DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:489-39-4
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inquiryTNJ is a chemical company since 2001. Our specialization, your Confidence ! We keep committing to meet the needs of both market and customers with our innovative technology, high stable quality products and excellent service. We always combine econ
Cas:489-39-4
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:489-39-4
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inquiryProduct Name: (+)-AROMADENDRENE Synonyms: 1H-Cycloprop[e]azulene, decahydro-1,1,7-trimethyl-4-methylene-, (1aR,4aR,7R,7aR,7bS)-(+)-;aromandendrene;(+)-AROMADENDRENE;AROMADENDRENE, (+);(1R,2S,8R,11R)-7-METHYLENE-3,3,11-TRIMETHYL-TRICYCL
Cas:489-39-4
Min.Order:1 Gram
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:489-39-4
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:489-39-4
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
superior quality Appearance:powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediates Transportation:as per your
Cas:489-39-4
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:489-39-4
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals
1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re
high quality AROMADENDRENE cas 489-39-4Appearance:Soily liquid Storage:It is recommended to store in a cool, dry and well ventilated areas and out of direct light. Store away from sources of heat or ignition. Keep containers well sealed when not in u
Cas:489-39-4
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inquiry1H-Cycloprop[e]azulene,decahydro-1,1,7-trimethyl-4-methylene-, (1aR,4aR,7R,7aR,7bS)-Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by expre
Cas:489-39-4
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:100mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any po
Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen
factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP
Changzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa
Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right
Cas:489-39-4
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inquiryOUR SERVICES Sourcing Service High quality, reliable supply, competitive pricing, regulatory compliance and fast delivery of your products are vital components of our sourcing strategy. We provide a one-stop sourcing service to global customers by s
Cas:489-39-4
Min.Order:1 Kilogram
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Type:Trading Company
inquiryShanghai LONGBANG , Boasts strong competitive advantages by our well-trained chemists with rich professional backgroud. We aim to win the market via quick response and fast delivery, as well as continous development for high-tech medical compoun
FINETECH INDUSTRY LIMITED is a LONDON based CRO company providing drug discovery & development services to worldwide clients. FINETECH INDUSTRY LIMITED supplies the (+)-AROMADENDRENE, CAS:489-39-4 with the most competitive price and the best quality.
High pure standard, Quick shippment COA with HPLC, MS and NMR spectra. Package:100mg Application:pharmaceutical industry, food industry, research
(+)-Aromadendrene, a sesquiterpenoid, is the major constituent of the essential oil of Eucalypfus globulus. Package:1 mL in glass bottle Application:(+)-Aromadendrene may be used as a chiral starting material to synthesize other sesquiterenes such as
Cas:489-39-4
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inquiryMethanesulfonic acid (1aR,4S,4aR,7R,7aR,7bS)-1,1,7-trimethyl-decahydro-cyclopropa[e]azulen-4-ylmethyl ester
