnesium / diethyl ether
1.2: 0.25 h / -20 °C
1.3: 2 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C
4.1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C
5.1: zinc dibromide / dichloromethane / 12 h
View Scheme
(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester
176966-79-3

(4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-2-oxo-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C
3: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C
4: zinc dibromide / dichloromethane / 12 h
View Scheme
tert-butyl (3S,4R)-3-(tert-butyldiphenylsilyloxy)-4-methyl-piperidine-1-carboxylate
176966-86-2

tert-butyl (3S,4R)-3-(tert-butyldiphenylsilyloxy)-4-methyl-piperidine-1-carboxylate

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C
2: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C
3: zinc dibromide / dichloromethane / 12 h
View Scheme
tert-butyl (3S,4R)-3-hydroxy-4-methyl-piperidine-1-carboxylate
176966-87-3

tert-butyl (3S,4R)-3-hydroxy-4-methyl-piperidine-1-carboxylate

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 2 h / 100 °C
2: zinc dibromide / dichloromethane / 12 h
View Scheme
Multi-step reaction with 3 steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 4 h / 0 - 90 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
2.2: 24 h / 20 °C
3.1: hydrogenchloride / tetrahydrofuran / 1 h / 20 °C
View Scheme
methyl-(1-trityl-4-methylpiperidin-3-yl)carbamate
1616760-91-8

methyl-(1-trityl-4-methylpiperidin-3-yl)carbamate

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 60 - 70 °C / Inert atmosphere
2.1: ethyl acetate / 3 h / 25 - 30 °C
3.1: potassium carbonate / ethyl acetate; water / pH 9 - 10
4.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
5.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
5.2: Reflux
View Scheme
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 60 - 70 °C / Inert atmosphere
2.1: hydrogenchloride / ethyl acetate / 0.5 h / 25 - 30 °C / pH 2 - 3
3.1: water; methanol / 8 - 9 h / 20 - 70 °C
4.1: potassium carbonate / ethyl acetate; water / pH 9 - 10
5.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
6.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
6.2: Reflux
View Scheme
Multi-step reaction with 7 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 60 - 70 °C / Inert atmosphere
2: ethyl acetate / 3 h / 25 - 30 °C
3: potassium carbonate / ethyl acetate; water / pH 9 - 10
4: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
5: sodium hydroxide / water; acetone / 55 - 60 °C
6: trifluoroacetic acid / dichloromethane / 1 h / 5 - 10 °C
7: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
1-triryI-N,4-dimethylpiperidin-3-amine hydrochloride

1-triryI-N,4-dimethylpiperidin-3-amine hydrochloride

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: water; methanol / 8 - 9 h / 20 - 70 °C
2.1: potassium carbonate / ethyl acetate; water / pH 9 - 10
3.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
4.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
4.2: Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / water / pH 7 - 8
2.1: ethyl acetate / 3 h / 25 - 30 °C
3.1: potassium carbonate / ethyl acetate; water / pH 9 - 10
4.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
5.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
5.2: Reflux
View Scheme
Multi-step reaction with 6 steps
1: water; methanol / 8 - 9 h / 20 - 70 °C
2: potassium carbonate / ethyl acetate; water / pH 9 - 10
3: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
4: sodium hydroxide / water; acetone / 55 - 60 °C
5: trifluoroacetic acid / dichloromethane / 1 h / 5 - 10 °C
6: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
1-triryI-N,4-dimethylpiperidin-3-amine
1616833-40-9

1-triryI-N,4-dimethylpiperidin-3-amine

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: ethyl acetate / 3 h / 25 - 30 °C
2.1: potassium carbonate / ethyl acetate; water / pH 9 - 10
3.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
4.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
4.2: Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogenchloride / ethyl acetate / 0.5 h / 25 - 30 °C / pH 2 - 3
2.1: water; methanol / 8 - 9 h / 20 - 70 °C
3.1: potassium carbonate / ethyl acetate; water / pH 9 - 10
4.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
5.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
5.2: Reflux
View Scheme
Multi-step reaction with 6 steps
1: ethyl acetate / 3 h / 25 - 30 °C
2: potassium carbonate / ethyl acetate; water / pH 9 - 10
3: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
4: sodium hydroxide / water; acetone / 55 - 60 °C
5: trifluoroacetic acid / dichloromethane / 1 h / 5 - 10 °C
6: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
(3R,4R)-1-trityl-N,4-dimethylpiperidin-3-amine di-p-toluyl-D-tartaric acid salt