(+)-aromadendrene
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In toluene at 100℃; for 18h; | 89% |
(1aR,4aR,7R,7aS,7bS)-1,1,7-Trimethyldecahydro-4H-cyclopropa[e]azulen-4-one
Methyltriphenylphosphonium bromide
(+)-aromadendrene
Conditions | Yield |
---|---|
Stage #1: Methyltriphenylphosphonium bromide With n-butyllithium In tetrahydrofuran at -78 - 0℃; for 0.166667h; Inert atmosphere; Stage #2: (1aR,4aR,7R,7aS,7bS)-1,1,7-Trimethyldecahydro-4H-cyclopropa[e]azulen-4-one In tetrahydrofuran at -78 - 20℃; for 24h; Inert atmosphere; | 60% |
Conditions | Yield |
---|---|
With pyridine; trichlorophosphate |
(+)-aromadendrene
Conditions | Yield |
---|---|
at 140℃; unter vermindertem Druck; |
methyl (+)-(1S,7R)-8,8-dimethyl-3-oxobicyclo<5.1.0>octane-4-carboxylate
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 15 steps 1: 100 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature 2: imidazole / dimethylformamide / 12 h / Ambient temperature 3: 90 percent / Ley's tetrapropylammonium perruthenate, 4-methylmorpholine N-oxide, molecular sieves / CH2Cl2 / 0.25 h / Ambient temperature 4: 1.) LDA, HMPA / 1.) THF, -78 deg C, 30 min, 2.) THF, from -78 deg C to RT, 4 h 5: 96 percent / PdCl2, CuCl, air / dimethylformamide; H2O / 4.5 h / Ambient temperature 6: 84 percent / NaHMDS, HMPA / tetrahydrofuran / 0.67 h / -78 - -50 °C / a) -78 deg C. 15 min, b) 0 deg C, 15 min, c) 50 deg C, 10 min 7: 1.) lithium hexamethyldisilazane, HMPA / 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to RT, 2 h 8: 86 percent / lithium tetramethyldisilazane, HMPA / tetrahydrofuran / 2 h / -78 - 20 °C 9: 93 percent / H2 / 5percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature 10: NaBH4 / methanol / 2 h / Ambient temperature 11: pyridine, DMAP / CH2Cl2 / 6 h / Ambient temperature 12: 68 percent / n-Bu3SnH, AIBN / toluene / 3 h / Heating 13: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 14: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 15: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 14 steps 1: imidazole / dimethylformamide / 12 h / Ambient temperature 2: 90 percent / Ley's tetrapropylammonium perruthenate, 4-methylmorpholine N-oxide, molecular sieves / CH2Cl2 / 0.25 h / Ambient temperature 3: 1.) LDA, HMPA / 1.) THF, -78 deg C, 30 min, 2.) THF, from -78 deg C to RT, 4 h 4: 96 percent / PdCl2, CuCl, air / dimethylformamide; H2O / 4.5 h / Ambient temperature 5: 84 percent / NaHMDS, HMPA / tetrahydrofuran / 0.67 h / -78 - -50 °C / a) -78 deg C. 15 min, b) 0 deg C, 15 min, c) 50 deg C, 10 min 6: 1.) lithium hexamethyldisilazane, HMPA / 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to RT, 2 h 7: 86 percent / lithium tetramethyldisilazane, HMPA / tetrahydrofuran / 2 h / -78 - 20 °C 8: 93 percent / H2 / 5percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature 9: NaBH4 / methanol / 2 h / Ambient temperature 10: pyridine, DMAP / CH2Cl2 / 6 h / Ambient temperature 11: 68 percent / n-Bu3SnH, AIBN / toluene / 3 h / Heating 12: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 13: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 14: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: pyridine, DMAP / CH2Cl2 / 6 h / Ambient temperature 2: 68 percent / n-Bu3SnH, AIBN / toluene / 3 h / Heating 3: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 4: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 5: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
(+)-(1S,2S,4R,7R)-4-tert-butyldimethylsiloxymethyl-8,8-dimethyl-2-(2-propenyl)bicyclo<5.1.0>octan-3-one
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1: 96 percent / PdCl2, CuCl, air / dimethylformamide; H2O / 4.5 h / Ambient temperature 2: 84 percent / NaHMDS, HMPA / tetrahydrofuran / 0.67 h / -78 - -50 °C / a) -78 deg C. 15 min, b) 0 deg C, 15 min, c) 50 deg C, 10 min 3: 1.) lithium hexamethyldisilazane, HMPA / 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to RT, 2 h 4: 86 percent / lithium tetramethyldisilazane, HMPA / tetrahydrofuran / 2 h / -78 - 20 °C 5: 93 percent / H2 / 5percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature 6: NaBH4 / methanol / 2 h / Ambient temperature 7: pyridine, DMAP / CH2Cl2 / 6 h / Ambient temperature 8: 68 percent / n-Bu3SnH, AIBN / toluene / 3 h / Heating 9: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 10: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 11: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
(+)-(1R,2S,4R,7S,8R,11S)-7-tert-butyldimethylsiloxymethyl-3,3,11-trimethyltricyclo<6.3.0.02,4>undecan-10-one
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: NaBH4 / methanol / 2 h / Ambient temperature 2: pyridine, DMAP / CH2Cl2 / 6 h / Ambient temperature 3: 68 percent / n-Bu3SnH, AIBN / toluene / 3 h / Heating 4: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 5: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 6: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
(+)-(1R,2R,4R,7S)-7-tert-butyldimethylsiloxymethyl-3,3-dimethyltricyclo<6.3.0.02,4>undec-8-en-10-one
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 1.) lithium hexamethyldisilazane, HMPA / 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to RT, 2 h 2: 86 percent / lithium tetramethyldisilazane, HMPA / tetrahydrofuran / 2 h / -78 - 20 °C 3: 93 percent / H2 / 5percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature 4: NaBH4 / methanol / 2 h / Ambient temperature 5: pyridine, DMAP / CH2Cl2 / 6 h / Ambient temperature 6: 68 percent / n-Bu3SnH, AIBN / toluene / 3 h / Heating 7: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 8: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 9: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
(+)-(1S,2S,4R,7R)-4-tert-butyldimethylsiloxymethyl-8,8-dimethyl-2-(2-oxopropyl)bicyclo<5.1.0>octan-3-one
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 84 percent / NaHMDS, HMPA / tetrahydrofuran / 0.67 h / -78 - -50 °C / a) -78 deg C. 15 min, b) 0 deg C, 15 min, c) 50 deg C, 10 min 2: 1.) lithium hexamethyldisilazane, HMPA / 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to RT, 2 h 3: 86 percent / lithium tetramethyldisilazane, HMPA / tetrahydrofuran / 2 h / -78 - 20 °C 4: 93 percent / H2 / 5percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature 5: NaBH4 / methanol / 2 h / Ambient temperature 6: pyridine, DMAP / CH2Cl2 / 6 h / Ambient temperature 7: 68 percent / n-Bu3SnH, AIBN / toluene / 3 h / Heating 8: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 9: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 10: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 68 percent / n-Bu3SnH, AIBN / toluene / 3 h / Heating 2: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 3: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 4: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
((1aR,4S,4aR,7R,7aR,7bS)-1,1,7-trimethyldecahydro-1H-cyclopropa[e]azulen-4-yl)methanol