(3R,4R)-1-trityl-N,4-dimethylpiperidin-3-amine di-p-toluyl-D-tartaric acid salt

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / ethyl acetate; water / pH 9 - 10
2.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
3.2: Reflux
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / ethyl acetate; water / pH 9 - 10
2: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
3: sodium hydroxide / water; acetone / 55 - 60 °C
4: trifluoroacetic acid / dichloromethane / 1 h / 5 - 10 °C
5: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / ethyl acetate; water / pH 9 - 10
2: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
3: trifluoroacetic acid / dichloromethane / 3 h / 5 - 10 °C
4: sodium hydroxide / water; acetone / 50 - 55 °C
5: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
(3R,4R)-1-trityl-N,4-dimethylpiperidin-3-amine
1616760-93-0

(3R,4R)-1-trityl-N,4-dimethylpiperidin-3-amine

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
2.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
2.2: Reflux
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
2: sodium hydroxide / water; acetone / 55 - 60 °C
3: trifluoroacetic acid / dichloromethane / 1 h / 5 - 10 °C
4: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
2: trifluoroacetic acid / dichloromethane / 3 h / 5 - 10 °C
3: sodium hydroxide / water; acetone / 50 - 55 °C
4: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
2,4-dichloro-7-p-methylbenzenesulfonyl-7H-pyrrole[2,3-d]pyrimidin-4-amine
934524-10-4

2,4-dichloro-7-p-methylbenzenesulfonyl-7H-pyrrole[2,3-d]pyrimidin-4-amine

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 70 - 75 °C
2.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
2.2: Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
2.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
2.2: Reflux
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 70 - 75 °C
2: sodium hydroxide / water; acetone / 55 - 60 °C
3: trifluoroacetic acid / dichloromethane / 1 h / 5 - 10 °C
4: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine
90213-66-4

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water; acetone / 2 - 3 h / 0 - 30 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 70 - 75 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
3.2: Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide / water; acetone / 2 - 3 h / 0 - 30 °C
2.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
3.2: Reflux
View Scheme
Multi-step reaction with 5 steps
1: sodium hydroxide / water; acetone / 2 - 3 h / 0 - 30 °C
2: potassium carbonate / N,N-dimethyl-formamide / 10 h / 70 - 75 °C
3: sodium hydroxide / water; acetone / 55 - 60 °C
4: trifluoroacetic acid / dichloromethane / 1 h / 5 - 10 °C
5: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
C39H38ClN5O2S
1616760-94-1

C39H38ClN5O2S

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: C39H38ClN5O2S With palladium 10% on activated carbon; hydrogen In methanol at 45 - 55℃; under 3750.38 Torr; for 10h;
Stage #2: With sodium hydroxide In methanol; water Reflux;
Multi-step reaction with 3 steps
1: sodium hydroxide / water; acetone / 55 - 60 °C
2: trifluoroacetic acid / dichloromethane / 1 h / 5 - 10 °C
3: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
Multi-step reaction with 3 steps
1: trifluoroacetic acid / dichloromethane / 3 h / 5 - 10 °C
2: sodium hydroxide / water; acetone / 50 - 55 °C
3: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
C20H24ClN5O2S
1616760-95-2

C20H24ClN5O2S

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water; acetone / 50 - 55 °C
2: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
C32H32ClN5
1616760-96-3

C32H32ClN5

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane / 1 h / 5 - 10 °C
2: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
N-((3R,4R)-4-methyl-piperidin-3-yl)-N-methyl-2-chloro-7H-pyrrolo[2,3-D]pyrimidine-4-amine
1616760-97-4

N-((3R,4R)-4-methyl-piperidin-3-yl)-N-methyl-2-chloro-7H-pyrrolo[2,3-D]pyrimidine-4-amine