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 2: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 15 steps 1: LiAlH4 / diethyl ether / 0.25 h / 0 °C 2: imidazole / dimethylformamide / 12 h / Ambient temperature 3: 90 percent / Ley's tetrapropylammonium perruthenate, 4-methylmorpholine N-oxide, molecular sieves / CH2Cl2 / 0.25 h / Ambient temperature 4: 1.) LDA, HMPA / 1.) THF, -78 deg C, 30 min, 2.) THF, from -78 deg C to RT, 4 h 5: 96 percent / PdCl2, CuCl, air / dimethylformamide; H2O / 4.5 h / Ambient temperature 6: 84 percent / NaHMDS, HMPA / tetrahydrofuran / 0.67 h / -78 - -50 °C / a) -78 deg C. 15 min, b) 0 deg C, 15 min, c) 50 deg C, 10 min 7: 1.) lithium hexamethyldisilazane, HMPA / 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to RT, 2 h 8: 86 percent / lithium tetramethyldisilazane, HMPA / tetrahydrofuran / 2 h / -78 - 20 °C 9: 93 percent / H2 / 5percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature 10: NaBH4 / methanol / 2 h / Ambient temperature 11: pyridine, DMAP / CH2Cl2 / 6 h / Ambient temperature 12: 68 percent / n-Bu3SnH, AIBN / toluene / 3 h / Heating 13: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 14: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 15: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 13 steps 1: 90 percent / Ley's tetrapropylammonium perruthenate, 4-methylmorpholine N-oxide, molecular sieves / CH2Cl2 / 0.25 h / Ambient temperature 2: 1.) LDA, HMPA / 1.) THF, -78 deg C, 30 min, 2.) THF, from -78 deg C to RT, 4 h 3: 96 percent / PdCl2, CuCl, air / dimethylformamide; H2O / 4.5 h / Ambient temperature 4: 84 percent / NaHMDS, HMPA / tetrahydrofuran / 0.67 h / -78 - -50 °C / a) -78 deg C. 15 min, b) 0 deg C, 15 min, c) 50 deg C, 10 min 5: 1.) lithium hexamethyldisilazane, HMPA / 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to RT, 2 h 6: 86 percent / lithium tetramethyldisilazane, HMPA / tetrahydrofuran / 2 h / -78 - 20 °C 7: 93 percent / H2 / 5percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature 8: NaBH4 / methanol / 2 h / Ambient temperature 9: pyridine, DMAP / CH2Cl2 / 6 h / Ambient temperature 10: 68 percent / n-Bu3SnH, AIBN / toluene / 3 h / Heating 11: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 12: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 13: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
tert-Butyl-dimethyl-((1aR,4S,4aR,7R,7aR,7bS)-1,1,7-trimethyl-decahydro-cyclopropa[e]azulen-4-ylmethoxy)-silane
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 2: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 3: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
(1S,4R,7R)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-8,8-dimethyl-bicyclo[5.1.0]octan-3-one
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1: 1.) LDA, HMPA / 1.) THF, -78 deg C, 30 min, 2.) THF, from -78 deg C to RT, 4 h 2: 96 percent / PdCl2, CuCl, air / dimethylformamide; H2O / 4.5 h / Ambient temperature 3: 84 percent / NaHMDS, HMPA / tetrahydrofuran / 0.67 h / -78 - -50 °C / a) -78 deg C. 15 min, b) 0 deg C, 15 min, c) 50 deg C, 10 min 4: 1.) lithium hexamethyldisilazane, HMPA / 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to RT, 2 h 5: 86 percent / lithium tetramethyldisilazane, HMPA / tetrahydrofuran / 2 h / -78 - 20 °C 6: 93 percent / H2 / 5percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature 7: NaBH4 / methanol / 2 h / Ambient temperature 8: pyridine, DMAP / CH2Cl2 / 6 h / Ambient temperature 9: 68 percent / n-Bu3SnH, AIBN / toluene / 3 h / Heating 10: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 11: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 12: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
(1aR,4S,7S,7aR,7bR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-1,1,7-trimethyl-1a,3,4,7,7a,7b-hexahydro-1H,2H-cyclopropa[e]azulen-6-one
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 93 percent / H2 / 5percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature 2: NaBH4 / methanol / 2 h / Ambient temperature 3: pyridine, DMAP / CH2Cl2 / 6 h / Ambient temperature 4: 68 percent / n-Bu3SnH, AIBN / toluene / 3 h / Heating 5: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 6: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 7: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
(1aR,4S,7R,7aR,7bR)-4-(tert-Butyl-dimethyl-silanyloxymethyl)-1,1,7-trimethyl-1a,3,4,7,7a,7b-hexahydro-1H,2H-cyclopropa[e]azulen-6-one
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 86 percent / lithium tetramethyldisilazane, HMPA / tetrahydrofuran / 2 h / -78 - 20 °C 2: 93 percent / H2 / 5percent Pd/C / methanol / 2 h / 760 Torr / Ambient temperature 3: NaBH4 / methanol / 2 h / Ambient temperature 4: pyridine, DMAP / CH2Cl2 / 6 h / Ambient temperature 5: 68 percent / n-Bu3SnH, AIBN / toluene / 3 h / Heating 6: 100 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 7: 100 percent / Et3N, DMAP / CH2Cl2 / 2 h / 0 °C 8: 89 percent / DBU / toluene / 18 h / 100 °C View Scheme |
Conditions | Yield |
---|---|
In chloroform for 48h; Ambient temperature; | 97% |
for 48h; Ambient temperature; | 96.6% |
In chloroform at 20℃; for 48h; | 74% |
(+)-aromadendrene
(1aR,4R,7R,7bS)-1,1,4,7-tetramethyl-1a,2,3,4,5,6,7,7b-octahydro-1H-cyclopropa[e]azulene
Conditions | Yield |
---|---|
With aluminum oxide at 100℃; | 96% |
With aluminum oxide; potassium In hexane at 0 - 20℃; for 12h; | 71% |
(+)-aromadendrene
[1aR-(1aα,7α,7aβ,7bα)]-1a,2,3,5,6,7,7a,7b-octahydro-1,1,4,7-tetramethyl-1H-cycloprop[e]azulene
Conditions | Yield |
---|---|
With potassium tert-butylate In dimethyl sulfoxide at 100℃; | 80% |
(+)-aromadendrene
(1aR)-4ξ-hydroxymethyl-1,1,7c-trimethyl-(1ar,4ac,7at,7bc)-decahydro-cycloprop[e]azulen-4ξ-ol
Conditions | Yield |
---|---|
With osmium(VIII) oxide; 4-methylmorpholine N-oxide In water; tert-butyl alcohol at 20℃; for 64h; | 79% |
With potassium permanganate In acetone | |
(i) OsO4, Et2O, (ii) aq. KOH, benzene, EtOH, mannitol; Multistep reaction; |
(+)-aromadendrene
phenylselenyl triflate
A
C21H30OSe
B
C21H30OSe
Conditions | Yield |
---|---|
With water In acetonitrile at 0 - 20℃; for 40h; optical yield given as %de; | A 56% B 40% |
Conditions | Yield |
---|---|
Stage #1: phenylselenyl triflate With sodium azide In chloroform at 0℃; for 0.5h; Stage #2: (+)-aromadendrene In acetonitrile at 20℃; for 30h; Further stages.; | A 54% B 16% |
Conditions | Yield |
---|---|
Stage #1: (+)-aromadendrene With ferrous(II) sulfate heptahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ozone In methanol; water at -78 - 20℃; for 0.0833333h; Stage #2: With magnesium bis(monoperoxyphthalate)hexahydrate In methanol; water at 0℃; for 2h; | A 54% B 37% |
(+)-aromadendrene
(1aR,4aR,7R,7aS,7bS)-1,1,7-Trimethyldecahydro-4H-cyclopropa[e]azulen-4-one
Conditions | Yield |
---|---|
Stage #1: (+)-aromadendrene With sodium hydrogencarbonate; ozone In methanol; dichloromethane at -78℃; for 0.5h; Stage #2: With triphenylphosphine In methanol; dichloromethane at 20℃; Inert atmosphere; | 43% |
With ozone | |
Multi-step reaction with 2 steps 1: O3 / pentane / -45 °C 2: 95 percent / Ph3P / CDCl3 View Scheme | |
Multi-step reaction with 2 steps 1: aq. KMnO4 / acetone 2: aq. NaIO4 / methanol View Scheme | |