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
With 10% palladium hydroxide on charcoal; hydrogen In methanol at 50 - 55℃; under 5250.53 - 6000.6 Torr; for 4h; Solvent; Reagent/catalyst; Temperature; Pressure; Time;25 g
O-methyl-N-(4-methylpyridin-3-yl)carbamate
694495-63-1

O-methyl-N-(4-methylpyridin-3-yl)carbamate

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 5wt.% Rh on activated alumina; hydrogen / acetic acid / 10 h / 70 - 75 °C / 5250.53 - 6000.6 Torr
2: triethylamine / acetonitrile / 10 h / 65 - 70 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 60 - 70 °C / Inert atmosphere
4: hydrogenchloride / ethyl acetate / 0.5 h / 25 - 30 °C / pH 2 - 3
5: water; methanol / 8 - 9 h / 20 - 70 °C
6: potassium carbonate / ethyl acetate; water / pH 9 - 10
7: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
8: sodium hydroxide / water; acetone / 55 - 60 °C
9: trifluoroacetic acid / dichloromethane / 1 h / 5 - 10 °C
10: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
Multi-step reaction with 10 steps
1: 5wt.% Rh on activated alumina; hydrogen / acetic acid / 10 h / 70 - 75 °C / 5250.53 - 6000.6 Torr
2: triethylamine / acetonitrile / 10 h / 65 - 70 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 60 - 70 °C / Inert atmosphere
4: hydrogenchloride / ethyl acetate / 0.5 h / 25 - 30 °C / pH 2 - 3
5: water; methanol / 8 - 9 h / 20 - 70 °C
6: potassium carbonate / ethyl acetate; water / pH 9 - 10
7: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
8: trifluoroacetic acid / dichloromethane / 3 h / 5 - 10 °C
9: sodium hydroxide / water; acetone / 50 - 55 °C
10: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
Multi-step reaction with 7 steps
1.1: 5wt.% Rh on activated alumina; hydrogen / acetic acid / 10 h / 70 - 75 °C / 5250.53 - 6000.6 Torr
2.1: triethylamine / acetonitrile / 10 h / 65 - 70 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 60 - 70 °C / Inert atmosphere
4.1: ethyl acetate / 3 h / 25 - 30 °C
5.1: potassium carbonate / ethyl acetate; water / pH 9 - 10
6.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
7.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
7.2: Reflux
View Scheme
3-amino-4-methylpyridine
3430-27-1

3-amino-4-methylpyridine

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: potassium tert-butylate / 1 h / 10 - 15 °C
2: 5wt.% Rh on activated alumina; hydrogen / acetic acid / 10 h / 70 - 75 °C / 5250.53 - 6000.6 Torr
3: triethylamine / acetonitrile / 10 h / 65 - 70 °C
4: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 60 - 70 °C / Inert atmosphere
5: ethyl acetate / 3 h / 25 - 30 °C
6: potassium carbonate / ethyl acetate; water / pH 9 - 10
7: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
8: sodium hydroxide / water; acetone / 55 - 60 °C
9: trifluoroacetic acid / dichloromethane / 1 h / 5 - 10 °C
10: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
Multi-step reaction with 10 steps
1: potassium tert-butylate / 1 h / 10 - 15 °C
2: 5wt.% Rh on activated alumina; hydrogen / acetic acid / 10 h / 70 - 75 °C / 5250.53 - 6000.6 Torr
3: triethylamine / acetonitrile / 10 h / 65 - 70 °C
4: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 60 - 70 °C / Inert atmosphere
5: ethyl acetate / 3 h / 25 - 30 °C
6: potassium carbonate / ethyl acetate; water / pH 9 - 10
7: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
8: trifluoroacetic acid / dichloromethane / 3 h / 5 - 10 °C
9: sodium hydroxide / water; acetone / 50 - 55 °C
10: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
Multi-step reaction with 11 steps
1: potassium tert-butylate / 1 h / 10 - 15 °C
2: 5wt.% Rh on activated alumina; hydrogen / acetic acid / 10 h / 70 - 75 °C / 5250.53 - 6000.6 Torr
3: triethylamine / acetonitrile / 10 h / 65 - 70 °C
4: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 60 - 70 °C / Inert atmosphere
5: hydrogenchloride / ethyl acetate / 0.5 h / 25 - 30 °C / pH 2 - 3
6: water; methanol / 8 - 9 h / 20 - 70 °C
7: potassium carbonate / ethyl acetate; water / pH 9 - 10
8: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
9: sodium hydroxide / water; acetone / 55 - 60 °C
10: trifluoroacetic acid / dichloromethane / 1 h / 5 - 10 °C
11: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
methyl-(4-methylpiperidin-3-yI)carbamate

methyl-(4-methylpiperidin-3-yI)carbamate

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / acetonitrile / 10 h / 65 - 70 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 60 - 70 °C / Inert atmosphere
3.1: ethyl acetate / 3 h / 25 - 30 °C
4.1: potassium carbonate / ethyl acetate; water / pH 9 - 10
5.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
6.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
6.2: Reflux
View Scheme
Multi-step reaction with 7 steps
1.1: triethylamine / acetonitrile / 10 h / 65 - 70 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 60 - 70 °C / Inert atmosphere
3.1: hydrogenchloride / ethyl acetate / 0.5 h / 25 - 30 °C / pH 2 - 3
4.1: water; methanol / 8 - 9 h / 20 - 70 °C
5.1: potassium carbonate / ethyl acetate; water / pH 9 - 10
6.1: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
7.1: palladium 10% on activated carbon; hydrogen / methanol / 10 h / 45 - 55 °C / 3750.38 Torr
7.2: Reflux
View Scheme
Multi-step reaction with 8 steps
1: triethylamine / acetonitrile / 10 h / 65 - 70 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 60 - 70 °C / Inert atmosphere
3: ethyl acetate / 3 h / 25 - 30 °C
4: potassium carbonate / ethyl acetate; water / pH 9 - 10
5: potassium carbonate / acetonitrile; N,N-dimethyl-formamide / 6 h / 70 - 75 °C
6: sodium hydroxide / water; acetone / 55 - 60 °C
7: trifluoroacetic acid / dichloromethane / 1 h / 5 - 10 °C
8: 10% palladium hydroxide on charcoal; hydrogen / methanol / 4 h / 50 - 55 °C / 5250.53 - 6000.6 Torr
View Scheme
N-(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine
477600-70-7

N-(3R,4R)-(1-benzyl-4-methylpiperidin-3-yl)-methylamine

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate / water / 48 h / 110 °C / Sealed tube
2: hydrogen; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal / methanol / 45 °C / 6000.6 Torr
View Scheme
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

formaldehyd
50-00-0

formaldehyd

C14H21N5

C14H21N5

Conditions
ConditionsYield
With acetic acid; zinc In water at 20℃; Reagent/catalyst; Concentration;99.25%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

citric acid
77-92-9

citric acid

Tofacitinib citrate

Tofacitinib citrate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In butan-1-ol at 80℃; for 0.166667h;96.4%
Stage #1: tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate; ethyl 2-cyanoacetate With 1,8-diazabicyclo[5.4.0]undec-7-ene In butan-1-ol at 40℃; for 20h; Inert atmosphere;
Stage #2: citric acid In water; butan-1-ol at 22 - 81℃; for 2.5h; Inert atmosphere;
93%
Stage #1: tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate; ethyl 2-cyanoacetate With 1,8-diazabicyclo[5.4.0]undec-7-ene In butan-1-ol at 35 - 45℃; for 7h; Inert atmosphere;
Stage #2: citric acid In water; butan-1-ol at 20 - 90℃; Inert atmosphere;
90.3%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

cyanoacetic acid
372-09-8

cyanoacetic acid

tasocitinib

tasocitinib

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; Schlenk technique;96%
With potassium carbonate; 4-pyrrolidin-1-ylpyridine; diisopropyl-carbodiimide In dichloromethane at 35℃; for 1h; pH=7 - 8; Solvent; Reagent/catalyst; Temperature; Inert atmosphere; Industrial scale;89.7%
With 1,1'-carbonyldiimidazole In dichloromethane at 40℃; for 10h;89.21%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

tasocitinib

tasocitinib

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In methanol at 5 - 20℃; for 8h; Temperature; Solvent;91%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 20 - 30℃; for 24h;78%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran at 60 - 65℃; Solvent;76.9%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