Multi-step reaction with 2 steps 1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / tert-butyl alcohol; water / 64 h / 20 °C 2: sodium periodate / water; methanol / 2 h / 20 °C / Inert atmosphere View Scheme |
(+)-aromadendrene
Conditions | Yield |
---|---|
With hexane; fluorosulfonylchloride; silver nitrate at -115 - -110℃; | 26% |
Conditions | Yield |
---|---|
Stage #1: isocyanate de chlorosulfonyle; (+)-aromadendrene In dichloromethane at 23℃; for 2h; Stage #2: With triethylamine In dichloromethane at 23℃; for 3h; Stage #3: With water In dichloromethane at 23℃; for 24h; diastereoselective reaction; | 25% |
(+)-aromadendrene
A
(1S,2S,4R,7R,8R,11R)-3,3,11-trimethyl-7-hydroxymethyl-tricyclo<6.3.0.02,4>undecan-7-ol
B
(1S,2S,3S,4R,7R,8R,11R)-3,7-bis(hydroxymethyl)-3,11-dimethyltricyclo<6.3.0.02,4>undecan-7-ol
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide for 168h; Bacillus megaterium DSM 32; | A 4 mg B 7 mg |
(+)-aromadendrene
Conditions | Yield |
---|---|
With nitrosylchloride |
Conditions | Yield |
---|---|
With fluorosulfonylchloride at -115 - -110℃; | A 65 % Chromat. B 18 % Chromat. |
With fluorosulfonylchloride; fluorosulphonic acid 2.) (C2H5)2O; Yield given. Multistep reaction. Yields of byproduct given; |
(+)-aromadendrene
Conditions | Yield |
---|---|
With formic acid Heating; Yield given; |
(+)-aromadendrene
Conditions | Yield |
---|---|
With methanol; fluorosulfonylchloride; fluorosulphonic acid 2.) (C2H5)2O; Yield given. Multistep reaction. Yields of byproduct given; |
(+)-aromadendrene
Conditions | Yield |
---|---|
With formic acid Heating; Yield given; |
(+)-aromadendrene
Conditions | Yield |
---|---|
With ozone In pentane at -45℃; |
(+)-aromadendrene
(1S,2S,4R,7R,8R,11R)-3,3,11-trimethyl-7-hydroxymethyl-tricyclo<6.3.0.02,4>undecan-7-ol
Conditions | Yield |
---|---|
With osmium(VIII) oxide; potassium carbonate; potassium hexacyanoferrate(III) In water; tert-butyl alcohol for 24h; Ambient temperature; | 900 mg |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 96 percent / K/Al2O3 / 100 °C 2.1: BF3*Et2O / CH2Cl2 / 3 h / 20 °C 2.2: 42 mg / sulfur / 1,3,5-trimethyl-benzene / 160 °C View Scheme |
(+)-aromadendrene
(1aR,4S,7R,7aS,7bR)-1,1,4,7-tetramethyl-1a,2,3,4,6,7,7a,7b-octahydro-1H-cyclopropa[e]azulen-4-ol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 80 percent / KOtBu / dimethylsulfoxide / 100 °C 2: 96 percent / oxone; NaHCO3; 18-crown-6 / CH2Cl2; H2O; acetone / 2 h / 0 °C 3: 57 percent / diethylamine; n-butyllithium / diethyl ether; hexane / 0 - 20 °C View Scheme |
(+)-aromadendrene
(1aR,4S,4aR,7R,7aS,7bR)-1,1,4,7-tetramethyldecahydro-4aH-cyclopropa[e]azulene-4,4a-diol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 80 percent / KOtBu / dimethylsulfoxide / 100 °C 2: 54 percent / KMnO4 / ethanol; H2O / 2 h / 0 °C View Scheme |
(+)-aromadendrene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 80 percent / KOtBu / dimethylsulfoxide / 100 °C 2: 54 percent / KMnO4 / ethanol; H2O / 2 h / 0 °C 3: acetic acid; iodine / tetrahydrofuran; H2O / 96 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 80 percent / KOtBu / dimethylsulfoxide / 100 °C 2: 96 percent / oxone; NaHCO3; 18-crown-6 / CH2Cl2; H2O; acetone / 2 h / 0 °C 3: 45 percent / sulfuric acid / tetrahydrofuran; H2O / 2 h / 30 °C View Scheme |
(+)-aromadendrene
(1R,3aR,4aS,6aR,7aR,7bS)-1,4a,7,7-tetramethyldecahydrocyclopropa[7,8]azuleno[3a,4-b]oxirene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 80 percent / KOtBu / dimethylsulfoxide / 100 °C 2: 96 percent / oxone; NaHCO3; 18-crown-6 / CH2Cl2; H2O; acetone / 2 h / 0 °C View Scheme |
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