3-(3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-(yl)amino)piperidin-1-yl)-3-oxopropionic acid

3-(3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-(yl)amino)piperidin-1-yl)-3-oxopropionic acid

Conditions
ConditionsYield
In acetonitrile at 20℃; Solvent; Temperature;87.7%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile citrate

3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile citrate

Conditions
ConditionsYield
Stage #1: tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate; ethyl 2-cyanoacetate With 1,8-diazabicyclo[5.4.0]undec-7-ene In butan-1-ol at 40℃; for 18h;
Stage #2: With citric acid monohydrate In water; butan-1-ol at 80℃; for 0.5h;
87.6%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

succinimidyl cyanoacetate
56657-76-2

succinimidyl cyanoacetate

tasocitinib

tasocitinib

Conditions
ConditionsYield
In ethanol at 20℃; for 2h;86%
In ethanol at 25℃; for 3h; Temperature; Time;
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In toluene at 40℃; for 2h; Large scale;
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

diethyl malonate
105-53-3

diethyl malonate

C18H25N5O3

C18H25N5O3

Conditions
ConditionsYield
With triethylamine In methanol for 9h; Reflux;85%
5-methyl-1,2-oxazole-4-carboxylic acid
42831-50-5

5-methyl-1,2-oxazole-4-carboxylic acid

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

((3R,4R)-4-methyl-3-(methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)(5-methylisoxazol-4-yl)methanone

((3R,4R)-4-methyl-3-(methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)(5-methylisoxazol-4-yl)methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate In dichloromethane at 20℃; for 3h; Inert atmosphere; Cooling with ice; Enzymatic reaction;80%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

cyanoacetic acid
372-09-8

cyanoacetic acid

N-methyl-N-[(3R,4R)-4-methyl-3-piperidyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine cyanoacetate

N-methyl-N-[(3R,4R)-4-methyl-3-piperidyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine cyanoacetate

Conditions
ConditionsYield
In acetonitrile at 60 - 65℃;80%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

cyanoacetic acid
372-09-8

cyanoacetic acid

citric acid
77-92-9

citric acid

Tofacitinib citrate

Tofacitinib citrate

Conditions
ConditionsYield
Stage #1: tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate; cyanoacetic acid With benzotriazol-1-ol In dichloromethane at 20℃; for 12h;
Stage #2: citric acid In acetone at 40℃; for 2h;
70%
Stage #1: cyanoacetic acid With pivaloyl chloride; triethylamine In dichloromethane at -15 - 0℃; for 2.5h;
Stage #2: tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate In dichloromethane at 0℃; for 1h;
Stage #3: citric acid In water; acetone at 55 - 65℃;
67.3%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

1-cyano-cyclopropanecarboxylic acid
6914-79-0

1-cyano-cyclopropanecarboxylic acid

1-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbonyl)cyclopropanecarbonitrile

1-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbonyl)cyclopropanecarbonitrile

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at -10 - 10℃;56.82%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

5-cyclopropylisoxazole-4-carboxylic acid
124845-04-1

5-cyclopropylisoxazole-4-carboxylic acid

(5-cyclopropylisoxazol-4-yl)((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)piperidin-1-yl)methanone

(5-cyclopropylisoxazol-4-yl)((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)piperidin-1-yl)methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate In dichloromethane at 20℃; for 1.5h; Inert atmosphere; Cooling with ice;53%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

5-Isopropyl-4-isoxazolecarboxylic acid
134541-05-2

5-Isopropyl-4-isoxazolecarboxylic acid

C20H26N6O2

C20H26N6O2

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate In dichloromethane at 20℃; for 1.5h; Inert atmosphere; Cooling with ice;53%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

N-((tert-butyloxy)carbonyl)iminodiacetic acid
56074-20-5

N-((tert-butyloxy)carbonyl)iminodiacetic acid

C30H41N11O2

C30H41N11O2

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide at 5 - 30℃; Reagent/catalyst; Temperature;43.7%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

2,2'-(4-methoxybenzyl)imino-diacetic acid
1217900-36-1

2,2'-(4-methoxybenzyl)imino-diacetic acid

C30H41N11O2

C30H41N11O2

Conditions
ConditionsYield
Stage #1: tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate; N-4-methoxyphenylmethyliminodiacetic acid With dmap; dicyclohexyl-carbodiimide at 10 - 35℃;
Stage #2: With palladium on activated charcoal; hydrogen at -10℃; under 11251.1 Torr;
40.8%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

methoxycarbonylimino-di-acetic acid

methoxycarbonylimino-di-acetic acid

C30H41N11O2

C30H41N11O2

Conditions
ConditionsYield
With 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide at 5 - 40℃; Temperature;35%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

methyl chloroformate
79-22-1

methyl chloroformate

methyl (3R,4R)-4-methyl-3-[methyl({7H-pyrrolo[2,3-d]pyrimidin-4-yl})amino]piperidine-1-carboxylate

methyl (3R,4R)-4-methyl-3-[methyl({7H-pyrrolo[2,3-d]pyrimidin-4-yl})amino]piperidine-1-carboxylate

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 0 - 20℃; for 0.333333h; Inert atmosphere; Schlenk technique;34%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

(S)-4-nitrophenyl 3-hydroxypyrrolidine-1-carboxylate
1269920-81-1

(S)-4-nitrophenyl 3-hydroxypyrrolidine-1-carboxylate

((S)-3-hydroxypyrrolidin-1-yl)((3R,4R)-4-methyl-3-(methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methanone
1259403-96-7

((S)-3-hydroxypyrrolidin-1-yl)((3R,4R)-4-methyl-3-(methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methanone

Conditions
ConditionsYield
With triethylamine In tert-butyl alcohol at 100℃; for 48h;33%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

acryloyl chloride
814-68-6

acryloyl chloride

1-((3R,4R)-4-methyl-3-(methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)prop-2-en-1-one

1-((3R,4R)-4-methyl-3-(methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)prop-2-en-1-one

Conditions
ConditionsYield
In dichloromethane at 0℃; for 1h;32%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

N-benzyliminodiacetic acid
3987-53-9

N-benzyliminodiacetic acid

C30H41N11O2

C30H41N11O2

Conditions
ConditionsYield
Stage #1: tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate; N-benzyliminodiacetic acid With dmap; dicyclohexyl-carbodiimide at 10 - 30℃;
Stage #2: With palladium on activated charcoal; hydrogen under 15001.5 Torr; for 10h; Temperature;
32%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

5-Ethyl-4-isoxazolecarboxylic acid
134541-03-0

5-Ethyl-4-isoxazolecarboxylic acid

(5-ethylisoxazol-4-yl)((3R,4R)-4-methyl-3-(methyl-(7H-pyrrolo[2,3-d]Pyrimidin-4-yl)amino)piperidin-1-yl)methanone

(5-ethylisoxazol-4-yl)((3R,4R)-4-methyl-3-(methyl-(7H-pyrrolo[2,3-d]Pyrimidin-4-yl)amino)piperidin-1-yl)methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate In dichloromethane at 20℃; for 1.5h; Inert atmosphere; Cooling with ice;31%
3-methyl isoxazole-4-carboxylic acid
17153-20-7

3-methyl isoxazole-4-carboxylic acid

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)(3-methylisoxazol-4-yl)methanone

((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)(3-methylisoxazol-4-yl)methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N,N-tetramethyluroniumhexafluorophosphate In dichloromethane at 20℃; for 3h; Inert atmosphere; Cooling with ice;23%
tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
477600-74-1

tert-butyl (3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate

acetyl chloride
75-36-5

acetyl chloride

1-{(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-ethanone

1-{(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-ethanone

Conditions
ConditionsYield
In pyridine; dichloromethane at 20℃; for 18h;15%

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View